381 results
Search Results
Now showing 1 - 10 of 381
Review Citation - WoS: 152Citation - Scopus: 194Challenges and Best Practices in Industry-Academia Collaborations in Software Engineering: a Systematic Literature Review(Elsevier, 2016) Garousi, Vahid; Petersen, Kai; Ozkan, BarisContext: The global software industry and the software engineering (SE) academia are two large communities. However, unfortunately, the level of joint industry-academia collaborations in SE is still relatively very low, compared to the amount of activity in each of the two communities. It seems that the two 'camps' show only limited interest/motivation to collaborate with one other. Many researchers and practitioners have written about the challenges, success patterns (what to do, i.e., how to collaborate) and anti-patterns (what not do do) for industry-academia collaborations. Objective: To identify (a) the challenges to avoid risks to the collaboration by being aware of the challenges, (b) the best practices to provide an inventory of practices (patterns) allowing for an informed choice of practices to use when planning and conducting collaborative projects. Method: A systematic review has been conducted. Synthesis has been done using grounded-theory based coding procedures. Results: Through thematic analysis we identified 10 challenge themes and 17 best practice themes. A key outcome was the inventory of best practices, the most common ones recommended in different contexts were to hold regular workshops and seminars with industry, assure continuous learning from industry and academic sides, ensure management engagement, the need for a champion, basing research on real world problems, showing explicit benefits to the industry partner, be agile during the collaboration, and the co-location of the researcher on the industry side. Conclusion: Given the importance of industry-academia collaboration to conduct research of high practical relevance we provide a synthesis of challenges and best practices, which can be used by researchers and practitioners to make informed decisions on how to structure their collaborations. (C) 2016 Elsevier B.V. All rights reserved.Editorial Citation - WoS: 5Citation - Scopus: 6Transcatheter Treatment Tricuspid Regurgitation by Valve-In Implantation With a Novel Balloon-Expandable Myval® Thv(Polish Cardiac Soc-polskie Towarzystwo Kardiologiczne, 2022) Ayhan, Huseyin; Karaduman, Bilge Duran; Keles, Telat; Bozkurt, Engin[No Abstract Available]Article Citation - WoS: 2Citation - Scopus: 22-Ag and Bone Marrow-Targeted Pcl Nanoparticles as Nanoplatforms for Hematopoietic Cell Line Mobilization(Bmc, 2024) Kose, Sevil; Varan, Cem; Onen, Selin; Nemutlu, Emirhan; Bilensoy, Erem; Korkusuz, PetekBackgroundThe use of mobilizing agents for hematopoietic stem cell (HSC) transplantation is insufficient for an increasing number of patients. We previously reported lipid made endocannabinoid (eCB) ligands act on the human bone marrow (hBM) HSC migration in vitro, lacking long term stability to be therapeutic candidate. In this study, we hypothesized if a novel 2-AG-loaded polycaprolactone (PCL)-based nanoparticle delivery system that actively targets BM via phosphatidylserine (Ps) can be generated and validated.MethodsPCL nanoparticles were prepared by using the emulsion evaporation method and characterized by Zetasizer and scanning electron microscopy (SEM). The encapsulation efficiency and release profile of 2-AG were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The presence of cannabinoid receptors (CBRs) in HSCs and monocytes was detected by flow cytometry. Cell morphology and viability were assessed using transmission electron microscopy (TEM), SEM, and the WST-1 viability assay. The migration efficacy of the 2-AG and 2-AG-loaded nanoparticle delivery system on HSCs and HPSCs (TF-1a and TF-1) and monocytes (THP-1) was evaluated using a transwell migration assay.ResultsThe 140-225 nm PCL nanoparticles exhibited an increasing polydispersity index (PDI) after the addition of Ps and 2-AG, with a surface charge ranging from - 25 to -50 mV. The nanoparticles released up to 36% of 2-AG within the first 8 h. The 2-AG-Ps-PCL did not affect cellular viability compared to control on days 5 and 10. The HSCs and monocytes expressed CB1R and CB2R and revealed increased migration to media containing 1 mu M 2-AG-Ps-PCL compared to control. The migration rate of the HSCs toward monocytes incubated with 1 mu M 2-AG-Ps-PCL was higher than that of the monocytes of control. The 2-AG-Ps-PCL formulation provided a real time mobilization efficacy at 1 mu M dose and 8 h time window via a specific CBR agonism.ConclusionThe newly generated and validated 2-AG-loaded PCL nanoparticle delivery system can serve as a stable, long lasting, targeted mobilization agent for HSCs and as a candidate therapeutic to be included in HSC transplantation (HSCT) protocols following scale-up in vivo preclinical and subsequent clinical trials.Article Citation - WoS: 38Citation - Scopus: 48Fixed Points of Modified f-contractive Mappings in Complete Metric-Like Spaces(Hindawi Ltd, 2015) Alsulami, Hamed H.; Karapinar, Erdal; Piri, HosseinWe introduce the notion of modified F-contractive mappings in the setting of complete metric-like spaces and we investigate the existence and uniqueness of fixed point of such mappings. The presented results unify, extend, and improve several results in the related literature.Article Citation - Scopus: 2The Effects of Paddy Cultivation and Microbiota Members on Arsenic Accumulation in Rice Grain(Mdpi, 2023) Ersoy Omeroglu, Esra; Bayer, Asli; Sudagidan, Mert; Ozalp, Veli Cengiz; Yasa, IhsanAccess to safe food is one of the most important issues. In this context, rice plays a prominent role. Because high levels of arsenic in rice grain are a potential concern for human health, in this study, we determined the amounts of arsenic in water and soil used in the rice development stage, changes in the arsC and mcrA genes using qRT-PCR, and the abundance and diversity (with metabarcoding) of the dominant microbiota. When the rice grain and husk samples were evaluated in terms of arsenic accumulation, the highest values (1.62 ppm) were obtained from areas where groundwater was used as irrigation water, whereas the lowest values (0.21 ppm) occurred in samples from the stream. It was observed that the abundance of the Comamonadaceae family and Limnohabitans genus members was at the highest level in groundwater during grain formation. As rice development progressed, arsenic accumulated in the roots, shoots, and rice grain. Although the highest arsC values were reached in the field where groundwater was used, methane production increased in areas where surface water sources were used. In order to provide arsenic-free rice consumption, the preferred soil, water source, microbiota members, rice type, and anthropogenic inputs for use on agricultural land should be evaluated rigorously.Article Citation - WoS: 25Citation - Scopus: 39Optimization and Thermal Analysis of Radial Ventilated Brake Disc To Enhance the Cooling Performance(Elsevier, 2022) Jafari, Rahim; Akyuz, RecepVentilated brake discs are preferable to automobile application because of their higher heat dissipation ability than solid discs. The shape, geometry and number of the cooling fins are interested parameters to be investigated to improve the cooling performance of the discs. In the present study, the optimum design of the brake disc with radial vanes is investigated numerically using the Taguchi design of experiments with taking into account nine design parameters. Finite element method is employed to simulate the detailed airflow and temperature distribution in the disc considering adjoined components as pads, rim, tire and dust shield. It has been found that the ventilation gap width has the highest impact on the brake disc cooling. The cooling time of the disc decreases 21% as the ventilation gap increases from 8 mm to 14 mm. In addition, it reduces about 10% with the increment of the channel width between two adjacent vanes (inverse of vane numbers from 43 to 30) and the twist point from 225 mm to 266 mm. In a decreasing order of importance, fin angle, inner and outer diameters of fin, dust shield, bell link and disc material affect the cooling performance of the ventilated disc.Article Citation - WoS: 5Citation - Scopus: 14Existence of a Solution of Integral Equations Via Fixed Point Theorem(Springeropen, 2013) Gulyaz, Selma; Karapinar, Erdal; Rakocevic, Vladimir; Salimi, PeymanIn this paper, we establish a solution to the following integral equation: u(t) = integral(T)(0) G(t, s)f(s, u(s)) ds for all t is an element of [0,T], (1) where T > 0, f : [0, T] x R -> R and G : [0, T] x [0, T] -> [0, infinity) are continuous functions. For this purpose, we also obtain some auxiliary fixed point results which generalize, improve and unify some fixed point theorems in the literature.Article Citation - WoS: 77Citation - Scopus: 81α-admissible mappings and related fixed point theorems(Springeropen, 2013) Hussain, Nawab; Karapinar, Erdal; Salimi, Peyman; Akbar, FarhanaIn this paper, we prove the existence and uniqueness of a fixed point for certain alpha-admissible contraction mappings. Our results generalize and extend some well-known results on the topic in the literature. We consider some examples to illustrate the usability of our results.Article Citation - WoS: 1Citation - Scopus: 2Chemical Mechanical Polishing as an Alternative Surface Treatment Technique for Corrosion Prevention of Carbon Steel in an Acidic Medium(Nature Portfolio, 2025) Ahmed, Mohamed; Ali Al-Timimi, Buthainah; Al-Ali, Maha; Abdullah, Ghassan H.; Khalaf Atiyaha, Safa; Yaseen Ali Aljanabi, Ahmed; Mel, MaizirwanChemical mechanical polishing (CMP) has been a standard technique in semiconductor manufacturing for achieving smooth surfaces. CMP utilizes a synergistic interplay of chemical and mechanical interactions to achieve the desired removal rates, selectivity, and ultimately planarity with different substrate materials. In this study, the impact of CMP on the surface properties of steel used in the petroleum industry was examined, with a focus on its corrosion behavior posttreatment. Steel samples were subjected to CMP with and without an oxidizer in a silica-based slurry, and their surface characteristics were compared to those of samples polished mechanically. The addition of an oxidizer to the slurry resulted in increased material removal rates and the formation of an oxide layer on the surface; this phenomenon was not observed in CMP without an oxidizer. However, in mechanical polishing, the action of silicon carbide grains on the steel surface led to an increase in the removal rate but caused a decrease in its corrosion resistance. Compared with other treatments, the oxide layer provided a good protective barrier against corrosion and improved the corrosion resistance of the steel substrate. Based on the results from the practical study, an improvement in the corrosion resistance properties was observed due to the chemical reaction of the oxidizer and the mechanical action of the silica nanoparticles; these results showed the importance of chemical mechanical polishing as an alternative method to reduce the corrosion of steel in acidic environments. Additionally, the effect of hydrogen peroxide in a silica slurry with respect to the wettability, surface roughness, and hardness of steel was examined using contact angle measurements, profilometry, scanning electron microscopy, and microhardness tests.Article Citation - WoS: 3Citation - Scopus: 3Paper-Based Aptasensor Assay for Detection of Food Adulterant Sildenafil(Mdpi, 2024) Kavruk, Murat; Ozalp, Veli CengizSildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension but is often illicitly added to energy drinks and chocolates. This study introduces a lateral flow strip test using aptamers specific to sildenafil for detecting its illegal presence in food. The process involved using graphene oxide SELEX to identify high-affinity aptamers, which were then converted into molecular gate structures on mesoporous silica nanoparticles, creating a unique signaling system. This system was integrated into lateral flow chromatography strips and tested on buffers and chocolate samples containing sildenafil. The method simplifies the lateral flow assay (LFA) for small molecules and provides a tool for signal amplification. The detection limit for these strips was found to be 68.2 nM (31.8 mu g/kg) in spiked food samples.
