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Subject: pandemic

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    Article
    Citation - WoS: 4
    Citation - Scopus: 7
    A Team-Oriented Course Development Experience in Distance Education for Multidisciplinary Engineering Design
    (Wiley, 2022) Say, Bilge; Erden, Zühal; Erden, Zuhal; Turhan, Cihan; Turhan, Cihan; Say, Bilge; Erden, Zühal; Turhan, Cihan; Say, Bilge; Energy Systems Engineering; Software Engineering; Mechatronics Engineering; Energy Systems Engineering; Mechatronics Engineering; Software Engineering
    Based on the multidisciplinary needs of today's complex and innovative technology, accreditation bodies of engineering demand proof of multidisciplinary teamwork in undergraduate engineering curricula. This article reports the design and conduct of a Multidisciplinary Engineering Design (MED) course initiated as a result of accreditation process requirements. The course, which consists of multidisciplinary lectures, practice sessions, and various phases of a multidisciplinary team project, was conducted online because of the COVID-19 pandemic by a multidisciplinary team of instructors using multiple software tools to enhance collaboration. In general, the course outcomes were satisfied under the current design, and several points for further improvement and elaboration were collected via quantitative and qualitative evaluations. Accordingly, the results show that the project-based and team-based MED course, in terms of multidisciplinary course management and its outcomes, can benefit from the use of software tools in creating a multidisciplinary team in distance education by means of enhanced cooperation and motivation among the participants.
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    Article
    Citation - WoS: 3
    Citation - Scopus: 4
    Predicted Sars-Cov Mirnas Associated With Epigenetic Viral Pathoge-Nesis and the Detection of New Possible Drugs for Covid-19
    (Bentham Science Publ Ltd, 2021) Cetin, Zafer; Bayrak, Tuncay; Ogul, Hasan; Saygili, Eyup Ilker; Akkol, Esra Kupeli
    Objective: The outbreak of COVID-19 caused by SARS-CoV-2 has promptly spread worldwide. This study aimed to predict mature miRNA sequences in the SARS-CoV-2 genome, their effects on protein-protein interactions in the affected cells, and gene-drug relationships to detect possible drug candidates. Methods: Viral hairpin structure prediction, classification of hairpins, mutational examination of precursor miRNA candidate sequences, Minimum Free Energy (MFE) and regional entropy analysis, mature miRNA sequences, target gene prediction, gene ontology enrichment, and Protein-Protein Interaction (PPI) analysis, and gene-drug interactions were performed. Results: A total of 62 candidate hairpins were detected by VMir analysis. Three hairpin structures were classified as true precursor miRNAs by miRBoost. Five different mutations were detected in precursor miRNA sequences in 100 SARS-CoV-2 viral genomes. Mutations slightly elevated MFE values and entropy in precursor miRNAs. Gene ontology terms associated with fibrotic pathways and immune system were found to be enriched in PANTHER, KEGG and Wiki pathway analysis. PPI analysis showed a network between 60 genes. CytoHubba analysis showed SMAD1 as a hub gene in the network. The targets of the predicted miRNAs, FAM214A, PPM1E, NUFIP2 and FAT4, were downregulated in SARS-CoV-2 infected A549 cells. Conclusion: miRNAs in the SARS-CoV-2 virus genome may contribute to the emergence of the Covid-19 infection by activating pathways associated with fibrosis in the cells infected by the virus and modulating the innate immune system. The hub protein between these pathways may be the SMAD1, which has an effective role in TGF signal transduction.