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Article Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development(John Wiley and Sons Inc, 2025) Didarian, Reza; Bargh, Saharnaz; Gulerman, Almina; Ozalp, Veli Cengiz; Erel, Ozcan; Yildirim-Tirgil, NimetThis work presents the pioneering development of an aptamer-based electrochemical biosensor for real-time monitoring of parathyroid hormone (PTH) levels, with a focus on intraoperative assessment during parathyroid surgery. It introduces, for the first time, the selection and characterization of aptamers targeting distinct segments of the PTH peptide. The study demonstrates the feasibility and efficacy of the biosensing platform through a precisely designed experimental framework, including SELEX-based aptamer selection, aptamer-peptide interaction analysis, and biosensor fabrication. The SELEX process yields aptamers with notable binding affinities to different fragments of PTH, with the PTH (53-84) aptamer showing particularly sensitive binding to the hormone's C terminus, allowing for precise PTH analysis. Electrochemical characterization reveals significant changes in electrochemical impedance spectroscopy (EIS) signals upon exposure to varying PTH concentrations, highlighting the sensor's sensitivity and selectivity. The increase in charge transfer resistance (Rct) values with rising PTH concentrations underscores the biosensor's capability to detect PTH-induced structural changes, validating its potential for accurate measurement. The biosensor shows remarkable selectivity in the presence of common interferents in serum samples, ensuring precise PTH detection. Stability assessments over a 45-day storage period demonstrate the biosensor's robustness and long-term reliability, affirming its practical suitability. In summary, the developed aptamer-based biosensor represents a promising tool for sensitive and selective PTH detection, with potential applications in biomedical research and clinical diagnostics, particularly for intraoperative PTH analysis during parathyroidectomy. Continued research and optimization efforts hold promise for enhancing its performance and expanding its utility in diverse healthcare settings.Article Citation - WoS: 10Citation - Scopus: 11Dispersive Optical Constants of Thermally Deposited Agin5s8< Thin Films(Elsevier Science Sa, 2008) Qasrawi, A. F.Agln(5)S(8) thin films were obtained by the thermal evaporation of Agln(5)S(8) crystals onto ultrasonically cleaned glass substrates. The films are found to exhibit polycrystalline cubic structure. The calculated lattice parameter of the unit cell (a) is 10.78 angstrom. The transmittance data of the as grown films which was recorded at 300 K in the incidence wavelength (lambda) range of 320-1000 nm are used to calculate the refractive, n(lambda). The transmittance and reflectance data are also used to calculate the absorption coefficient of the as grown Agln5S8 thin films. The fundamental absorption edge is found to be corresponding to a direct allowed transitions energy band gap. This band-to-band transition energy is found to be 1.78 eV and it is consistent with that reported for Agln(5)S(8) single crystals. (c) 2007 Elsevier B.V. All rights reserved.Article Citation - WoS: 3Citation - Scopus: 3How Do Implant Threads and Diameters Affect the All-On Success? a 3d Finite Element Analysis Study(IOS Press BV, 2022) Zor,Z.F.; Klllnç,Y.; Erkmen,E.; Kurt,A.; Kilinc, YelizBACKGROUND: The effect of different thread designs and diameters on the all-on-four concept is unclear. OBJECTIVE: The aim of the study was to clarify the differences in stress distribution of dental implants with various thread designs and diameters based on the all-on-four concept with three dimensional (3D) finite element analysis (FEA). METHODS: A 3D model of a totally edentulous mandible was used to perform the FEA. Four different models (M1, M2, M3, and M4) including 3.5 and 4.3 mm diameter dental implants with active and passive threaded designs were generated. The dental implants were positioned according to the all-on-four concept. The Von Mises stresses on dental implants and maximum and minimum principal stresses (Pmax and Pmin) on bony structures were calculated under vertical, oblique and horizontal loads. RESULTS: For Von Mises stresses, the highest stress values were detected on the distal implants for all models. Distal implants had also the highest stress values for vertical loading. The Von Mises stresses were found to be concentrated around the implant's neck. In all models the highest Pmax and Pmin stresses occurred in the bone surrounding the distal implant. It was noted that the active threaded implants showed the highest Pmax and Pmin stress values. CONCLUSION: The implant thread design and diameter might have a strong influence on the stress values in the all-on-four concept. © 2022 - IOS Press. All rights reserved.Article Bacterial Profiling of Brined Grapevine Leaves Collected From Different Local Markets in Türkiye(John Wiley and Sons Inc, 2025) Ucak, S.; Yegin, Z.; Yurt, M.N.Z.; Sudagidan, M.; Altunbas, O.; Ozalp, V.C.Microorganisms linked to the grapevine, Vitis vinifera, can impact crop quality, plant growth, and human and plant health. This study examined the bacterial community structures of brined grapevine leaves (n = 56) taken from seven distinct regions in Türkiye using next-generation sequencing technology. Investigations were also conducted into the samples' chemical properties. Firmicutes was the dominant phylum, followed by Proteobacteria, Actinobacteria, and Bacteroidetes. Bacillaceae was the predominant family in the analyzed samples, followed by Clostridiaceae, Peptostreptococcaceae, and Enterobacteriaceae. Bacillus was the dominant genus, followed by Lysinibacillus and Clostridium sensu stricto. The samples exhibited differences in terms of pH, total acidity, and salt content. The pH values of the brined grapevine leaves ranged from 2.31 to 6.91, the acidity levels ranged from 0.09% to 1.80%, and the salt percentages ranged from 3.39% to 49.14%. This research provides pioneering information for bacterial community analysis of brined grapevine leaves. © 2025 Wiley-VHCA AG, Zurich, Switzerland.Article Citation - WoS: 1Citation - Scopus: 1Left Ventricular Geometry as a Predictor of Carotid Artery Stenosis Severity in Patients Undergoing Carotid Artery Stenting(Wiley, 2020) Karaduman, Bilge Duran; Ayhan, Huseyin; Keles, Telat; Bozkurt, Engin; Duran Karaduman, BilgeBackground and Aim Cerebrovascular diseases are the second most common cause of death worldwide. Moderate and severe carotid artery stenosis causes nearly 10% of all strokes. LV geometry is a familiar prognostic and diagnostic factor in several populations; yet, data on its role in carotid artery stenosis are unknown. In our study, we investigated the prognostic value of LV geometry in predicting carotid artery stenosis severity in patients undergoing carotid artery stenting. Methods Patients who underwent carotid artery stenting between January 2012 and January 2016 at our tertiary care center were evaluated retrospectively. Two hundred fifty-five patients who underwent carotid artery stenting were included in the study. Accessible echocardiographic documentation of ninety-eight patients was accessed and evaluated. Results LV normal geometry was detected in 37 (37.7%) of the 98 carotid artery stenting (CAS) patients, concentric hypertrophy in 13 (13.2%), eccentric hypertrophy in 9 (9.1%), and concentric remodeling in 39 (39.7%). By a majority, distal filter was used in normal geometry and eccentric hypertrophy groups (82.9% vs 100%, P: .017). Considering the relationship between carotid artery stenosis severity and LV geometry, we determined that the stenosis severity was statistically significantly higher in the concentric hypertrophy group (p:0.012). However, although no complications were detected in the concentric hypertrophy group, it did not reach statistical significance between the groups (P: .058). LVMi and as expected, Doppler velocity showed a significant correlation with stenosis severity (r = .23 vs .54; P: .021, <.001, respectively). Conclusion Echocardiographic evaluation of LV geometry provided prognostic information in the development of carotid artery stenosis. Abnormal LV geometry is an independent predictor in detecting the severity of carotid artery stenosis undergoing carotid artery stenting.Article Citation - WoS: 20Citation - Scopus: 28Bug Severity Assessment in Cross Project Context and Identifying Training Candidates(World Scientific Publ Co Pte Ltd, 2017) Singh, V. B.; Misra, Sanjay; Sharma, MeeraThe automatic bug severity prediction will be useful in prioritising the development efforts, allocating resources and bug fixer. It needs historical data on which classifiers can be trained. In the absence of such historical data cross project prediction provides a good solution. In this paper, our objective is to automate the bug severity prediction by using a bug metric summary and to identify best training candidates in cross project context. The text mining technique has been used to extract the summary terms and trained the classifiers using these terms. About 63 training candidates have been designed by combining seven datasets of Eclipse projects to develop the severity prediction models. To deal with the imbalance bug data problem, we employed two approaches of ensemble by using two operators available in RapidMiner: Vote and Bagging. Results show that k-Nearest Neighbour (k-NN) performance is better than the Support Vector Machine (SVM) performance. Naive Bayes f-measure performance is poor, i.e. below 34.25%. In case of k-NN, developing training candidates by combining more than one training datasets helps in improving the performances (f-measure and accuracy). The two ensemble approaches have improved the f-measure performance up to 5% and 10% respectively for the severity levels having less number of bug reports in comparison of major severity level. We have further motivated the paper with a cross project bug severity prediction between Eclipse and Mozilla products. Results show that Mozilla products can be used to build reliable prediction models for Eclipse products and vice versa in case of SVM and k-NN classifiers.Article Citation - WoS: 3Citation - Scopus: 7Erp System Implementation in Fmcg Sector(Univ Osijek, Tech Fac, 2010) Mishra, Alok; Mishra, Deepti; Computer Engineering; Software EngineeringToday's businesses have become extremely complex. Enterprise Resource Planning (ERP) systems can help enterprises to reduce operating costs, generate more accurate forecasts of demand, accelerate production cycles and enhance customer service. This paper reports challenges, opportunities and outcome of ERP implementation in a top Fast Moving Consumer Goods (FMCG) house in South-East Asia with diversified interests in varied businesses. This study will facilitate the understanding of the transition, constraints and implementation of ERP in this sector and also provide guidelines from lessons learned in this regard to researchers and practising managers.Article Citation - WoS: 18Citation - Scopus: 19Heat Treatment Effects on the Structural and Electrical Properties of Thermally Deposited Agin5s8< Thin Films(Pergamon-elsevier Science Ltd, 2011) Qasrawi, A. F.; Kayed, T. S.; Ercan, FilizThe heat treatment effects on structural and electrical properties of thermally deposited AgIn5S8 thin films have been investigated. By increasing the annealing temperature of the sample from 450 to 500 K, we observed a change in the crystallization direction from (420) to (311). Further annealing of the AgIn5S8 films at 550, 600 and 650 K resulted in larger grain size in the (311) preferred direction. The room temperature electrical resistivity, Hall coefficient and Hall mobility were significantly influenced by higher annealing temperatures. Three impurity levels at 230, 150, and 78 meV were detected for samples annealed at 350 K. The electrical resistivity decreased by four orders of magnitude when the sample annealing temperature was raised from 350 to 450 K. The temperature dependent electrical resistivity and carrier concentration of the thin film samples were studied in the temperature ranges of 25-300 K and 140-300 K, respectively. A degenerate-nondegenerate semiconductor transition at approximately 180 was observed for samples annealed at 450 and 500 K. Similar type of transition was observed at 240 K for samples annealed at 600 and 650 K. (C) 2011 Elsevier Ltd. All rights reserved.Article Citation - WoS: 9Citation - Scopus: 9Elektrik Direnç Punta Kaynağı ile Birleştirilen %15 Deforme Edilmiş Twıp Çeliğinde Kaynak Akımının Mikroyapı ve Mekanik Özellikler Üzerindeki Etkisi(Gazi Univ, Fac Engineering Architecture, 2020) Aydın, Hakan; Tutar, Mümin; Davut, Kemal; Bayram, AliÇalışmada, %15 deforme edilmiş TWIP saclarının elektrik direnç punta kaynağıyla birleştirmelerindekaynak akımının mikroyapı ve mekanik özellikler üzerindeki etkisi incelenmiştir. Mikroyapıkarakterizasyonunda optik mikroskop, taramalı elektron mikroskobu (SEM), SEM/Enerji dağılımlı X-ışınıSpektroskopisi (SEM-EDS) ve SEM/Elektron Geri Saçılım Kırınımı (SEM-EBSD) teknikleri kullanılmıştır.Mekanik özelliklerin belirlenmesinde, mikrosertlik ölçümleri ve çekme testleri yapılmıştır. Kaynak akımıartışı ile erime bölgesindeki kaynak boşlukları azalırken, çekirdek çapı, çökme miktarı ve ısı tesiri altındakibölge (ITAB) genişliği yaklaşık lineer bir şekilde artmıştır. Kaynak bölgesinde deformasyon ikizleri ortadankalkarken, ITAB’da iri tavlama ikizleri ortaya çıkmıştır. Ayrıca, kaynak akımı artışıyla ITAB’daki taneirileşmesi ve ikiz kalınlıkları artmıştır. Ancak, kaynak işlemi kaynak bölgesinde herhangi bir fazdönüşümüne neden olmamıştır. Bu sebeple, kaynak bölgesi sertlik değerleri temel malzemenin sertlikdeğerlerinden oldukça düşük kalmıştır. Genel itibariyle, en düşük sertlikler ITAB’da gözlenmiştir. Kaynakakımı ile kaynak bölgesi sertlik değerleri arasında herhangi bir korelasyon elde edilmemiştir. Kopma yükükaynak akımı ile artmıştır: En yüksek kopma yükü 10 kA kaynak akımında elde edilmiştir. Düşük kaynakakımlarında aryüzey tipi kırılma meydana gelirken yüksek kaynak akımlarında buton çekirdek tipi kırılmalarortaya çıkmıştır. Kırılma karakteristikleri genel itibariyle gevrek-sünek karışımıdır. Daha yüksekmukavemete sahip numunelerde gevrek-sünek kırılma bölgesinde sünek kırılma, gevrek kırılma bölgesindeise trans-granular kırılma karakteristikleri artış göstermiştir.Article Citation - WoS: 10A DISCUSSION ON ASSURING SOFTWARE QUALITY IN SMALL AND MEDIUM SOFTWARE ENTERPRISES: AN EMPIRICAL INVESTIGATION(Univ Osijek, Tech Fac, 2011) Pusatli, O. Tolga; Misra, SanjayUnder the studies of general core activities including software inspection, review and testing to achieve quality objectives in small-medium size enterprises (SMEs), the paper presents a contemporary view of such companies against quality measures. The results from a local empirical investigation of quality standards in the Turkish software industry are reported. Around 150 software companies have been approached from which 17 detailed feedback inform that in order to ensure software quality, standards including internationally recognized International Standards Organization (ISO) and Capability Maturity Model Integration (CMMI) are given credit. However the substantial workload and resources required to obtain them are also reported as serious; downscaled frameworks of such large models proposed in the literature are not well known by the SMEs either. The paper also discusses "work around" that bypasses such standards to ease delivery of products while keeping certificates as labels just to acquire new jobs for the business.
