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Article Citation - WoS: 1Citation - Scopus: 2Parametric Sensitivity Analysis and Performance Evaluation of High-Temperature Macro-Encapsulated Packed-Bed Latent Heat Storage System Operating With Transient Inlet Boundary Conditions(Mdpi, 2022) Mehrtash, Mehdi; Tari, IlkerThis paper presents the results of comprehensive numerical analyses in the performance of a packed-bed latent heat storage (PBLHS) system in terms of key performance indicators, namely charging time, charging rate, charging capacity, and charging efficiency. Numerical simulations are performed for the packed bed region using a transient two-dimensional axisymmetric model based on the local thermal non-equilibrium (LTNE) approach. The model considers the variation in the inlet temperature of the system as these storage systems are typically integrated with solar collectors that operate with intermittent solar radiation intensity. The model results are validated using the experimental data for temperature distribution throughout the bed. The simulations are carried out while changing the operating parameters such as the capsule diameter, bed porosity, inlet velocity, and the height-to-diameter aspect ratio to investigate their impact on the performance indicators. Observations indicate that low porosity, large-sized capsules, low inlet velocity, and a low height-to-diameter aspect ratio increase the charging time. In terms of achieving a high charging rate, a bed with low porosity, small-sized capsules, a high inflow velocity, and a high height-to-diameter aspect ratio is deemed advantageous. It is shown that raising the flow velocity and the height-to-diameter aspect ratio can improve the charging efficiency. These findings provide recommendations for optimizing the design and operating conditions of the system within the practical constraints.Article Citation - WoS: 4Citation - Scopus: 4The Effect of Cerium Oxide (ceo2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice With Streptozocin-Induced Diabetes(Mdpi, 2024) Ozer, Abdullah; Sengel, Necmiye; Kucuk, Ayseguel; Yigman, Zeynep; Ozdemir, Cagri; Kilic, Yigit; Arslan, MustafaObjective: Lower extremity ischemia-reperfusion injury (IRI) may occur with trauma-related vascular injury and various vascular diseases, during the use of a tourniquet, in temporary clamping of the aorta in aortic surgery, or following acute or bilateral acute femoral artery occlusion. Mitochondrial dysfunction and increased basal oxidative stress in diabetes may cause an increase in the effects of increased reactive oxygen species (ROS) and mitochondrial dysfunction due to IRI. It is of great importance to examine therapeutic approaches that can minimize the effects of IRI, especially for patient groups under chronic oxidative stress such as DM. Cerium oxide (CeO2) nanoparticles mimic antioxidant enzymes and act as a catalyst that scavenges ROS. In this study, it was aimed to investigate whether CeO2 has protective effects on skeletal muscles in lower extremity IRI in mice with streptozocin-induced diabetes. Methods: A total of 38 Swiss albino mice were divided into six groups as follows: control group (group C, n = 6), diabetes group (group D, n = 8), diabetes-CeO2 (group DCO, n = 8), diabetes-ischemia/reperfusion (group DIR, n = 8), and diabetes-ischemia/reperfusion-CeO2 (group DIRCO, n = 8). The DCO and DIRCO groups were given doses of CeO2 of 0.5 mg/kg intraperitoneally 30 min before the IR procedure. A 120 min ischemia-120 min reperfusion period with 100% O-2 was performed. At the end of the reperfusion period, muscle tissues were removed for histopathological and biochemical examinations. Results: Total antioxidant status (TAS) levels were found to be significantly lower in group DIR compared with group D (p = 0.047 and p = 0.022, respectively). In group DIRCO, total oxidant status (TOS) levels were found to be significantly higher than in group DIR (p < 0.001). The oxidative stress index (OSI) was found to be significantly lower in group DIR compared with group DCO (p < 0.001). Paraoxanase (PON) enzyme activity was found to be significantly increased in group DIR compared with group DCO (p < 0.001). The disorganization and degeneration score for muscle cells, inflammatory cell infiltration score, and total injury score in group DIRCO were found to be significantly lower than in group DIR (p = 0.002, p = 0.034, and p = 0.001, respectively). Conclusions: Our results confirm that CeO2, with its antioxidative properties, reduces skeletal muscle damage in lower extremity IRI in diabetic mice.Article Citation - WoS: 13Citation - Scopus: 13Investigating Space Utilization in Skyscrapers Designed with Prismatic Form(Mdpi, 2024) Ilgin, Hueseyin Emre; Aslantamer, Ozlem NurThe enduring appeal of prismatic shapes, historically prevalent in office building designs, persists in contemporary skyscraper architecture, which is attributed particularly to their advantageous aspects concerning cost-efficiency and optimal space utilization. Space efficiency is a crucial factor in prismatic skyscraper design, carrying substantial implications for sustainability. However, the current academic literature lacks a complete exploration of space efficiency in supertall towers with prismatic forms, despite their widespread use. This paper seeks to address this significant gap by conducting a comprehensive analysis of data gathered from a carefully selected set of 35 case studies. The primary discoveries presented in this paper are outlined as follows: (i) average space efficiency stood at approximately 72%, covering a range that extended from 56% to 84%; (ii) average core to gross floor area ratio averaged around 24%, spanning a spectrum that ranged from 12% to 36%; (iii) the majority of prismatic skyscrapers utilized a central core approach, mainly customized for residential use; (iv) the dominant structural system observed in the analyzed cases was the outriggered frame system, with concrete being the commonly utilized material for the structural components; and (v) the impact of diverse structural systems on space efficiency showed no significant deviation, although differences in function led to variations in average space efficiency. The authors expect that these findings will provide valuable guidance, especially for architects, as they strive to enhance the sustainable planning of prismatic towers.Article Citation - WoS: 5Citation - Scopus: 6High Persistence and Nonlinear Behavior in Financial Variables: a More Powerful Unit Root Testing in the Estar Framework(Mdpi, 2021) Omay, Tolga; Corakci, Aysegul; Hasdemir, EsraIn this study, we consider the hybrid nonlinear features of the Exponential Smooth Transition Autoregressive-Fractional Fourier Function (ESTAR-FFF) form unit root test. As is well known, when developing a unit root test for the ESTAR model, linearization is performed by the Taylor approximation, and thereby the nuisance parameter problem is eliminated. Although this linearization process leads to a certain amount of information loss in the unit root testing equation, it also causes the resulting test to be more accessible and consistent. The method that we propose here contributes to the literature in three important ways. First, it reduces the information loss that arises due to the Taylor expansion. Second, the research to date has tended to misinterpret the Fourier function used with the Kapetanios, Shin and Snell (2003) (KSS) unit root test and considers it to capture multiple smooth transition structural breaks. The simulation studies that we carry out in this study clearly show that the Fourier function only restores the Taylor residuals of the ESTAR type function rather than accounting forthe smooth structural break. Third, the new nonlinear unit root test developed in this paper has very strong power in the highly persistent near unit root environment that the financial data exhibit. The application of the Kapetanios Shin Snell- Fractional Fourier (KSS-FF) test to ex-post real interest rates data of 11 OECD countries for country-specific sample periods shows that the new test catches nonlinear stationarity in many more countries than the KSS test itself.Article Effects of Pomegranate Seed Oil on Lower Extremity Ischemia-Reperfusion Damage: Insights into Oxidative Stress, Inflammation, and Cell Death(MDPI, 2025) Bozok, Ummu Gulsen; Ergorun, Aydan Iremnur; Kucuk, Aysegul; Yigman, Zeynep; Dursun, Ali Dogan; Arslan, MustafaAim: This study sought to clarify the therapeutic benefits and mechanisms of action of pomegranate seed oil (PSO) in instances of ischemia–reperfusion (IR) damage in the lower extremities. Materials and Methods: The sample size was determined, then 32 rats were randomly allocated to four groups: Control (C), ischemia–reperfusion (IR), low-dose PSO (IR + LD, 0.15 mL/kg), and high-dose PSO (IR + HD, 0.30 mL/kg). The ischemia model in the IR group was established by occluding the infrarenal aorta for 120 min. Prior to reperfusion, PSO was delivered to the IR + LD and IR + HD groups at doses of 0.15 mL/kg and 0.30 mL/kg, respectively, followed by a 120 min reperfusion period. Subsequently, blood and tissue specimens were obtained. Statistical investigation was executed utilizing Statistical Package for the Social Sciences version 20.0 (SPSS, IBM Corp., Armonk, NY, USA). Results: Biochemical tests revealed significant variations in total antioxidant level (TAS), total oxidant level (TOS), and the oxidative stress index (OSI) across the groups (p < 0.0001). The IR group had elevated TOS and OSI levels, whereas PSO therapy resulted in a reduction in these values (p < 0.05). As opposed to the IR group, TASs were higher in the PSO-treated groups. Histopathological analysis demonstrated muscle fiber degeneration, interstitial edema, and the infiltration of cells associated with inflammation in the IR group, with analogous results noted in the PSO treatment groups. Immunohistochemical analysis revealed that the expressions of Tumor Necrosis Factor-alpha (TNF-α), Nuclear Factor kappa B (NF-κB), cytochrome C (CYT C), and caspase 3 (CASP3) were elevated in the IR group, while PSO treatment diminished these markers and attenuated inflammation and apoptosis (p < 0.05). The findings demonstrate that PSO has a dose-dependent impact on IR injury. Discussion: This research indicates that PSO has significant protective benefits against IR injury in the lower extremities. PSO mitigated tissue damage and maintained mitochondrial integrity by addressing oxidative stress, inflammation, and apoptotic pathways. Particularly, high-dose PSO yielded more substantial enhancements in these processes and exhibited outcomes most comparable to the control group in biochemical, histological, and immunohistochemical investigations. These findings underscore the potential of PSO as an efficacious natural treatment agent for IR injury. Nevertheless, additional research is required to articulate this definitively.Article Citation - WoS: 28Citation - Scopus: 44Digital Transformation Strategies, Practices, and Trends: a Large-Scale Retrospective Study Based on Machine Learning(Mdpi, 2023) Gurcan, Fatih; Boztas, Gizem Dilan; Dalveren, Gonca Gokce Menekse; Derawi, MohammadThe purpose of this research is to identify the areas of interest, research topics, and application areas that reflect the research nature of digital transformation (DT), as well as the strategies, practices, and trends of DT. To accomplish this, the Latent Dirichlet allocation algorithm, a probabilistic topic modeling technique, was applied to 5350 peer-reviewed journal articles on DT published in the last ten years, from 2013 to 2022. The analysis resulted in the discovery of 34 topics. These topics were classified, and a systematic taxonomy for DT was presented, including four sub-categories: implementation, technology, process, and human. As a result of time-based trend analysis, "Sustainable Energy", "DT in Health", "E-Government", "DT in Education", and "Supply Chain" emerged as top topics with an increasing trend. Our findings indicate that research interests are focused on specific applications of digital transformation in industrial and public settings. Based on our findings, we anticipate that the next phase of DT research and practice will concentrate on specific DT applications in government, health, education, and economics. "Sustainable Energy" and "Supply Chain" have been identified as the most prominent topics in current DT processes and applications. This study can help researchers and practitioners in the field by providing insights and implications about the evolution and applications of DT. Our findings are intended to serve as a guide for DT in understanding current research gaps and potential future research topics.Article Citation - WoS: 5Citation - Scopus: 7Enhancing Urban Sustainability With Novel Vertical-Axis Wind Turbines: a Study on Residential Buildings in Çeşme(Mdpi, 2025) Saleh, Yousif Abed Saleh; Durak, Murat; Turhan, CihanThis study investigates the integration of three types of vertical-axis wind turbines (VAWTs)-helical, IceWind, and a combined design-on residential buildings in & Ccedil;e & scedil;me, T & uuml;rkiye, a region with an average wind speed of 7 m/s. The research explores the potential of small-scale wind turbines in urban areas, providing sustainable solutions for renewable energy generation and reducing reliance on conventional energy sources. The turbines were designed and analyzed using SolidWorks and ANSYS Fluent, achieving power outputs of 350 W for the helical turbine, 430 W for the IceWind turbine, and 590 W for the combined turbine. A total of 42 turbines were mounted on a five-storey residential building model, and DesignBuilder software was utilized to simulate and evaluate the energy consumption. The baseline energy consumption of 172 kWh/m2 annually was reduced by 18.45%, 22.93%, and 30.88% for the helical, IceWind, and combined turbines, respectively. Furthermore, the economic analysis showed payback periods of 12.89 years for the helical turbine, 10.60 years for the IceWind turbine, and 10.49 years for the combined turbine. These findings emphasize the viability of integrating VAWTs into urban buildings as an effective strategy for reducing energy consumption, lowering costs, and enhancing energy efficiency.Article Citation - WoS: 1Citation - Scopus: 2Current New Approach in Thoracoscopic Surgery: Non-Intubated Uniportal Video-Assisted Thoracoscopic Surgery (Ni-Univats)(Mdpi, 2025) Agar, Mehmet; Gulcek, Ilham; Kalkan, Muhammed; Ulutas, Hakki; Celik, Muhammet Reha; Aksu, Ahmet; Cakmak, MuharremBackground and Objectives: Non-intubated uniportal video-assisted thoracoscopic surgery (NI-UniVATS) is a minimally invasive technique performed using a single port, allowing the entire surgical procedure to be completed with spontaneous breathing without the need for general anesthesia. Materials and Methods: This retrospective study included 51 patients who underwent NI-UniVATS between 2020 and 2023. The intraoperative and postoperative data of patients who underwent NI-UniVATS were evaluated. Results: Among the cases, 37 (72.5%) were male, and 14 (46.6%) were female, with a mean age of 47.73 +/- 20.43 years (range: 18-78 years). The mean operative time was 25.92 +/- 7.31 min. No perioperative complications were observed in any patient. The mean postoperative hospital stay was 4.17 +/- 1.76 days (range: 2-9 days). A right hemithoracic approach was performed in 28 patients (54.9%), whereas a left hemithoracic approach was used in 23 patients (45.1%). The procedures performed included wedge resection in 27 patients (52.9%), biopsy in 22 patients (43.1%), pericardial window creation in one patient (2%), and intrathoracic foreign body removal in one patient (2%). Conclusions: NI-UniVATS allows for safer surgery by preventing the adverse effects and complications associated with general anesthesia. NI-UniVATS can be recommended as a safe and feasible approach for both minor and major thoracic procedures.Article Citation - WoS: 11Citation - Scopus: 14Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damagein Rats with Experimental Lower-Extremity Ischemia–Reperfusion Injury(MDPI, 2025) Demirtas, Hueseyin; Ozer, Abdullah; Yildirim, Alperen Kutay; Dursun, Ali Dogan; Sezen, Saban Cem; Arslan, MustafaBackground and Objectives: Ischemia–reperfusion (I/R) injury can affect multiple distant organs following I/R in the lower extremities. BPC-157’s anti-inflammatory and free radical-neutralizing properties suggest its potential in mitigating ischemia–reperfusion damage. This study evaluates the protective effects of BPC-157 on remote organ damage, including the kidneys, liver, and lungs, in a rat model of skeletal muscle I/R injury. Materials and Methods: A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB). Some 45 min of ischemia of lower extremity was followed by 2 h of reperfusion of limbs. BPC-157 was applied to groups B and I/RB at the beginning of the procedure. After 2 h of reperfusion, liver, kidney and lung tissues were harvested for biochemical and histopathological analyses. Results: In the histopathological examination, vascular and glomerular vacuolization, tubular dilation, hyaline casts, and tubular cell shedding in renal tissue were significantly lower in the I/RB group compared to other groups. Lung tissue showed reduced interstitial edema, alveolar congestion, and total damage scores in the I/RB group. Similarly, in liver tissue, sinusoidal dilation, necrotic cells, and mononuclear cell infiltration were significantly lower in the I/RB group. Additionally, the evaluation of TAS, TOS, OSI, and PON-1 revealed a statistically significant increase in antioxidant activity in the liver, lung, and kidney tissues of the I/RB group. Conclusions: The findings of this study demonstrate that BPC-157 exerts a significant protective effect against distant organ damage in the liver, kidneys, and lungs following lower extremity ischemia–reperfusion injury in rats.Article Citation - WoS: 26Citation - Scopus: 38A Rule-Based Approach To Embedding Techniques for Text Document Classification(Mdpi, 2020) Aubaid, Asmaa M.; Mishra, AlokWith the growth of online information and sudden expansion in the number of electronic documents provided on websites and in electronic libraries, there is difficulty in categorizing text documents. Therefore, a rule-based approach is a solution to this problem; the purpose of this study is to classify documents by using a rule-based. This paper deals with the rule-based approach with the embedding technique for a document to vector (doc2vec) files. An experiment was performed on two data sets Reuters-21578 and the 20 Newsgroups to classify the top ten categories of these data sets by using a document to vector rule-based (D2vecRule). Finally, this method provided us a good classification result according to the F-measures and implementation time metrics. In conclusion, it was observed that our algorithm document to vector rule-based (D2vecRule) was good when compared with other algorithms such as JRip, One R, and ZeroR applied to the same Reuters-21578 dataset.
