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Article Citation - Scopus: 0The Reliability of Youtube as an Information Resource for Parents About Retinopathy of Prematurity(Slack Incorporated, 2025) Alacamli, G.; Yakar, K.Purpose: To investigate the quality and reliability of YouTube videos about retinopathy of prematurity (ROP) to direct parents of infants with the disease to access more accurate content. Methods: The term “retinopathy of prematurity” has been searched on YouTube containing all of the videos between January 2 and February 2, 2024. The first 200 videos were evaluated by two ophthalmologists. Duplicated-split videos, videos shorter than 60 seconds, videos presented in languages other than English or with an incomprehensible accent, and videos unrelated to ROP were excluded. Video uploaders, types, continental origins, durations, and viewer interactions were noted. DISCERN, The Journal of the American Medical Association (JAMA), and the Global Quality Score (GQS) scoring systems were used to evaluate the quality of the videos. Results: The mean quality of all videos was poor in all scoring systems. Academic societies and medical institutes scored highest in video uploaders, followed by physicians; patient experience videos had the lowest quality. Of the video types, the medical education seminars were of the highest quality. Although a strong positive correlation was detected between video duration and video quality, this same strong correlation was not observed between viewer interactions and video quality. There was no significant difference between video origins in terms of video quality. Conclusions: It would be wiser to direct the parents of patients with ROP to watch longer videos uploaded by the academic community, medical institute, or physicians, and to watch the medical training seminars. Also, it might be important to warn them not to take user interactions too seriously. © SLACK Incorporated.Article Citation - Scopus: 1The Effect of a 6-Week Balance Exercise Program on Balance Parameters in Frailty Syndrome: a Randomized Controlled, Double-Blind, Prospective Study(Georgian Association of Business Press, 2023) Karagül, S.; Kibar, S.; Ay, S.; Evcik, D.; Ergin, S.Objective: This study assessed the effectiveness of a six-week balance exercise program on balance parameters and fall frequency in geriatric patients with frailty syndrome. Methodology: This randomized prospective study evaluated a total of 216 patients after referral to a physical medicine and rehabilitation outpatient clinic. Participants were divided into group 1 (flexibility exercises) and group 2 (balance exercises, including kinesthetic ability trainer [KAT] balance exercises, and flexibility exercises). Both groups performed exercises five days per week for six weeks. Balance assessments included the Berg Balance Scale and time-up-and-go test to evaluate dynamic and functional balance, while the one-leg stand test and KAT 4000 static balance test were done to evaluate static balance. Results: Frailty was observed in 37 patients (17.12%). Patients without frailty syndrome initially performed significantly better (p <0.001). Group 2 demonstrated statistically significant improvements after six weeks (p <0.05). Conclusion: Long-term exercise programs improve balance parameters and exercise performance in older adults with frailty. © 2023 Georgian Association of Business Press. All rights reserved.Article Citation - WoS: 0Bacterial Profiling of Brined Grapevine Leaves Collected From Different Local Markets in Türkiye(Wiley-v C H verlag Gmbh, 2025) Ucak, Samet; Yegin, Zeynep; Yurt, Mediha Nur Zafer; Sudagidan, Mert; Altunbas, Osman; Ozalp, Veli CengizMicroorganisms linked to the grapevine, Vitis vinifera, can impact crop quality, plant growth, and human and plant health. This study examined the bacterial community structures of brined grapevine leaves (n = 56) taken from seven distinct regions in T & uuml;rkiye using next-generation sequencing technology. Investigations were also conducted into the samples' chemical properties. Firmicutes was the dominant phylum, followed by Proteobacteria, Actinobacteria, and Bacteroidetes. Bacillaceae was the predominant family in the analyzed samples, followed by Clostridiaceae, Peptostreptococcaceae, and Enterobacteriaceae. Bacillus was the dominant genus, followed by Lysinibacillus and Clostridium sensu stricto. The samples exhibited differences in terms of pH, total acidity, and salt content. The pH values of the brined grapevine leaves ranged from 2.31 to 6.91, the acidity levels ranged from 0.09% to 1.80%, and the salt percentages ranged from 3.39% to 49.14%. This research provides pioneering information for bacterial community analysis of brined grapevine leaves.Article Citation - WoS: 0Citation - Scopus: 0A Novel Deep Learning-Based Framework With Particle Swarm Optimisation for Intrusion Detection in Computer Networks(Public Library Science, 2025) Yilmaz, Abdullah AsimIntrusion detection plays a significant role in the provision of information security. The most critical element is the ability to precisely identify different types of intrusions into the network. However, the detection of intrusions poses a important challenge, as many new types of intrusion are now generated by cyber-attackers every day. A robust system is still elusive, despite the various strategies that have been proposed in recent years. Hence, a novel deep-learning-based architecture for detecting intrusions into a computer network is proposed in this paper. The aim is to construct a hybrid system that enhances the efficiency and accuracy of intrusion detection. The main contribution of our work is a novel deep learning-based hybrid architecture in which PSO is used for hyperparameter optimisation and three well-known pre-trained network models are combined in an optimised way. The suggested method involves six key stages: data gathering, pre-processing, deep neural network (DNN) architecture design, optimisation of hyperparameters, training, and evaluation of the trained DNN. To verify the superiority of the suggested method over alternative state-of-the-art schemes, it was evaluated on the KDDCUP'99, NSL-KDD and UNSW-NB15 datasets. Our empirical findings show that the proposed model successfully and correctly classifies different types of attacks with 82.44%, 90.42% and 93.55% accuracy values obtained on UNSW-B15, NSL-KDD and KDDCUP'99 datasets, respectively, and outperforms alternative schemes in the literature.Article Citation - WoS: 0Citation - Scopus: 0The Relationship Between Concentric and Isometric Strength of Knee Flexor and Extensor Muscles and Postural Stability in Mild Stage Multiple Sclerosis Patients(Taylor & Francis Ltd, 2025) Yilmaz, Seval; Unluer, Nezehat OzgulBackground Multiple sclerosis (MS) affects muscle strength and postural stability. However, the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS is not well known. The aim of the study was to examine the relationship between concentric and isometric strength of knee flexors and extensors and postural stability in mild stage MS patients. Materials and Methods The study included 21 mild-stage MS patients with an EDSS score of 4 or less and 21 healthy controls. The concentric and isometric strength of knee flexors and extensors was measured with the Biodex System 4 Dynamometer, and postural stability with the Biodex Balance System under eyes-open and eyes-closed conditions on a rigid surface. Results Mild-stage MS patients had reduced concentric strength of knee extensors and flexors and increased postural sway compared with healthy controls (p < 0.05). Isometric strength of knee extensors and flexors in mild stage MS patients were similar to healthy controls (p > 0.05). There was a moderate positive correlation between concentric strength of knee extensors and flexors and isometric strength of knee flexors and open-eye postural stability indexes in mild stage multiple sclerosis patients (p < 0.05). Conclusions While isometric strength of knee extensors and flexors was preserved, concentric strength of knee extensors and flexors was decreased, and postural stability was adversely affected in mild stage MS patients. The increase in the strength of the knee muscles was associated with an increase in their postural sway in mild stage MS patients.Article Citation - WoS: 0The Effect of a Single Session Rubber Hand Illusion on Pressure Pain Is Not Long-Lasting(Wiley, 2025) Ceylan, Hatice; Acet, Nagihan; Gunendi, ZaferBackgroundRubber hand illusion (RHI) is an experience that causes changes in body perception and awareness as a result of the integration of simultaneous perceived visual and tactile stimuli. After synchronous brush strokes with rubber and real hands, the person perceives the rubber hand as their own. RHI is known to alter pain perception. In this study, it was aimed to evaluate the effects of RHI on pressure pain threshold and continuity of this effect.MethodsTwenty-three volunteers who developed RHI were included in our study and two conditions, illusion (synchronous) and control (asynchronous), were applied. The illusion condition was created by synchronous brush strokes, while the control condition was created by asynchronous brush application using different frequency and different finger areas in the same individuals. In both conditions, pressure pain threshold measurements with an algometer were performed at four times: baseline/1st measurement, during the brush stroke/2nd measurement, at the end of the brush stroke/3rd measurement and after the hand was removed from the environment/4th measurement.ResultsIt was shown that RHI increased the pressure-pain threshold (p = 0.004) in healthy volunteers. Asynchronous brush strokes arranged as a control trial significantly decreased the pressure pain threshold (p = 0.002).ConclusionsIt was found that the threshold values that change during the brush strokes return to the initial state after the brush strokes are terminated and the rubber hand is removed from the environment so that the effect of the illusion does not last for a long time with a single session application.Article Citation - WoS: 1Perceived Health Outcomes of Recreation Scale: Measurement Invariance Over Gender(Iranian Scientific Society Medical Entomology, 2022) Kose, Elif; Yerlisu-Lapa, Tennur; Uzun, Nezaket Bilge; Kaas, Evren Tercan; Serdar, Emrah; Aras, GoksenBackground: Research handling structural differences among groups presume that the measurement tool works similarly among the groups and the results of measurements provide similar psychometric properties. Therefore, the aim of the study is to provide evidence for measurement invariance of the construct validity Perceived Health Outcomes of Recreation Scale (PHORS).Methods: The research sample consisted of a total of 1984 adults who exercise, including 864 women and 1120 men during 2021-2022 in Antalya City, Turkey. The MI of the PHORS was tested by multigroup con-firmatory factor analyses, which test the invariance of the covariance structures within the scope of structural equation modelling. Invariance tests were gradually conducted for the implicit variables in the model, CFI (comparative fit index criteria) and AIC (Akaike information criterion) were inquired between structural invari-ance, where no restriction was applied on the analyses and the other invariance tests (metric invariance, scalar invariance and string invariance respectively) where more restraints are applied.Results: The study yielded evidence showing that the measurement model defined for the factor structure of the scale provided measurement invariance by gender. increment CFI values were <= 0.010 in all subscales for metric and scalar invariance.Conclusion: The items of PHORS represented the same psychological structure, different groups responded to the items in the same way, the constant values in regression equations generated for the items in regression equations were equal/invariable between the groups.Article Citation - Scopus: 0Recovery Of Myocardial Functions After Kidney Transplantation İn Patients With Heart Failure Due To Uremic Cardiomyopathy;(2025) Saltan Özateş, Y.; Odabaşı, A.Y.; Yıldız, U.; Genç Albayrak, D.; İnan, D.; Baş, S.; Tekkeşin, A.İ.OBJECTIVE: Although left ventricular hypertrophy frequently accompanies end-stage renal disease, heart failure (HF) with reduced ejection fraction (EF) is also observed in a subset of patients. In those patients kidney transplantation (KT) is generally avoided due to an increased risk of mortality in addition to the risks associated with HF. This prospective study was designed to follow patients with HF who were being prepared for KT. METHODS: Twenty-five patients with HF due to uremic cardiomyopathy (UC) who had suitable donors (Group 1), 22 patients with HF who could not undergo KT due to a lack of kidney donors (Group 3), and 25 KT candidates with normal ventricular function (Group 2) were included in the study. Left ventricular ejection fraction (LVEF), left atrial diameter (LAD), mitral annular systolic velocity (Sm), left ventricular global longitudinal strain (GLS), and left ventricular mass index (LVMI) values were recorded across four sessions, from pre-transplant to six months post-transplantation. Endomyocardial biopsy was performed for detailed examination of the myocardium in patients in Group 1 and Group 3, and cardiac magnetic resonance imaging (MRI) was performed in all three groups before transplantation. RESULTS: In Group 1, LVEF, Sm, and left ventricular global longitudinal strain (LV-GLS) increased significantly, while LAD and LVMI decreased, all reaching normal levels. In contrast, no changes were observed in Group 3 and Group 2 (P < 0.01 for LVEF, P < 0.01 for GLS, P < 0.01 for LAD, and P < 0.01 for LVMI measurements). No differences in cardiac MRI and biopsy findings were observed between Group 1 and Group 3. CONCLUSION: Since myocardial function improved significantly and normalized in all patients with HF, it has been demonstrated that UC can be substantially reversible when treated with KT.Article Citation - WoS: 0Evaluation of the Effects of Avatar on Learning Temporomandibular Joint in a Metaverse-Based Training(Wiley, 2024) Basmaci, Fulya; Bulut, Ali Can; Ozcelik, Erol; Ekici, Saliha Zerdali; Kilicarslan, Mehmet Ali; Cagiltay, Nergiz ErcilPurposeAvatars, representing users in the digital world, can influence users' behavior and attitudes. This study evaluates the impact of representing dental students receiving temporomandibular joint (TMJ) education in the metaverse via an anonymous or identified avatar.MethodsParticipants included 80 dental students in their fourth and fifth years of study. They were randomly assigned to either the avatar group (identified avatar) or the control group (anonymous avatar). Prior to training, participants completed a demographic questionnaire and a pretraining knowledge assessment. TMJ training was conducted in the metaverse for both groups. Pre- and post-training assessments included the Spielberger State-Trait Anxiety Inventory and a shyness scale to ensure group comparability. A post-test consisting of five questions was administered to both groups after 2 weeks of training.ResultsThere were no significant differences in pretraining scores for prior knowledge (p = 0.67), trait anxiety (p = 0.28), state anxiety (p = 0.92), or shyness (p = 0.42) between the avatar and control groups, indicating comparability at baseline. Post-training analysis revealed significantly higher post-test scores in the avatar group (median = 80) compared to the control group (median = 60) (p = 0.03).ConclusionsMetaverse environments offer various benefits for students, educators, and educational institutions in health education programs. Representing learners and their identities in training environments can enhance learning outcomes.Article Citation - WoS: 0Citation - Scopus: 0Evaluating Efficacy and Outcomes: Comparison of Laser Treatment and Crystallized Phenol in Pilonidal Sinus Disease(Frontiers Media Sa, 2025) Emral, Ahmet Cihangir; Gulen, Merter; Ege, BahadirObjective The aim of this study is to comprehensively evaluate the efficacy of laser ablation and crystallized phenol application in the treatment of pilonidal sinus disease, focusing on treatment success, recurrence rates, complications, and the patients' return to normal life.Material and method Data from patients treated for pilonidal sinus disease with laser ablation and crystallized phenol application at our clinic between January 2020 and September 2023 were retrospectively reviewed. Preoperative data including pit counts, disease stage, preoperative pilonidal abscess history, disease duration (week), treatment success, recurrence/persistent disease, postoperative complications, healing time (days), and visual analogue scale (VAS) scores on postoperative days 1 and 7, as well as return to normal life (days), were analyzed.Results A total of 121 patients were included in the study, with 51 receiving laser ablation and 70 receiving crystallized phenol application. The postoperative outcomes revealed that the wound healing period and postoperative VAS values were statistically significantly better in the laser ablation group.Conclusion Wound healing was faster and postoperative pain was less in the laser group compared to the phenol group. According to this study, both methods can successfully treat the disease in selected cases.Article Citation - WoS: 0Citation - Scopus: 0Effects of Lotrafilcon a and Senofilcon a Bandage Contact Lenses on Visual Outcome and Ocular Comfort After Photorefractive Keratectomy(Galenos Publ House, 2024) Yakar, Konuralp; Alacamli, GoeksuObjectives: To compare the efficacy of two different silicone hydrogel bandage contact lenses (BCLs) in terms of visual rehabilitation and ocular discomfort following photorefractive keratectomy (PRK). Materials and Methods: This prospective study included 60 eyes of 30 patients who underwent bilateral PRK surgery to correct myopia and/ or astigmatism refractive errors. Following surgery, lotrafilcon A BCLs were applied to the right eye and senofilcon A BCLs were applied to the left eye. When the BCLs were removed on postoperative day 5, subjective ocular symptoms of discomfort were evaluated on a scale of 0 to 10, where 0 indicated no discomfort and 10 indicated maximum discomfort. The postoperative spherical equivalents (SE) of both eyes were compared at 15 days and 1 month. Postoperative SE <= +/- 0.50 diopters was accepted as emmetropia. The number of patients who achieved emmetropia was also compared at 15 days and 1 month postoperatively. Results: Scores for ocular discomfort in the first 5 days postoperatively did not differ significantly between the BCLs (p>0.05). However, a statistically significant difference was observed between the two lenses in terms of SE values at postoperative 15 days and 1 month (p<0.05). Eyes fitted with the senofilcon A BCL demonstrated better postoperative visual rehabilitation. Conclusion: Although post-PRK ocular discomfort scores did not differ significantly between the two BCLs, the senofilcon A lenses performed better in terms of achieving the target SE postoperatively.Article Citation - WoS: 0Citation - Scopus: 0Cannabinoid Receptor Ligands Modulate Fibrosis and Inflammation in Idiopathic Pulmonary Fibrosis: a Preliminary Study(Tubitak Scientific & Technological Research Council Turkey, 2024) Kose, Sevil; Onen, Selin; Gizer, Merve; Boduroglu, Esin; Gonullu, Ugur; Korkusuz, PetekBackground/aim: No specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF) exists. Therefore, new antiinflammatory therapeutic strategies are needed. Cannabinoids (CBs), known for their inflammation-modulating and antifibrotic effects, may be potential medication candidates for treating IPF. We aim to evaluate the inflammation-modulating and antifibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide-stimulated normal human lung fibroblast, epithelial cells, IPF fibroblast cells, and monocytes. Materials and methods: We detected CBRs in normal human lung fibroblasts (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry. We determined TGF-(31, IL-8, and TNF-alpha inflammatory cytokines in the LL24, LL29, A549, and THP-1 cell culture supernatants on days 1 and 5 by ELISA. We evaluated the cell viability in LL24, LL29, and A549 cells on days 1, 3, and 5 spectrophotometrically and detected collagen Type I (ColI) production in the LL24 and LL29 cell culture supernatants on days 1, 3, and 5 by ELISA. Results: LL24, LL29, A549, and THP-1 cells exhibited CB1 (CB1R) and CB2 (CB2R) receptors. CB1R and CB2R agonists WIN55,2122 and JWH015 inhibited fibroblastic and epithelial cell proliferation on day 5. TGF-(31 and TNF-alpha release increased, while IL-8 release decreased in LL24, LL29, A549, and THP-1 cells in response to the administration of WIN55,212-2 and JWH015 at a 10-2 mM concentration. CB1R and CB2R antagonists AM251 and AM630 did not block agonistic responses, suggesting a nonclassical CBRmediated pathway. CB2R agonist JWH015 decreased ColI expression in IPF lung fibroblasts LL29 on day 3. Conclusion: These results suggest that CB signaling regulates the progression of pulmonary inflammation and fibrosis via CBR activation. This may offer a potential pharmacological tool for developing antifibrosis therapies.Article Citation - WoS: 0Citation - Scopus: 0A Novel Injectable Nanotherapeutic Platform Increasing the Bioavailability and Anti-Tumor Efficacy of Arachidonylcyclopropylamide on an Ectopic Non-Small Cell Lung Cancer Xenograft Model: A Randomized Controlled Trial(Elsevier, 2025) Boyacioglu, Ozge; Varan, Cem; Bilensoy, Erem; Aykut, Zaliha Gamze; Recber, Tuba; Nemutlu, Emirhan; Korkusuz, PetekRapid progressing non-small cell lung adenocarcinoma (NSCLC) decreases treatment success. Cannabinoids emerge as drug candidates for NSCLC due to their anti-tumoral capabilities. We previously reported the controlled release of Arachidonylcyclopropylamide (ACPA) selectively targeting cannabinoid 1 (CB1) receptor in NSCLC cells in vitro. Hydrophobic polymers like polycaprolactone (PCL) offer prolonged circulation time and slower drug clearance which is suitable for hydrophobic molecules like ACPA. Thus, the extended circulation time with enhanced bioavailability and half-life of nanoparticular ACPA is crucial for its therapeutic performance in the tumor area. We assumed that a novel high technology-controlled release system increasing the bioavailability of ACPA compared to free ACPA could be transferred to the clinic when validated in vivo. Plasma profile of ACPA and ACPA-loaded PCL-based nanomedicine by LC-MS/MS and complete blood count (CBC) was assessed in wild-type Balb/c mice. Tumor growth in nanomedicine-applied NSCLC-induced athymic nude mice was assessed using bioluminescence imaging (BLI) and caliper measurements, histomorphometry,immunohistochemistry, TUNEL assay, and Western blot on days 7-21. Injectable NanoACPA increased its systemic exposure to tissues 5.5 times and maximum plasma concentration 6 times higher than free ACPA by substantially improving bioavailability. The potent effect of NanoACPA lasted for at least two days on ectopic NSCLC model through Akt/PI3K, Ras/MEK/Erk, and JNK pathways that diminished Ki-67 proliferative and promoted TUNEL apoptotic cell scores on days 7-21. The output reveals that NanoACPA platform could be a chemotherapeutic for NSCLC in the clinic following scale-up GLP/GMP-based phase trials, owing to therapeutic efficacy at a safe low dose window.Article Citation - WoS: 0Citation - Scopus: 0Turkish Nurses' Knowledge, Attitudes and Practices in the Management of Incontinence Associated Dermatitis: a Descriptive and Cross-Sectional Study(Elsevier Sci Ltd, 2025) Sonmez, Munevver; Kisacik, Oznur Gurlek; Korkmaz, SerapObjective: This study aimed to determine nurses' current knowledge, attitudes, and practices in adult intensive care units and palliative care clinics regarding incontinence-associated dermatitis (IAD). Materials and methods: This descriptive cross-sectional study was conducted with 355 nurses in adult intensive care and palliative services at two hospitals. Data were collected between 5.03.2022 and 15.06.2022 using the" Nurse Demographic Form" and the "Knowledge, Attitude and Practice of Nurses in Managing Incontinence- Associated Dermatitis Questionnaire". Results: The nurses' mean scores for "Knowledge of IAD Etiology and Diagnosis" were 19.11 (SD 3.29), mean scores for "Knowledge of IAD Risk Factors" were 23.82 (SD 4.27), mean scores for "Attitude Toward IAD Prevention" were 10.1 (SD 2.49), and mean scores for "Practices for IAD Prevention" were 23.71 (SD 3.97). It was found that nurses who used a risk assessment tool to diagnose IAD (p = 0.001), had a procedure or protocol (p = 0.001), and received training on IAD (p < 0.001) had significantly higher "Attitude Towards Prevention of IAD" scores. There was a positive correlation between the number of patients with IAD cared for by the nurses participating in the study and the scores of "Practices to Prevent IAD"and "Knowledge of IAD Risk Factors", "Knowledge of IAD Etiology and Diagnosis"and "Attitude Towards Preventing IAD"(p < 0.001). Conclusion: This study found that intensive care and palliative care nurses' knowledge, attitudes, and practices regarding IAD were insufficient. Considering that IAD is encountered more frequently in these units, it is essential to provide continuous and practical training to nurses about IAD, use risk assessment tools to prevent and treat IAD, determine protocols, establish clinical guidelines, and implement and standardize them.Article Citation - WoS: 0Citation - Scopus: 0Comparison of the Escape Room and Storytelling Methods in Learning the Stress Response: a Randomized Controlled Pilot Study(Elsevier Sci Ltd, 2025) Dogu, Nilgun; Boztepe, Handan; Topal, Cansu Akdag; Sonmez, Munevver; Yuceer, Bugse; Bayraktar, NurhanAim: The purpose of this study was to evaluate the effect of the Escape Room and Storytelling methods on nursing students' learning about the topic of stress response. Background: It is recommended that new generations be trained using innovative teaching methods that differ from traditional teaching methods. The Escape Room and Storytelling methods are among the techniques that have been used and recommended for this purpose. Design: The study was conducted with a randomized, controlled design. Methods: Thirty-five (n = 35) second-year undergraduate nursing students were randomly divided into two groups, one group was trained on stress response using the Escape Room method, while the other group was trained using the Storytelling method. Focus-group interviews were conducted with the students after the interventions. Results: There was a significant difference between the groups in terms of the median post-intervention knowledge assessment score. It was determined that the students in the Escape Room group scored significantly higher than those in the Storytelling group (p < 0.05) Conclusions: The use of these methods, which ensure the active participation of students and increase their motivation, effectively contributes to meeting the educational needs of students and increases their level of satisfaction.Article Citation - WoS: 0Citation - Scopus: 0Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage(Mdpi, 2024) Gunes, Isin; Dursun, Ali Dogan; Ozdemir, Cagri; Kucuk, Aysegul; Sezen, Saban Cem; Arslan, Mustafa; Ozer, AbdullahBackground and Objectives: Ischemia-reperfusion (I/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO2) affects systemic anti-inflammatory response and inflammation. Therefore, in our study, we aimed to investigate whether CeO2 administration has a protective effect against myocardial I/R injury in the liver and kidneys. Materials and Methods: Twenty-four rats were randomly divided into four groups after obtaining approval from an ethics committee. A control (group C), cerium oxide (group CO), IR (group IR), and Cerium oxide-IR (CO-IR group) groups were formed. Intraperitoneal CeO2 was administered at a dose of 0.5 mg/kg 30 min before left thoracotomy and left main coronary (LAD) ligation, and myocardial muscle ischemia was induced for 30 min. After LAD ligation was removed, reperfusion was performed for 120 min. All rats were euthanized using ketamine, and blood was collected. Liver and kidney tissue samples were evaluated histopathologically. Serum AST (aspartate aminotransferase), ALT (alanine aminotransaminase), GGT (gamma-glutamyl transferase), glucose, TOS (Total Oxidant Status), and TAS (Total Antioxidant Status) levels were also measured. Results: Necrotic cell and mononuclear cell infiltration in the liver parenchyma of rats in the IR group was observed to be significantly increased compared to the other groups. Hepatocyte degeneration was greater in the IR group compared to groups C and CO. Vascular vacuolization and hypertrophy, tubular degeneration, and necrosis were increased in the kidney tissue of the IR group compared to the other groups. Tubular dilatation was significantly higher in the IR group than in the C and CO groups. TOS was significantly higher in all groups than in the IR group (p < 0.0001, p < 0.0001, and p = 0.006, respectively). However, TAS level was lower in the IR group than in the other groups (p = 0.002, p = 0.020, and p = 0.031, respectively). Renal and liver histopathological findings decreased significantly in the CO-IR group compared to the IR group. A decrease in the TOS level and an increase in the TAS level were found compared to the IR group. The AST, ALT, GGT, and Glucose levels are shown. Conclusions: CeO2 administered before ischemia-reperfusion reduced oxidative stress and ameliorated IR-induced damage in distant organs. We suggest that CeO2 exerts protective effects in the myocardial IR model.Article Citation - WoS: 0Citation - Scopus: 0Paper-Based Aptasensor Assay for Detection of Food Adulterant Sildenafil(Mdpi, 2024) Kavruk, Murat; Ozalp, Veli CengizSildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but is often illicitly added to energy drinks and chocolates. This study introduces a lateral flow strip test using aptamers specific to sildenafil for detecting its illegal presence in food. The process involved using graphene oxide SELEX to identify high-affinity aptamers, which were then converted into molecular gate structures on mesoporous silica nanoparticles, creating a unique signaling system. This system was integrated into lateral flow chromatography strips and tested on buffers and chocolate samples containing sildenafil. The method simplifies the lateral flow assay (LFA) for small molecules and provides a tool for signal amplification. The detection limit for these strips was found to be 68.2 nM (31.8 mu g/kg) in spiked food samples.Article Citation - WoS: 1Citation - Scopus: 1Prognostic Implications and Predictors of Mitral Regurgitancy Reduction After Transcatheter Aortic Valve Implantation(Mdpi, 2024) Guney, Murat Can; Suygun, Hakan; Polat, Melike; Ayhan, Huseyin; Keles, Telat; Ertop, Zeynep Seyma Turinay; Bozkurt, EnginBackground: Mitral regurgitation (MR) is a common condition observed in patients undergoing transcatheter aortic valve implantation (TAVI) for the treatment of aortic stenosis (AS). However, the impact of TAVI on MR outcomes and the factors predicting MR improvement remains uncertain. Understanding these predictors can enhance patient management and guide clinical decisions. Methods: This retrospective cohort study included 156 patients with moderate to severe MR undergoing TAVI. MR severity was assessed via echocardiography at baseline, as well as 6 months and 1 year after TAVI. Patients were divided into groups based on MR reduction: no improvement or worsening, one-degree improvement, and at least two-degree improvement. Clinical, echocardiographic, and procedural characteristics were evaluated as predictive factors for MR improvement after TAVI. Results: MR reduction occurred in 68% of patients at 6 months and 81% at 1 year. Factors predicting a reduction of two grades or more in MR severity included lower baseline LVEDD (OR = 1.345, 95% CI: 1.112-1.628, p = 0.002) lower baseline LA (OR = 1.121, 95% CI: 1.015-1.237, p = 0.024), lower baseline LVMI (OR = 1.109, 95% CI: 1.020-1.207, p = 0.024), and higher baseline EF levels (OR = 1.701, 95% CI: 1.007-2.871, p = 0.047). No significant association was found between MR reduction at 6 months and one-year mortality. (p = 0.65). Conclusions: Baseline echocardiographic parameters are valuable in predicting MR improvement post-TAVI, with LVMI emerging as a novel predictor. However, MR reduction did not independently predict survival, underscoring the need for further research to optimize patient selection and management strategies in TAVI candidates.Article Citation - WoS: 0Citation - Scopus: 0Evaluating Anterior Segment Stability and Corneal Endothelium After Prolene Gonioscopy Assisted Transluminal Trabeculotomy (gatt) in Open-Angle Glaucoma(Springer, 2024) Aribas, Yavuz Kemal; Aktas, Zeynep; Ertop, MestanIntroduction This study investigates the short-term effects of prolene gonioscopy-assisted transluminal trabeculotomy (GATT) on anterior segment parameters and corneal endothelium in patients with open-angle glaucoma. Methods This retrospective study included 30 eyes from 30 patients who underwent GATT surgery. Demographic data, ophthalmological examination findings, and intraocular pressure (IOP) measurements using a Goldman applanation tonometer were recorded. Scheimpflug images were acquired at the pre-operative stage, as well as on the 1st day, 1st week, and 1st month postoperatively. Corneal endothelial cell counts were obtained via specular microscopy. Results The mean age of patients was 60.3 +/- 15.5 years. Anterior chamber depth and central corneal thickness increased on the 1st postoperative day (p:0.002, p < 0.001, respectively). Changes in anterior chamber depth values at the postoperative 1st week and 1st month compared to baseline were not statistically significant. Central corneal thickness decreased significantly at the 1st postoperative month compared to baseline (p:0.007). Corneal endothelial cell counts at the 1st month were comparable to baseline values (p:0.936). Conclusion Our findings reveal that prolene gonioscopy-assisted transluminal trabeculotomy induces temporary changes in anterior segment parameters but preserves corneal endothelial cell count within the first month, suggesting a promising profile for GATT in glaucoma management.Article Citation - WoS: 0Citation - Scopus: 0Cold War Aviation: American Technology Transfer and the Construction of Turkey's First International Civilian Airport in Yeşilköy, Istanbul, 1944-1953(Cambridge Univ Press, 2024) Tunc, Tanfer Emin; Tunc, GokhanWith the economic and political support of the United States, in July 1947, Turkey signed contracts withthe Westinghouse Electric International Company and J.G. White Engineering Corporation to constructits first international civilian airport, Istanbul'sYe & scedil;ilk & ouml;y Airport. As this article will argue, the buildingof Ye & scedil;ilk & ouml;y (1949-53), through a partnership with two American engineering firms, is essentially anearly Cold War narrative of transnational exchange involving the multidirectional flow of technicalknowledge, expertise and resources between the United States and Turkey; the circulation of geopol-itically significant (and frequently competing) military, civilian and government actors; and thelocal and global implications of these transmissions. Yet the Ye & scedil;ilk & ouml;y construction narrative also illus-trates how post-war technology transfer was a highly political process of constant adaptation, modifi-cation and negotiation. Fraught with unforeseen friction and thorny challenges, Ye & scedil;ilk & ouml;y exemplifiesthe complicated American Cold War strategy of creating and maintaining alliances through engineeringknowledge, personnel and practices, often with unintended consequences. Moreover, as a case study,Ye & scedil;ilk & ouml;y opens a new window into the cautious science diplomacy that occurred along the IronCurtain, while filling a notable historiographic gap with respect to aviation in early Cold War Turkey.
