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Article Citation - WoS: 4Citation - Scopus: 3Insomnia Severity Predicts Psychiatric Symptoms: a Cross-Sectional Study Investigating the Partial Mediations of Worry and Rumination(Routledge Journals, Taylor & Francis Ltd, 2024) Turkarslan, Kutlu Kagan; Cinarbas, Deniz CanelObjective: Insomnia as a disorder on its own or as a symptom of other mental disorders can lead to significant distress and lower quality of life. By exacerbating negative affect and emotion dysregulation, poor sleep and insomnia can contribute to the initiation and maintenance of mental disorders. The aim of this cross-sectional study was to investigate the relationship between insomnia severity and overall psychiatric symptoms (anxiety, depression, obsessive-compulsive symptoms, somatization, phobic anxiety, hostility, interpersonal sensitivity, paranoid ideation, and psychoticism), and the mediational roles of worry and rumination in this relationship. Method: The data was collected from a community sample of 1444 participants (females 69.39%, M-age=27.95, SD=9.37) who completed self-report measures of insomnia severity, worry, rumination, and psychiatric symptoms. The mediational roles of worry and rumination were tested with mediation analysis using the PROCESS Macro. Results: It was found that insomnia severity (beta=0.20, p<.001) significantly predicted psychiatric symptoms directly and via worry and rumination (beta=0.33, p<.001), meaning that worry and rumination partially mediated the relationship between insomnia severity and psychiatric symptoms. The findings were similar after controlling for smoking status, daily screen time, coffee consumption in the evening, weekly exercise frequency, and pre-sleep screen time. Conclusions: Interventions targeting the reduction of insomnia severity and maladaptive emotion regulation strategies (e.g., worry and rumination), as well as the enhancement of adaptive emotion regulation strategies (e.g., positive refocusing and mindfulness), may alleviate the adverse effects of insomnia on psychiatric symptoms.Article Citation - WoS: 5Citation - Scopus: 5Development and Psychometric Analysis of a Pediatric Oncology Nurses' Educational Needs Scale(Wiley, 2023) Kudubes, Asli Akdeniz; Semerci, Remziye; Ozbay, Sevil Cinar; Ay, Ayse; Boztepe, HandanBackground/objectivesIt is important to determine the educational needs of pediatric oncology nurses in order to maximize and implement nursing care interventions. Therefore, this study aims to develop a valid and reliable measurement tool to determine pediatric oncology nurses' educational needs and examine its psychometric properties. Design/methodsThis methodological study was conducted with 215 pediatric oncology nurses in Turkey between December 2021 and July 2022. Data were collected with the "Nurse Information Form" and "Pediatric Oncology Nurses' Educational Needs Scale." IBM SPSS 21.0 and IBM AMOS 25.0 software programs were used for data analysis, and descriptive statistics were used to analyze numeric variables. Exploration and confirmatory factor analyses were performed to determine the scale's factorial structure. ResultsThe factorial analysis was used to test the structural validity of the scale. A five-factor structure consisting of 42 items was developed. The Cronbach's alpha coefficient for "Illness" was .978, "Chemotherapy and Side Effect" was .978, "Another Therapy and Side Effect" was .974, "Palliative Care" was .967, "Supportive Care" was .985, and the total score was .990. Fit indices resulting from the study were chi(2)/SD: 3.961, root mean square error of approximation (RMSEA): 0.072, goodness-of-fit index (GFI): 0.95, comparative-of-fit index (CFI): 0.96, and normed fit index (NFI): 0.95. ConclusionThe Pediatric Oncology Nurses' Educational Needs Scale is a valid and reliable scale for pediatric oncology nurses to determine their educational needs.Article Citation - WoS: 5Citation - Scopus: 7G-Csf Treatment of Healthy Pediatric Donors Affects Their Hematopoietic Microenvironment Through Changes in Bone Marrow Plasma Cytokines and Stromal Cells(Academic Press Ltd- Elsevier Science Ltd, 2021) Aerts-Kaya, Fatima; Kilic, Emine; Kose, Sevil; Aydin, Gozde; Cagnan, Ilgin; Kuskonmaz, Baris; Uckan-Cetinkaya, DuyguAlthough G-CSF mobilized peripheral blood stem cell (PBSC) transplantation is commonly used in adults, bone marrow (BM) is still the preferred stem cell source in pediatric stem cell transplantation. Despite the fact that G-CSF is increasingly being used to enhance the hematopoietic stem/progenitor cell (HSPC) yield in BM transplantation (G-BM), the direct effects of G-CSF on the pediatric BM microenvironment have never been investigated. The BM hematopoietic niche provides the physical space where the HSPCs reside. This BM niche regulates HSPC quiescence and proliferation through direct interactions with other niche cells, including Mesenchymal Stromal Cells (MSCs). These cells have been shown to secrete a wide range of hematopoietic cytokines (CKs) and growth factors (GFs) involved in differentiation, retention and homing of hematopoietic cells. Here, we assessed changes in the BM microenvironment by measuring levels of 48 different CKs and GFs in G-BM and control BM (C-BM) plasma from pediatric donors. In addition, the effect of G-CSF on cell numbers and characteristics of HSPCs and MSCs was assessed. IL-16, SCGF-b, MIP-1b (all >1000 pg/mL) and RANTES (>10.000 pg/mL) were highly expressed in healthy donor pediatric BM plasma. Levels of IL-3, IL-18, GROa, MCP-3 (p<0.05) were increased in G-BM, whereas levels of RANTES (p<0.001) decreased after G-CSF treatment. We found a negative correlation with increasing age for IL2-Ra and LIF (p<0.05). In addition, a concomitant increase in the number of both hematopoietic and fibroblast colony forming units was observed, indicating that G-CSF affects both HSPC and MSC numbers. In conclusion, G-CSF treatment of healthy pediatric donors affects the hematopoietic BM microenvironment by expansion of HSPC and MSC numbers and modifying local CK and GF levels.Article Factors Influencing the Transition Time From Psoriasis to Psoriatic Arthritis: A Real-World Multicenter Analysis(Springer Heidelberg, 2025) Kilic, Gamze; Kilic, Erkan; Tekeoglu, Ibrahim; Sargin, Betul; Cengiz, Gizem; Balta, Nihan Cuzdan; Nas, KemalTo identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within +/- 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO). Demographic, clinical, and laboratory characteristics, disease activity, and patient-reported outcomes were compared between groups. Logistic regression was employed to determine independent predictors of prolonged transition. Among 799 patients (mean age 46.8 +/- 12.3 years), 237 (29.7%) had concurrent onset and 562 (70.3%) had a prolonged transition, with a mean PsO-to-PsA interval of 12.9 +/- 9.6 years. Depression (p = 0.005) and fatigue levels (p = 0.011) were significantly higher in patients with prolonged transition to PsA. Multivariate analysis revealed that scalp psoriasis (OR = 7.162), nail psoriasis (OR = 3.270), family history of PsO (OR = 1.813), and enthesitis ever (OR = 2.187) were associated with prolonged transition. Conversely, family history of PsA (OR = 0.421) and older age at PsO onset (OR = 0.957) predicted shorter transition. Prolonged transition from PsO to PsA is influenced by distinct clinical and demographic factors. Scalp/nail psoriasis, family history of PsO, and enthesitis ever may signal higher risk for prolonged PsA onset. Recognizing these markers can support timely referral and intervention, minimizing diagnostic delay and improving long-term patient outcomes.Article Citation - WoS: 36Citation - Scopus: 66Cybersecurity Enterprises Policies: a Comparative Study(Mdpi, 2022) Mishra, Alok; Alzoubi, Yehia Ibrahim; Gill, Asif Qumer; Anwar, Memoona JaveriaCybersecurity is a critical issue that must be prioritized not just by enterprises of all kinds, but also by national security. To safeguard an organization's cyberenvironments, information, and communication technologies, many enterprises are investing substantially in cybersecurity these days. One part of the cyberdefense mechanism is building an enterprises' security policies library, for consistent implementation of security controls. Significant and common cybersecurity policies of various enterprises are compared and explored in this study to provide robust and comprehensive cybersecurity knowledge that can be used in various enterprises. Several significant common security policies were identified and discussed in this comprehensive study. This study identified 10 common cybersecurity policy aspects in five enterprises: healthcare, finance, education, aviation, and e-commerce. We aimed to build a strong infrastructure in each business, and investigate the security laws and policies that apply to all businesses in each sector. Furthermore, the findings of this study reveal that the importance of cybersecurity requirements differ across multiple organizations. The choice and applicability of cybersecurity policies are determined by the type of information under control and the security requirements of organizations in relation to these policies.Article Citation - WoS: 6A Light Bulb in Every House the Istanbul General Electric Factory and American Technology Transfer To Turkey(Johns Hopkins Univ Press, 2022) Tunc, Tanfer Emin; Tunc, GokhanIn 1946, Turkish entrepreneur Vehbi Koc signed an agreement with the U.S. firm General Electric to build and operate its first light bulb factory in the Near/Middle East, in Istanbul. This private joint venture introduced new manufacturing techniques, business practices, and consumer habits to Turkey, opening channels of postwar technological exchange. Closer examination of the GE-Koc partnership reveals that during the early Cold War, the transfer and embedding of American technologies in Turkey was a politically complicated process of innovation that required constant adaptation. Fraught with unforeseeable obstacles, it also required cautious negotiation with multiple transnational actors. The story of the GE-Koc partnership thus adds a new dimension to historical understandings of the Turkish Cold War experience and the Americanization of the region. It illustrates how transferring a nonmilitary, soft-power, domestic technologythe light bulb-played a significant role in Turkish-American relations and therefore contributes to studies of U.S. Cold War diplomacy through transnational investment in innovation.Conference Object Citation - WoS: 5Citation - Scopus: 3Evaluation of Efficiencies of Diffuse Allochthonous and Autochthonous Nutrient Input Control in Restoration of a Highly Eutrophic Lake(I W A Publishing, 2002) Muhammetoglu, A; Muhammetoglu, H; Soyupak, SMogan Lake is an important recreational area for Metropolitan Ankara-Turkey. It is a shallow eutrophic lake with a dense growth of macrophytes. The main contributors of nutrients and other pollutants to the lake are the creeks carrying the runoff water from the watershed and upland farming land, in addition to the domestic and industrial wastewater discharges from a nearby town and industries. Hydrodynamic and water quality modeling techniques were used to determine the optimum management schemes for the lake restoration and diffuse pollution control. Management scenarios were devised and tested to control allochthonous and autochthonous nutrient inputs to the lake. Phosphorus and nitrogen load reductions were the main test elements for the control of allochthonous nutrient inputs. The scenario analysis revealed that reduction of phosphorus and nitrogen loads from diffused sources will have a marginal effect on controlling eutrophication if macrophyte growth is left uncontrolled. Scenarios employing macrophyte harvesting and sediment dredging have been evaluated for autochthonous nutrient input control. Sediment dredging alone has been shown to yield the most favorable conditions for water quality improvement in Mogan Lake. Further, control of diffuse pollution was an essential final step to achieve an acceptable long-term sustainable water quality improvement in the lake.Article Citation - WoS: 21Citation - Scopus: 36Deep Learning-Based Computer-Aided Diagnosis (cad): Applications for Medical Image Datasets(Mdpi, 2022) Kadhim, Yezi Ali; Khan, Muhammad Umer; Mishra, AlokComputer-aided diagnosis (CAD) has proved to be an effective and accurate method for diagnostic prediction over the years. This article focuses on the development of an automated CAD system with the intent to perform diagnosis as accurately as possible. Deep learning methods have been able to produce impressive results on medical image datasets. This study employs deep learning methods in conjunction with meta-heuristic algorithms and supervised machine-learning algorithms to perform an accurate diagnosis. Pre-trained convolutional neural networks (CNNs) or auto-encoder are used for feature extraction, whereas feature selection is performed using an ant colony optimization (ACO) algorithm. Ant colony optimization helps to search for the best optimal features while reducing the amount of data. Lastly, diagnosis prediction (classification) is achieved using learnable classifiers. The novel framework for the extraction and selection of features is based on deep learning, auto-encoder, and ACO. The performance of the proposed approach is evaluated using two medical image datasets: chest X-ray (CXR) and magnetic resonance imaging (MRI) for the prediction of the existence of COVID-19 and brain tumors. Accuracy is used as the main measure to compare the performance of the proposed approach with existing state-of-the-art methods. The proposed system achieves an average accuracy of 99.61% and 99.18%, outperforming all other methods in diagnosing the presence of COVID-19 and brain tumors, respectively. Based on the achieved results, it can be claimed that physicians or radiologists can confidently utilize the proposed approach for diagnosing COVID-19 patients and patients with specific brain tumors.Article Citation - WoS: 29Citation - Scopus: 33Health Literacy of Nursing Students and Its Effective Factors(Wiley-hindawi, 2019) Ozen, Nurten; Ozkaptan, Bilge Bal; Coskun, Sabahat; Terzioglu, FusunBackground The insufficiency of health literacy negatively affects the national economy as it leads to increased health service expenditure. It is very important for individuals to have accurate health-related information to reduce these negative effects. Aim The aim of the study is to examine the health literacy of nursing students and its effective factors. Methods This descriptive study was carried out with students from the nursing department of a vocational school of health sciences between September and October 2018 in Turkey. A semi-structured questionnaire regarding the descriptive features of the participants and the European Health Literacy Scale were used for data collection. Results The study included 283 nursing students; 29.3% had a problematic-limited health literacy level. The study found a statically significant difference between student year, high school graduation and family's income level and the total mean score of the HLS-EU scale. Conclusion The subject of health literacy should be integrated into the educational program of nursing students. The nurses are the most important workforce in health services, and awareness about this subject should be raised.Article Effectiveness of Boric Acid in Sepsis in Rats With Cecal Perforation(Springer Nature, 2025) Kurtipek, Ali Can; Dursun, Ali Dogan; Yigman, Zeynep; Ozdemir, Cagri; Kucuk, Aysegul; Gonullu, Ugur; Arslan, MustafaIntroduction and AimSepsis is a systemic inflammatory response that develops in the host against microorganisms, which results in end-organ damage. Boric acid (BA) has been shown to have immune modulatory effects in vitro and in animal studies. The aim of the study is to investigate the effects of high dose BA on lung and kidney tissues in rats with sepsis induced by the CLP method.Method28 rats were randomly divided into four groups: Group C (control group), Group BA, Group CLP (cecal ligation and puncture), and Group CLP + BA. Cecum was ligated below the ileocecal valve and punctured. BA was administered to the treatment groups at an intraperitoneal dose of 200 mg/kg, and at the end of 24 h, lung and kidney tissue samples were collected and evaluated for biochemical and histopathological parameters.ResultsHistopathologically, in kidney tissue, CLP + BA group showed significantly less peritubular capillary dilatation and brush border loss in the proximal tubule epithelium compared to the CLP group. In lung tissue, CLP + BA group had significantly less alveolar wall thickening compared to the CLP group. Biochemical analyses indicated that BA administration reduced oxidative stress in both renal and lung tissues.ConclusionWe found that intraperitoneal administration of high dose boric acid partially ameliorated the tissue damage in rats subjected to CLP induced sepsis. Further studies are needed regarding the dosage and application at different time points.
