WOS

Permanent URI for this collectionhttps://ada.atilim.edu.tr/handle/123456789/18

Browse

Now showing 1 - 20 of 4344

The Psychometric Properties of the Hogg Eco-Anxiety Scale in the Turkish Context
(Hogrefe Ag-hogrefe Ag Suisse, 2023) Turkarslan, Kutlu Kagan; Kozak, Ekin Doga; Yildirim, Julide Ceren
The Effects of Substituting Cladribine for Fludarabine on Outcomes of a Reduced Intensity Conditioning Regimen
(Lippincott Williams & Wilkins, 2024) Sahin, Ugur; Urlu, Selin Merih; Gokmen, Ayla; Arslan, Onder; Ozcan, Muhit
Syntactic Scrambling in Broca's Aphasia: a Turkish Sample
(Karger, 2025) Arslan, Berkay; Ciyiltepe, Muge Muzeyyen; Karaman, Muzeyyen
Introduction: Broca's aphasia (BA) is a language disorder that causes grammatical errors in the language production skills of patients. Contemporary studies revealed the fact that patients with BA (PBA) also have difficulty in analyzing the meaning of phrases and sentences and comprehending the real meaning of the discourse produced by the speaker. The purpose of this study was to investigate possible effect of syntactic movement by changing the word positions in the sentence with morphological markers in order to produce clauses without changing the meaning on the phrasal comprehension skills of Turkish-speaking patients with BA. Method: A total of 300 participants were divided as study (n = 150) and control (n = 150) groups between ages of 27-89. A test that included 20 relative clauses and 9 noun clauses (in total 29 phrases) was assigned to the PBA and the control group (CG). Relative clause phrases originated from simple sentences by adding suffixes to the verb as a function of Turkish morphology. Each suffix indicated a specific noun, object, or subject, and each figure in the test was related to one of them. A researcher asked participants to match the demanded clause with the 6 possibly related pictures for relative clause and 3 for noun clauses. Results: Findings indicated that BA patients in our study had a lack of comprehending relative clauses due to the syntactic movement of words in the object and subject positions. Compared to the responses of the CG, PBA had significantly lower scores when the object and subject positions have moved from their original positions. BA patients also obtained significantly lower scores in object type questions. Conclusion: Our findings support the fact that comprehension processing in PBA should be investigated profoundly to be able to understand the nature of the disorder in different languages. In Turkish, syntactic movement of words to form a relative clause caused the BA patients to have significant problems to assign the semantic roles to the words in the existence of movement or change in their original positions.
Millimeter-Wave Sar Imaging for Sub-Millimeter Defect Detection With Non-Destructive Testing
(Mdpi, 2025) Yalcinkaya, Bengisu; Aydin, Elif; Kara, Ali
This paper introduces a high-resolution 77-81 GHz mmWave Synthetic Aperture Radar (SAR) imaging methodology integrating low-cost hardware with modified radar signal characteristics specifically for NDT applications. The system is optimized to detect minimal defects in materials, including low-reflectivity ones. In contrast to the existing studies, by optimizing key system parameters, including frequency slope, sampling interval, and scanning aperture, high-resolution SAR images are achieved with reduced computational complexity and storage requirements. The experiments demonstrate the effectiveness of the system in detecting optically undetectable minimal surface defects down to 0.4 mm, such as bonded adhesive lines on low-reflectivity materials with 2500 measurement points and sub-millimeter features on metallic targets at a distance of 30 cm. The results show that the proposed system achieves comparable or superior image quality to existing high-cost setups while requiring fewer data points and simpler signal processing. Low-cost, low-complexity, and easy-to-build mmWave SAR imaging is constructed for high-resolution SAR imagery of targets with a focus on detecting defects in low-reflectivity materials. This approach has significant potential for practical NDT applications with a unique emphasis on scalability, cost-effectiveness, and enhanced performance on low-reflectivity materials for industries such as manufacturing, civil engineering, and 3D printing.
Predictive Factors of Cardiac Function Recovery and Mortality in Patients With Reduced Ejection Fraction Undergoing Transcatheter Aortic Valve Implantation
(Mdpi, 2025) Guney, Murat Can; Suygun, Hakan; Polat, Melike; Ayhan, Huseyin; Keles, Telat; Ertop, Zeynep Seyma Turinay; Bozkurt, Engin
Background and Objectives: Patients with reduced left ventricular ejection fraction (LVEF) are reported to have unfavorable outcomes following transcatheter aortic valve implantation (TAVI). This study aims to evaluate outcomes and identify predictive factors for LVEF recovery following TAVI in patients with reduced LVEF. Materials and Methods: This retrospective study analyzed 114 patients with symptomatic severe aortic stenosis (AS) with LVEF < 40% who underwent TAVI between 2011 and 2023 at two centers. Echocardiographic parameters, including LVEF, ventricular dimensions, and relative wall thickness (RWT), were assessed at baseline and during follow-up. The outcomes and predictors of substantial LVEF improvement and mortality were analyzed using univariate and multivariate logistic regression methods. Results: Anemia (OR = 4.345, 95% CI: 1.208-15.626, p = 0.024), RWT (OR = 1.224, 95% CI: 1.064-1.407, p = 0.005), and early post-procedural changes in left ventricular end-systolic dimension (LVESD) (OR = 1.297, 95% CI: 1.037-1.622, p = 0.023) and left ventricular end-diastolic dimension (LVEDD) (OR = 1.346, 95% CI: 1.034-1.753, p = 0.027) at one-month follow-up were identified as significant factors associated with LVEF recovery at one year. Regarding factors related to mortality, higher baseline AVMG levels were associated with a lower probability of death after one year (OR = 0.926, 95% CI: 0.875-0.979, p = 0.007). Conversely, a more limited increase in LVEF from baseline to the final follow-up was linked to poor prognosis and higher mortality at one year (95% CI: 1.045-1.594, p = 0.018). Conclusions: This study demonstrated that TAVI in patients with AS and reduced LVEF can be performed with high procedural success, low mortality, and significant improvement in cardiac function during follow-up. Additionally, anemia, baseline RWT, and early post-procedural changes in LVESD and LVEDD were identified as factors associated with LVEF recovery. Baseline AVMG and changes in LVEF at the final follow-up were found to be significant predictors of total mortality.
Examining the Relationship Between Fear of Childbirth During Pregnancy and Prenatal Attachment
(Springer Publishing Co, 2025) Sari, Tugba; Gurhan, Nermin
OBJECTIVE: Giving birth is one of the most stressful events in many women's lives. Fear of childbirth is common among pregnant women, also it becomes a serious issue if it affects daily life. Psychological problems such as fear of birth in pregnancy negatively affect prenatal bonding. The aim of this study is to investigate the relationship between fear of birth and prenatal attachment in pregnancy and examine the risk factors. METHODS: The sample of the study consisted of 500 pregnant women at 20 and above weeks of gestation. Descriptive statistics (percentage, mean, standard deviation), independent groups t test, One Way ANOVA, Pearson correlation and multiple linear regression analyzes were used to evaluate the research data. RESULTS: It was found that the mean score of the pregnant women from the Wijma delivery expectancy/experience questionnaire version A scale was 58.93 +/- 21.21 and the mean score of the Prenatal Attachment scale was 52.73 +/- 8.75. As the correlation between the mean scores of the scales was examined, it was determined that there was a significant and high correlation in the negative direction. CONCLUSIONS: As a result, fear of childbirth was found to be moderate in the study and there is an inverse relationship between fear of childbirth and prenatal attachment. In addition, fear of childbirth is affected by sociodemographic factors and obstetric characteristics.
Baby Steps of Parenting: Turkish Adaptation of Infancy Parenting Styles Questionnaire and Mother- and Infant-Related Characteristics Affecting Parenting in Infancy
(Wiley, 2025) Bahtiyar-Saygan, Bahar
The crucial importance of parenting for human development is well known, yet there has been little investigation, particularly regarding infancy parenting. This study investigates mother- and infant-related characteristics affecting parenting styles in the first year after birth. Additionally, adapting an Infancy Parenting Styles Questionnaire (IPSQ) to Turkish is aimed. In total, 110 mothers with babies in the first year of their lives (M age in months = 6.39, SDage in months = 3.72; 70 girls) participated in the study. Mothers filled out the IPSQ, Early Parenting Attitudes Questionnaire (EPAQ), Karitane Parental Self-Confidence Scale (KPSC), and Parental Stress Index-Short Form (PSI-SF). Four components emerged: involvement, discipline, anxiety, and routine. The IPSQ was found to be reliable (alpha = .81) and valid. The findings revealed that income, the number of children, and parental confidence were significant predictors for involvement; maternal education, parental confidence, parenting stress, and sleep wellness of the baby were significant predictors for discipline; and the number of caregivers and parental confidence were significant predictors for routine sub-components. Also, results indicated higher involvement and lower discipline in primiparous compared to multiparous mothers. The findings were discussed in light of the literature regarding the antecedents of parenting and its developmental outcomes.
Association Between the Degree of Nonalcoholic Fatty Liver Disease and Nocturnal Hypertension
(Lippincott Williams & Wilkins, 2025) Astan, Ramazan; Kacmaz, Fehmi; Saricam, Ersin; Ozyer, Esref Umut; Ilkay, Erdogan
Nighttime blood pressure (BP) decreases have prognostic significance owing to circadian patterns. The prevalence of nonalcoholic fatty liver disease (NAFLD) has rapidly increased in recent years. We aimed to investigate circadian blood pressure changes in patients with NAFLD. The present study included 114 patients diagnosed with nonalcoholic fatty liver disease and no previous hypertension diagnosis. Thirty patients comprised the control group (no hepatosteatosis and no hypertension). The patients were divided into 3 groups based on nocturnal BP dipping. Blood pressure patterns using night-day ratios were classified as dipper (ratio <= 0, 9), nondipper (0, 9 < ratio <= 1, 0), or nocturnal hypertension (ratio > 1, 0). There were no significant differences in sex, age, presence of diabetes, or biochemical test results between the groups. According to the blood pressure pattern, the nondipper rate in the hepatosteatosis group was significantly higher than that in the control group. Patients were compared in terms of the presence and severity of hepatosteatosis according to night blood pressure patterns. A significant difference was observed between the groups (P < .001 and P = .001, respectively). We found an association between hepatosteatosis severity and night blood pressure patterns. Patients with nonalcoholic fatty liver disease have a higher incidence of nocturnal hypertension. We observed impaired circadian blood pressure changes in patients with nonalcoholic fatty liver disease.
Moocs and Economic Disadvantage: a Path Analysis of 3.5 Million Mitx Learners
(Routledge Journals, Taylor & Francis Ltd, 2025) Cagiltay, Nergiz Ercil; Toker, Sacip; Cagiltay, Kursat
Massive Online Open Courses (MOOCs) are offered by universities and companies to provide quality education to anyone, anyplace and at any time. The impact of economic disadvantage on these courses has not been fully explored despite several studies. This study aimed to investigate the impact of country's income level on the success of 3,523,692 learners from 204 countries enrolled in 174 MITx MOOCs. The countries were classified as low- and lower-middle-income (L&LM) or high- and upper-middle-income (H&UM). A structural equation modelling with multigroup analysis conducted. The findings revealed that learners in the L&LM group performed better academically. Completion rates were 66% for L&LM and 25% for H&UM, and certification rates were 95% for L&LM and 99% for H&UM. This shows that L&LM learners may be more motivated because they believe MOOCs might help their careers. These results are essential for creating MOOCs that fit diverse learner demographics.
Does Dexmedetomidine Induce Bone Regeneration in Cranial Defects in Rabbits
(Taylor & Francis Ltd, 2025) Erkan, Gozde Nur; Tekin, Umut; Boyacioglu, Ozge; Korkusuz, Petek; Orhan, Kaan; Kirman, Betul; Onder, Mustafa Ercument
Dexmedetomidine has been shown to exert protective and curative effects on various tissues and organs in different pathological processes. This study aimed to investigate the effect of dexmedetomidine on the regeneration process after making holes in the parietal bones of rabbits. Twenty-four male Oryctolagus cuniculus rabbits were allocated to three groups, and an 8-mm circular parietal critical-sized bone defect was induced in each animal. Group_C (control) received saline; Group_LD (low dose) was given dexmedetomidine 2.75 mu g/kg; Group_HD (high dose), dexmedetomidine 5.5 mu g/kg; all were administered intraperitoneally for 7 days. After 8 weeks the bones were examined by micro-computed tomography (micro-CT) and histomorphometry. The results indicated that regeneration was improved in both the dexmedetomidine-treated groups. The lower dose increased the bone volume ratio (BV/TV) more than the higher dose. Trabecular thickness, connectivity value, and connectivity density were also higher in Group_LD than in Group_HD. Significant intramembranous ossification was observed in the dexmedetomidine-treated groups, and active osteoblasts were seen at the margins of new bone trabeculae. We conclude that dexmedetomidine, especially at the lower dosage, increases osteoblastic activity and regeneration quality.
Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions
(Springer, 2025) Dehghani, Sam; Ocakci, Ozgecan; Hatipoglu, Pars Tan; Ozalp, Veli Cengiz; Tevlek, Atakan
Neurodegenerative diseases (NDs) like Alzheimer's, Parkinson's, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis and effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity and specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability and insufficient blood-brain barrier (BBB) permeability. Recently, exosomes-nanoscale vesicles packed with proteins, RNAs, and lipids-have emerged as promising agents with the potential to reshape diagnostic and therapeutic approaches to these diseases. Unlike conventional drug carriers, they naturally traverse the BBB and can deliver bioactive molecules to affected neural cells. Their molecular cargo can influence cell signaling, reduce neuroinflammation, and potentially slow neurodegenerative progression. Moreover, exosomes serve as non-invasive biomarkers, enabling early and precise diagnosis while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded with therapeutic molecules, enhance this capability by targeting diseased neurons and overcoming conventional treatment barriers. By offering enhanced specificity, reduced immunogenicity, and an ability to bypass physiological limitations, exosome-based strategies present a transformative advantage over existing diagnostic and therapeutic approaches. This review examines the multifaceted role of exosomes in NDDs, emphasizing their diagnostic capabilities, intrinsic therapeutic functions, and transformative potential as advanced treatment vehicles.
A Novel Technique- Subendometrial Autologous Platelet Rich Plasma Injection in Patients With Unresponsive Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: a Prospective Cohort Study
(BMC, 2025) Cakiroglu, Yigit; Tohma, Yusuf Aytac; Yuceturk, Aysen; Karaosmanoglu, Ozge; Aslan, Ilke Ozer; Kopuk, Sule Yildirim; Tiras, Bulent
Background The purpose of this study was to investigate the effects of subendometrial PRP injection on endometrial thickness and pregnancy outcomes in patients with a history of unresponsive thin endometrium undergoing frozen-thawed embryo transfer (FET). Methods This prospective cohort study was conducted at Acibadem Mehmet Ali Aydinlar University-Istanbul, Turkey. Women with a history of suboptimal endometrial proliferation (< 7 mm) were offered to participate in the study. Group 1 consisted of 100 individuals who consented to subendometrial PRP injection, while Group 2 consisted of 100 individuals who did not accept PRP injection. Within ten days of the menstrual cycle ending, autologous PRP was produced by centrifuging peripheral blood and administered transvaginally into the subendometrial region under ultrasound monitoring. After the PRP procedure, 14 days of oral estradiol supplementation were started as part of the hormonal treatment on the 2-4th day of the second menstrual cycle. Women determined to have adequate endometrial thickness following the initiation were scheduled for embryo transfers. Embryo transfer was scheduled for women who were found to have adequate endometrial thickness after the initiation of progesterone. Pregnancy (positive serum hCG) and livebirth rates were followed. Results A total of 200 women (age 36.4 +/- 5.8) were included in the study. Endometrial thickness increased after PRP therapy as compared to the control group (7.7 +/- 1.9 mm vs. 6.1 +/- 1.2 mm; p < 0.01). Three women (3.0%) in the PRP group conceived spontaneously, whereas 97 women (97.0%) attempted FET; no spontaneous pregnancies occurred in the control group. Compared to 75/100 (75% of the total) in the control group, 33/97 women (34.0%) in the PRP group were unable to undertake ET because of persistently unresponsive thin endometrium or fluid in the endometrial cavity (p < 0.001). The PRP group had a considerably higher percentage of positive serum hCG tests than the control group (25.8% vs. 9.0%; p = 0.002). Additionally, the PRP group had a higher clinical pregnancy rate (22.7% vs. 7.0%; p = 0.002). The live birth rate was significantly higher in the PRP group than the controls (17.5% vs. 2.0%; p < 0.001). Conclusions In women with a history of suboptimal endometrial development, subendometrial PRP injection was associated with improved endometrial thickness and livebirth rate.
Experiences of Parents Who Have Children With Disabilities
(Lippincott Williams & Wilkins, 2025) Acar, Serra; Er, Dudu Melek; Volk, Katherine T.; Spence, Christine M.
This study aimed to understand the experiences of parents who have young children with disabilities in T & uuml;rkiye during COVID-19. We conducted a qualitative analysis of semistructured virtual interviews with eight parents. We used a collective within-case and across-case approach to analyze and interpret the interviews. Parents noted difficulties with the EI/ECSE programs and the need for individualized and functional services for their children. Furthermore, parents reported the need for high-quality, inclusive early childhood programs and the importance of well-trained educators. Parents also expressed interest in learning more about how to support their child's development and learning. Results may inform research, policy, and practice initiatives for children with disabilities and their families. The findings highlight the importance of including parent voices in the continued capacity-building efforts of EI/ECSE systems.
Detection of Sexually Transmitted Infection Agents in Pregnant Women Using Multiplex Polymerase Chain Reaction Method
(BMC, 2025) Bakir, Ayfer; Cendek, Busra Demir; Usluca, Selma; Aral, Murat; Korkut, Gizem; Morkoc, Mehmet; Keskin, Huseyin Levent
BackgroundSexually transmitted infections (STIs) are a significant public health concern that can lead to serious outcomes such as infertility, pregnancy complications, and neonatal infections. This study aimed to evaluate the prevalence of STI and their associated risk factors in symptomatic and asymptomatic pregnant women.MethodsBetween July and October 2024, a total of 300 pregnant women in their third trimester, including 113 symptomatic and 187 asymptomatic individuals aged 18 to 45 years, who sought antenatal care at the Gynecology and Obstetrics Clinic of Ankara Etlik City Hospital, were included in the study. The detection of STIs agents in vaginal swab samples was performed using multiplex polymerase chain reaction in the Molecular Diagnosis Laboratory of the Department of Microbiology.ResultsThe overall prevalence of STIs was 34.3% (103/300), with single and multiple infections accounting for 28.3% and 6.0% of cases, respectively. The most frequently detected pathogens were Ureaplasma parvum/urealiticum (29.0%), Mycoplasma hominis (4.6%), and Chlamydia trachomatis (2.3%). Co-infections were commonly observed between Ureaplasma parvum/urealiticum and Mycoplasma hominis. No significant difference in STI prevalence was observed between the symptomatic (35.4%) and asymptomatic (33.7%) groups. Co-infection with non-STI bacterial agents, such as Gardnerella vaginalis and Streptococcus agalactiae, increased the risk of STIs by 1.96 times (p = 0.006).ConclusionsThis study revealed that STIs occur at similar rates among symptomatic and asymptomatic pregnant women. This finding highlights the critical importance of detecting asymptomatic cases to prevent the spread of silent infections and to safeguard maternal and neonatal health. Ureaplasma parvum/urealiticum were identified as the most common pathogens. Given that co-infections with non-STI bacterial agents significantly increase the risk of STIs, multiplex PCR-based multicenter and prospective studies are essential to refine screening strategies for pregnant women.
Protective Effects of Bosentan Via Endothelin Receptor Antagonism in Experimental Ischemia-Reperfusion Injury in the Lower Limb of Rats
(Dove Medical Press Ltd, 2025) Demirtas, Hueseyin; Oezer, Abdullah; Guelcan, Mehmet Burak; Yigman, Zeynep; Kuecuek, Ayseguel; Tekin, Esra; Arslan, Mustafa
Objective: This study aimed to evaluate the protective effects of bosentan, a dual endothelin receptor antagonist, against skeletal muscle ischemia-reperfusion injury (IRI) in rats. Methods: A total of 24 male Wistar Albino rats were divided into four groups: control (C, n=6), bosentan-treated (B, n=6), ischemiareperfusion (IR, n=6), and bosentan plus ischemia-reperfusion (B+IR, n=6). Bosentan (10 mg/kg) was administered 30 minutes prior to reperfusion. In the IR and B+IR groups, ischemia was induced using vascular bulldog clamps for 45 minutes, followed by 120 minutes of reperfusion. Results: Histological and biochemical assessments revealed significant differences among the groups. The disorganization and degeneration scores of the muscle cells in the B+IR group were significantly lower than those in the IR group (P = 0.001). The degree of interstitial edema in the IR group was markedly more severe than in the C and B groups (all P < 0.001), while the interstitial edema score in the B+IR group was significantly lower than that in the IR group (P < 0.001). The total muscle injury scores were markedly reduced in the B+IR group compared to the IR group (P < 0.001). Biochemically, TAS levels were significantly higher in the B+IR group compared to the IR group (1.03 f 0.18 vs 0.59 f 0.10 mmol/L, P = 0.016). Conversely, TOS (1.97 f 0.39 vs 2.86 f 0.43 IU/mg, P < 0.001) and OSI levels (P < 0.001) were significantly lower in the B+IR group. Additionally, paraoxonase (PON-1) enzyme activity was significantly reduced in the B+IR group compared to the IR group (P < 0.001). These findings suggest that bosentan exerts its protective effects by antagonizing endothelin-1 receptors, thereby mitigating vasoconstriction, oxidative stress, and inflammation. The observed reductions in muscle cell disorganization, interstitial edema, hemorrhage, neutrophil infiltration and oxidative stress markers underscore bosentan's potential as a therapeutic agent for managing ischemia-reperfusion injury. Conclusion: Bosentan demonstrates significant protective effects against skeletal muscle IRI by reducing oxidative stress and inflammation through endothelin receptor antagonism. These findings underscore bosentan's potential as a therapeutic agent for mitigating ischemia-reperfusion injury in vascular surgeries and managing critical limb ischemia in clinical settings. Further research is warranted to explore the long-term effects of bosentan on muscle recovery and systemic health following ischemia-reperfusion injury.
Fcnc Decays of Spin-1/2 Double Heavy Baryons To Spin-3/2 Single Heavy Baryons
(E D P Sciences, 2024) Aliev, Tahmasib; Askan, Emre; Ozpineci, Altug; Sarac, Yasemin
In recent years, there have been many discoveries in the spectroscopy of hadrons containing heavy quarks. Almost all baryons containing a single heavy quark are discovered in experiments. The quark model predicts the existence of many baryons with double heavy quarks. Among the possible double heavy baryons, only Xi(+)(cc) and Xi(++)(cc) have been experimentally observed in LHCb. Flavor-changing neutral current (FCNC) processes represent a promising platform for precise testing of SM and looking for new physics beyond the SM. In this study, the weak decays of spin-1/2 double heavy baryons to spin3/2 single heavy baryons induced by FCNC are studied within the light cone QCD sum rules method. First, the transition form factors of Xi(0,-)(bb) -> Xi(*0,(l) over bar l)(b), Xi(0,-)(bb) -> Sigma(*0,(l) over bar l)(b), Omega(-)(bb) -> Sigma(b)*(-(l) over barl), Omega(-)(bb) -> Sigma(*0,(l) over bar l)(b) decays are calculated. Then, the corresponding decay widths are estimated using the results for the form factors.
Predicting Software Functional Size Using Natural Language Processing: an Exploratory Case Study
(IEEE, 2024) Unlu, Huseyin; Tenekeci, Samet; Ciftci, Can; Oral, Ibrahim Baran; Atalay, Tunahan; Hacaloglu, Tuna; Demirors, Onur
Software Size Measurement (SSM) plays an essential role in software project management as it enables the acquisition of software size, which is the primary input for development effort and schedule estimation. However, many small and medium-sized companies cannot perform objective SSM and Software Effort Estimation (SEE) due to the lack of resources and an expert workforce. This results in inadequate estimates and projects exceeding the planned time and budget. Therefore, organizations need to perform objective SSM and SEE using minimal resources without an expert workforce. In this research, we conducted an exploratory case study to predict the functional size of software project requirements using state-of-the-art large language models (LLMs). For this aim, we fine-tuned BERT and BERT_SE with a set of user stories and their respective functional size in COSMIC Function Points (CFP). We gathered the user stories included in different project requirement documents. In total size prediction, we achieved 72.8% accuracy with BERT and 74.4% accuracy with BERT_SE. In data movement-based size prediction, we achieved 87.5% average accuracy with BERT and 88.1% average accuracy with BERT_SE. Although we use relatively small datasets in model training, these results are promising and hold significant value as they demonstrate the practical utility of language models in SSM.
An Example of the Threat From Italy To Turkey: Piracy in the Mediterranean
(Selcuk Univ, Inst Turkish Studies, 2024) Birlik, Gultekin K.
In August 1937, with the sinking of Spanish ships in front of Bozcaada and the sighting of foreign submarines in the Sea of Marmara, the Italian threat from piracy affected Turkey for the first time. While Turkey took measures against foreign submarines, including sinking them in the Sea of Marmara, it endeavored to prevent the possibilities that could create an atmosphere of conflict with Italy in the Aegean Sea. In the Anglo-French plan, which was first discussed at the Nyon Conference against piracy, it was envisaged that the north of the Aegean Sea would be controlled by the Turkish and the Soviet Union, and the south of it would be controlled by the navies of Greece and Yugoslavia. Due to the tension between the Soviet Union and Italy, Atat & uuml;rk saw this situation as ananti-Italy initiative and brought up the issue of giving assurance to Turkey against Italy. Prime Minister & Idot;smet & Idot;n & ouml;n & uuml; also thought that this situation harbored the possibility of conflict with Italy and argued that guarantees should be requested from England and France. As a result of the objections of Greece and Yugoslavia as well as Turkey; England and France had to undertake duty in the Aegean Sea against piracy. The fact that Turkey, Greece and Yugoslavia did not want Italy to take part in the Aegean Sea during the negotiations for Italy's participation in the Mediterranean Agreements, and that they would not allow it to enter the territorial waters and ports, shows that the Balkan Pact states implemented a common policy against Italy. The Turkish Ministry of Foreign Affairs' advocacy that in the face of the problems experienced in the process of Italy's accession to the Mediterranean Agreements, it was necessary to establish a policy together with Greece and Yugoslavia, explains this situation
Optimal Design and Technoeconomic Analysis of On-Site Hydrogen Refueling Station Powered by Wind and Solar Photovoltaic Hybrid Energy Systems
(Pergamon-elsevier Science Ltd, 2025) Ozturk, Reyhan Atabay; Devrim, Yilser
In this study, a grid-connected on-site hydrogen filling station (HRS) integrated with renewable energy systems is designed and examined for different daily hydrogen refueling capacities. The installation location of the HRS is selected in Izmir (Turkey) and daily solar radiation and wind speed data are used in the calculations. The HRS station was integrated with a hybrid energy system using photovoltaic panels (PV), wind turbine (WT) and PV/ WT and five different daily refueling scenarios were investigated. A techno-economic analysis is conducted for the designed HRS system, considering the initial investment capital, installation and operating costs. The levelized cost of hydrogen (LCOH) is evaluated according to different refueling capacity scenarios, periods of operation and renewable energy installation capacities. The lowest LCOH is obtained as 4.5 /kg H2 in the PVintegrated HRS system for a 20-year investment scenario. The results prove the suitability of the HRS system for integrating renewable energy in the identified region. It is recommended to integrate analytical models for the system components to increase the reliability of the design and optimization process in future planned studies.
Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damagein Rats with Experimental Lower-Extremity Ischemia–Reperfusion Injury
(MDPI, 2025) Demirtas, Hueseyin; Ozer, Abdullah; Yildirim, Alperen Kutay; Dursun, Ali Dogan; Sezen, Saban Cem; Arslan, Mustafa; https://orcid.org/0000-0001-9056-0025; Basic Sciences
Background and Objectives: Ischemia–reperfusion (I/R) injury can affect multiple distant organs following I/R in the lower extremities. BPC-157’s anti-inflammatory and free radical-neutralizing properties suggest its potential in mitigating ischemia–reperfusion damage. This study evaluates the protective effects of BPC-157 on remote organ damage, including the kidneys, liver, and lungs, in a rat model of skeletal muscle I/R injury. Materials and Methods: A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB). Some 45 min of ischemia of lower extremity was followed by 2 h of reperfusion of limbs. BPC-157 was applied to groups B and I/RB at the beginning of the procedure. After 2 h of reperfusion, liver, kidney and lung tissues were harvested for biochemical and histopathological analyses. Results: In the histopathological examination, vascular and glomerular vacuolization, tubular dilation, hyaline casts, and tubular cell shedding in renal tissue were significantly lower in the I/RB group compared to other groups. Lung tissue showed reduced interstitial edema, alveolar congestion, and total damage scores in the I/RB group. Similarly, in liver tissue, sinusoidal dilation, necrotic cells, and mononuclear cell infiltration were significantly lower in the I/RB group. Additionally, the evaluation of TAS, TOS, OSI, and PON-1 revealed a statistically significant increase in antioxidant activity in the liver, lung, and kidney tissues of the I/RB group. Conclusions: The findings of this study demonstrate that BPC-157 exerts a significant protective effect against distant organ damage in the liver, kidneys, and lungs following lower extremity ischemia–reperfusion injury in rats.

Browse

Recent Submissions