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  • Article
    Citation - WoS: 36
    Citation - Scopus: 45
    Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering
    (Elsevier, 2021) Topsakal, Aysenur; Midha, Swati; Yuca, Esra; Tukay, Ari; Sasmazel, Hilal Turkoglu; Kalaskar, Deepak M.; Gunduz, Oguzhan
    Over the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.
  • Article
    Citation - WoS: 113
    Citation - Scopus: 147
    Experiments and Finite Element Simulations on Micro-Milling of Ti-6al Alloy With Uncoated and Cbn Coated Micro-Tools
    (Elsevier, 2011) Oezel, T.; Thepsonthi, T.; Ulutan, D.; Kaftanoglu, B.
    This paper presents experimental investigations and finite element simulations on micro-milling of Ti-6Al-4V alloy with fine grain uncoated and cBN coated micro-end mills. Micro-milling of Ti-6Al-4V using uncoated and cBN coated tungsten carbide micro-end mills are conducted; surface roughness, burr formation and tool wear are measured. Effects of machining parameters on surface roughness, burr formation, and tool wear for uncoated and cBN coated micro-tools are investigated. Finite element modelling is utilized to predict forces, temperatures, and wear rate for uncoated and cBN coated micro-tools. Predicted temperature and tool wear contours for uncoated and cBN coated micro-tool edges reveal advantages of cBN coatings. Optimization studies on the experimental results are also conducted to identify the optimum process parameters which minimize both surface roughness and burr formation concurrently. (C) 2011 CIRP.
  • Review
    Citation - WoS: 73
    Citation - Scopus: 118
    Hybrid Blockchain Platforms for the Internet of Things (iot): a Systematic Literature Review
    (Mdpi, 2022) Alkhateeb, Ahmed; Catal, Cagatay; Kar, Gorkem; Mishra, Alok
    In recent years, research into blockchain technology and the Internet of Things (IoT) has grown rapidly due to an increase in media coverage. Many different blockchain applications and platforms have been developed for different purposes, such as food safety monitoring, cryptocurrency exchange, and secure medical data sharing. However, blockchain platforms cannot store all the generated data. Therefore, they are supported with data warehouses, which in turn is called a hybrid blockchain platform. While several systems have been developed based on this idea, a current state-of-the-art systematic overview on the use of hybrid blockchain platforms is lacking. Therefore, a systematic literature review (SLR) study has been carried out by us to investigate the motivations for adopting them, the domains at which they were used, the adopted technologies that made this integration effective, and, finally, the challenges and possible solutions. This study shows that security, transparency, and efficiency are the top three motivations for adopting these platforms. The energy, agriculture, health, construction, manufacturing, and supply chain domains are the top domains. The most adopted technologies are cloud computing, fog computing, telecommunications, and edge computing. While there are several benefits of using hybrid blockchains, there are also several challenges reported in this study.
  • Article
    Citation - WoS: 10
    Citation - Scopus: 8
    Beyond expectations: disease duration and psychological burden in psoriatic arthritis
    (Springer Heidelberg, 2023) Kilic, Gamze; Kilic, Erkan; Tekeoglu, Ibrahim; Sargin, Betul; Cengiz, Gizem; Balta, Nihan Cuzdan; Nas, Kemal
    This study aims to investigate the relationship between disease duration and psychological burden in PsA and to identify the risk factors associated with psychological distress. Patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network. Patients were categorized into three groups based on disease duration: early stage (< 5 years), middle stage (& GE; 5, < 10 years), and late stage (& GE; 10 years). All patients underwent clinical and laboratory assessment using standardized protocol and case report forms. The associations between psychological variables and clinical parameters were assessed by a multivariate analysis. Of the 1113 patients with PsA (63.9% female), 564 (%50.7) had high risk for depression and 263 (%23.6) for anxiety. The risk of psychological burden was similar across all PsA groups, and patients with a higher risk of depression and anxiety also experienced greater disease activity, poorer quality of life, and physical disability. Multivariate logistic regression revealed that female gender (OR = 1.52), PsAQoL (OR = 1.13), HAQ (OR = 1.99), FiRST score (OR = 1.14), unemployment/retired (OR = 1.48) and PASI head score (OR = 1.41) were factors that influenced the risk of depression, whereas the current or past enthesitis (OR = 1.45), PsAQoL (OR = 1.19), and FiRST score (OR = 1.26) were factors that influenced the risk of anxiety. PsA patients can experience a comparable level of psychological burden throughout the course of their disease. Several socio-demographic and disease-related factors may contribute to mental disorders in PsA. In the present era of personalized treatment for PsA, evaluating psychiatric distress can guide tailored interventions that improve overall well-being and reduce disease burden.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 3
    Electrical Characterization of Zninse2 Thin-Film Heterojunction
    (Springer, 2019) Gullu, H. H.; Parlak, M.
    ZnInSe2/Cu0.5Ag0.5InSe2 diode structures have been fabricated by thermal evaporation of stacked layers on indium tin oxide-coated glass substrates. Temperature-dependent dark current-voltage measurements were carried out to extract the diode parameters and to determine the dominant conduction mechanisms in the forward- and reverse-bias regions. The heterostructure showed three order of magnitude rectifying behavior with a barrier height of 0.72 eV and ideality factor of 2.16 at room temperature. In the high forward-bias region, the series and shunt resistances were calculated with the help of parasitic resistance relations, yielding room-temperature values of 9.54 x 10(2) Omega cm(2) and 1.23 x 10(3) Omega cm(2), respectively. According to the analysis of the current flow in the forward-bias region, abnormal thermionic emission due to the variation of the ideality factor with temperature and space-charge-limited current processes were determined to be the dominant conduction mechanisms in this heterostructure. In the reverse-bias region, the tunneling mechanism was found to be effective in the leakage current flow with trap density of 10(6) cm(-3). Spectral photocurrent measurements were carried out to investigate the spectral working range of the device structure. The main photocurrent peaks observed in the spectrum corresponded to the band-edge values of the active thin-film layers.
  • Article
    Citation - WoS: 10
    Citation - Scopus: 11
    Structural and Temperature-Tuned Bandgap Characteristics of Thermally Evaporated β-in2< Thin Films
    (Springer, 2021) Surucu, O.; Isik, M.; Terlemezoglu, M.; Gasanly, N. M.; Parlak, M.
    In2S3 is one of the attractive compounds taking remarkable interest in optoelectronic device applications. The present study reports the structural and optical characteristics of thermally evaporated beta-In2S3 thin films. The crystalline structure of the thin films was found as cubic taking into account the observed diffraction peaks in the X-ray diffraction pattern. The atomic compositional ratio of constituent elements was obtained as consistent with chemical formula of In2S3. Three peaks around 275, 309 and 369 cm(-1) were observed in the Raman spectrum. Temperature-tuned bandgap energy characteristics of the In2S3 thin films were revealed from the investigation of transmittance spectra obtained at various temperatures between 10 and 300 K. The analyses of the transmittance spectra indicated that direct bandgap energy of the In2S3 thin films decreases from 2.40 eV (at 10 K) to 2.37 eV (at 300 K) with the increase of measurement temperature. The bandgap energy vs. temperature relation was investigated by means of Varshni optical model. The fitting of the experimental data under the light of theoretical expression revealed the absolute zero bandgap energy, the rate of change of bandgap energy and Debye temperature.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Controlling Heterogeneous Structure of Smooth Breaks in Panel Unit Root and Cointegration Testing
    (Springer, 2023) Omay, Tolga; Iren, Perihan
    This study aims to show the consequences of a restrictive homogeneity assumption of frequency in heterogeneous panel unit root and cointegration testing with Flexible Fourier Form. For this purpose, we use a simple panel unit root and residual based cointegration test with Flexible Fourier Form in a heterogeneous frequency setting using a bootstrap algorithm. The power of the test statistics and empirical analysis results indicate that failing to take into account a heterogeneous frequency may lead to misleading inferences, thereby leading to misspecified tests and erroneous conclusions concerning the stochastic behavior of the data in the panel sample.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    The Effect of Zn Concentration on the Structural and Optical Properties of Cd1-xznx< Nanostructured Thin Films
    (Springer, 2021) Isik, M.; Terlemezoglu, M.; Isik, S.; Erturk, K.; Gasanly, N. M.
    The structural and optical properties of electrodeposited Cd1-xZnxS nanostructured thin films were investigated in the present paper for compositions of x = 0, 0.03, 0.06 and 0.09. X-ray diffraction patterns of the deposited thin films consisted of diffraction peaks related to cubic crystal lattice. The atomic compositional ratios were determined by performing energy dispersive spectroscopy measurements. Scanning electron microscopy images indicated that deposited thin films have nanostructured forms. Raman spectra of the Cd1-xZnxS thin films exhibited two vibrational modes associated with longitudinal optical mode and its first overtone. Transmission measurements were performed on the deposited thin films to get their band gap energies. It was seen from the analyses of absorption coefficient that band gap energy of Cd1-xZnxS thin films increases almost linearly from 2.40 to 2.51 eV as the composition was increased from x = 0 to x = 0.09.
  • Article
    The Relationship Between Operational Efficiency and Financial Efficiency in the Shipping Industry: An Example From Privatized Ports in Türkiye
    (EDP Sciences S A, 2025) Kaya, Ebru Nur; Mete, Mevlut Hurol; Belgin, Onder
    Since the ports are the backbone of international trade they need to be managed efficiently. This study addresses to analyze the operational and financial efficiency of the selected privatized ports that have been belonged to TCDD (Republic of T & uuml;rkiye State Railways). For this purpose, EATWOS (Efficiency Analysis Technique with Output Satisfying) method is employed, and the weights of the inputs and outputs are determined using LOPCOW (Logarithmic Percentage Change-Driven Objective Weighting), MEREC (Method Based on the Removal Effects of Criteria), and CRITIC (Criteria Importance Through Intercriteria Correlation) methods. After obtaining the weights from these objective methods, the comprehensive weights are calculated using TPOP (Technique of Precise Order Preference) method. Finally, Spearman's rank-order correlation shows that there is no relationship between the operational and financial efficiency of the ports. The number of studies that address both operational and financial efficiency of ports is limited, and this study distinguishes itself by investigating the relationship between both efficiency types.
  • Article
    Citation - WoS: 6
    Citation - Scopus: 5
    Synthesis of a regular polymer containing pseudo-polyether cages
    (Elsevier Science Sa, 2005) Cihaner, A; Önal, AM
    A new compound consisting of 2-thienyl units linked by polyether bridge has been synthesized and its electrochemical polymerization was performed via constant potential electrolysis (CPE) in an electrolytic solution containing 0.1 M tetrabutylammonium hexafluorophosphate (TBAPF(6)) dissolved in CH3CN. Chemical polymerization was carried out using FeCl3 as oxidizing agent. It is found that both methods gave the same polymer product without any cleavage of the polyether bridge between thiophene (Th) rings. Although as synthesized polymers exhibited no conductivity, they gain conductivity via chemical doping using 12 vapor exposure. The polymers were characterized using FTIR spectroscopic technique and 12 doping was monitored using in-situ electron spin resonance (ESR) spectroscopy. Thermal behavior of electrochemically prepared polymer was investigated using differential scanning calorimetry, DSC and thermogravimetric analysis, TGA. (c) 2005 Elsevier B.V. All rights reserved.