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Book Part Clinical Development of Quinone-Based Drugs(Elsevier, 2024) Altuner, E.E.; Issa, G.; Ozalp, V.C.; Aldemir, O.; Torlak, Y.; Dar, U.A.This chapter provides a detailed explanation of the clinical investigations, pharmacological effects, and characteristics of quinone and quinone derivatives, along with references to pertinent sources. Although quinones have an oxygen group in their structure, they are quickly oxidized and interact with reactive oxygen species. This demonstrates how quinones work as drugs. Quinones and their derivatives are used as medications to treat a wide range of diseases, including cancer, lung, kidney, brain, and tumor disorders. Each of the following has effects on a different area of health; lapochols, anthraquinones, naphthoquinone and its derivatives, and other wide range of quinone derivatives are thoroughly explored in this chapter. © 2025 Elsevier Inc. All rights reserved.Article From Simulators To Skies: Engineering and Educational Advancements in Pilot Training: a Bibliometric Perspective(2025) Yılmaz, Ayşe AslıThe integration of advanced engineering innovations into pilot training has brought transformative changes to aviation education, emphasizing the role of technologies such as flight simulators, virtual reality (VR), augmented reality (AR), and artificial intelligence (AI). This study employs a bibliometric analysis to explore research trends, influential contributors, and thematic focuses in pilot training from 2000 to 2025, using data from 350 peer-reviewed articles indexed in the Web of Science. Findings reveal a significant rise in publications during the last decade, driven by advancements in simulation technologies, competency-based training, and human factors research. While the field has experienced rapid technological evolution, challenges such as cost barriers, integration complexities, and gaps in long-term performance evaluation remain. This paper highlights emerging trends, including competency-based training and assessment (CBTA) and scenario-based training (SBT) as well as physiological monitoring, offering a comprehensive roadmap for future research and innovation in aviation training.Article Bir Yüksek Hızlı Trenin Aktif Süspansiyonu için Modelleme ve LQR Geribildirim Kontrolü(2025) Karahan, MehmetYüksek hızlı demiryolu araçlarında sürüş konforu ve yolculuğun kalitesi önemlidir. Tren hareket halindeyken rayların neden olduğu çeşitli titreşimlerle karşılaşır. Bu titreşimlerin uzun süreli yaşanması yolcularda sağlık sorunlarına yol açabilir. Ayrıca trenin titreşimler nedeniyle dayanıklılığı azalır, performansı düşer ve bakım maliyetleri artar. Trenin iyi kullanılabilmesi için rijit bir süspansiyon sistemine ihtiyaç vardır. Geleneksel bir süspansiyon olan pasif süspansiyon, trenin sürüş kalitesi ile yolcu konforu arasında bir denge kurar. Ancak pasif süspansiyon sabit bir süspansiyon sistemidir ve süspansiyon sertliğini değişen koşullara göre ayarlayamaz. Aktif süspansiyon ise süspansiyon sertliğini değişen koşullara göre ayarlayabilir. Bu araştırmada tren gövdesini kontrol etmek için Doğrusal Karesel Düzenleyici tarafından kontrol edilen aktif bir süspansiyon tasarlanmıştır. Böylece titreşimler en aza indirilmiş ve yolcu konforu arttırılmıştır. Pasif ve aktif süspansiyonları karşılaştırmak için çeşitli simülasyonlar yapılmış ve aktif süspansiyonun üstünlüğü kanıtlanmıştır.Article Potential Protective Effects of Boldine in Rat With an Experimental Myocardial Ischemia-Reperfusion Model(2025) Küçük, Ayşegül; Dursun, Alı Dogan; Arslan, Mustafa; Sezen, Şaban Cem; Yıldırım, Alperen Kutay; Özer, Abdullah; Yığman, ZeynepObjectives: Myocardial ischemia-reperfusion injury (MIRI) remains a major challenge in cardiovascular medicine due to its complex pathophysiology involving oxidative stress, inflammation, and cellular dysfunction. Boldine, a potent natural alkaloid with antioxidant and anti-inflammatory properties, has demonstrated protective effects in various pathological conditions. However, its potential cardioprotective effects in MIRI remain largely unexplored. This study aims to evaluate the protective effects of Boldine in a rat model of MIRI by assessing oxidative stress markers, histopathological changes, and inflammatory responses. Materials and Methods: Male Albino Wistar rats were randomly assigned to four groups: Control, Boldine, myocardial ischemia-reperfusion (MIR), and myocardial ischemia-reperfusion + Boldine (MIR+B). Myocardial ischemia was induced by ligating the left anterior descending coronary artery for 30 minutes, followed by 120 minutes of reperfusion. Boldine (50 mg/kg) was administered intraperitoneally at the onset of reperfusion. Cardiac tissue samples were collected for histopathological evaluation and biochemical analysis, including total antioxidant status (TAS), total oxidant status (TOS), and Oxidative Stress index (OSI). Results: Histopathological analysis revealed significant myocardial disorganization and inflammation in the MIR group compared to controls (p=0.05). Boldine treatment significantly reduced inflammation and myocardial disorganization in the MIR+B group (p<0.05), suggesting a protective effect. Biochemical analysis showed a marked decrease in TAS levels and an increase in TOS and OSI in the MIR group (p<0.001). However, Boldine administration significantly restored TAS levels and reduced TOS and OSI in the MIR+B group (p< 0.001), indicating attenuation of oxidative stress. Conclusion: Boldine exhibits significant cardioprotective effects in a rat model of MIRI by reducing oxidative stress, mitigating myocardial disorganization, and alleviating inflammation. These findings suggest that Boldine may serve as a therapeutic agent in ischemic heart disease. Further research is warranted to elucidate its precise mechanisms of action and potential clinical applications.Article Impact of Operations on a Series Per Reliability Perspective(2025) Yucesan, OngunThe Mean Time Between Failure (MTBF) figures are the average of test durations between failure observations formed into a series. They can be seen to suit classical statistical distributions. An equally possible condition is that they are not stationary as a contradiction to the previous statement. In such worse conditions accepting availability of a concealed statistical property, this paper tries to identify the impact of Bi-sample Differencing and Bi-sample mean manipulations. In other words, operating on reliability observations series to reveal concealed statistical knowledge. Experimentation based on observation over a stationary series as a controlled experiment. As an outcome of experiments, the differencing seems to be alleviating the trend and seasonality to a degree. The bi-sample averaging is observed to be hiding variant conditions.Article Evaluation of Turkish Health System Capacity at Provincial Level by WISP Method Based on Weighting Methods(2025) Bulut, TevfikAmaç: Bu çalışmanın birincil amacı, Türkiye sağlık sisteminin kapasite ve kapasite açıklarını il düzeyinde göreceli olarak değerlendirmektir. Çalışmanın ikincil amacı ise R programlama dilinde kullanılan ağırlıklandırma yöntemleri için uygulama algoritmaları geliştirmektir. Yöntem: Sağlık sistemi kapasitesinin değerlendirilmesinde kullanılan karar kriterleri CRITIC, Shannon Entropy ve NMV yöntemleri ile ağırlıklandırılmıştır. İllerin sağlık sistemi kapasitesini değerlendirmek için WISP yöntemi kullanılmıştır. Veriler Sağlık Bakanlığı'nın 2022 Sağlık İstatistikleri Yıllığı'ndan alınmıştır. Bulgular: Tunceli, Bayburt ve Kilis, CRITIC tabanlı WISP skorlarına göre Türkiye'de sağlık sistemi kapasitesi açısından 81 il arasında optimal çözüme en yakın üç ildir. Buna karşılık, Bursa, İstanbul ve Şanlıurfa optimal çözümden en uzak üç ildir. Özgünlük: İl düzeyinde, sağlık sisteminin kapasitesindeki boşlukları tespit edebilir ve geliştirebiliriz. Kendi kendine yeterli sağlık sistemi kapasitesi oluşturabilir ve sağlık sistemini daha dirençli hale getirilebilir. Öte yandan, ağırlıklandırma yöntemleri için uygulama algoritmalarının geliştirilmesi önemli bir katkıdır. Böylece karar vericiler küçük ve özellikle büyük ölçekli veri setleri üzerinde anlık çözümler üretebilir.Book Part Drawing a Portrait of Refugee Representation in Turkish Newspapers: A Framing Analysis of Hürriyet and Sabah(Bloomsbury Publishing Plc., 2020) Özoran, Beris Artan; Seyidov, IlgarArticle Catalyst-Free Synthesis of Thiourea-Linked Dumbbell-Shaped POSS for Ultrasensitive Determination of Prilocaine in Human Blood with Computational Insights(Elsevier Inc., 2026) Bilge, S.; Bayraktar, E.N.; Erkmen, C.; Balci, B.; Abofoul, A.; Içli-Özkut, M.I.; Cihaner, A.Although various electrochemical sensors have been reported for the determination of local anesthetic drugs, most existing platforms suffer from limited sensitivity, insufficient surface stability, or inadequate electron-transfer efficiency, particularly when applied to complex biological matrices. Moreover, the potential of hybrid polyhedral oligomeric silsesquioxane (POSS)-based nanostructures combined with metal oxide nanoparticles for improving electroanalytical performance has not yet been thoroughly explored. In this study, a high-sensitivity electrochemical nanosensor was developed for the determination of prilocaine (PC), an amide-type local anesthetic, using a glassy carbon (GC) electrode modified with POSS‑titanium dioxide (TiO2) nanoparticles (Nps). The combination of modifications provided a unique electrode surface by combining the high stability of POSS with the strong adsorption properties of TiO2 Nps, thereby increasing both surface loading and adsorption capacity. To elucidate the structure of the modification combination, 1H and 13C nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopic techniques, as well as Brunauer–Emmett–Teller (BET), X-Ray diffraction (XRD), Electrochemical impedance spectroscopy (EIS), and high-resolution transmission electron microscopy (HRTEM) analysis techniques were used, respectively. The analytical performance of the developed nanosensor was systematically optimized using differential pulse voltammetry (DPV), adsorptive stripping differential pulse voltammetry (AdSDPV), square wave voltammetry (SWV), and adsorptive stripping square wave voltammetry (AdSSWV) techniques. As a result of the optimization studies, the lowest limit of detection (LOD) was 3.66 × 10−8 M with the AdSSWV technique. DFT results corroborated the mechanism, indicating ring-centered electron donation (HOMO) and adsorption-favored N/O regions (MEP). Low LOD values were also recorded with other techniques, demonstrating the method's high sensitivity in analyte detection. In real sample analysis tests, PC recovery value in human blood samples was determined to be 98.69% using the AdSDPV technique. Despite the matrix effect, the nanosensor demonstrated high accuracy and reproducibility. The results indicate that the developed POSS-TiO2 Nps modified GC electrode sensor offers a high-performance, reliable, and good electrochemical detection platform suitable for use in biological and clinical applications. © 2024Conference Object Need for a Software Development Methodology for Research-Based Software Projects(Institute of Electrical and Electronics Engineers Inc., 2018) Cereci,I.; Karakaya,Z.Software development is mostly carried by a group of individuals. Software development methodologies are heavily utilized to organize these individuals and keep track of the entire software development process. Although previously proposed software development methodologies meet the needs of the industry and the firms, they are not usually suitable for research-based software projects that are carried by universities and individual researchers. In this paper, we aim to show the necessity of a new software development methodology for research-based problems carried by universities. The literature review will show the differences between industry and university software projects from certain aspects. These findings will be supported by the authors own research on the area. This qualitative research involves collecting data through interviews and applying Grounded Theory to better understand the development process. © 2018 IEEE.Book Part Candidacy Versus Membership: Is Turkey the Greatest Beneficiary of the European Union(Bloomsbury Publishing Plc., 2013) Temel, B.
