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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14411/19

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Policy Frameworks Without Practice? Exploring Marine Governance and Climate Integration Challenges in Türkiye
(Elsevier Ltd, 2026) Karlı, A.
The marine-climate nexus has emerged as a critical frontier in global environmental governance, yet its integration into national policy frameworks remains uneven. This article examines the case of Türkiye, a middle-income country with extensive coastlines and increasing exposure to climate risks, to explore how marine and climate governance interact in practice. Drawing on 22 semi-structured interviews with experts from government, civil society, and academia, the study applies thematic analysis to identify six interrelated challenges: (1) the gap between legal frameworks and implementation, (2) crisis-based governance, (3) institutional fragmentation and coordination deficits, (4) dependence on European Union funding and external alignment, (5) societal indifference and limited marine literacy, and (6) the contested discourse of the blue economy. The findings demonstrate that although Türkiye has adopted robust legal instruments and aligned with EU standards, enforcement and institutional integration remain weak. Governance is often reactive, fragmented, and externally driven, with limited societal demand for ambitious reforms. These dynamics reflect broader patterns in global marine-climate governance but are compounded by Türkiye’s context specific political and institutional constraints. The article argues that bridging the persistent policy-practice gap will require stronger institutional coordination, investments in capacity and literacy, and reframing the blue economy as a vehicle for climate adaptation and mitigation rather than narrow economic growth. © 2025 Elsevier Ltd.
Earthquake Response Framework With IoT-Based E-Government Services
(Modestum, 2026) Mishra, A.; Alzoubi, Y.I.; Ibrahim, T.
Earthquakes present a genuine threat to both lives and property, necessitating the minimization of their impact wherever possible. This is especially critical in countries like Iraq, which suffer from inadequate infrastructure. Consequently, this study developed a framework aimed at bolstering Iraq’s current disaster management system to respond to earthquakes. The designation of this system stems from its integration of information and communication technology principles alongside the Internet of things (IoT). The framework’s development was built based on related literature and data collected from websites related to disaster management, including the Ministry of Environment and the Ministry of Communication. The resultant framework was constructed utilizing unified modeling language diagrams, including both use-case and activity diagrams. This endeavor represents one of the few initiatives undertaken in the context of Iraq. Future research endeavors focusing on disaster planning in Iraq and similar contexts may utilize the findings of this study as a foundational resource. © 2026 by Author/s and Licensed by Modestum DOO, Serbia.
Mean Radiant Temperature Sensing: Comparison of Methods for a Non-Uniform Radiant Floor Heating
(Springer Science and Business Media Deutschland GmbH, 2026) Özbey, M.F.; Licina, D.; Meggers, F.; Khovalyg, D.
Non-uniform radiant floor heating is increasingly explored for improving localized and personalized thermal comfort. Accurate mean radiant temperature (Tr) measurement is crucial due to its separation from air temperature (Ta) unlike convective systems. This study evaluates the accuracy of Tr obtained using the globe thermometer versus a novel mini.RES cube sensor and examines the differences between Ta and Tr in non-uniform heating environments. Experiments were conducted in a 62 m3 climatic chamber in Fribourg, Switzerland, with four cases: one without heating, two with non-uniform heating to simulate radiant asymmetry, and one with uniform heating for comparison. Additionally, an uncertainty analysis was performed to evaluate measurement precision for the Tr measurements using the globe thermometer. The results indicate that the globe thermometer method can introduce errors of up to 4% in determining the Tr. Moreover, the uncertainty values for the Tr values were found between 1.60 ℃ and 2.31 ℃. In cases with non-uniform heating available, the Tr was found to vary by more than 2 ℃ than the Ta, highlighting the need to consider Tr separately when assessing thermal comfort. These findings emphasize the error of obtaining the Tr with globe thermometer and the difference between Tr and Ta in non-uniform heating scenarios. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.
Reinterpreting Architectural Precedents: the Enduring Relevance and Transformative Capacity of Villa Savoye’s Design Principles
(Istanbul Teknik Universitesi, Faculty of Architecture, 2025) Cinar, Sinem
This paper examines the evolving role of architectural precedents, focusing on Le Corbusier’s Villa Savoye, and emphasizes their continued relevance and transformative capacity within architectural design culture. It illustrates how engagement with precedents influences their reinterpretation and adaptation in changing contexts. Villa Savoye, a defining example of Modern Architecture, gained renewed attention during the COVID-19 pandemic, particularly through its freestanding washbasin at the entrance. This feature suggested a transitional, hygienic space addressing emerging concerns about sanitization upon returning home. Such recognition highlights how precedents can acquire new meaning when viewed through altered perspectives. Building on the idea that precedents like Villa Savoye offer fresh insights as inquiries evolve, this paper extends discourse on precedent and design. It explores the project’s continued relevance to contemporary architecture, emphasizing adaptability of its design principles. The study assesses the lasting impact of these principles—pilotis, open plan, roof garden, horizontal windows, free façade, and architectural promenade— on both Le Corbusier’s later works and contemporary practices. Through an interpretive-historical methodology, the research integrates primary sources and theoretical critiques to illustrate how evolving perspectives shape the relationship between precedent and design. Comparative analyses examine reinterpretations of these principles in Le Corbusier’s later works and contemporary architecture. Ultimately, this study contributes to architectural literature by framing precedents as dynamic resources that facilitate meaningful dialogue between past and present. It emphasizes their capacity to revitalize architectural culture, generating continuous insights in response to evolving challenges. © 2025, Istanbul Teknik Universitesi, Faculty of Architecture. All rights reserved.
Observation of Collider Neutrinos without Final State Muons with the SND at LHC Experiment
(American Physical Society, 2025) Abbaneo, D.; Ahmad, S.; Albanese, R.; Alexandrov, A.; Alicante, F.; Androsov, K.; Zamora-Saá, J.
We report the observation of neutrino interactions without final state muons at the LHC, with a significance of 6.4σ. A dataset of proton-proton collisions at s=13.6 TeV collected by SND@LHC in 2022 and 2023 is used, corresponding to an integrated luminosity of 68.6 fb-1. Neutrino interactions without a reconstructed muon are selected, resulting in an event sample consisting mainly of neutral-current and electron neutrino charged-current interactions in the detector. After selection cuts, 9 neutrino interaction candidate events are observed with an estimated background of 0.32 events. © 2025 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.
If Europe Lived the Same Lifestyle: Insights Into Cardiovascular Risk From the European Social Survey
(KeAi Communications Co., 2025) Valko, M.; Walker, M.D.; Htoon, April; Dumlao, Jocelyn; Lane, H.; Lee, Isabella G.; Bursová, J.
Background: Cardiovascular disease remains the leading cause of mortality across the European region. Despite marked regional variations, cross-national differences in underlying risk factors have received comparatively little attention. Objective: To use European Social Survey, a unique cross-European dataset, to examine regional patterns in prevalence and lifestyle risks. Methods: This study employs clustering analysis and nested logistic modelling. Counterfactual analysis was conducted to illustrate how lifestyle modifications could reduce risk. Results: The prevalence of heart problems was highest in Latvia (25.6 %, 95 % CI: 23.0 to 28.2), Lithuania (17.6 %, 95 % CI: 15.5 to 19.7), and Bulgaria (14.9 %, 95 % CI: 13.4 to 19.4). Regionally, heart problems were higher in Northern and Eastern Europe (15 % and 11.9 %) than Western and Southern Europe (10.8 % and 9.5 %). Among the risk factors, modelling emphasised the importance of modifiable factors including education, body mass index and physical activity. Conclusion: The results underline that cardiovascular disease is influenced by interrelated socioeconomic, environmental and lifestyle determinants. Public policy interventions could be targeted at those countries where greatest reductions are obtainable and concentrate on interventions on those lifestyle traits identified. The study utilised a social science dataset, thereby illustrating how multidisciplinary resources can benefit epidemiological research. © 2025
Psychological Benefits and Detrimental Effects of Online Social Networking
(IGI Global, 2022) Orta, I.M.; Celik-Orucu, M.Ç.
With the growing prevalence of wireless communication technologies, social networking sites (SNSs) such as Facebook, Twitter, etc. have become an important venues for interpersonal communication. This chapter provides a detailed overview of the current literature on online social networking with respect to its beneficial and detrimental effects on psychological wellbeing. In particular, it provides empirical evidence for the associations of SNS use with depression, self-esteem, loneliness, subjective wellbeing, social anxiety, attachment, personality traits, and addiction. Furthermore, it identifies the characteristics of individuals who are more prone to social networking, and presents possible mediators and moderators playing a role in the relationship between social networking and mental health. The chapter overall provides a comprehensive guideline to parents, researchers, educators, healthcare, and communication professionals to the issue of online social networking from a psychological perspective. © 2022 by IGI Global. All rights reserved.
Citation - Scopus: 2
Stress, Coping, and Social Media Use
(IGI Global, 2022) Demirtepe-Saygılı, D.
Social media has become a part of people’s lives and many psychological processes are suggested to be related with social media use. This chapter examines social media use from a stress and coping perspective. Social media can be a stressor for users with the content of posts they see, with a fear of negative evaluation, as an unhealthy attachment to social media accounts, and as a result of cyberbullying. Social media use can also be a problem-focused coping as a source of information, an emotion-focused coping as a distraction, and a source of social support. Lastly, it can be a predictor or a part of well-being as well as a moderator or mediator between coping and well-being. After elaborating on social media use as a part of the coping process, implications for research and practice are discussed. The key points from a coping viewpoint are specified for users, parents, teachers, and professionals. While problematic use of social media can be part of dysfunctional coping and a worse well-being, healthy use can help individuals deal with stresses and lead to a better well-being. © 2022 by IGI Global. All rights reserved.
How TikTok Works for Digital Diplomacy During Conflict/War Times: The Cases of Russia-Ukraine and Israel-Gaza Conflicts
(Routledge Journals, Taylor & Francis Ltd, 2025) Artan Ozoran, Beris; Seyidov, Ilgar; Erdogan, Burak
During times of conflict and war, public diplomacy undergoes a significant transformation, with strategic communication shifting from traditional channels to highly visual and participatory digital platforms. Among these, TikTok has emerged as a key arena for states to shape perceptions and mobilize international audiences. This study explores how TikTok is utilized as a tool of digital diplomacy by examining the official accounts of Ukraine and Israel during the Russia - Ukraine war and the Israel - Gaza conflict. Drawing on Strategic Narrative Theory (SNT), the analysis categorizes state-produced content into system, identity, and issue narratives and investigates how these narrative types effect audience engagement on the platform. By integrating narrative analysis with quantitative engagement metrics, this research not only extends SNT into the context of short-form video platforms but also contributes to the growing literature on digital diplomacy in wartime contexts.
Reconfiguring Stoicism: Convergence of Self-Improvement and Masculinity on TikTok
(Taylor & Francis Ltd, 2025) Agaoglu, Erhan
This research examines the multimodal representations of Stoic content within TikTok. The research aimed to explore the multifaceted structure of an emerging digital philosophy discourse and its implications for contemporary socio-cultural dynamics. It explores a fragmented version of Stoicism, focussing on the affordances of algorithm-driven platforms and modularity principles. For multimodal discourse analysis, 20 highly viewed (>300,000) videos under the hashtags of #stoic and #stoicism are selected through purposeful sampling. It identifies the emergence of a fragmented Stoicism, built upon platform affordances and audio-visual modularity. Emerging themes include self-improvement, being dangerous and traditional masculinity remarking a divergence from popular and classical interpretations of Stoicism. Through these key themes, construction of an arbitrary link between hegemonic masculinity, glorified individualism and Stoicism is explored. Employing elements of aggression, self-isolation and self-improvement, TikTok content creates a novel discourse of Stoicism which is elusive, abstract, and reliant on visually driven narratives.
Persuasive Appeals, Thematic Content, and Affordances on TikTok: Evidence From the 2023 Turkey Presidential Elections
(Routledge Journals, Taylor & Francis Ltd, 2025) Artan Ozoran, Beris; Seyidov, Ilgar; Agaoglu, Erhan
TikTok has become a central arena for political communication, especially in engaging younger voters. This study examines how Recep Tayyip Erdo & gbreve;an and Kemal K & imath;l & imath;& ccedil;daro & gbreve;lu employed TikTok during the 2023 Turkish Presidential Election by analysing 265 videos through quantitative content analysis. Rather than directly measuring voter attitudes, we focus on how leaders' use of affordances (association, editability), thematic content, and rhetorical appeals related to audience engagement (likes, comments, shares). Results show that both leaders prominently highlighted the economy and relied on pathos-driven appeals, consistent with personalization in Turkish political campaigning. Regression analyses revealed that K & imath;l & imath;& ccedil;daro & gbreve;lu's 'other' and 'law/justice' themes significantly boosted engagement, while high use of association features (hashtags and mentions) reduced it. In Erdo & gbreve;an's case, ethos and pathos appeals strongly decreased engagement, whereas logos-based messages performed relatively better. For both leaders, longer videos predicted lower engagement. These findings illustrate how affordances and persuasive strategies interact to shape engagement on TikTok.
Living Between Belief and Consumption: Religiosity, Hedonism, and Life Satisfaction Among Turkish Youth
(Routledge Journals, Taylor & Francis Ltd, 2025) Gungordu Belbag, Aybegum; Erbil, Cihat
This study examines the relationships among religiosity, materialistic hedonism, control, discomfort, and life satisfaction among 256 young individuals in Turkey. Structural equation modeling shows that religiosity does not curb materialistic hedonism and positively affects control. Life satisfaction is positively influenced by control and materialistic hedonism, and negatively by discomfort. Turkish youth form hybrid identities and practices that integrate both faith and consumer desires. A few studies examine contexts like Turkey, where secularism and religiosity coexist, and religious beliefs fulfill broader social and economic functions. The co-existence of religious beliefs and consumerism -especially among middle and lower class youth- remains underexplored.
Impact of Water Consumption on Structural Members in RC Frames Using Multi-Objective Metaheuristics Algorithm
(Taylor & Francis Ltd, 2025) Nader Negarestani, Mohammad; Fatehi-Nobarian, Bahador; Alizadeh Tabrizi, Sina
The construction industry has a significant global water footprint because buildings incorporate large quantities of embedded materials, such as concrete and steel, whose production consumes substantial amounts of water throughout their life cycle. The grey wolf optimizer (GWO) is particularly suitable for this problem because it is a population-based metaheuristic with strong exploration and exploitation balance, which makes it effective in navigating large discrete search spaces such as structural design variables. GWO has demonstrated robustness in multi-objective problems by efficiently approximating Pareto fronts and avoiding local optima. A numerical structural analysis and design model was developed via an application programming interface. This study is indeed the first optimization of the weight of reinforced concrete (RC) structural elements considering virtual water, with the given structural specifications and using the proposed multi-objective metaheuristic methodology. Results showed the optimal structural weight to be 266 tons, with virtual water usage reaching approximately 253 m3. These findings provide actionable insights for sustainable structural design, guiding material selection and early-stage decision-making to minimize virtual water consumption in RC buildings. This study addresses the research gap by introducing virtual water, alongside structural weight, as a novel objective function within multi-objective metaheuristic optimization of RC frames.
The Relationship Between Operational Efficiency and Financial Efficiency in the Shipping Industry: An Example From Privatized Ports in Türkiye
(EDP Sciences S A, 2025) Kaya, Ebru Nur; Mete, Mevlut Hurol; Belgin, Onder
Since the ports are the backbone of international trade they need to be managed efficiently. This study addresses to analyze the operational and financial efficiency of the selected privatized ports that have been belonged to TCDD (Republic of T & uuml;rkiye State Railways). For this purpose, EATWOS (Efficiency Analysis Technique with Output Satisfying) method is employed, and the weights of the inputs and outputs are determined using LOPCOW (Logarithmic Percentage Change-Driven Objective Weighting), MEREC (Method Based on the Removal Effects of Criteria), and CRITIC (Criteria Importance Through Intercriteria Correlation) methods. After obtaining the weights from these objective methods, the comprehensive weights are calculated using TPOP (Technique of Precise Order Preference) method. Finally, Spearman's rank-order correlation shows that there is no relationship between the operational and financial efficiency of the ports. The number of studies that address both operational and financial efficiency of ports is limited, and this study distinguishes itself by investigating the relationship between both efficiency types.
Design and Fabrication of Dual-Layered PCL/PEG Theranostic Platforms Using 3D Melt Electrowriting for Targeted Delivery and Post-Treatment Monitoring
(Springer, 2025) Ege, Zeynep Ruya; Enguven, Gozde; Ege, Hasan; Durukan, Barkan Kagan; Sasmazel, Hilal Turkoglu; Gunduz, Oguzhan
Advanced pancreatic tumors remain highly resistant to treatment due to their dense stromal environment and poor vascularization, which limit drug penetration and efficacy. Even after surgical resection, the high recurrence rate frequently leads to poor prognosis and mortality. To address these challenges, we developed solvent-free three-dimensional (3D) melt electrowritten (MEW) theranostic microfiber patches composed of poly(epsilon-caprolactone) (PCL) and polyethylene glycol (PEG). The patches were designed as dual-layered, 10-layer structures, with gemcitabine (GEM) loaded in the bottom five layers for localized chemotherapy to suppress tumor recurrence, and indocyanine green (ICG) incorporated in the top five layers to enable fluorescence-based post-surgical monitoring. Following fabrication, the patches were characterized both materially and in vitro, with GEM loaded at 100, 250, or 500 mu g/ml. PEG incorporation improved patch flexibility, facilitating the implantation process. In vitro release analysis demonstrated an initial burst followed by sustained, pH-responsive GEM release (similar to 70% at pH 4.0 and similar to 30% at pH 7.4 for 500 mu g/mL GEM at 168 h), while ICG release reached similar to 25% (pH 7.4) and similar to 10% (pH 4.0). GEM-loaded patches significantly reduced Capan-1 cell viability in a dose- and time-dependent manner, achieving >= 50% reduction at 72 h with 500 mu g/mL. Importantly, ICG incorporation did not impair GEM cytotoxicity; confocal imaging confirmed ICG internalization in viable cells and showed a decline in ICG-positive cells with increasing GEM dose, supporting the potential for concurrent therapy and monitoring. Thus, the theranostic patches enable localized, pH-responsive GEM delivery with integrated ICG-based fluorescence imaging, achieving significant cytotoxicity against pancreatic cancer cells while providing a platform for post-surgical surveillance. This solvent-free, layer-addressable approach represents a promising strategy for personalized, locally implantable theranostic systems in pancreatic cancer treatment.
Bibliometric Analysis of Authors Contributing to the Development of Health Management and Studies Published in WOS in the Field of Health Management
(Sage Publications India Pvt Ltd, 2025) Tengilimoglu, Dilaver; Tas, Merve Ozzeybek; Seyhan, Firat; Younis, Mustafa Z.
In this study, scientific publications on the management of health institutions and health services, which are becoming increasingly important both in the country and in the world agenda, have been analysed, and it is aimed to make a comprehensive determination by analysing the annual publication amounts, most cited works, most relevant and influential source analysis, source co-citation network analysis, most relevant and influential author analysis, cooperation between authors analysis, author co-citation network analysis, and country's scientific production map and cooperation analysis. The result of the analysis showed that 3,940 article-type documents were published from 1,466 different sources between 1977 and 2021. The country that published the highest number of articles in the field of study was the USA, with 3,405 articles. In the analysis of the most relevant and influential sources, the most relevant source was found as 'Health Policy', which has published 80 articles since its first publication in 1986. The most relevant author in the study field was Yasumura who published 63 articles in total and was found to be one of the most influential authors in the study field. This study is evaluated to provide a macroscopic perspective for all stakeholders interested in the subject and those involved in the health system by providing a holistic perspective.
From Street Canyons To Corridors: Adapting Urban Propagation Models for an Indoor IQRF Network
(MDPI, 2025) Doyan, Talip Eren; Yalcinkaya, Bengisu; Dogan, Deren; Dalveren, Yaser; Derawi, Mohammad
Among wireless communication technologies underlying Internet of Things (IoT)-based smart buildings, IQRF (Intelligent Connectivity Using Radio Frequency) technology is a promising candidate due to its low power consumption, cost-effectiveness, and wide coverage. However, effectively modeling the propagation characteristics of IQRF in complex indoor environments for simple and accurate network deployment remains challenging, as architectural elements like walls and corners cause substantial signal attenuation and unpredictable propagation behavior. This study investigates the applicability of a site-specific modeling approach, originally developed for urban street canyons, to characterize peer-to-peer (P2P) IQRF links operating at 868 MHz in typical indoor scenarios, including line-of-sight (LoS), one-turn, and two-turn non-line-of-sight (NLoS) configurations. The received signal powers are compared with well-known empirical models, including international telecommunication union radio communication sector (ITU-R) P.1238-9 and WINNER II, and ray-tracing simulations. The results show that while ITU-R P.1238-9 achieves lower prediction error under LoS conditions with a root mean square error (RMSE) of 5.694 dB, the site-specific approach achieves substantially higher accuracy in NLoS scenarios, maintaining RMSE values below 3.9 dB for one- and two-turn links. Furthermore, ray-tracing simulations exhibited notably larger deviations, with RMSE values ranging from 7.522 dB to 16.267 dB and lower correlation with measurements. These results demonstrate the potential of site-specific modeling to provide practical, computationally efficient, and accurate insights for IQRF network deployment planning in smart building environments.
Clinicopathological Predictors of Central Lymph Node Metastasis in Clinically Node-Negative Papillary Thyroid Carcinoma: A Retrospective Cohort Analysis
(Springer, 2025) Sakiz, Davut; Calapkulu, Murat; Sencar, Muhammed Erkam; Unsal, Ilknur Ozturk; Kartal, Mehmet Zabit; Ucan, Bekir; Cakal, Erman
PurposeThis retrospective cohort study aimed to identify clinicopathological predictors of central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC).MethodsA total of 503 patients with PTC who underwent thyroidectomy with central lymph node dissection were included. Preoperative clinical data, ultrasonographic features, and postoperative histopathological characteristics were analyzed.ResultsCLNM was detected in 209 (41.55%) patients. Male sex (odds ratio [OR] = 3.12, 95% CI: 1.82-5.35), irregular nodule borders (OR = 2.02, 95% CI: 1.25-3.26) and higher risk categories in the American Thyroid Association (ATA) ultrasonographic pattern stratification system (OR = 13.312, 95% CI: 8.623-20.551) were identified as independent preoperative predictors of CLNM. A simplified model incorporating only the ATA ultrasonographic pattern stratification system and male sex achieved 83.5% accuracy in predicting CLNM. Histopathological evaluation revealed lymphovascular invasion (OR = 4.61, 95% CI: 2.81-7.55), extrathyroidal extension (OR = 2.41, 95% CI: 1.52-3.83), and multifocality (OR = 1.58, 95% CI: 1.04-2.40) as independent predictors of CLNM, while lymphocytic thyroiditis (OR = 0.59, 95% CI: 0.39-0.89) was a protective factor.ConclusionThis study establishes that ATA ultrasonographic suspicion patterns combined with the male sex provide an accurate and simplified model for preoperative CLNM prediction in PTC, outperforming complex nomograms. Key independent predictors included male sex, irregular nodule margins, ATA high-risk patterns, lymphovascular invasion, extrathyroidal extension, and multifocality, while lymphocytic thyroiditis was protective. According to the current study, risk assessment and personalized management should favor a holistic approach, rather than focusing solely on individual risk factors.
Effectiveness of Boric Acid in Sepsis in Rats With Cecal Perforation
(Springer Nature, 2025) Kurtipek, Ali Can; Dursun, Ali Dogan; Yigman, Zeynep; Ozdemir, Cagri; Kucuk, Aysegul; Gonullu, Ugur; Arslan, Mustafa
Introduction and AimSepsis is a systemic inflammatory response that develops in the host against microorganisms, which results in end-organ damage. Boric acid (BA) has been shown to have immune modulatory effects in vitro and in animal studies. The aim of the study is to investigate the effects of high dose BA on lung and kidney tissues in rats with sepsis induced by the CLP method.Method28 rats were randomly divided into four groups: Group C (control group), Group BA, Group CLP (cecal ligation and puncture), and Group CLP + BA. Cecum was ligated below the ileocecal valve and punctured. BA was administered to the treatment groups at an intraperitoneal dose of 200 mg/kg, and at the end of 24 h, lung and kidney tissue samples were collected and evaluated for biochemical and histopathological parameters.ResultsHistopathologically, in kidney tissue, CLP + BA group showed significantly less peritubular capillary dilatation and brush border loss in the proximal tubule epithelium compared to the CLP group. In lung tissue, CLP + BA group had significantly less alveolar wall thickening compared to the CLP group. Biochemical analyses indicated that BA administration reduced oxidative stress in both renal and lung tissues.ConclusionWe found that intraperitoneal administration of high dose boric acid partially ameliorated the tissue damage in rats subjected to CLP induced sepsis. Further studies are needed regarding the dosage and application at different time points.
Evaluation of Anti-Tetanus IgG Antibody Levels and Influencing Factors in Patients Undergoing Hemodialysis
(Frontiers Media Sa, 2025) Ozsoy, Metin; Ozturk, Hakki; Tuna, Aysegul; Varlibas, Artuner; Cesur, Salih; Aksoy, Altan; Demir, Mehmet Emin
Aim: This study aimed to assess anti-tetanus IgG antibody levels and identify determinants of inadequate tetanus immunity among maintenance hemodialysis (HD) patients. Methods: In this cross-sectional study, anti-tetanus IgG levels were measured by quantitative ELISA in 162 adult HD patients from two dialysis centers in Ankara, Turkey. Protective immunity was evaluated using both international (>= 0.1 IU/mL) and robust (>= 0.5 IU/mL) cut-offs. Demographic and clinical factors associated with immunity were analyzed by multivariate logistic regression. Results: Only 16.7% of HD patients achieved robust protection (>= 0.5 IU/mL), whereas 49.8% had minimal protection (>= 0.1 IU/mL). Protective immunity was independently associated with younger age (OR 1.07 per year; p = 0.004), shorter dialysis duration (OR 1.07; p = 0.030), male sex (female OR 2.92; p = 0.048), and recent booster vaccination within 10 years (OR 0.11; p < 0.001). Diabetes mellitus was not an independent factor. Conclusion: Most HD patients lacked durable tetanus immunity, particularly older females on long-term dialysis. The findings highlight the need for regular antibody monitoring, early revaccination, and structured booster programs to maintain adequate protection in this high-risk population.

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