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Article Citation - WoS: 22Citation - Scopus: 23On Residual Lifetime of Coherent Systems After the rth Failure(Springer, 2013) Eryilmaz, SerkanIn this article we study the residual lifetime of a coherent system after the rth failure, i.e. the time elapsed from the rth failure until the system failure given that the system operates at the time of the rth failure. We provide a mixture representation for the corresponding residual lifetime distribution in terms of signature. We also obtain some stochastic ordering results for the residual lifetimes.Article Citation - WoS: 36Citation - Scopus: 45Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering(Elsevier, 2021) Topsakal, Aysenur; Midha, Swati; Yuca, Esra; Tukay, Ari; Sasmazel, Hilal Turkoglu; Kalaskar, Deepak M.; Gunduz, OguzhanOver the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.Book Non-Discrimination in Turkey(Springer International Publishing, 2022) Yilmaz,G.The book “Non-discrimination in Turkey” focuses on issue areas within the broader non-discrimination framework in Turkey. It looks domestic change in Turkey regarding non-discrimination across time. The book unpacks the principle of non-discrimination and provides analysis in many issue areas like LGBTI rights, disability rights or age discrimination that rely under the framework of non-discrimination. Adopting a comprehensive approach including many areas within non-discrimination, the book will be useful for the students, scholars and researchers of international relations, political science, Middle East and Turkish studies and those interested in human rights. © The Editor(s)(if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.Editorial Citation - WoS: 5Citation - Scopus: 5Transcatheter Treatment Tricuspid Regurgitation by Valve-In Implantation With a Novel Balloon-Expandable Myval® Thv(Polish Cardiac Soc-polskie Towarzystwo Kardiologiczne, 2022) Ayhan, Huseyin; Karaduman, Bilge Duran; Keles, Telat; Bozkurt, Engin[No Abstract Available]Article Citation - WoS: 2Citation - Scopus: 22-Ag and Bone Marrow-Targeted Pcl Nanoparticles as Nanoplatforms for Hematopoietic Cell Line Mobilization(Bmc, 2024) Kose, Sevil; Varan, Cem; Onen, Selin; Nemutlu, Emirhan; Bilensoy, Erem; Korkusuz, PetekBackgroundThe use of mobilizing agents for hematopoietic stem cell (HSC) transplantation is insufficient for an increasing number of patients. We previously reported lipid made endocannabinoid (eCB) ligands act on the human bone marrow (hBM) HSC migration in vitro, lacking long term stability to be therapeutic candidate. In this study, we hypothesized if a novel 2-AG-loaded polycaprolactone (PCL)-based nanoparticle delivery system that actively targets BM via phosphatidylserine (Ps) can be generated and validated.MethodsPCL nanoparticles were prepared by using the emulsion evaporation method and characterized by Zetasizer and scanning electron microscopy (SEM). The encapsulation efficiency and release profile of 2-AG were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The presence of cannabinoid receptors (CBRs) in HSCs and monocytes was detected by flow cytometry. Cell morphology and viability were assessed using transmission electron microscopy (TEM), SEM, and the WST-1 viability assay. The migration efficacy of the 2-AG and 2-AG-loaded nanoparticle delivery system on HSCs and HPSCs (TF-1a and TF-1) and monocytes (THP-1) was evaluated using a transwell migration assay.ResultsThe 140-225 nm PCL nanoparticles exhibited an increasing polydispersity index (PDI) after the addition of Ps and 2-AG, with a surface charge ranging from - 25 to -50 mV. The nanoparticles released up to 36% of 2-AG within the first 8 h. The 2-AG-Ps-PCL did not affect cellular viability compared to control on days 5 and 10. The HSCs and monocytes expressed CB1R and CB2R and revealed increased migration to media containing 1 mu M 2-AG-Ps-PCL compared to control. The migration rate of the HSCs toward monocytes incubated with 1 mu M 2-AG-Ps-PCL was higher than that of the monocytes of control. The 2-AG-Ps-PCL formulation provided a real time mobilization efficacy at 1 mu M dose and 8 h time window via a specific CBR agonism.ConclusionThe newly generated and validated 2-AG-loaded PCL nanoparticle delivery system can serve as a stable, long lasting, targeted mobilization agent for HSCs and as a candidate therapeutic to be included in HSC transplantation (HSCT) protocols following scale-up in vivo preclinical and subsequent clinical trials.Article Citation - WoS: 29Citation - Scopus: 36Massive Mimo Systems for 5g: a Systematic Mapping Study on Antenna Design Challenges and Channel Estimation Open Issues(inst Engineering Technology-iet, 2021) Benzaghta, Mohamed; Rabie, Khaled M.The next generation of mobile networks (5G) is expected to achieve high data rates, reduce latency, as well as improve the spectral and energy efficiency of wireless communication systems. Several technologies are being explored to be used in 5G systems. One of the main promising technologies that is seen to be the enabler of 5G is massive multiple-input multiple-output (mMIMO) systems. Numerous studies have indicated the utility of mMIMO in upcoming wireless networks. However, there are several challenges that needs to be unravelled. In this paper, the latest progress of research on challenges in mMIMO systems is tracked, in the context of mutual coupling, antenna selection, pilot contamination and feedback overhead. The results of a systematic mapping study performed on 63 selected primary studies, published between the year 2017 till the second quarter of 2020, are presented. The main objective of this secondary study is to identify the challenges regarding antenna design and channel estimation, give an overview on the state-of-the-art solutions proposed in the literature, and finally, discuss emerging open research issues that need to be considered before the implementation of mMIMO systems in 5G networks.Article Hopping Conduction in Ga4se3< Layered Single Crystals(Pergamon-elsevier Science Ltd, 2008) Qasrawi, A. F.; Gasanly, N. M.The conduction mechanism in Ga4Se3S single crystals has been investigated by means of dark and illuminated conductivity measurements for the first time. The temperature-dependent electrical conductivity analysis in the region of 100-350 K, revealed the dominance of the thermionic emission and the thermally assisted variable range hopping (VRH) of charged carriers above and below 170 K, respectively. The density of states near the Fermi level and the average hopping distance for this crystal in the dark were found to be 7.20 x 10(15) cm(-3) eV(-1) and 7.56 x 10(-6) cm, respectively. When the sample was illuminated, the Mott's VRH parameters are altered, particularly, the average hopping distance and the density of states near the Fermi level increase when light intensity increases. This action is attributed to the electron generation by photon absorption, which in turn leads to the Fermi level shift and/or trap density reduction by electron-hole recombination. (C) 2008 Elsevier Ltd. All rights reserved.Article Citation - Scopus: 5Comparative Analysis of Three Innovative Housing Models in Copenhagen for Social Mix(Istanbul Teknik Universitesi, Faculty of Architecture, 2020) Bıcan,N.B.Copenhagen has been attracting residents both from abroad and other regions of Denmark, embracing a comprehensive development plan following an economic boom since the 1990s. Local decision-makers have been striving to transform the housing stock of the city in line with the evolving demographics of the city and consequent new demands of the urban society. At the same time, people are seeking cheaper and flexible alternatives of living; thus, social housing (almen bolig) emerges as an affordable option with reasonable qualities for Copenhagen residents. This study uses a comparative analysis to evaluate spatial approaches of three innovative social housing models developed by partnerships of some non-profit housing associations with Copenhagen municipality in 2015. Each model has a distinct motto; Generationernes Byhus (GBYH) builds up neighbourhood across generations; Boliger for Alle (BOFA) provides opportunity of transition across ownership types; and Almene Storbyboliger (ASBB) creates flexible/plastic system addressing demographical structure under change. Methodologically, the research is based on interviews with key stakeholders and in-depth analysis of visual and written documents. It provides a comparative analysis of the models, concentrating particularly on dwelling design approaches which address social mix and diversity. The paper concludes that although the social housing market is strictly controlled for socio-economic reasons, it still has the potential to support the evolution of the urban demography of Danish society thanks to embracement of innovative perspectives both by governmental authorities and forerunning housing associations. © 2020, Istanbul Teknik Universitesi, Faculty of Architecture. All rights reserved.Article Citation - WoS: 32Citation - Scopus: 45Fixed Point Theorems for a Class of Α-Admissible Contractions and Applications To Boundary Value Problem(Hindawi Publishing Corporation, 2014) Alsulami, Hamed H.; Gulyaz, Selma; Karapinar, Erdal; Erhan, Inci M.A class of alpha-admissible contractions defined via altering distance functions is introduced. The existence and uniqueness conditions for fixed points of such maps on complete metric spaces are investigated and related fixed point theorems are presented. The results are reconsidered in the context of partially ordered metric spaces and applied to boundary value problems for differential equations with periodic boundary conditions.Article Citation - WoS: 11Citation - Scopus: 10Synthesis and Characterization of Hydrothermally Grown Potassium Titanate Nanowires(Korean Assoc Crystal Growth, inc, 2015) Kapusuz, Derya; Kalay, Y. Eren; Park, Jongee; Ozturk, Abdullah; Metallurgical and Materials EngineeringPotassium titanate (KT) nanowires were synthesized by a one-step hydrothermal reaction between TiO2 and aqueous KOH solution. The effects of KOH concentration and reaction time on hydrothermal formation and KT nanowire growth were investigated. The nanowire growth mechanism was elucidated using a combined study of powder X-ray diffraction, and scanning and transmission electron microscopy. The results revealed that hydrothermal growth was initiated by the formation of amorphous-like Ti-O-K sheets in anatase. Increasing hydrothermal reaction time caused the transformation of anatase to Ti-O-K sheets, from which potassium hexa-titanate (K2Ti6O13) nuclei formed and grew to establish one-dimensional morphology through preferential growth along the b-axis. It was revealed that the hydrothermal reactions followed a quite different mechanism than the well-known calcination route. Potassium tetra-titanate (K2Ti4O9) crystals formed in the amorphous region using the hexa-titanate phase as a nucleation site for heterogeneous crystallization. Increasing the KOH concentration in the solution accelerated the hydrothermal reaction rate.
