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Scopus Q: Q2Subject: Covid-19

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    Citation - WoS: 9
    Citation - Scopus: 7
    Identifying the Cycles in Covid-19 Infection: the Case of Turkey
    (Taylor & Francis Ltd, 2023) Akdi, Yilmaz; Karamanoglu, Yunus Emre; Unlu, Kamil Demirberk; Bas, Cem
    The new coronavirus disease, called COVID-19, has spread extremely quickly to more than 200 countries since its detection in December 2019 in China. COVID-19 marks the return of a very old and familiar enemy. Throughout human history, disasters such as earthquakes, volcanic eruptions and even wars have not caused more human losses than lethal diseases, which are caused by viruses, bacteria and parasites. The first COVID-19 case was detected in Turkey on 12 March 2020 and researchers have since then attempted to examine periodicity in the number of daily new cases. One of the most curious questions in the pandemic process that affects the whole world is whether there will be a second wave. Such questions can be answered by examining any periodicities in the series of daily cases. Periodic series are frequently seen in many disciplines. An important method based on harmonic regression is the focus of the study. The main aim of this study is to identify the hidden periodic structure of the daily infected cases. Infected case of Turkey is analyzed by using periodogram-based methodology. Our results revealed that there are 4, 5 and 62 days cycles in the daily new cases of Turkey.
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    Citation - WoS: 1
    The Socio-Economic Impact of the Covid-19 Pandemic on Syrian Refugees in Turkey
    (Uluslararasi Iliskiler Konseyi dernegi, 2024) Memisoglu, Fulya; Ozkil, Altan; Kilinc, Tuna
    Building upon empirical research, this study examines the socio-economic impact of the Covid-19 pandemic on Syrian refugees in Turkey by analyzing its implications on employment, livelihood opportunities, and social cohesion. More specifically, it focuses on the experiences of Syrian refugees to examine the ways in which they exert their agency to cope with the structural constraints when faced with 'multiple crises' in host countries, intersecting with the dynamics of a 'normalized refugee crisis'. Our findings from fieldwork conducted in the top six refugee-hosting cities reveal that loss of jobs, limited access to decent work, increased dependency on external financial assistance, and social exclusion have been some of the most acute effects of the pandemic on refugees. Meanwhile, the perceived effects that refugees have on the host community's welfare trigger problems that impede social cohesion. All in all, the study intends to highlight the far-reaching effects of the pandemic beyond its direct health implications by addressing the structural vulnerability of refugees and the importance of providing an enabling environment for socio-economic self-reliance.
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    Citation - WoS: 3
    Citation - Scopus: 3
    Predicted Sars-Cov Mirnas Associated With Epigenetic Viral Pathoge-Nesis and the Detection of New Possible Drugs for Covid-19
    (Bentham Science Publ Ltd, 2021) Cetin, Zafer; Bayrak, Tuncay; Ogul, Hasan; Saygili, Eyup Ilker; Akkol, Esra Kupeli
    Objective: The outbreak of COVID-19 caused by SARS-CoV-2 has promptly spread worldwide. This study aimed to predict mature miRNA sequences in the SARS-CoV-2 genome, their effects on protein-protein interactions in the affected cells, and gene-drug relationships to detect possible drug candidates. Methods: Viral hairpin structure prediction, classification of hairpins, mutational examination of precursor miRNA candidate sequences, Minimum Free Energy (MFE) and regional entropy analysis, mature miRNA sequences, target gene prediction, gene ontology enrichment, and Protein-Protein Interaction (PPI) analysis, and gene-drug interactions were performed. Results: A total of 62 candidate hairpins were detected by VMir analysis. Three hairpin structures were classified as true precursor miRNAs by miRBoost. Five different mutations were detected in precursor miRNA sequences in 100 SARS-CoV-2 viral genomes. Mutations slightly elevated MFE values and entropy in precursor miRNAs. Gene ontology terms associated with fibrotic pathways and immune system were found to be enriched in PANTHER, KEGG and Wiki pathway analysis. PPI analysis showed a network between 60 genes. CytoHubba analysis showed SMAD1 as a hub gene in the network. The targets of the predicted miRNAs, FAM214A, PPM1E, NUFIP2 and FAT4, were downregulated in SARS-CoV-2 infected A549 cells. Conclusion: miRNAs in the SARS-CoV-2 virus genome may contribute to the emergence of the Covid-19 infection by activating pathways associated with fibrosis in the cells infected by the virus and modulating the innate immune system. The hub protein between these pathways may be the SMAD1, which has an effective role in TGF signal transduction.