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Article Citation - Scopus: 1An Investigation on the Dna Binding Activities of Melamine, Cyanuric Acid and Uric Acid(Editura Acad Romane, 2021) Senol, Ali; Devrim, Alparslan Kadir; Sudagidan, Mert; Ozalp, Veli CengizMelamine can be added to various foods such as milk, milk powder, baby food, pet, and livestock feed for cheating purposes due to its high nitrogen content. Regarding its usage in food products, there is a need to investigate its possible interactions with DNA. Thus, this study aimed to investigate the interactions of melamine and its metabolized products, cyanuric acid and uric acid with genomic DNA, isolated from eukaryotic (calf thymus) and prokaryotic (Staphylococcus aureus) sources. UV-absorbance spectrophotometry, fluorescence spectrophotometry, and agarose gel electrophoresis techniques were used to evaluate these interactions. The five different concentrations of melamine, cyanuric acid, and uric acid were incubated with fixed DNA concentration and it was determined that the test compounds interacted with the DNA molecules. The data obtained by UV-absorbance and fluorescence spectrophotometry techniques revealed an increase in wave peaks observed with the increasing substance concentration. After the obtained data of the aforementioned techniques were evaluated together, it was concluded that melamine, cyanuric acid, and uric acid bonded to the eukaryotic and prokaryotic genomic DNA materials via groove binding.Article Citation - WoS: 6A Light Bulb in Every House the Istanbul General Electric Factory and American Technology Transfer To Turkey(Johns Hopkins Univ Press, 2022) Tunc, Tanfer Emin; Tunc, GokhanIn 1946, Turkish entrepreneur Vehbi Koc signed an agreement with the U.S. firm General Electric to build and operate its first light bulb factory in the Near/Middle East, in Istanbul. This private joint venture introduced new manufacturing techniques, business practices, and consumer habits to Turkey, opening channels of postwar technological exchange. Closer examination of the GE-Koc partnership reveals that during the early Cold War, the transfer and embedding of American technologies in Turkey was a politically complicated process of innovation that required constant adaptation. Fraught with unforeseeable obstacles, it also required cautious negotiation with multiple transnational actors. The story of the GE-Koc partnership thus adds a new dimension to historical understandings of the Turkish Cold War experience and the Americanization of the region. It illustrates how transferring a nonmilitary, soft-power, domestic technologythe light bulb-played a significant role in Turkish-American relations and therefore contributes to studies of U.S. Cold War diplomacy through transnational investment in innovation.Letter Medical Education During the Covid-19 Pandemic: Experience From a Newly Established Medical School(Springer india, 2020) Tulek, Necla; Gonullu, Ugur[No Abstract Available]Letter Theoretical Modelling of Magnetron Sputtering of Boron Nitride Coating(Springer Heidelberg, 2023) Rake, Nakka; Kaftanoglu, Bilgin; Hacaloglu, Tugce; Aydogan, AsudeThe fundamentals of the magnetron sputtering (MS) technique are simple. However, the complex interplay of various physical and chemical sub-processes lies in its simplicity. The direct simulation Monte Carlo (DSMC) method is used to model the MS of the Boron Nitride (BN) coating. The Lorentz force, which is created by an electric field, magnetic field and particle collision, is utilised to model the BN coating. Three distinct bias voltages are used to generate three different BN-coating models under the same conditions. The modelling of BN coatings reveals that the deposition rate decreases as the substrate voltage increases.Article A New Method To Determine the Continuous Refractive Index of an Absorbing Film by Generalized Stockwell Transform(Elsevier Sci Ltd, 2023) Coskun, Emre; Emir, Cansu; Selamet, Semanur; Parlak, Mehmet; Ozder, SerhatGeneralized Stockwell Transform (GST) was adapted to analyze a transmittance signal to continuously determine the refractive index and extinction coefficient. The process is built by analyzing oscillation frequencies of the transmission signal where oscillations exist. The simulation studies clearly show the advantage of the locally referenced phase property of the presented method. The validity of the method was checked for a CdS thin film. The results determined by the GST method are consistent with the results determined by envelope and other signal analyzing methods, and the literature. The noise and relative error analysis of the method was also discussed.Article Citation - WoS: 22Citation - Scopus: 26Mesenchymal Stem Cells Promote Spermatogonial Stem/Progenitor Cell Pool and Spermatogenesis in Neonatal Mice in Vitro(Nature Portfolio, 2022) Onen, Selin; Kose, Sevil; Yersal, Nilgun; Korkusuz, PetekPrepubertal cancer treatment leads to irreversible infertility in half of the male patients. Current in vitro spermatogenesis protocols and cryopreservation techniques are inadequate to expand spermatogonial stem/progenitor cells (SSPC) from testicles. Bone marrow derived mesenchymal stem cells (BM-MSC) bearing a close resemblance to Sertoli cells, improved spermatogenesis in animal models. We asked if a co-culture setup supported by syngeneic BM-MSC that contributes to the air-liquid interphase (ALI) could lead to survival, expansion and differentiation of SSPCs in vitro. We generated an ALI platform able to provide a real-time cellular paracrine contribution consisting of syngeneic BM-MSCs to neonatal C57BL/6 mice testes. We aimed to evaluate the efficacy of this culture system on SSPC pool expansion and spermatogenesis throughout a complete spermatogenic cycle by measuring the number of total germ cells (GC), the undifferentiated and differentiating spermatogonia, the spermatocytes and the spermatids. Furthermore, we evaluated the testicular cell cycle phases, the tubular and luminal areas using histochemical, immunohistochemical and flow cytometric techniques. Cultures in present of BM-MSCs displayed survival of ID4(+) spermatogonial stem cells (SSC), expansion of SALL4(+) and OCT4(+) SSPCs, VASA(+) total GCs and Ki67(+) proliferative cells at 42 days and an increased number of SCP3(+) spermatocytes and Acrosin(+) spermatids at 28 days. BM-MSCs increased the percentage of mitotic cells within the G2-M phase of the total testicular cell cycle increased for 7 days, preserved the cell viability for 42 days and induced testicular maturation by enlargement of the tubular and luminal area for 42 days in comparison to the control. The percentage of PLZF(+) SSPCs increased within the first 28 days of culture, after which the pool started to get smaller while the number of spermatocytes and spermatids increased simultaneously. Our findings established the efficacy of syngeneic BM-MSCs on the survival and expansion of the SSPC pool and differentiation of spermatogonia to round spermatids during in vitro culture of prepubertal mice testes for 42 days. This method may be helpful in providing alternative cures for male fertility by supporting in vitro differentiated spermatids that can be used for round spermatid injection (ROSI) to female oocyte in animal models. These findings can be further exploited for personalized cellular therapy strategies to cure male infertility of prepubertal cancer survivors in clinics.Review Citation - WoS: 91Citation - Scopus: 105Recommendations for Head and Neck Surgical Oncology Practice in a Setting of Acute Severe Resource Constraint During the Covid-19 Pandemic: an International Consensus(Elsevier Science inc, 2020) Mehanna, Hisham; Hardman, John C.; Shenson, Jared A.; Abou-Foul, Ahmad K.; Topf, Michael C.; AlFalasi, Mohammad; Holsinger, F. ChristopherThe speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is an urgent need to identify consensus statements on head and neck surgical oncology practice. We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. Endorsed by 39 societies and professional bodies, these consensus practice recommendations aim to decrease inconsistency of practice, reduce uncertainty in care, and provide reassurance for clinicians worldwide for head and neck surgical oncology in the context of the COVID-19 pandemic and in the setting of acute severe resource constraint and high risk of infection to patients and staff.Book Part Impacts of Economic and Institutional Dynamics on New Media Applications Penetration: Sample Country Analysis(IGI Global, 2020) Benli,H.E.New media applications become vital in order to compete as a country and as human beings. Despite the positive impact and increasing global usage of new media applications, some countries have low new media applications penetration when others have high. This should be analyzed and evaluated within the countries' own macroeconomic and institutional dynamics. Dynamic motives as institutional, macroeconomic, infrastructural, and political factors heavily divined and also easily damage the current and future conditions of the countries. This work conceptually and concretely investigated the role of specific factors. Macroeconomic factors are determined as population, GDP growth rate, and population rate of the countries. Institutional factors are evaluated through political stability index, rule of law index, and civil liberties index of each sample country. Infrastructural factors, business environment, and investments were analyzed with looking at international internet bandwidth per internet users and competitiveness data for countries. © 2021, IGI Global.Book Part Citation - Scopus: 1Design of Recycled Aluminium (AA7075)-Based Composites Reinforced with Nano Filler NiAl Intermetallic and Nano Niobium Powder Produced with Vacuum Arc Melting for Aeronautical Applications(CRC Press, 2023) Kasar,C.; Aslan,O.; Gatamorta,F.; Miskioglu,I.; Bayraktar,E.In the frame of the common research project, the mechanical properties of recycled gas atomized scrap aluminium (AA 7075)-based composites reinforced with nano filler NiAl intermetallic and niobium (Nb) elements have been evaluated. Firstly, the mixture was homogenized by means of a ball milling process for 4 hours. After cold compaction of the compositions, the final specimens have been produced with “vacuum arc melting” for aeronautical applications. Static and dynamic compression tests have been conducted. Additional tensile tests have also been carried out. Experimental results were compared with a finite element method. The interface and microstructure of these composites have also been evaluated by a scanning electron microscopy. © 2024 selection and editorial matter, N. M. Nurazzi, E. Bayraktar, M. N. F. Norrrahim, H. A. Aisyah, N. Abdullah, and M. R. M. Asyraf; individual chapters, the contributors.Article Citation - WoS: 12Citation - Scopus: 12Investigation of a Candidate Spin-1/2 Hidden-Charm Triple Strange Pentaquark State pcsss<(Amer Physical Soc, 2023) Azizi, K.; Sarac, Y.; Sundu, H.A candidate triple strange pentaquark state, P-csss, is investigated through its strong decay channel P-csss -> C2-J=y/. To calculate the relevant strong coupling constants, two possible interpolating currents with spin-parity JP 1/4 1 - are used. Though the chosen currents for the state under consideration have spin-parity quantum numbers JP 1/4 1 -, they couple to both the positive and negative parity states simultaneously and the corresponding decay widths are obtained for both parities. These widths are obtained as foP(csss) -> J=y/C2- +/_ 1/4 201.4 82.5 MeV for the negative and fo P similar to csss -> J=y/C2- +/_ 1/4 316.4 107.8 MeV for the positive parity state when the first current is used. For the second current, we obtain foP(csss) -> J=y/C2- +/_ 1/4 252.5 116.7 MeV for the negative and fo P similar to csss -> J=y/C2- +/_ 1/4 361.1 ; 98.4 MeV for the positive parity state. These results may provide insights into future experimental observations of such candidate states and help to distinguish and fix their properties.
