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Article Citation - WoS: 4Citation - Scopus: 2Partner Phubbing and Sleep Quality: Serial Mediation Models With Relationship Satisfaction and Perceived Stress(Sage Publications inc, 2024) Dikdere, Busra; Turkarslan, Kutlu KaganThe increasing integration of technology into our lives has been affecting our daily routines and even our sleeps. Being a relatively new concept, phubbing refers to the act of overly engaging with one's phone while dismissing those around in the social settings. In this context, partner phubbing involves individuals exhibiting this neglect in the presence of their romantic partners. Evidence suggests that higher partner phubbing may lead to lower relationship satisfaction and higher perceived stress. The aim of the present cross-sectional study was to examine whether relationship satisfaction and perceived stress mediate the relationship between partner phubbing and sleep quality. Four hundred twenty-three individuals (females = 78.5%, M-age = 29.19, SD = 6.87) participated in the study and completed the measures of partner phubbing, relationship satisfaction, perceived stress, and sleep quality. The results of the serial mediation analyses showed that partner phubbing was not a direct predictor of sleep quality. However, the relationship between partner phubbing and sleep quality was mediated by the four indirect paths through relationship satisfaction (beta = 0.04, p < .05), perceived stress (beta = 0.09, p < .05), relationship satisfaction-perceived stress (beta = 0.02, p < .05), and perceived stress-relationship satisfaction (beta = 0.00, p < .05). The findings suggest that partner phubbing may diminish sleep quality by reducing relationship satisfaction and increasing perceived stress levels. Alternatively, perceived stress exacerbated by partner phubbing could reduce relationship satisfaction, which eventually worsens sleep quality. Digital detox programs, group interventions, emotion-focused couple interventions, and stress management training can help overcome the effects of partner phubbing on sleep quality.Article Role of Latissimus Dorsi-Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients With Chronic Low Back Pain: A Randomised Clinical Trial(Wiley, 2025) Ulug, Naime; Kodak, Seyde Busra; Kodak, Muhammed Ihsan; Aslan, Sema NurBackground Fascial stretching is gaining interest as a potential intervention for pain management. However, evidence regarding the effect of latissimus dorsi-thoracolumbar fascia (LD-TLF) complex stretching in patients with chronic low back pain (CLBP) remains limited. Therefore, this study aimed to investigate the effects of LD-TLF complex stretching on pain-related factors and disability in patients with CLBP. Methods Thirty patients with CLBP were randomly assigned to a study group (n = 15; 7 men, 8 women) and a control group (n = 15; 7 men, 8 women). The study group received 4 weeks of LD-TLF complex stretching in combination with conventional physiotherapy, while the control group received conventional physiotherapy only. Outcomes were assessed before and after the interventions, including primary measures of pain pressure thresholds (PPT) at thoracolumbar fascia levels (L1, L3 and 12th costa), and secondary measures included the Pain Sensitivity Questionnaire (PSQ), the effects of pain on daily activities measured by the Brief Pain Inventory (BPI), and disability assessed by the Oswestry Disability Questionnaire (ODQ). Results Pre- and post-treatment PPTs, at the L1, L3 vertebrae and 12th costa levels, demonstrated significant differences between the study group and control groups. Post-treatment thresholds were significantly higher compared to pre-treatment thresholds (p < 0.001, eta p(2) = 0.67; p < 0.001, eta p(2) = 0.61; p < 0.001, eta p(2) = 0.74). Additionally, significant improvements were found in PSC, BPI and ODQ scores in the study group compared to the control group (p < 0.05). Conclusion The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF complex stretching, when used in combination with conventional physiotherapy, appears to provide improved pain thresholds, decreased pain sensitivity and pain during activity, as well as reduced disability compared to conventional physiotherapy alone in patients with CLBP.Article Citation - WoS: 1Citation - Scopus: 2The Detailed Transseptal Puncture Technique for Optimal Closure in Patients With a Patent Foramen Ovale(Frontiers Media Sa, 2024) Ilkay, Erdogan; Saricam, Ersin; Kacmaz, Fehmi; Yakici, Aysel; Koca, Cigdem; Ozeke, Ozcan; Onal, Mehmet ZulkufBackground The closure of a patent foramen ovale (PFO) using transseptal puncture has particular advantages and disadvantages. Thus, transseptal puncture should be re-evaluated in detail. Aims We aimed to assess the effectiveness of the detailed transseptal puncture technique in patients who underwent PFO closure due to cryptogenic stroke or transient ischemic attack in terms of residual shunts and atrial fibrillation. Methods We prospectively analyzed 144 consecutive patients who underwent PFO closure by the detailed transseptal puncture technique between February 2013 and April 2023 in two centers. All of the patients had a >10 mm long-tunnel PFO. Results The procedural success rate was 100%. However, after the procedure, moderate pericardial effusion developed in one patient (0.7%) and an acute pulmonary embolism related to femoral vein thrombosis was observed in one patient (0.7%) during the first month. Complications related to the procedure were noted in two patients (1.4%) during the first month of follow-up. Residual shunts were observed in 1.4% of cases after PFO closure. Conclusion We demonstrated that the detailed transseptal technique is safe and effective for PFO closure. The detailed transseptal PFO closure technique significantly reduced the risk of atrial fibrillation, and the occurrence of residual shunts was significantly low following the closure.Article Patient Safety in Healthcare: A Proposal for Ensuring the Use of Regulation-Compliant Safety Devices(Springer Heidelberg, 2025) Bayrak, TuncayMedical devices used in health care should fulfill the requirements of the technical regulations to protect patient health. Difficulties in enforcing stricter rules in the new medical device regulations may negatively affect the continuity of care. This study examines the status of manufacturers' compliance with medical device regulations, based on predefined criteria, and proposes a collaborative action plan and an approach to verify regulatory compliance. We conducted a nationwide survey comprising questions grouped by criteria to understand the status of the manufacturers in terms of compliance with the Medical Device Regulation. Four hundred sixty-seven manufacturers participated in the survey. We achieved a Cronbach's alpha of 0.77, which indicates that the survey is statistically reliable. We applied the independent samples t-test to the responses to determine significant features per question and employed factor analysis to investigate the relationships of the questions. The results of independent samples t-tests showed statistically significant differences across groups in replies to several survey items (p < 0.05), indicating that participants' opinions varied based on their demographic characteristics. We applied Exploratory Factor Analysis to introduce the relationships between the questions. The analysis revealed that manufacturers continue to face substantial challenges in acquiring sufficient knowledge and operational capability to meet MDR requirements. In light of these findings, we focused on the person responsible for regulatory compliance, who plays a central role in maintaining regulatory compliance within manufacturing organizations. We proposed an action plan at the macro level to introduce more effective action plans in cooperation with other stakeholders, including healthcare providers, and a verification approach for regulatory compliance to enhance the Person Responsible for Regulatory Compliance's competence. Manufacturers should implement effective postmarketing clinical follow-up plans involving device-oriented parameters for monitoring in the healthcare system, especially in collaboration with health professionals.Article Citation - WoS: 20Citation - Scopus: 21Sensitivity Analysis of the Effect of Current Mood States on the Thermal Sensation in Educational Buildings(Wiley-hindawi, 2022) Ozbey, Mehmet Furkan; Ceter, Aydin Ege; Orfioglu, Sevval; Alkan, Nese; Turhan, CihanAdaptive thermal comfort is a model which considers behavioral and psychological adjustments apart from Fanger's Predicted Mean Vote (PMV)/Percentage of Dissatisfied (PPD) method. In the literature, the differences between the PMV/PPD method and adaptive thermal comfort were mainly considered in aspects of behavioral adjustments in an environment. Conversely, limited studies related to psychological adjustments were considered in detail for thermal comfort. This study purposes to investigate the effects of current mood state subscales on thermal sensation of the occupants for the first time in the literature. To this aim, the Profile of Mood States (POMS) questionnaire is used to determine the mood state of the occupants with six different subscales: Anger, Confusion, Vigor, Tension, Depression, and Fatigue. The experiments were conducted in a university study hall in Ankara, Turkey, which is in warm-summer Mediterranean climate (Csb) according to Koppen-Geiger Climate Classification. The distributions of each subscale were examined via Anderson Darling and Shapiro-Wilk tests accordingly given responses from the occupants. The sensitivity analysis was applied to the six subscales of the POMS with Monte Carlo simulation method by considering the distributions of each subscale. The results revealed that the current mood state has a crucial effect on the thermal sensation of the occupants. The subscales of the Depression and Vigor were found as the most vital ones among the six subscales. Only the pure effects of the Vigor and Depression would change the thermal sensation of the occupants 0.31 and 0.30, respectively. The Confusion was determined as the least effective subscale to the thermal sensation of the occupants. Moreover, with the combination of all the six subscales, the thermal sensation might change up to 1.32. Findings in this study would help researchers to develop the personalized thermal comfort systems.Editorial Citation - WoS: 5Citation - Scopus: 6Transcatheter Treatment Tricuspid Regurgitation by Valve-In Implantation With a Novel Balloon-Expandable Myval® Thv(Polish Cardiac Soc-polskie Towarzystwo Kardiologiczne, 2022) Ayhan, Huseyin; Karaduman, Bilge Duran; Keles, Telat; Bozkurt, Engin[No Abstract Available]Article Citation - WoS: 2Citation - Scopus: 22-Ag and Bone Marrow-Targeted Pcl Nanoparticles as Nanoplatforms for Hematopoietic Cell Line Mobilization(Bmc, 2024) Kose, Sevil; Varan, Cem; Onen, Selin; Nemutlu, Emirhan; Bilensoy, Erem; Korkusuz, PetekBackgroundThe use of mobilizing agents for hematopoietic stem cell (HSC) transplantation is insufficient for an increasing number of patients. We previously reported lipid made endocannabinoid (eCB) ligands act on the human bone marrow (hBM) HSC migration in vitro, lacking long term stability to be therapeutic candidate. In this study, we hypothesized if a novel 2-AG-loaded polycaprolactone (PCL)-based nanoparticle delivery system that actively targets BM via phosphatidylserine (Ps) can be generated and validated.MethodsPCL nanoparticles were prepared by using the emulsion evaporation method and characterized by Zetasizer and scanning electron microscopy (SEM). The encapsulation efficiency and release profile of 2-AG were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The presence of cannabinoid receptors (CBRs) in HSCs and monocytes was detected by flow cytometry. Cell morphology and viability were assessed using transmission electron microscopy (TEM), SEM, and the WST-1 viability assay. The migration efficacy of the 2-AG and 2-AG-loaded nanoparticle delivery system on HSCs and HPSCs (TF-1a and TF-1) and monocytes (THP-1) was evaluated using a transwell migration assay.ResultsThe 140-225 nm PCL nanoparticles exhibited an increasing polydispersity index (PDI) after the addition of Ps and 2-AG, with a surface charge ranging from - 25 to -50 mV. The nanoparticles released up to 36% of 2-AG within the first 8 h. The 2-AG-Ps-PCL did not affect cellular viability compared to control on days 5 and 10. The HSCs and monocytes expressed CB1R and CB2R and revealed increased migration to media containing 1 mu M 2-AG-Ps-PCL compared to control. The migration rate of the HSCs toward monocytes incubated with 1 mu M 2-AG-Ps-PCL was higher than that of the monocytes of control. The 2-AG-Ps-PCL formulation provided a real time mobilization efficacy at 1 mu M dose and 8 h time window via a specific CBR agonism.ConclusionThe newly generated and validated 2-AG-loaded PCL nanoparticle delivery system can serve as a stable, long lasting, targeted mobilization agent for HSCs and as a candidate therapeutic to be included in HSC transplantation (HSCT) protocols following scale-up in vivo preclinical and subsequent clinical trials.Review Citation - WoS: 75Citation - Scopus: 120Hybrid Blockchain Platforms for the Internet of Things (iot): a Systematic Literature Review(Mdpi, 2022) Alkhateeb, Ahmed; Catal, Cagatay; Kar, Gorkem; Mishra, AlokIn recent years, research into blockchain technology and the Internet of Things (IoT) has grown rapidly due to an increase in media coverage. Many different blockchain applications and platforms have been developed for different purposes, such as food safety monitoring, cryptocurrency exchange, and secure medical data sharing. However, blockchain platforms cannot store all the generated data. Therefore, they are supported with data warehouses, which in turn is called a hybrid blockchain platform. While several systems have been developed based on this idea, a current state-of-the-art systematic overview on the use of hybrid blockchain platforms is lacking. Therefore, a systematic literature review (SLR) study has been carried out by us to investigate the motivations for adopting them, the domains at which they were used, the adopted technologies that made this integration effective, and, finally, the challenges and possible solutions. This study shows that security, transparency, and efficiency are the top three motivations for adopting these platforms. The energy, agriculture, health, construction, manufacturing, and supply chain domains are the top domains. The most adopted technologies are cloud computing, fog computing, telecommunications, and edge computing. While there are several benefits of using hybrid blockchains, there are also several challenges reported in this study.Article Correlation of Clinical Signs and Magnetic Resonance Imaging Findings in Patients With Lumbar Spondylosis(Turkish League Against Rheumatism, 2023) Altan, Lale; Ökmen, Burcu Metin; Tuncer, Tiraje; Sindel, Dilşad; Çay, Hasan Fatih; Hepgüler, Simin; Uğurlu, HaticeObjectives: The purpose of the study was to contribute further to this debated topic by investigating the correlation of magnetic resonance imaging (MRI) findings with the clinical picture in lumbar spondylosis patients. Patients and methods: This multicenter retrospective study (as part of the epidemiological project of the TLAR-OASG [Turkish League Against Rheumatism-Osteoarthritis Study Group]) included 514 patients (101 males, 413 females; mean age: 63.6±10.8 years; range, 40 to 85 years) who were diagnosed as lumbar spondylosis by clinical examination and direct X-ray between December 2016 and June 2018. Demographic characteristics of patients, Visual Analog Scale for pain, presence of radiating pain, Roland-Morris disability questionnaire, straight leg raise test, deep tendon reflexes, neurogenic intermittent claudication symptoms, any decrease of muscle strength, and abnormality of sensation were recorded. Lumbar MRI findings of the patients were recorded as positive or negative in terms of disc herniation, intervertebral disc degeneration, root compression, osteophytes, spinal stenosis. Statistical analysis was done to assess the correlation between the clinical symptoms, physical examination, and MRI findings. Results: Correlation analysis of the MRI results and the clinical findings showed a significant correlation between straight leg raise test and root compression (p<0.001, r=0.328) and a significant correlation between neurogenic intermittent claudication and spinal stenosis (p<0.001, r=0.376). Roland-Morris disability questionnaire had a significant correlation with all MRI findings (p<0.05, r<0.200). Conclusion: The results of this study corroborate the notion that diligent patient history and physical examination are more valuable than MRI findings, even though a higher incidence of abnormal MRI findings have been obtained in patients with disability and dermatomal radiating pain.Article Citation - WoS: 10Citation - Scopus: 8Beyond expectations: disease duration and psychological burden in psoriatic arthritis(Springer Heidelberg, 2023) Kilic, Gamze; Kilic, Erkan; Tekeoglu, Ibrahim; Sargin, Betul; Cengiz, Gizem; Balta, Nihan Cuzdan; Nas, KemalThis study aims to investigate the relationship between disease duration and psychological burden in PsA and to identify the risk factors associated with psychological distress. Patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network. Patients were categorized into three groups based on disease duration: early stage (< 5 years), middle stage (& GE; 5, < 10 years), and late stage (& GE; 10 years). All patients underwent clinical and laboratory assessment using standardized protocol and case report forms. The associations between psychological variables and clinical parameters were assessed by a multivariate analysis. Of the 1113 patients with PsA (63.9% female), 564 (%50.7) had high risk for depression and 263 (%23.6) for anxiety. The risk of psychological burden was similar across all PsA groups, and patients with a higher risk of depression and anxiety also experienced greater disease activity, poorer quality of life, and physical disability. Multivariate logistic regression revealed that female gender (OR = 1.52), PsAQoL (OR = 1.13), HAQ (OR = 1.99), FiRST score (OR = 1.14), unemployment/retired (OR = 1.48) and PASI head score (OR = 1.41) were factors that influenced the risk of depression, whereas the current or past enthesitis (OR = 1.45), PsAQoL (OR = 1.19), and FiRST score (OR = 1.26) were factors that influenced the risk of anxiety. PsA patients can experience a comparable level of psychological burden throughout the course of their disease. Several socio-demographic and disease-related factors may contribute to mental disorders in PsA. In the present era of personalized treatment for PsA, evaluating psychiatric distress can guide tailored interventions that improve overall well-being and reduce disease burden.
