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Article Recovery of Myocardial Functions After Kidney Transplantation in Patients With Heart Failure Due To Uremic Cardiomyopathy(Kare Publ, 2025) Ozates, Yelda Saltan; Odabasi, Ahmet Yener; Yildiz, Ufuk; Albayrak, Duygu Genc; Inan, Duygu; Bas, Serap; Tekkesin, Ahmet IlkerObjective: Although left ventricular hypertrophy frequently accompanies end-stage renal disease, heart failure (HF) with reduced ejection fraction (EF) is also observed in a subset of patients. In those patients kidney transplantation (KT) is generally avoided due to an increased risk of mortality in addition to the risks associated with HF. This prospective study was designed to follow patients with HF who were being prepared for KT. Methods: Twenty-five patients with HF due to uremic cardiomyopathy (UC) who had suitable donors (Group 1), 22 patients with HF who could not undergo KT due to a lack of kidney donors (Group 3), and 25 KT candidates with normal ventricular function (Group 2) were included in the study. Left ventricular ejection fraction (LVEF), left atrial diameter (LAD), mitral annular systolic velocity (Sm), left ventricular global longitudinal strain (GLS), and left ventricular mass index (LVMI) values were recorded across four sessions, from pre-transplant to six months post-transplantation. Endomyocardial biopsy was performed for detailed examination of the myocardium in patients in Group 1 and Group 3, and cardiac magnetic resonance imaging (MRI) was performed in all three groups before transplantation. Results: In Group 1, LVEF, Sm, and left ventricular global longitudinal strain (LV-GLS) increased significantly, while LAD and LVMI decreased, all reaching normal levels. In contrast, no changes were observed in Group 3 and Group 2 (P < 0.01 for LVEF, P < 0.01 for GLS, P < 0.01 for LAD, and P < 0.01 for LVMI measurements). No differences in cardiac MRI and biopsy findings were observed between Group 1 and Group 3. Conclusion: Since myocardial function improved significantly and normalized in all patients with it has been demonstrated that UC can be reversible when treated with KT.Article Citation - WoS: 1Citation - Scopus: 1Karotis Arter Stentlemesinin Etkinliği ve Güvenliği: Tek Merkez Deneyimi(Kare Publ, 2020) Karaduman, Bilge Duran; Karaduman, Bilge Duran; Ayhan, Hüseyin; Ayhan, Hüseyin; Keles, Telat; Bozkurt, Engin; Karaduman, Bilge Duran; Ayhan, HüseyinAmaç: İnternal karotis arterdeki orta ve şiddetli darlıklar tüm inmelerin %10–15’ine neden olmaktadır. Bu çalışmada, üçüncü basamak bir referans merkezde karotis arter stentlemesinin (KAS) güvenliğini ve kısa dönem etkinliğini değerlendirmeyi amaçladık. Yöntemler: Üçüncü basamak merkezimizde Ocak 2017 ile Mayıs 2018 arasında KAS uygulanan hastalar geriye dönük olarak değerlendirildi. KAS uygulanan 145 hasta çalışmaya dahil edildi. Bulgular: Hastaların ortalama yaşı 70.1±8.6 yıl idi ve tüm grubun %75.2’si erkek olup %37.9’unda hipertansiyon mevcuttu. Hastaların 81’i (%55.9) semptomatik, 64’ü (%44.1) asemptomatik olarak gruplandırıldı. Semptomatik hastalarda koroner girişimler daha çok KAS sonrası (%38.9) yapılırken, asemptomatik grupta ise KAS öncesi (%25.9) ve sonrasında (%25.9) benzer oranlarda yapıldığı görüldü ama gruplar arasında istatistiksel fark yoktu. Semptomatik hastalarda (%59.2), asemptomatik hastalarda (%78.7) olduğu gibi distal emboli koruyucu cihaz (EKC), proksimal EKC’ye göre daha fazla kullanıldı. Ancak proksimal EKC, semptomatik hastalarda asemptomatik hastalara kıyasla anlamlı olarak daha fazla kullanıldı. Hastane içi ölüm görülmedi ve tüm popülasyonda 5 (%3.4) hastada inme veya geçici iskemik atak (GİA) gözlendi. Asemptomatik grupta GİA veya inme gözlenmedi, semptomatik grupta 2 hastada (%2.4) inme ve 3 hastada (%3.7) GİA görüldü. Sonuç: Bu çalışma kabul edilebilir komplikasyon oranları ile KAS’ın güvenirliğini ve uygulanabilirliğini ortaya koymuştur. KAS prosedürü, deneyimli girişimciler tarafından optimal tıbbi tedavi altında, agresif risk modifikasyonu ile EKC kullanılarak, uygun hastalarda en az komplikasyonla gerçekleştirilmelidir.Review Citation - WoS: 7Citation - Scopus: 8Stereotactic Radiosurgery After Subtotal Resection of Critically-Located Grade I Meningioma: a Single-Center Experience and Review of Literature(Turkish Neurosurgical Soc, 2021) Karaaslan, Burak; Celtikci, Emrah; Bulduk, Erkut Baha; Borcek, Alp Ozgun; Kurt, Gokhan; Kaymaz, Memduh; Emmez, HakanAIM: To analyze the results of stereotactic radiosurgery in 295 patients with residual Grade I meningiomas located at parasellar region, petroclival region, cerebellopontine angle and parasagittal region. MATERIAL and METHODS: A total of 295 patients with Grade 1 residual Meningiomas (197 women, 98 men), who were treated by adjuvant radiosurgery in Gazi University Gamma Knife Center between 2004-2015 were analyzed. WHO Grade 2 and 3 meningiomas were not included in our study. Minimum radiological follow-up was 24 months. The median follow-up was 54 months. The tumor volume, location, treatment dose, morbidity, progression free survival and tumor control rate were analyzed. RESULTS: The median tumor volume was 5.2 cm(3) (0.04-39.7), median age was 50 (20-80), median dose was 14 Gy and tumor control rate was 94.5% (stationary in 85.0%, volume reduction in 9.5%). Increase in tumor volume was seen in 16 patients (5.5%) and re-operation was performed in 5 of them (1.6%). Stereotactic radiosurgery was performed again for 8 patients (2.7%).The location of the tumors was as follows: 39.3% parasellar region, 20% cerebellopontine angle, 13.6% petroclival and 27.1% was parasagittal, falcine or convexity. Major morbidities were detected in 6 (2%) patients. Minor morbidities were detected in 18 (6.1%) patients. CONCLUSION: Stereotactic radiosurgery is an effective and safe treatment modality for residual Grade I meningiomas.Article Citation - WoS: 6A Light Bulb in Every House the Istanbul General Electric Factory and American Technology Transfer To Turkey(Johns Hopkins Univ Press, 2022) Tunc, Tanfer Emin; Tunc, GokhanIn 1946, Turkish entrepreneur Vehbi Koc signed an agreement with the U.S. firm General Electric to build and operate its first light bulb factory in the Near/Middle East, in Istanbul. This private joint venture introduced new manufacturing techniques, business practices, and consumer habits to Turkey, opening channels of postwar technological exchange. Closer examination of the GE-Koc partnership reveals that during the early Cold War, the transfer and embedding of American technologies in Turkey was a politically complicated process of innovation that required constant adaptation. Fraught with unforeseeable obstacles, it also required cautious negotiation with multiple transnational actors. The story of the GE-Koc partnership thus adds a new dimension to historical understandings of the Turkish Cold War experience and the Americanization of the region. It illustrates how transferring a nonmilitary, soft-power, domestic technologythe light bulb-played a significant role in Turkish-American relations and therefore contributes to studies of U.S. Cold War diplomacy through transnational investment in innovation.Article Citation - WoS: 1Citation - Scopus: 1Kardiyovasküler Aldatma-Salgını: Kardiyovasküler Tedavilerde Kandırma ve Yanlış Bilgilendirme Epidemisinin Yaygınlaşması(Baycınar Medical Publishing - Baycınar Tıbbi Yayıncılık, 2024) Demirkılıç, Ufuk; Tosun, BurcuSon zamanlarda, bazı kalp damar cerrahları sıklıkla yanıltıcı terimler kullanarak pazarlama amacıyla sosyal medyayı giderek daha fazla kullanmaktadır. “Kardiyovasküler aldatma- salgını” olarak adlandırdığımız bu eğilim, kardiyovasküler tedaviler için yanıltıcı reklamların salgın benzeri bir şekilde yayılmasını içeren bir durumu yansıtmaktadır. Bu tür yanlış bilgilere maruz kalmanın, profesyonel kaynaklardan gelen bilgiye doğal olarak güvenen hastaları tehlikeye atmakla kalmayıp, aynı zamanda tıbbi etik ve bilimsel doğruluğa olan kamu güvenini de zedelemektedir. Ayrıca, bu durum tedavi reddine ve olumsuz sağlık sonuçlarına da katkıda bulunmaktadır. Bu sorunları değerlendiren kapsamlı küresel düzenlemelerin yetersizliği, acilen daha etkili uygulama önlemlerine gereksinim olduğunu ortaya çıkarmaktadır.Book Part Citation - WoS: 7Citation - Scopus: 11Magnetic-Based Cell Isolation Technique for the Selection of Stem Cells(Humana Press inc, 2019) Korkusuz, Petek; Kose, Sevil; Yersal, Nilgun; Onen, SelinMagnetic-activated cell sorting (MACS) is the technology that is recently used as a magnetic-based cell isolation/purification technique. This technique enables the isolation and selection of germ, hematopoietic, and somatic stem cells including skin stem cells (SkSCs). Here, we have tried to describe the isolation of stem cells by MACS using CD34 antigen for SkSCs, again CD34 for hematopoietic stem cells (HSCs) and Thy-1 for spermatogonial stem cells (SpSCs). MACS allowed the isolation of CD34+, CD34+, and Thy-1+ human SkSCs, HSCs, and SpSCs with minimum 98% purity.Article Citation - WoS: 3Citation - Scopus: 3How Do Implant Threads and Diameters Affect the All-On Success? a 3d Finite Element Analysis Study(IOS Press BV, 2022) Zor,Z.F.; Klllnç,Y.; Erkmen,E.; Kurt,A.; Kilinc, YelizBACKGROUND: The effect of different thread designs and diameters on the all-on-four concept is unclear. OBJECTIVE: The aim of the study was to clarify the differences in stress distribution of dental implants with various thread designs and diameters based on the all-on-four concept with three dimensional (3D) finite element analysis (FEA). METHODS: A 3D model of a totally edentulous mandible was used to perform the FEA. Four different models (M1, M2, M3, and M4) including 3.5 and 4.3 mm diameter dental implants with active and passive threaded designs were generated. The dental implants were positioned according to the all-on-four concept. The Von Mises stresses on dental implants and maximum and minimum principal stresses (Pmax and Pmin) on bony structures were calculated under vertical, oblique and horizontal loads. RESULTS: For Von Mises stresses, the highest stress values were detected on the distal implants for all models. Distal implants had also the highest stress values for vertical loading. The Von Mises stresses were found to be concentrated around the implant's neck. In all models the highest Pmax and Pmin stresses occurred in the bone surrounding the distal implant. It was noted that the active threaded implants showed the highest Pmax and Pmin stress values. CONCLUSION: The implant thread design and diameter might have a strong influence on the stress values in the all-on-four concept. © 2022 - IOS Press. All rights reserved.Article Citation - WoS: 29Citation - Scopus: 33Risk Factors for Linezolid-Associated Thrombocytopenia and Negative Effect of Carbapenem Combination(J infection developing Countries, 2019) Kilic, Esra Kaya; Bulut, Cemal; Sonmezer, Meliha Cagla; Ozel, Ozlem; Hatipoglu, Cigdem Ataman; Ertem, Gunay Tuncer; Kinikli, Sami; Tuncer Ertem, Günay; Ataman Hatipoğlu, Çiğdem; Kaya Kılıç, EsraIntroduction: Linezolid is a synthetic antimicrobial agent with a broad spectrum of activity against virtually all Gram-positive bacteria. Although linezolid is generally well tolerated, the prolonged use of linezolid can lead to myelosuppression, including neutropenia, thrombocytopenia, and anemia. The aim of this study was investigating the risk factors for thrombocytopenia in patients who received linezolid therapy. Methodology: This retrospective study was performed on patients who received linezolid therapy between July 2007 and December 2017. Thrombocytopenia was defined as either a platelets count of < 100x10(9)/L or a 25% reduction from the baseline platelet count. Results: A total of 371 patients, (198 (53%) male and 173(47%) female were included into the study. Mean duration of therapy was 12.81 +/- 5.19 days. Linezolid-induced thrombocytopenia was detected in a total of 111 patients. Using the univariate analysis advanced sex, serum urea concentration, baseline platelet level and low eGFR value were found to be risk factors for linezolid associated thrombocytopenia (p < 0.05). According to a multivariate analysis, patients undergoing carbapenem treatment combination therapy (p = 0.003) and with a baseline platelet level of < 200x10(9)/L (p = 0.00) were found to have a high risk of developing thrombocytopenia. Conclusions: Several factors may influence of linezolid associated thrombocytopenia. Platelet count should be monitored during therapy and thrombocytopenia should be kept in mind in patients with baseline platelet level of < 200x10(9)/L, low eGFR, linezolid-carbapenem combination therapy.Article Citation - WoS: 3Citation - Scopus: 3Characterization of Mesenchymal Stem Cells in Mucolipidosis Type Ii (i-Cell Disease)(Tubitak Scientific & Technological Research Council Turkey, 2019) Köse, Sevil; Kaya, Fatima Aerts; Kuşkonmaz, Bülent Barış; Çetinkaya, Duygu Uçkan; Aerts Kaya, Fatima; Uckan Cetinkaya, DuyguMucolipidosis type II (ML-II, I-cell disease) is a fatal inherited lysosomal storage disease caused by a deficiency of theenzyme N-acetylglucosamine-1-phosphotransferase. A characteristic skeletal phenotype is one of the many clinical manifestationsof ML-II. Since the mechanisms underlying these skeletal defects in ML-II are not completely understood, we hypothesized that adefect in osteogenic differentiation of ML-II bone marrow mesenchymal stem cells (BM-MSCs) might be responsible for this skeletalphenotype. Here, we assessed and characterized the cellular phenotype of BM-MSCs from a ML-II patient before (BBMT) and afterBM transplantation (ABMT), and we compared the results with BM-MSCs from a carrier and a healthy donor. Morphologically, wedid not observe differences in ML-II BBMT and ABMT or carrier MSCs in terms of size or granularity. Osteogenic differentiation wasnot markedly affected by disease or carrier status. Adipogenic differentiation was increased in BBMT ML-II MSCs, but chondrogenicdifferentiation was decreased in both BBMT and ABMT ML-II MSCs. Immunophenotypically no significant differences were observedbetween the samples. Interestingly, the proliferative capacity of BBMT and ABMT ML-II MSCs was increased in comparison to MSCsfrom age-matched healthy donors. These data suggest that MSCs are not likely to cause the skeletal phenotype observed in ML-II, butthey may contribute to the pathogenesis of ML-II as a result of lysosomal storage-induced pathology.Article Evaluation of the Family Medicine Practice in Ankara Province by Family Physicians(Southern Public Administration Education Foundation, Inc, 2016) Tengilimoǧlu,D.; Menawi,W.; Dinçer,M.; Kisa,A.; Younis,M.Z.Turkey's family physician or practice system was established in the beginning of the 2010 across Turkey's 81 provinces and provides low-cost health care, preventive and curative basic medical services to the population. Public health centers across Turkey have now become Family Health Centers (ASMs) as part of Turkey's efforts to harmonize its health care system with that of the European Union. The aim of This studyis to analyz and evaluate the implementation and performance of Family Practice in Ankara province by family physicians. A questionairre form of 42 question was designed and used to determine opinions of the physicians about effective service & quality improvement, patient-physician relationship, efficiency in the area of responsibility, productivity, job satisfaction and equity. The result of the study shows that family physicians were defined to be generally satisfied with the system and performance implementation and significant differences were found according to work seniority, gender and productivity of the participants. Finally this study should be taken within it's limiation. The work seniority and gender was one of the most important factor to improve satfications and productivity for family physcains in Turkey. The sample size was represenative for the country, however, one limitation might be cosnidred the increase of sample size in future research if appropriate funding becaome avlaible in the future. This study did not have any souirce of funding. © 2016, Southern Public Administration Education Foundation, Inc. All rights reserved.
