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Article Citation - WoS: 7Citation - Scopus: 6A platinum blue complex exerts its cytotoxic activity via DNA damage and induces apoptosis in cancer cells(Wiley, 2017) Adiguzel, Zelal; Ozalp-Yaman, Seniz; Celik, Gokalp; Salem, Safia; Bagci-Onder, Tugba; Senbabaoglu, Filiz; Acilan, CeydaHere, we describe the characteristics of a Pt-blue complex [Pt-4(2-atp)(8)(H2O)(OH)] (2-atp: 2-aminothiophenol) as a prodrug for its DNA-binding properties and its use in cancer therapy. The nature of the interaction between the Pt-blue complex and DNA was evaluated based on spectroscopic measurements, the electronic absorption spectra, thermal behavior, viscosity, fluorometric titration, and agarose gel electrophoresis. Our results suggested that the compound was able to partially intercalate DNA and appeared to induce both single- and double-stranded breaks (DBS) on DNA in vitro, but no DSBs in cells. The ability of the compound to induce DNA damage was dependent on reactive oxygen species (ROS) in vitro. There was also elevated formation of ROS and SOD expression in response to drug treatment in cell culture. The complex was found to be more cytotoxic to cancer cells in comparison with noncancer controls using WST-1 assay. The mean of cell death was determined to be apoptosis as assessed via biochemical, morphological, and molecular observations, including DNA condensation/fragmentation analysis, live cell imaging microscopy, TUNEL analyses, and increase in the levels of pro-apoptotic genes such as Bag3, Bak, Bik, Bmf, and Hrk. Hence, the Pt-blue complex under study grants premise for further studies.Article Citation - WoS: 139Citation - Scopus: 140CaXH3 (X = Mn, Fe, Co) perovskite-type hydrides for hydrogen storage applications(Wiley, 2020) Surucu, Gokhan; Gencer, Aysenur; Candan, Abdullah; Gullu, Hasan H.; Isik, MehmetHydrogen storage is one of the attractive research interests in recent years due to the advantages of hydrogen to be used as energy source. The studies on hydrogen storage applications focus mainly on investigation of hydrogen storage capabilities of newly introduced compounds. The present paper aims at characterization of CaXH3 (X: Mn, Fe, or Co) perovskite-type hydrides for the first time to understand their potential contribution to the hydrogen storage applications. CaXH3 compounds have been investigated by density functional theory studies to reveal their various characteristics and hydrogen storage properties. CaXH3 compounds have been optimized in cubic crystal structure and the lattice constants of studied compounds have been obtained as 3.60, 3.50, and 3.48 angstrom for X: Mn, Fe, and Co compounds, respectively. The optimized structures have negative formation enthalpies pointing out that studied compounds are thermodynamically stable and could be synthesized experimentally. The gravimetric hydrogen storage densities of X: Mn, Fe, and Co compounds were found in as 3.09, 3.06, and 2.97 wt%, respectively. The revealed values for hydrogen storage densities indicate that CaXH3 compounds may be potential candidates for hydrogen storage applications. Moreover, various mechanical parameters of interest compounds like elastic constants, bulk modulus, and Poisson's ratio have been reported throughout the study. These compounds were found mechanically stable with satisfying Born stability criteria. Further analyses based on Cauchy pressure and Pugh criterion, showed that they have brittleness nature and relatively hard materials. In addition, the electronic characteristics, band structures, and associated partial density of states of CaXH3 hydrides have been revealed. The dynamic stability behavior of them was verified based on the phonon dispersion curves.Article Role of Latissimus Dorsi-Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients With Chronic Low Back Pain: A Randomised Clinical Trial(Wiley, 2025) Ulug, Naime; Kodak, Seyde Busra; Kodak, Muhammed Ihsan; Aslan, Sema NurBackground Fascial stretching is gaining interest as a potential intervention for pain management. However, evidence regarding the effect of latissimus dorsi-thoracolumbar fascia (LD-TLF) complex stretching in patients with chronic low back pain (CLBP) remains limited. Therefore, this study aimed to investigate the effects of LD-TLF complex stretching on pain-related factors and disability in patients with CLBP. Methods Thirty patients with CLBP were randomly assigned to a study group (n = 15; 7 men, 8 women) and a control group (n = 15; 7 men, 8 women). The study group received 4 weeks of LD-TLF complex stretching in combination with conventional physiotherapy, while the control group received conventional physiotherapy only. Outcomes were assessed before and after the interventions, including primary measures of pain pressure thresholds (PPT) at thoracolumbar fascia levels (L1, L3 and 12th costa), and secondary measures included the Pain Sensitivity Questionnaire (PSQ), the effects of pain on daily activities measured by the Brief Pain Inventory (BPI), and disability assessed by the Oswestry Disability Questionnaire (ODQ). Results Pre- and post-treatment PPTs, at the L1, L3 vertebrae and 12th costa levels, demonstrated significant differences between the study group and control groups. Post-treatment thresholds were significantly higher compared to pre-treatment thresholds (p < 0.001, eta p(2) = 0.67; p < 0.001, eta p(2) = 0.61; p < 0.001, eta p(2) = 0.74). Additionally, significant improvements were found in PSC, BPI and ODQ scores in the study group compared to the control group (p < 0.05). Conclusion The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF complex stretching, when used in combination with conventional physiotherapy, appears to provide improved pain thresholds, decreased pain sensitivity and pain during activity, as well as reduced disability compared to conventional physiotherapy alone in patients with CLBP.Article Epistemic Extraction Zones in Migration Studies: Rethinking Over-Research and Research Fatigue Among Syrian Refugees in Turkey(Wiley, 2025) Ozdemir, ZelalThis paper explores the phenomenon of over-research among Syrian refugees in Turkey, highlighting how sustained and repetitive research attention has created research saturation zones that shape both refugee experiences and knowledge production. Drawing on unstructured conversations with six Syrian refugees in Ankara, the study examines how research fatigue manifests not only as reluctance to participate but also as strategic responses through which refugees navigate frequent encounters with researchers. While existing literature has addressed research fatigue and ethics in refugee studies, less attention has been given to how academic incentives, humanitarian logics, and policy imperatives intersect to produce systematic inequalities in knowledge production. To address this gap, the paper advances the concept of epistemic extraction zones, referring to contexts where knowledge is persistently mined from marginalized communities to satisfy institutional demands with limited reciprocity or epistemic agency. This conceptual lens shifts the debate from individual withdrawal to the structural political economy of knowledge production. The analysis identifies three key dynamics. First, the emergence of research saturation zones in contexts of protracted displacement, where the same communities are repeatedly targeted for study; second, refugees' strategic yet ambivalent engagement with research, combining pragmatic hope with critical awareness of its limited effects; and third, the paradoxical consequences of over-research, where intensified attention produces epistemic extraction that narrows the circulation of knowledge and reinforces hierarchies. The article also reflects critically on the researcher's own position within these dynamics. By theorizing epistemic extraction zones, the paper contributes not only to refugee studies but also to broader sociological debates on power, inequality, and the ethics of knowledge production, highlighting the need for more reflexive and politically accountable research practices.Article Citation - WoS: 19Citation - Scopus: 21Development of Effective Bimetallic Catalyst for High-Temperature Pem Fuel Cell To Improve Co Tolerance(Wiley, 2021) Al-Tememy, Mogdam Gassy Hussein; Devrim, YilserIn this study, it is aimed to examine the effect of multi-walled carbon nanotube doped graphene nanoplatelet (MWCNT-GNP) supported PtPd bimetallic catalyst on the performance of the high-temperature proton-exchange membrane fuel cell (HT-PEMFC). In addition, PtPd/GNP and PtPd/MWCNT bimetallic catalysts were also investigated for performance comparison. The characterizations of these catalysts were examined by ICP-MS, XRD, HR-TEM, and TGA analysis. The electrochemical characterizations of the catalysts were performed for both cyclic voltammetry (CV) and CO stripping experiments, as well as HT-PEMFC tests. The specific surface area (SSA) for PtPd/GNP and PtPd/MWCNT catalysts was obtained as 148 and 137 m(2)/g, respectively, while the highest SSA was achieved as 164 m(2)/g for PtPd/MWCNT-GNP. The performance of the catalysts was confirmed with the HT-PEMFC tests, based on the H-2/air and reformate gas/air experiments. The electrocatalytic results display that PdPt bimetallic catalysts exhibited higher catalytic property than that of commercial Pt/C catalyst. The highest performance was achieved with PtPd/MWCNT-GNP catalyst as 0.390 and 0.310 W/cm(2)at 160 degrees C for H-2/air and reformat/air, respectively. The obtained results indicate that the PtPd/MWCNT-GNP catalyst is appropriate for HT-PEMFC operations.Article Citation - WoS: 4Citation - Scopus: 3Boundary Value Problems on Half-Line for Second-Order Nonlinear Impulsive Differential Equations(Wiley, 2018) Akgol, S. D.; Zafer, A.We obtain sufficient conditions for existence and uniqueness of solutions of boundary value problems on half-line for a class of second-order nonlinear impulsive differential equations. Our technique is different than the traditional ones, as it is based on asymptotic integration method involving principal and nonprincipal solutions. Examples are provided to illustrate the relevance of the results.Article How Do Visual, Auditory and Motor Dual-Tasking Each Affect Swallowing and Chewing Function?(Wiley, 2024) Begen, Sena Nur; Arslan, Selen SerelBackground: It can be challenging to perform a second task at the same time as swallowing. Objective(s)The study aimed to investigate the effect of visual, auditory and motor dual-tasking on swallowing and chewing function in healthy young adults. Method: Right-handed healthy adults without any psychological and cognitive problems were included in the study. Swallowing was evaluated based on the dysphagia limit in different liquid textures such as water and nectar consistencies, and chewing was evaluated by the Test of Masticating and Swallowing Solids. For the second task, visual and auditory performance was assessed using reaction time, and the motor performance was assessed using a bilateral tapping task. Assessments were performed in two steps: baseline and dual-task. For baseline, all evaluation methods were applied individually. After completing the baseline assessment, dual-task assessment were carried out the following day. For dual-task assessment, the swallowing and chewing tasks were performed simultaneously with visual, auditory and motor tasks. Results: Results showed a significant decrease in dysphagia limit in the nectar consistency, and significant increase in chewing time, visual reaction time and tapping rate (right-left) when compared to baseline and dual-task conditions (chi(2)(3) = 9.61, p = .02; chi(2)(3) = 9.02, p = .02; chi(2)(3) = 28.09, p < .001; chi(2)(3) = 28.97, p < .001; chi(2)(3) = 21.56, p < .001, respectively). However, there were no differences in dysphagia limit in the water and auditory reaction time compared to baseline and dual-task conditions (chi(2)(3) = 3.18, p = .36; chi(2)(3) = 2.56, p = .50, respectively). Conclusion: Results shedding light on how simultaneous dual tasks can influence swallowing and chewing. Dual-tasking cause a decrease in both swallowing/chewing and the visual/motor performances. These results may provide valuable information for designing interventions or strategies aimed at improving or maintaining optimal swallowing and chewing during in various populations during daily life.Article Citation - WoS: 4Citation - Scopus: 5Stability Analysis of an Epidemic Model With Vaccination and Time Delay(Wiley, 2023) Turan, Mehmet; Adiguzel, Rezan Sevinik; Koc, F.This paper presents an epidemic model with varying population, incorporating a new vaccination strategy and time delay. It investigates the impact of vaccination with respect to vaccine efficacy and the time required to see the effects, followed by determining how to control the spread of the disease according to the basic reproduction ratio of the disease. Some numerical simulations are provided to illustrate the theoretical results.Article Citation - WoS: 21Citation - Scopus: 21Investigation of Hydrogen Production From Sodium Borohydride by Carbon Nano Tube-Graphene Supported Pdru Bimetallic Catalyst for Pem Fuel Cell Application(Wiley, 2022) Al-Msrhad, Tuqa Majeed Hameed; Devrim, Yilser; Uzundurukan, Arife; Budak, YagmurIn this study, hydrogen (H-2) generation from the hydrolysis of sodium borohydride (NaBH4) catalyzed by bimetallic Palladium-Ruthenium (PdRu) supported on multiwalled carbon nanotube-graphene (MWCNT-GNP) hybrid material is investigated. The effect of various parameters such as temperature, NaBH4 concentration, and catalyst loading and effect of base concentration are examined to observed optimum operating conditions. Experimental results show that the PdRu/MWCNT-GNP bimetallic catalyst has high catalytic activity on NaBH4 hydrolysis reaction. It has been found that PdRu/MWCNT-GNP catalyst shows low activation energy of 22.33 kJ/mol for hydrolysis reaction of NaBH4. The PdRu/MWCNT-GNP catalyst also exhibits H-2 generation rate of 79.2 mmol/min center dot g(cat) at 45 degrees C. It shows good cycle stability in the catalyst reusability test and retained 89% of its initial catalytic activity after fifth use. The high catalytic activity of the PdRu/MWCNT-GNP catalyst makes it promising in H-2 generation from NaBH4 hydrolysis for commercial proton exchange membrane fuel cell (PEMFC) applications.Article Citation - WoS: 4Citation - Scopus: 4An Integrated Economy-Demography Model Reframed in a System Dynamics Setting(Wiley, 2019) Dural-Selcuk, Gozdem; Tunc, Huseyin; Tarim, S. ArmaganIn recent history, there has been an increasing concern about population aging and the associated increased economic burden in terms of high health-care expenses and pension payments. The need for decision support tools that can explore population dynamics has become a prominent issue. This study presents a comprehensive framework where one can scrutinize the key demographic drives of fertility (Total Fertility Rate/Age-Specific Fertility Rate) over macroeconomic indicators (technology, education, human capital) under exogenous mortality. The integrated model in this article is developed based on a reformulation of the unified growth theory. In the reformulated model, namely the "economy-demography model," the population age/sex structure is preserved, age-specific mortality is included, and fertility is measured in conventional demographic terms. The model is then presented in system dynamics framework, and its practical use is showcased with data obtained from the Turkish Statistical Institute. Copyright (c) 2020 System Dynamics Society
