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Article Citation - WoS: 96Citation - Scopus: 100Effect of Progesterone on Dppc Membrane: Evidence for Lateral Phase Separation and Inverse Action in Lipid Dynamics(Elsevier Science inc, 2005) Korkmaz, F; Severcan, FInteractions of progesterone with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) triultilamellar liposomes were investigated as a function of temperature and progesterone concentration by using three non-invasive techniques namely Fourier transform infrared spectroscopy, turbidity at 440 nm, and differential scanning calorimetry. The results reveal that progesterone changes the physical properties of DPPC bilayers by decreasing the main phase-transition temperature, abolishing the pre-transition, broadening the phase-transition profile, disordering the system both in gel and liquid crystalline phase, increasing the dynamics at low concentrations whereas stabilizing the membrane at high concentrations, and inducing phase separation. Progesterone does not change the hydration of the C=O groups, while it strengthens the hydrogen bonding between the PO (2) over bar groups of lipids and the water molecules around. (c) 2005 Elsevier Inc. All rights reserved.Article Citation - WoS: 5Citation - Scopus: 7Comparison of Nat1, Nat2 & Gstt2-2 Activities in Normal and Neoplastic Human Breast Tissues(Aepress Sro, 2006) Geylan-SU, YS; Isgör, B; Coban, T; Kapucuoglu, N; Aydintug, S; Iscan, M; Güray, T; Chemical EngineeringIn this study, arylamine N-acetyltransferases, NATs (E.C.2.3.1.5) and glutathione-S-transferase-T2-2, GSTT2-2 (E.C.2.5.1.18) enzyme activities in the breast tumor and surrounding tumor-free tissues of 22 female breast cancer patients with infiltrating ductal carcinoma were measured. The possible impacts of grade of malignancy, chemotherapy treatment, estrogen receptor status and menopausal status on all enzyme activities were evaluated. The results showed that, both NAT2 and GSTT2-2 display significant differences between tumor and tumor-free breast tissues, while no difference was observed in NAT1. Grade of malignancy seems to be positively associated with NAT1 and negatively associated with GSTT2-2. Though, both NAT2 and GSTT2-2 have increased mean tumor activities, the grade of malignancy, chemotherapy status, menopausal status or estrogen receptor status are not correlated statistically.Conference Object Citation - WoS: 5Citation - Scopus: 3Evaluation of Efficiencies of Diffuse Allochthonous and Autochthonous Nutrient Input Control in Restoration of a Highly Eutrophic Lake(I W A Publishing, 2002) Muhammetoglu, A; Muhammetoglu, H; Soyupak, SMogan Lake is an important recreational area for Metropolitan Ankara-Turkey. It is a shallow eutrophic lake with a dense growth of macrophytes. The main contributors of nutrients and other pollutants to the lake are the creeks carrying the runoff water from the watershed and upland farming land, in addition to the domestic and industrial wastewater discharges from a nearby town and industries. Hydrodynamic and water quality modeling techniques were used to determine the optimum management schemes for the lake restoration and diffuse pollution control. Management scenarios were devised and tested to control allochthonous and autochthonous nutrient inputs to the lake. Phosphorus and nitrogen load reductions were the main test elements for the control of allochthonous nutrient inputs. The scenario analysis revealed that reduction of phosphorus and nitrogen loads from diffused sources will have a marginal effect on controlling eutrophication if macrophyte growth is left uncontrolled. Scenarios employing macrophyte harvesting and sediment dredging have been evaluated for autochthonous nutrient input control. Sediment dredging alone has been shown to yield the most favorable conditions for water quality improvement in Mogan Lake. Further, control of diffuse pollution was an essential final step to achieve an acceptable long-term sustainable water quality improvement in the lake.Article Citation - WoS: 102Citation - Scopus: 113A 1.6-Mm, Metal Tube Ultrasonic Motor(Ieee-inst Electrical Electronics Engineers inc, 2003) Cagatay, S; Koc, B; Uchino, KA miniaturized metal tube ultrasonic motor, the dimensions of which are 1.6 mm in diameter and 6 rum in length, was developed. Two flattened surfaces with 90-degrees were ground on the outer surface of the stator. Two PZT-based piezoelectric ceramics were bonded onto these flat surfaces. The asymmetrical surface of the stator developed the split of the two degenerated orthogonal bending modes, resulting in a wobble motion. The working frequency of the 1.6-mm motor with 6 mm in length was 130 kHz. A torque of 0.5 mNm was reached at a maximum power of 45 mW with a speed of 45 rad/sec. The maximum efficiency was 16%.Article Citation - WoS: 23Citation - Scopus: 25Comparison of Cellular Proliferation on Dense and Porous Pcl Scaffolds(Ios Press, 2008) Sasmazel, Hilal Tuerkoglu; Gumusderelioglu, Menemse; Gurpinar, Aylin; Onur, Mehmet AliIn this contribution, PCL (poly-e caprolactone) scaffolds were prepared by solvent-casting/particle-leaching technique in the presence of two pore formers, PEG(4000) or sucrose molecules in different quantities (0, 10, 20, 30, 40, 50, 55 w/w% PEG(4000)/PCL; 10, 20 w/w% Sucrose/ PCL). The surface and bulk properties of the resulting scaffolds were studied by SEM, DSC and FTIR. SEM photographs showed that, macroporosity was obtained in the PCL structures prepared with sucrose crystals while microporous structure was obtained in the presence of PEG(4000) molecules. Average pore diameters calculated from SEM photographs were 40.1 and 191.2 mu m for 40% PEG(4000)/PCL and 10% Sucrose/PCL scaffolds, respectively. The DSC and FTIR results confirmed that there is no any interaction between pore formers and PCL during structural formation, and both pore formers, PEG(4000) and sucrose, remained independently in the scaffolds. L929 mouse fibroblast cells were seeded onto PCL structures and maintained during 7 days to evaluate cell proliferation. Cell culture results showed that, 10% Sucrose/ PCL scaffold was the most promising substrate for L929 cell growth due to 3-D architecture and macroporous structure of the scaffold.Article Citation - WoS: 21Citation - Scopus: 23Comparison of Biomechanical Behaviour of Maxilla Following Le Fort 1 Osteotomy With 2-Versus 4-Plate Fixation Using 3d-Fea Part 2: Impaction Surgery(Churchill Livingstone, 2009) Atac, M. S.; Erkmen, E.; Yucel, E.; Kurt, A.The aim of the second part of this Study was to evaluate the mechanical behaviour of 2- versus 4-plate fixation and bony structures after Le Fort I impaction surgeries using three-dimensional finite element analysis (3D-FEA). Two 3D-FEA models were created to fixate the impacted maxilla at the Le Fort I level as 2-plate fixation at the piriform rims (IMP-2 model) and 4-plate fixation at the zygomatic buttresses and piriform rims (IMP-4 model). The IMP-2 model contained 225 664 elements and 48 754 nodes and the IMP-4 model consisted of 245 929 elements and 53 670 nodes. The stresses in each maxillary model were computed. The models were loaded on one side, at the molar-premolar region, in vertical, horizontal and oblique directions to reflect the chewing process. It was concluded that the use of 4-plate fixation following Le Fort I advancement Surgery provides fewer stress fields on the maxillary bones and fixation materials than 2-plate fixation from a mechanical point of view.Article Citation - WoS: 31Citation - Scopus: 35Comparison Between Alternating Aerobic-Anoxic and Conventional Activated Sludge Systems(Pergamon-elsevier Science Ltd, 2007) Balku, SaziyeConventional activated sludge systems ensure removal of colloidal and dissolved carbonaceous organic matter whereas alternating aerobic-anoxic systems, in addition, satisfy a further reduction in nitrogen content of wastewater. Main difference between them is that the alternating system should also include an anoxic operation mode which satisfies denitrification. In other words conventional systems are operated under aerobic conditions whereas alternating systems require a periodical change from aerobic conditions to anoxic conditions. So the most important problem in alternating systems is to find the appropriate durations for both sequences. In this study a comparison between conventional and alternating systems is considered in terms of nitrogen removal and aeration time by simulation under the same conditions together with an optimization algorithm. The results show that an activated sludge system can be operated as an alternating aerobic-anoxic system so that nitrogen removal is also possible during treatment without any additional investment or operational cost. (C) 2007 Elsevier Ltd. All rights reserved.Article Citation - WoS: 41Citation - Scopus: 48Platinated Copper(3-Clip Complexes as Effective Dna-Cleaving and Cytotoxic Agents(Wiley-v C H verlag Gmbh, 2008) Ozalp-Yaman, Seniz; de Hoog, Paul; Amadei, Giulio; Pitie, Marguerite; Gamez, Patrick; Dewelle, Janique; Reedijk, JanThe synthesis and biological activity of three heteronuclear platinum-copper complexes based on 3-Clip-Phen are reported. These rigid complexes have been designed to alter the intrinsic mechanism of action of both the platinum moiety and the Cu(3-Clip-Phen) unit. The platinum centers of two of these complexes are coordinated to a 3-Clip-Phen moiety, an ammine ligand and two chlorides, which are either cis or trans to each other. The third complex comprises two 3-Clip-Phen units and two chloride ligands bound in a trans fashion to the platinum ion. DNA-cleavage experiments show that the complexes are highly efficient nuclease agents. In addition, a markedly difference in their aptitude to perform direct double-strand cleavage is observed, which appears to be strongly related to the ability of the platinum unit to coordinate to DNA. Indeed, complex 6 is unable to coordinate to DNA, which is reflected by its incapability to carry out double-strand breaks. Nonetheless, this complex exhibits efficient DNA-cleavage activity, and its cytotoxicity is high for several cell lines. Complex 6 shows better antiproliferate activity than both cisplatin and Cu(3-Clip-Phen) toward most cancer cell lines. Furthermore, the cytotoxicity observed for 1 is for most cell lines close to that of cisplatin, or even better. Cu(3-Clip-Phen) induces very low cytotoxic effects, but a marked migratory activity. Complex 6 presents DNA-cleavage properties comparable to the one of Cu(3-Clip-Phen), but it does not show any migratory activity. Interestingly, both Cu(3-Clip-Phen) and 6 induces vacuolisation processes in the cell in contrast to complex 1 and cisplatin. Thus, the four complexes cisplatin tested, Cu(3-Clip-Phen), I and 6 stimulate different cellular responses.Conference Object Citation - WoS: 5Citation - Scopus: 5Assessment of Nitrogen Excess in an Agricultural Area Using a Nitrogen Balance Approach(I W A Publishing, 2005) Muhammetoglu, H; Muhammetoglu, A; Soyupak, SA pilot study has been initiated to develop an approach for quantification of nitrogen excesses from agricultural activities that involve greenhouse farming in Kumluca Plain, Turkey. Detailed calculations utilizing the nitrogen balance method (NBM) were carried out at nine different locations within the plain over a time period of one year. The major contributing factors and governing operative mechanisms taken into consideration were nitrogen application rates both as organic and chemical fertilizers, irrigation water to application practices, and nitrogen uptake by plants. The adopted approach yielded valuable information such as plant nitrogen uptake efficiencies, excess nitrogen, leaching rates and leachate nitrogen concentrations. Further, a site specific multiple linear regression model has been developed to estimate the ratio (N-leachate/N-groundwater) as a function of independent variables: farming age, excess nitrogen application and SEEPAGE Index Number. The negative sign of the model parameters implies that the ratio (N-leachate/N-groundwater) decreases as values of the independent variables increase. The adopted approach and the obtained results can beneficially be applied to similar sites to establish basic parameters of irrigation and fertilizer application operations.Article Citation - WoS: 33Citation - Scopus: 36Comparison of Biomechanical Behaviour of Maxilla Following Le Fort I Osteotomy With 2-Versus 4-Plate Fixation Using 3d-Fea. Part 1: Advancement Surgery(Churchill Livingstone, 2008) Atac, M. S.; Erkmen, E.; Yucel, E.; Kurt, A.The study aimed to calculate the location and intensity of the maximum stress fields on the fixation plates and surrounding maxilla following Le Fort I osteotomies after advancement procedures using three-dimensional finite element analysis. The models were generated using skull CT scan data. Le Fort I osteotomy Simulations were made and two separate impacted maxillary models were designed. The ADV-2 model has 2 plate fixations bilaterally at the piriform rims, the ADV-4 model has 4 plate fixations at the zygomatic buttresses and piriform rims. The stress fields on bone, plate and screws were computed for each model. Posterior occlusal loads were simulated on one side in the molar-premolar region, in all three directions, reflecting the chewing forces. The increased locations of highest Von Mises stresses on the plates and highest maximum principle stresses on the bones were determined in ADV-2 models especially Under horizontal and oblique loads when compared with ADV-4 models. Evaluation of the highest Von Mises Stress Values and maximum principal stress revealed that oblique load in the ADV-2 model received the highest values. 4-plate fixation following Le Fort I advancement Surgery exerts less stress on the maxillary bones and fixation materials than 2-plate fixation.
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