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Article Citation - WoS: 18Citation - Scopus: 21Musculoskeletal Pain, Related Factors, and Posture Profiles Among Adolescents: a Cross-Sectional Study From Turkey(Elsevier Science inc, 2021) Ozdemir, Serpil; Gencbas, Dercan; Tosun, Betul; Bebis, Hatice; Sinan, OzlemPurpose: The aim of the study was to evaluate musculoskeletal pain due to mechanical reasons and related risk factors in adolescents and to define posture profiles of adolescents. Design: A cross-sectional study. Methods: The study was conducted with 2221 adolescents between February 2015 and May 2015. The questionnaire used to collect data consisted of three parts: (1) descriptive characteristics of the participants, (2) pain assessment of 14 parts of the body, and (3) Back Pain and Body Posture Evaluation Instrument (BackPEI). Results: The prevalence of low back pain among the participants was 73.3% (n = 1,343), while the prevalence of back pain was 68.4% (n = 1,254). The participants attributed their pain to their poor sitting postures at school (38.1%, n = 847) and carrying school backpacks (84.1%, n = 1,713). There was a statistically significant difference in the physical activities of adolescents and the BackPEI score (z = 4.40; p = .001). Posture factors of the BackPEI score increased while school desk comfort score increased (Spearman's rho = 0.148; p = .001), but it decreased while the school grades of the adolescents increased (Spearman's rho [rho] = -0.161; p = .001). Conclusions: According to this study, body posture was related to musculoskeletal pain and was correlated with physical activities, school desk comfort, and school grades of the adolescents. It is suggested that correct posture and ergonomic positions should be taught to adolescents when using computers, carrying school backpacks, and sitting in school chairs to prevent musculoskeletal pain. (C) 2020 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.Article Citation - WoS: 59Citation - Scopus: 70Effects of Reflexology and Progressive Muscle Relaxation on Pain, Fatigue, and Quality of Life During Chemotherapy in Gynecologic Cancer Patients(Elsevier Science inc, 2019) Dikmen, Hacer Alan; Terzioglu, FusunPurpose: Our aim was to investigate the effect of reflexology and progressive muscle relaxation (PMR) exercises on pain, fatigue, and quality of life (QoL) of gynecologic cancer patients during chemotherapy. Methods: Eighty participants were randomly assigned to one of four groups: reflexology, progressive muscle relaxation (PMR) exercises, both (reflexology + PMR), or a control group. Data were collected with a general data collection form, Brief Pain and Fatigue inventories, and Multidimensional Quality-of-Life Scale-Cancer. Results: In reflexology and reflexology + PMR groups, a significant decrease in pain severity and fatigue and an increase in QoL were found (p < .05). In the PMR alone group, pain severity and fatigue decreased significantly (p < .05), but there was no significant change identified in QOL (p > .05). Conclusions: Reflexology and PMR exercises given to gynecologic cancer patients during chemotherapy were found to decrease pain and fatigue and increase QoL. (C) 2019 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.Article Citation - WoS: 9Citation - Scopus: 9Ir-Spectroscopic Characterization of an Elongated Ompg Mutant(Elsevier Science inc, 2015) Korkmaz, Filiz; van Pee, Katharina; Yildiz, OezkanOmpG is a nonselective, pH dependent outer membrane protein from Escherichia coli. It consists of 281 residues, forming a 14-stranded beta-sheet structure. In this study, OmpG is extended by 38 amino acids to produce a 16-stranded beta-barrel (OmpG-16S). The resulting protein is investigated by IR-spectroscopy. The secondary structure, pH-dependent opening/closing mechanism, buffer accessibility and thermal stability of OmpG-16S are compared to OmpG-WT. The results show that OmpG-16S is responsive to pH change as indicated by the Amide I band shift upon a switch from acidic to neutral pH. This spectral shift is consistent with that observed in OmpG-WT, which confirms the existence of structural differences consistent with the presence of the open or closed state. Secondary structure analysis after curve-fitting of Amide I band revealed that the additional residues do not fold into beta-sheet; rather they are in the form of turns and unordered structure. In thermal stability experiments, OmpG-16S is found to be as stable as OmpG-WT. Additionally, H/D exchange experiments showed no difference in the exchange rate of OmpG-16S between the acidic and alkaline pH, suggesting that the loop L6 is no longer sufficient to block the pore entrance at acidic pH. (C) 2015 Elsevier Inc. All rights reserved.Article Citation - WoS: 33Social Jetlag Is Associated With the Frequency of Consumption of Sugar-Sweetened Beverages and a High Bmi Percentile in Adolescents: Results of the Cross-Sectional Family Life, Activity, Sun, Health, and Eating (flashe) Study(Elsevier Science inc, 2021) Cetiner, Ozlem; Yildirim, Gonca; Kalyoncu, Zeynep BegumBackground Social jetlag (SJL) occurs in adolescents due to misalignment of the bio-logical and social clocks, so that most teens wake up earlier than their biological clocks on weekdays and delay bedtime and wake up time on weekends. This shift in sleep timing among adolescents is associated with an adverse endocrine and behavioral risk profile, in addition to increased food consumption and increased body mass index (BMI). Objective The aim of this study was to determine the association between SJL, and the frequency of consumption of multiple food and beverage groups and BMI percentile in adolescents. Design Publicly available data from the cross-sectional Family Life, Activity, Sun, Health, and Eating (FLASHE) study were analyzed. Participants Participants from the FLASHE study were recruited from all regions of the United States between April and October 2014. Among the 1,581 adolescents aged 12 through 17 years in the original study, 1,556 with complete sleep data were analyzed. Main outcome measures The difference between the frequency of dietary consump-tion according to the Dietary Screener Questionnaire and BMI percentile was assessed in adolescents grouped according to SJL, as follows: no SJL: less than 1-hour difference; mild SJL: 1-to 2-hour difference; and severe SJL: more than 2-hour difference. Statistical analyses performed Differences in the frequency of food consumption were analyzed using the Kruskal-Wallis test. Secondary outcomes were analyzed using logistic regression models. Results Daily consumption frequency of sugar-sweetened beverages and fruits and vegetables differed among the 3 groups. Likewise, the BMI percentile differed among the 3 groups and was highest in the severe SJL group. Those in the severe SJL group had a 1.84-fold higher probability of having overweight or obesity (95% CI 1.83 to 1.84) than those in the no SJL group. Conclusions Severe SJL is associated with a higher frequency of sugar-sweetened beverage consumption and higher odds of having overweight or obesity compared with no SJL in adolescents. J Acad Nutr Diet. 2021;121(9):1721-1731.Article Citation - WoS: 1Citation - Scopus: 1Long-Term Intermittent Caloric Restriction Remodels the Gut Microbiota in Mice Genetically Prone To Breast Cancer(Elsevier Science inc, 2024) Keles, Nazim Arda; Dogan, Soner; Dogan, Aysenur; Sudagidan, Mert; Balci, Tugce Nur; Cetiner, Ozlem; Tuna, Bilge GuvencObjectives: Gut microbiota dysbiosis is among the risk factors for breast cancer development, together with genetic background and dietary habits. However, caloric restriction has been shown to remodel the gut microbiota and slow tumor growth. Here, we investigated whether the gut microbiota mediates the preventive effects of long-term chronic or intermittent caloric restriction on breast cancer predisposition. Methods: 10-week-old transgenic breast cancer-prone mice were randomly assigned to dietary groups (ad libitum, chronic caloric restriction, and intermittent caloric restriction groups) and fed up to week 81. Stool samples were collected at weeks 10 (baseline), 17 (young), 49 (adult), and 81 (old). 16S rRNA gene sequencing was performed to identify the gut microbiota profile of the different groups. In order to investigate the breast cancer gut microbiota profile within genetically predisposed individuals regardless of diet, mammary tumor-bearing mice and mammary tumor-free but genetically prone mice were selected from the ad libitum group (n = 6). Results: Intermittent caloric restriction increased the microbial diversity of adult mice and modified age- related compositional changes. A total of 13 genera were differentially abundant over time. Pathogenic Mycoplasma was enriched in the re-feeding period of the old intermittent caloric restriction group compared with baseline. Furthermore, mammary tumor-free mice showed shared gut microbiota characteristics with mammary tumor-bearing mice, suggesting an early link between genetic predisposition, gut microbiota, and breast cancer development. Conclusions: Our study revealed the role of gut microbes in the preventive effects of caloric restriction against breast cancer development, implying the significance of diet and microbiome interplay. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Article Citation - WoS: 3Citation - Scopus: 6Outcomes of Pain Management Among Postoperative Patients: a Cross-Sectional Study(Elsevier Science inc, 2024) Akire, Sandra Chirota; Bayraktar, NurhanPurpose: Postoperative pain management has always been a significant challenge for both hospital staff and surgical patients. Determination of pain management outcomes among surgically treated patients may help develop pain management strategies, improve health services that would yield better outcomes, and increase patient satisfaction. This study aimed to assess the outcomes of pain management among postoperative patients. Design: The study was a descriptive cross-sectional study. Methods: The research was performed on postoperative patients at two university hospitals in North Cyprus from July to September 2019. The study sample consisted of 90 patients from both hospitals. The Turkish Version of the revised American Pain Society Patient Outcome Questionnaire (APS-POQ-R-TR) was used for data collection. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was used to report the present study. Findings: This study showed that the overall mean for pain severity and the worst pain experienced by patients after 24 hours was slightly higher than medium. Examination of interference of the pain with functions demonstrated that patients experienced problems with physical activities and sleeping. The most experienced side effects were nausea and drowsiness, and the most common emotions were anxiety and helplessness during the postsurgery period. The satisfaction rate of the patients with postoperative pain management was relatively high. Conclusions: A holistic approach with evidence-based practices is crucial for adequate postoperative pain management. The recommendations include the development of individual pain outcome strategies to improve overall satisfaction with pain management among postoperative patients. (c) 2024 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.Article Citation - WoS: 94Citation - Scopus: 99Effect of Progesterone on Dppc Membrane: Evidence for Lateral Phase Separation and Inverse Action in Lipid Dynamics(Elsevier Science inc, 2005) Korkmaz, F; Severcan, FInteractions of progesterone with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) triultilamellar liposomes were investigated as a function of temperature and progesterone concentration by using three non-invasive techniques namely Fourier transform infrared spectroscopy, turbidity at 440 nm, and differential scanning calorimetry. The results reveal that progesterone changes the physical properties of DPPC bilayers by decreasing the main phase-transition temperature, abolishing the pre-transition, broadening the phase-transition profile, disordering the system both in gel and liquid crystalline phase, increasing the dynamics at low concentrations whereas stabilizing the membrane at high concentrations, and inducing phase separation. Progesterone does not change the hydration of the C=O groups, while it strengthens the hydrogen bonding between the PO (2) over bar groups of lipids and the water molecules around. (c) 2005 Elsevier Inc. All rights reserved.Article Citation - WoS: 4Citation - Scopus: 4Thioredoxin System and Mir-21, Mir-23a/B and Let-7a as Potential Biomarkers for Brain Tumor Progression: Preliminary Case Data(Elsevier Science inc, 2022) Kilic, Nedret; Boyacioglu, Ozge; Saltoglu, Gamze Turna; Bulduk, Erkut Baha; Kurt, Gokhan; Korkusuz, PetekBACKGROUND: The thioredoxin system and microRNAs (miRNAs) are potential targets for both cancer progression and treatment. However, the role of miRNAs and their relation with the expression profile of thioredoxin system in brain tumor progression remains unclear. METHODS: In this study, we aimed to determine the expression profiles of redox components Trx-1, TrxR-1 and PRDX-1, and oncogenic miR-21, miR-23a/b and let-7a and oncosuppressor miR-125 in different brain tumor tissues and their association with increasing tumor grade. We studied Trx-1, TrxR-1, and PRDX-1 messenger RNA expression levels by quantitative real-time polymerase chain reaction and protein levels by Western blot and miR-23a, miR-23b, miR-125a, miR-21, and let-7a miRNA expression levels by quantitative real-time polymerase chain reaction in 16 glioma, 15 meningioma, 5 metastatic, and 2 benign tumor samples. We also examined Trx-1, TrxR-1, and PRDX-1 protein levels in serum samples of 36 patients with brain tumor and 37 healthy volunteers by enzyme-linked immunosorbent assay. RESULTS: We found that Trx-1, TrxR-1, and PRDX-1 presented high messenger RNA expression but low protein expression in low-grade brain tumor tissues, whereas they showed higher protein expression in sera of patients with low-grade brain tumors. miR-23b, miR-21, miR-23a, and let-7a were highly expressed in low-grade brain tumor tissues and positively correlated with the increase in thioredoxin system activity. CONCLUSIONS: Our findings showed that Trx-1, TrxR-1, miR-21, miR-23a/b, and let-7a might be used for brain tumor diagnosis in the clinic. Further prospective studies including molecular pathway analyses are required to validate the miRNA/Trx system regulatory axis in brain tumor progression.
