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Investigation of Tetanus Seropositivity Levels in Adult Patients with Rabies Risk Exposure Admitted To a Hospital in Ankara
(Journal of Infection in Developing Countries, 2025) Gürkaynak, P.; Demircan, Ş.A.; Tulek, N.; Kinikli, S.; Erdi̇Nç, F.Ş.; Tuncer, G.; 01. Atılım University
Introduction: This study aimed to assess tetanus seropositivity levels among adult patients admitted to a tertiary care hospital following rabies risk exposure, and to explore potential factors influencing their immunological status. Methodology: This cross-sectional descriptive epidemiological study included 182 adult individuals (68 females and 114 males) who presented to the hospital following rabies risk exposure. The demographic data was collected during a face-to-face interview, and the tetanus antibody concentrations were assessed using a micro-enzyme-linked immunosorbent assay (ELISA) kit. Serum antibody levels of ≥ 0.1 IU/mL were defined as “seropositive”, while values below this threshold were considered “seronegative”. Results: Seropositivity was identified in 81.9% of the patients. There was a significant decline in antibody levels with age (p < 0.001). The Spearman correlation analysis showed a moderately significant negative correlation between age and antibody titers (r = – 0.404, p < 0.001). In addition, there were significantly higher tetanus antibody levels in patients from urban areas, those vaccinated during pregnancy, and those vaccinated within the past 10 years (p = 0.025, 0.036, and 0.013, respectively). Conclusions: Overall, the results highlight a reduction in tetanus antibody levels with age, emphasizing the importance of receiving a booster dose every 10 years. In addition, rabies risk exposure, particularly in older adults, presents a valuable opportunity to administer tetanus vaccination. © 2025 Gürkaynak et al.
Evaluation of Food Intake, Malnutrition, Growth and Development in Children with Esophageal Atresia: A Pilot Study from Turkey
(BioMed Central Ltd, 2025) Konyalıgil, D.B.; Koc, N.; Çalışkan, D.; Kara-Uzun, A.; Şenel, E.; 01. Atılım University
Background: This study aimed to evaluate the relationships among nutritional intake, malnutrition, and growth and development in children under 2 years of age with esophageal atresia. Methods: A survey was administered to the parents of healthy children and children with esophageal atresia who were followed up at Ankara City Hospital Pediatric Surgery Polyclinic. Nutrition education was provided, a follow-up visit was scheduled three months later, and the assessments were repeated. Results: The study included 20 children with esophageal atresia and 40 controls under 2 years of age. Height-for-age, weight-for-age and head circumference measurements were significantly lower in children with esophageal atresia than in the control group (p < 0.05). At the second interview, triceps skinfold thickness for age and mid-upper arm circumference for age were also significantly lower in children with esophageal atresia compared to control group (p < 0.05). Statistically significant differences were observed in dietary and food consistency preferences, eating status, and swallowing function (p < 0.05). In addition, according to the Pediatric Eating Assessment Tool-10 and Screening Tool for Risk of Impaired Nutritional Status and Growth, a high prevalence of swallowing disorders and a moderate risk of malnutrition were identified in children with esophageal atresia (p < 0.05). At the end of follow-up, significant increases in weight-for-age and height-for-age z scores were observed over time in children with esophageal atresia (p < 0.05). Furthermore, the percentages meeting daily requirements for protein, carbohydrates and dietary fiber increased over time (p < 0.05). Swallowing symptoms improved over time in children with esophageal atresia, and their current dietary patterns remained significantly different from those of the control group (p < 0.05). Conclusions: Appropriate nutritional support delivered with a multidisciplinary approach and long-term follow-up can help children to achieve a growth rate appropriate for their peers. © The Author(s) 2025.
Evaluation of Clinical Characteristics, Risk Factors and Prognosis of Herpes Zoster (Shingles) Infection in Türkiye: Varicomp-Adult Study
(Elsevier B.V., 2025) Özgen-Top, O.; Karacaer, Z.; Ozkan, E.F.; Ozger, H.S.; Saltoǧlu, N.; Öztoprak Çuvalci, N.; Şenol, E.; 01. Atılım University
Objective The study aimed to determine the estimated prevalence of herpes zoster (HZ) infection in the adult population in Türkiye and the rates of HZ-associated complications and risk factors. Methods This retrospective, multicenter ( n = 11), cross-sectional study was conducted between January 2016 and January 2022 and included all patients aged ≥18 years diagnosed with shingles following screening based on ICD-10 codes. The prevalence of HZ infection was calculated; rates of HZ-related complications (recurrence, hospitalization, postherpetic neuralgia [PHN]) and associated risk factors were determined. Results A total of 6114 HZ patients were included; the estimated 5-year HZ prevalence in Türkiye was 908.7 per 100,000 population. Of the patients, 851 (14.2%) were immunocompromised, 366 (6%) were hospitalized due to HZ, 284 (8.9%) experienced PHN, 97 (3.2%) experienced recurrence of the patients. Risk factors for PHN were older age (≥50 years [OR = 3.19; P < 0.001)], and trigeminal dermatome involvement (OR = 2.45; P = 0.006). Antiviral use was associated with reduced PHN risk (OR = 0.16; P < 0.001). Conclusions Our multicenter cross-sectional study revealed the high burden of HZ in Türkiye and highlighted the potential for increasing prevalence due to risk factors including aging and comorbidities. © 2025 The Authors.
Organ-Protective Effects of Fullerenol and Desflurane in a Rat Model of Ischemia–Reperfusion Injury
(Nature Research, 2025) Kip, G.; Köksal, Z.; Yigman, Z.; Küçük, A.; Arslan, M.; Akarca-Dizakar, S.Ö.; Sivgin, V.; 01. Atılım University
To investigate the protective effects of fullerenol applied before ischemia induction and desflurane anesthesia applied during ischemia–reperfusion (IR) induction in the lungs and kidneys of a lower-extremity IR injury rat model. After receiving ethical approval, we randomly divided 30 rats into five groups: sham (S), IR, IR with 100 mg/kg fullerenol (IR-FUL), IR with 6.7% desflurane (IR-DES), IR with 100 mg/kg fullerenol and 6.7% desflurane (IR-FUL-DES). Fullerenol was administered 30 min before the IR procedure in the IR-FUL and IR-FUL-DES groups, and desflurane was administered during the IR procedure in the IR-DES and IR-FUL-DES groups. During the procedure, an atraumatic microvascular clamp was placed in the aorta for 120 min. The clamp was then removed to achieve reperfusion for 120 min. Finally, at the end of reperfusion, we evaluated the extracted lung and kidney tissue samples and assessed them biochemically and histopathologically. The lung damage scores of the IR-FUL, IR-DES, and IR-FUL-DES groups were significantly lower than those of the IR group (p <.0001, p =.002, and p <.0001, respectively). The renal tubule injury scores of the IR, IR-FUL, IR-DES, and IR-FUL-DES groups were significantly higher than those of the S group (p <.0001). By contrast, the renal tubule injury scores of the IR-FUL and IR-FUL-DES groups were significantly lower than those of the IR group (p <.0001 and p =.001, respectively). Moreover, kidney intercellular adhesion molecule 1 (ICAM1) expression was significantly lower in all the treatment groups, particularly the IR-FUL group, than in the IR group, and lung ICAM1 expression was significantly lower in the IR-FUL and IR-FUL-DES groups than in the other treatment groups. In the lung and kidney tissues, thiobarbituric acid reactive substance levels, catalase activity, glutathione-S-transferase activity, and arylesterase activity were relatively high in the treatment groups. The application of fullerenol before and after desflurane anesthesia during IR has protective effects on rat lungs and kidneys. In particular, histopathology confirmed that the application of fullerenol 30 min before IR induction and desflurane anesthesia during IR induction reduced oxidative stress and alleviated IR-related damage in the lungs and kidneys. These findings may have important translational relevance, suggesting potential perioperative strategies for protecting organs from ischemia–reperfusion injury in clinical settings. © The Author(s) 2025.
Rehabilitation in Neuromuscular Diseases: Best Turkish Practice Recommendations by Multidisciplinary Experts
(Springer Heidelberg, 2025) Umay, Ebru; Tanigor, Goksel; Toraman, Fusun; Karaahmet, Ozgur; Bilgilisoy, Meral; Sertpoyraz, Filiz; Nazli, Fatma; 01. Atılım University
Background and aim:Neuromuscular diseases (NMDs) are a heterogeneous group of diseases including motor neurone diseases (MND), muscle diseases (MD), neuropathies and neuromuscular junction diseases (NMJD). NMDs are characterized by a wide range of symptoms and findings, depending on different underlying issues. Therefore, the literature includes specific management and/or rehabilitation recommendations for each subgroup and even for some diseases within these subgroups. Currently, neither in our country nor globally is there a comprehensive recommendation study that thoroughly addresses all aspects of NMD rehabilitation developed by experienced and specialized multidisciplinary experts in the field.Materials and methodsThe recommendations in this paper have been created by a multidisciplinary team for all patients without age limitation under the headings of peripheral neuropathy/polyneuropathy, MND, MD and NMJD using the seven-step and 3 round modified Delphi method via e-mail. The strength of agreements (SOA) was calculated for each item (recommendation) using percentages (response of between 8 and 10%), median values, and interquartile range with Kappa method.ResultsThe opinions of the experts were analysed according to the 3-round modified Delphi method, and a list of 110 items of recommendations for patients with NMDs of all ages was prepared in as much detail as possible to shed light on almost all questions and problems that may be encountered in clinical practice. There were 5 recommendations in the general management subsection, 20 recommendations in the rehabilitation indications subsection, 8 recommendations in the rehabilitation contraindications section, and 77 recommendations in the rehabilitation section (general principles 7 recommendations, modalities 13 recommendations, exercise characteristics 57 recommendations).ConclusionWe think that this study will be a light for physicians dealing with this patient group in clinical practice, as it includes fine details up to exercise prescriptions.
Transoral Robotic Surgery (TORS) for Head and Neck Cancer in the Elderly Population: Functional Outcomes, Survival, and Complications
(Wiley, 2025) Pamuk, Erim; Beharry, Avinash; Lambercy, Karma; Dalla-Vale, Margaux; Wahler, Nina; Hosal, Sefik; Simon, Christian; 08. Medical School; 01. Atılım University; Surgical Sciences
Objective: To compare functional and oncologic outcomes in elderly (>= 70 years) and nonelderly (< 70 years) patients after transoral robotic surgery (TORS). Methods: A retrospective chart review was conducted on 114 patients who underwent TORS for head and neck squamous cell carcinoma between 2012 and 2022. Patient and tumor characteristics, perioperative details, complications, and survival parameters were analyzed. Swallowing function was assessed using the Functional Outcome Swallowing Scale (FOSS). Results: Of the 114 patients, 37 (32.5%) were elderly, and 77 (67.5%) were nonelderly. Elderly patients had higher comorbidity scores (p < 0.001). Oropharyngeal and oral cavity primaries were more common in the nonelderly group, whereas laryngeal primaries predominated in elderly patients (p < 0.01). Complication rates were higher in nonelderly (37.6%) than in elderly (18.9%) patients, though not statistically significant (p = 0.07). In elderly patients, FOSS scores showed no significant change preoperatively, postoperatively (< 3 months), or at the last follow-up (median 36 months). The nonelderly group experienced worse early postoperative FOSS scores compared to baseline but showed significant improvement, returning to preoperative levels by the last follow-up. Nonelderly patients had better FOSS scores at last follow-up compared to elderly patients (p = 0.014). Overall and recurrence-free survival outcomes were better in the nonelderly group, but disease-specific survival rates were comparable. Conclusion: Despite higher comorbidity rates in the elderly, TORS demonstrated favorable complication rates in the elderly population. Swallowing function returned to baseline after 3 months in both groups. TORS appears safe for elderly patients with comparable oncologic outcomes.
Right Renal Ectopia Following Major Weight Loss
(BMJ Publishing Group, 2025) Abdulrasool, Amjed Safaa; Noack, Morten Westergaard; Overgaard, Ellen Kristine; Abdulrasool, Mujtaba; 01. Atılım University
Presenting with severe stomach pain from sigmoid volvulus, a woman in her 90s was effectively treated with colonoscopic desufflation. Interestingly, serial imaging over 16 years demonstrated gradual cranial displacement of the right kidney to the hepato-diaphragmatic space without prior trauma, surgery or congenital abnormalities. The patient remained asymptomatic with respect to renal function despite significant anatomical displacement. No specific intervention was required for the ectopic kidney. It is important to recognise the potential for organ migration associated with ageing, significant weight loss or metabolic alterations, particularly in the context of increasing use of weight-loss medications. Awareness of such anatomical variants can prevent misinterpretation of incidental findings on clinically indicated imaging. Routine imaging solely to detect asymptomatic positional changes is not justified.
Predicting Stroke Risk Using Machine Learning: A Data-Driven Approach to Early Detection and Prevention
(Wiley, 2025) Sutcu, Muhammed; Jouda, Dana; Yildiz, Baris; Katrib, Juliano; Almustafa, Khaled Mohamad; Industrial Engineering; 06. School Of Engineering; 01. Atılım University
Stroke is a major global health concern and a leading cause of disability and mortality, emphasizing the need for early risk prediction and intervention. This study leverages statistical analysis, machine learning (ML) classification, clustering, and survival modeling to identify key stroke predictors using a dataset of 5110 records. Descriptive statistics reveal that age, glucose levels, BMI, hypertension, and heart disease are the most influential risk factors. Stroke prevalence is notably higher among hypertensive (13.25%) and heart disease patients (17.03%), as well as among former (7.91%) and current smokers (5.32%). Clustering analysis using PCA and t-SNE highlights high-risk groups with elevated glucose levels and advanced age. Among ML models, XGBoost offers the best trade-off between precision and recall, while na & iuml;ve Bayes achieves the highest recall (0.404), detecting more stroke cases despite higher false positives. Feature importance analysis ranks glucose, BMI, and age as dominant predictors, with XGBoost emphasizing cardiovascular conditions. Survival analysis confirms increasing stroke risk beyond age 60, with the Kaplan-Meier and Cox models showing a 31.9% risk increase linked to hypertension. These findings underscore the importance of early screening, lifestyle intervention, and targeted care. Future research should explore data-balancing methods like SMOTE and develop real-time tools to support clinical decision-making.
The Effect of Two Different Types of Daily Disposable Monofocal Contact Lenses on Ocular Wavefront Aberrations
(Elsevier, 2025) Yakar, Konuralp; 01. Atılım University
Background: To compare the effect of two daily disposable soft contact lenses on ocular wavefront aberrations. Methods: This study included 34 eyes from 17 patients aged 18 to 40 years (mean age: 27.12 +/- 8.3 years) with identical myopic refractive errors in both eyes without astigmatism and requesting contact lens use. Initially, wavefront aberrations; total, tilt, high, total coma, total trefoil, total 4.foil, sphere, high astigmatism, RMS (3 mm/5 mm) were measured using Nidek OPD Scan II aberrometer/topograph in both eyes without contact lenses. Acuvue Oasys with HydraLuxe 1-Day (senofilcon A) daily disposable contact lenses were applied to the right eye, while Precision 1 (verofilcon A) daily disposable contact lenses were applied to the left eye based on refractive errors. Wavefront aberration measurements were repeated 60 min later with contact lenses, and aberrations were compared to baseline and fellow eyes' measurements. The magnitudes of aberration changes after contact lens application were analyzed. Results: Both types of daily disposable contact lenses reduced total wavefront aberrations. Acuvue Oasys with HydraLuxe 1-Day contact lenses showed a significant increase in total trefoil aberration (p = 0.048). Precision 1 contact lenses showed a significant increase (p = 0.034) only in total tilt aberrations compared to baseline. No significant differences were found between the lenses regarding changes in all wavefront aberrations. Conclusion: Both daily disposable lenses effectively reduced total wavefront aberrations, though they increased certain subtypes of high-order aberrations in young adult myopes.
Role of Latissimus Dorsi–Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients with Chronic Low Back Pain: A Randomised Clinical Trial
(John Wiley and Sons Inc, 2025) Uluǧ, N.; Kodak, S.B.; Kodak, M.İ.; Aslan, S.N.; 01. Atılım University
Background: Fascial stretching is gaining interest as a potential intervention for pain management. However, evidence regarding the effect of latissimus dorsi–thoracolumbar fascia (LD-TLF) complex stretching in patients with chronic low back pain (CLBP) remains limited. Therefore, this study aimed to investigate the effects of LD-TLF complex stretching on pain-related factors and disability in patients with CLBP. Methods: Thirty patients with CLBP were randomly assigned to a study group (n = 15; 7 men, 8 women) and a control group (n = 15; 7 men, 8 women). The study group received 4 weeks of LD-TLF complex stretching in combination with conventional physiotherapy, while the control group received conventional physiotherapy only. Outcomes were assessed before and after the interventions, including primary measures of pain pressure thresholds (PPT) at thoracolumbar fascia levels (L1, L3 and 12th costa), and secondary measures included the Pain Sensitivity Questionnaire (PSQ), the effects of pain on daily activities measured by the Brief Pain Inventory (BPI), and disability assessed by the Oswestry Disability Questionnaire (ODQ). Results: Pre- and post-treatment PPTs, at the L1, L3 vertebrae and 12th costa levels, demonstrated significant differences between the study group and control groups. Post-treatment thresholds were significantly higher compared to pre-treatment thresholds (p < 0.001, ηp2 = 0.67; p < 0.001, ηp2 = 0.61; p < 0.001, ηp2 = 0.74). Additionally, significant improvements were found in PSC, BPI and ODQ scores in the study group compared to the control group (p < 0.05). Conclusion: The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF complex stretching, when used in combination with conventional physiotherapy, appears to provide improved pain thresholds, decreased pain sensitivity and pain during activity, as well as reduced disability compared to conventional physiotherapy alone in patients with CLBP. Significance Statement: Chronic low back pain (CLBP) is a multifactorial condition, with the thoracolumbar fascia increasingly recognized as a potential contributing factor. This study suggests that stretching the latissimus dorsi-thoracolumbar fascia complex in combination with conventional physiotherapy, enhances pain thresholds, reduces pain sensitivity, and decreases disability in individuals with CLBP. Incorporating fascia-specific interventions into CLBP treatment programs could offer significant benefits for both patients and clinicians. © 2025 Elsevier B.V., All rights reserved.
Erratum: Correction to: Stem Cell and Advanced Nano Bioceramic Interactions (Advances in Experimental Medicine and Biology (2018) 1077 Doi: 10.1007/978-981-13-0947-2_17.)
(2018) Köse, S.; Kankilic, B.; Gizer, M.; Ciftci Dede, E.; Bayramli, E.; Korkusuz, P.; Korkusuz, F.; 01. Atılım University
Factors Affecting Dentists' Intention To Adopt Artificial Intelligence: An Extension of the Unified Theory of Acceptance and Use of Technology (UTAUT) Model
(Emerald Group Publishing Ltd, 2025) Alqaifi, Faten; Tengilimoglu, Dilaver; Business; 05. School of Business; 01. Atılım University
PurposeAdvancements in science and technology have integrated artificial intelligence (AI) into dentistry, improving treatment processes, operational efficiency, and clinical outcomes. However, AI adoption among dentists remains underexplored, hindering progress in oral healthcare. This study aims to identify key barriers to AI adoption and examine factors influencing dentists' intention to use AI.Design/methodology/approachA quantitative cross-sectional approach was employed, utilizing self-administered questionnaires distributed online and across various dental clinics and hospitals in Ankara, Turkey. A total of 440 dentists participated in the study. Data analysis was conducted using SPSS and SmartPLS.FindingsThe study found that AI-anxiety negatively affects the intention to adopt AI in dentistry, showing a medium (almost large) effect that is stronger than other UTAUT factors such as performance expectancy, effort expectancy, and social influence, which demonstrated only small effects. Dentists with higher anxiety about learning and sociotechnical blindness are less likely to adopt AI, while concerns about job replacement and AI-configuration have less but still significant impact.Research limitations/implicationsThese results contribute to the growing body of knowledge on technology adoption in oral healthcare and provide practical implications for technology developers, policymakers, and other stakeholders seeking to facilitate AI integration in dentistry.Originality/valueThis study provides novel insights into AI adoption in dentistry, offering guidance for future development and integration, and addressing a critical research gap in a growing field-particularly in Turkey, where implementation is still in its early stages.
Transcatheter Aortic Valve Implantation in Nonagenarians: A Comparative Analysis of Baseline Characteristics and 1-Year Outcomes
(MDPI, 2025) Guney, Murat Can; Bozkurt, Engin; 01. Atılım University
Background: Transcatheter aortic valve implantation (TAVI) is increasingly used in elderly patients with severe aortic stenosis, yet data on nonagenarians remain limited. This study aimed to compare clinical characteristics and outcomes of patients aged >= 90 years with those aged <90 years undergoing TAVI. Methods: We retrospectively analyzed 620 patients who underwent transfemoral TAVI. Patients were divided into two groups: <90 years (n = 545) and >= 90 years (n = 75). Baseline clinical, procedural, and outcome data were compared. Results: Nonagenarians had lower body mass index (BMI) and a lower prevalence of comorbidities such as diabetes, hyperlipidemia, and prior coronary artery bypass grafting CABG (all p < 0.05). All-cause mortality was higher in nonagenarians at 1 month (8.0% vs. 5.5%, p = 0.425), 6 months (9.3% vs. 7.9%, p = 0.838), and 1 year (21.3% vs. 16.7%, p = 0.405), though these differences were not statistically significant. In-hospital stroke occurred more frequently in patients >= 90 years (6.7% vs. 2.2%, p = 0.044). Conclusions: Despite a higher rate of in-hospital stroke, nonagenarians undergoing TAVI had comparable mortality outcomes to younger patients. These findings support the feasibility of TAVI in selected very elderly patients, while highlighting the need for tailored stroke prevention strategies. Trial Registration: The trial is retrospectively registered, and a clinical trial number is not applicable.
The Effect of Perceived Birth Trauma in Women With Planned Cesarean Section on Maternal and Paternal Attachment: Path Analysis Model
(Sage Publications Ltd, 2025) Mert-Karadas, Merve; Topal, Cansu Akdag; Karakurt, Irem; Boztepe, Handan; Nursing; 07. School of Health Sciences; 01. Atılım University
Perceived birth trauma can disrupt parent-infant bonding and affect family dynamics. This study examined the impact of perceived birth trauma on maternal and paternal attachment using path analysis. An analytical cross-sectional study was conducted with 134 mother-father pairs in Turkey, 6 months postpartum, following planned cesarean sections. Data were collected using the Traumatic Childbirth Perception Scale, Mother-to-Infant Bonding Scale, and Paternal-Infant Attachment Scale. Descriptive statistics and reliability analyses were conducted using R software. Path analysis was performed with the R package "lavaan" to assess direct and indirect relationships. Higher perceived birth trauma was significantly associated with increased maternal bonding difficulties and decreased paternal bonding. A significant negative covariance between maternal and paternal bonding scores indicated interdependent bonding dynamics. The model explained 6% of the variance in maternal bonding and 3.7% in paternal bonding. These findings underscore the need for family-centered, trauma-informed postpartum care to support healthy parent-infant attachment.
Citation - WoS: 1
Utilising Uniportal Video-Assisted Thoracoscopic Surgery for Pericardial Window: A 12-Year Single-Centre Experience in the Diagnosis and Treatment of Pericardial Effusion
(Wolters Kluwer Medknow Publications, 2025) Agar, Mehmet; Gulcek, Ilham; Kalkan, Muhammed; Ulutas, Hakki; Celik, Muhammet Reha; Surgical Sciences; 08. Medical School; 01. Atılım University
Introduction:Uniportal video-assisted thoracoscopic surgery (Uni-VATS) is an effective minimally invasive technique for pericardial drainage, biopsy and window creation in cases of pericardial effusion (PE).Patients and Methods:This retrospective study evaluated 73 patients with PE who underwent pericardial window procedures between 2012 and 2024. Intraoperative and post-operative data related to Uni-VATS were assessed.Results:The mean age of the patients was 53.79 +/- 17.79 years (10-82 years), with 34 (46.6%) females and 39 (53.4%) males. The mean volume of pericardial fluid drained after window creation was 446.23 +/- 199.81 cc (75-1100 cc). The mean operation time was 42.87 +/- 12.79 min, and chest drain removal occurred after an average of 1.8 +/- 1.2 days. The mean duration until discharge or referral to the follow-up clinic was 5.98 +/- 2.14 days. In addition to the pericardial window procedure, pleural biopsy was performed in 12 patients, mediastinal mass biopsy in eight patients and wedge resection for parenchymal nodules in six patients. Microbiologic and virologic cultures of the fluids were negative in all cases. Among the 41 patients with benign cytology, pericardial biopsy results indicated tuberculosis in four patients (5.4%), amyloidosis in one patient (1.3%) and chronic or subacute nonspecific pericarditis in the remaining patients.Conclusion:Uni-VATS is a novel and safe technique that may be the preferred choice for pericardial window due to its diagnostic and therapeutic efficacy, ability to perform simultaneous procedures, favourable impact on operation duration/hospital stay, low complication rates and superiority compared to traditional methods.
Development and Validation of an ICF-Based New Scale-Atilim Kinesiophobia Scale: A Methodological Study
(Lippincott Williams & Wilkins, 2025) Ulug, Naime; Parmaksiz, Ayhan; Begen, Sena Nur; Can Karahan, Zehra; Yilmaz, Seval; Adali, Mehmet Fatih; Kilic, Erden; Er, Dudu Melek; 01. Atılım University; Child Development; 07. School of Health Sciences
It is important to assess kinesiophobia, which increases the risk of disability by limiting physical activity. In this cross-sectional study, we aimed to develop a scale that assesses kinesiophobia with the multidimensional structure of International Classification of Functioning, Disability and Health (ICF). Atilim Kinesiophobia Scale (AKS) was developed in Turkish by an expert panel using questionnaires replied by 367 subjects. Finally, 38 questions based on the sub-domains of the ICF described by World Health Organization. In the scope of this cross-sectional study content validity and reliability were assessed; construct validity (both convergent and divergent validity) was checked against Tampa Kinesiophobia Scale-17 and Visual Analog Scale. AKS demonstrated good internal consistency and convergent validity, with significant correlations observed with the Tampa Scale for Kinesiophobia-17 (r = 0.478, P < .001). Divergent validity was supported by insignificant correlations with the Visual Analog Scale (r = 0.019, P = .855). The Cronbach alpha coefficient of 0.862 indicates a high level of internal consistency for the AKS. Based on these findings, the final version of AKS was refined to include 4 factors and 14 items, demonstrating good internal validity. We developed and validated the AKS to assess kinesophobia in patients with acute and/or chronic musculoskeletal pain. This new ICF-based scale can be used to assess kinesiophobia; however further studies are required to prove its validity and reliability in other languages.
Citation - WoS: 1
Anti-Immigration Conspiracy Beliefs Are Associated With Endorsement of Conventional and Violent Actions Opposing Immigration and Attitudes Towards Democracy Across 21 Countries
(SpringerNature, 2025) Thomas, Emma F.; Stothard, Christina; Besta, Tomasz; Akbas, Gulcin; Becker, Julia C.; Becker, Maja; van Zomeren, Martijn; Department of Psychology; 02. School of Arts and Sciences; 01. Atılım University
Despite widespread speculation that conspiracy beliefs foster anti-democratic outcomes, the empirical picture is inconsistent. To clarify this literature, we examine the relationships that conspiracy beliefs have with commitment to reactionary action and criticism of democracy, focusing on a global issue: immigration. We expected that people who believe that their government uses immigration to diversify the population against citizens' wishes (anti-migration conspiracy beliefs) would be more committed to conventional and violent action to oppose immigration, and more critical of democracy. However, societal-level factors - economic performance and democratic functioning - were expected to influence (strengthen, weaken) these links. As hypothesized, multi-level analyses (N = 4353) from 21 countries revealed that economic prosperity attenuated the positive link between anti-migration conspiracy beliefs and commitment to reactionary action. Paradoxically, more democratic societies evidenced stronger links between conspiracy beliefs and conventional (but not violent) action to oppose immigration. Thus, more democratic societies appear to invite conventional forms of action to oppose immigration which may, in turn, weaken democratic norms of inclusion. Results highlight the interplay of individual- and societal-level factors underlying illiberal movements.
Prevalence of Toxoplasma Gondii in Patients with Schizophrenia and Its Association with Clinical Symptoms
(Pergamon-Elsevier Science Ltd, 2025) Kurkcu, Muhammed Furkan; Korkut, Gizem; Varli, Mehmet Ridvan; Yilmaz, Gulsum; Usluca, Selma; Bakir, Ayfer; Basic Sciences; 08. Medical School; 01. Atılım University
Background: Schizophrenia is a multifactorial neuropsychiatric disorder influenced by both genetic predisposition and environmental factors. Recent evidence suggests a possible link between latent Toxoplasma gondii infection and schizophrenia, though the underlying mechanisms remain unclear. Objective: To compare the seroprevalence of T. gondii in patients with schizophrenia and healthy individuals, and to evaluate the relationship between seropositivity and clinical parameters. Methods: A total of 265 participants (155 schizophrenia patients and 110 healthy controls) were enrolled. IgG and IgM antibodies were detected using electrochemiluminescence immunoassay (ECLIA), avidity was assessed using ELISA, and DNA presence was tested with real-time PCR. Clinical symptoms were evaluated using the Brief Psychiatric Rating Scale (BPRS). Statistical analysis included logistic regression and non-parametric tests (p < 0.05). Results: T. gondii IgG seropositivity was significantly higher in schizophrenia patients (29 %) than in controls (18.2 %) (p = 0.044, OR = 1.84; 95 % CI: 1.01-3.34). IgM positivity and DNA detection did not differ significantly. All seropositive participants showed high IgG avidity, indicating latent infection. BPRS scores and illness duration were higher in IgG-positive individuals, but the differences were not significant. Conclusion: Latent T. gondii infection may be associated with schizophrenia. However, further multicenter studies integrating molecular and serological approaches are needed to clarify its role in disease pathogenesis.
Factors Influencing the Transition Time From Psoriasis to Psoriatic Arthritis: A Real-World Multicenter Analysis
(Springer Heidelberg, 2025) Kilic, Gamze; Kilic, Erkan; Tekeoglu, Ibrahim; Sargin, Betul; Cengiz, Gizem; Balta, Nihan Cuzdan; Nas, Kemal; 01. Atılım University
To identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within +/- 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO). Demographic, clinical, and laboratory characteristics, disease activity, and patient-reported outcomes were compared between groups. Logistic regression was employed to determine independent predictors of prolonged transition. Among 799 patients (mean age 46.8 +/- 12.3 years), 237 (29.7%) had concurrent onset and 562 (70.3%) had a prolonged transition, with a mean PsO-to-PsA interval of 12.9 +/- 9.6 years. Depression (p = 0.005) and fatigue levels (p = 0.011) were significantly higher in patients with prolonged transition to PsA. Multivariate analysis revealed that scalp psoriasis (OR = 7.162), nail psoriasis (OR = 3.270), family history of PsO (OR = 1.813), and enthesitis ever (OR = 2.187) were associated with prolonged transition. Conversely, family history of PsA (OR = 0.421) and older age at PsO onset (OR = 0.957) predicted shorter transition. Prolonged transition from PsO to PsA is influenced by distinct clinical and demographic factors. Scalp/nail psoriasis, family history of PsO, and enthesitis ever may signal higher risk for prolonged PsA onset. Recognizing these markers can support timely referral and intervention, minimizing diagnostic delay and improving long-term patient outcomes.
Toxoplasma gondii Coinfection in HIV-Positive Patients at a Tertiary Care Hospital
(Bentham Science Publ Ltd, 2025) Kurkcu, Muhammed Furkan; Bakir, Ayfer; Kaba, Semiha Berra Topsakal; Kusabbi, Ilknur Alkan; Usluca, Selma; Basic Sciences; 08. Medical School; 01. Atılım University
Introduction: Toxoplasma gondii (T. gondii) can cause serious complications in both immunocompetent and immunosuppressed individuals. This study aims to assess the seroprevalence of T. gondii among HIV-positive individuals and to investigate its association with age, sex, CD4+ T cell count, HIV RNA levels, and hematological parameters. Methods: This study included 247 HIV-positive individuals followed up at a tertiary care hospital between November 1, 2022, and November 30, 2024. We analyzed serum samples for T. gondii IgG antibodies using electrochemiluminescent microparticle immunoassay. Results: The prevalence of T. gondii IgG seropositivity was found to be 32.8% (n=81; 95% CI: 26.9-39). The median age of seropositive individuals was 52 years (IQR: 42-61), which was significantly higher compared to seronegative individuals (p<0.001). The highest IgG seropositivity rate (66.7%) was observed in the 61-80 age group. Hemoglobin levels were significantly lower in IgG seropositive individuals (p=0.040). Logistic regression analysis indicated an increased risk of T. gondii infection with advancing age. The odds ratio for the 41-60 age group was 13.3 (95% CI: 1.6-106, p=0.02), while for the 61-80 age group, it was 28 (95% CI: 3.3-240, p=0.002). Discussion: The seroprevalence of T. gondii in HIV-positive individuals was lower than both global and regional averages. Age was identified as an independent risk factor for T. gondii seropositivity. Additionally, hematological alterations associated with anemia were observed in seropositive individuals. Further large-scale, multi-center, and regionally representative studies are required to optimize T. gondii infection management and screening strategies in people living with HIV. Conclusion: These findings suggest that T. gondii infection in HIV-positive individuals increases with age and may be associated with anemia, highlighting the need for age-focused screening and management strategies.

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