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COAR Access Rights: metadata only accessSubject: Biocompatibility

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Now showing 1 - 3 of 3
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    Book Part
    Citation - Scopus: 16
    Surface Modification of Polymeric Biomaterials
    (Wiley-VCH Verlag, 2013) Guney,A.; Kara,F.; Ozgen,O.; Aksoy,E.A.; Hasirci,V.; Hasirci,N.
    Summary: The effectiveness of a biomaterial placed into the body or in contact with the body is strongly dependent on its interactions with the body fluids and cells. These interactions determine how the body elements accept the material. Thus, depending on the specific application area of the biomaterial, it is necessary to understand cell-material, tissue-material, and blood-material interactions in order to optimize the properties of the material. The response of the host organism to biomaterials at macroscopic, cellular, and molecular levels is especially related with the properties of the surface of the material as that is the part that first comes in contact and reacts. In implants, tissue engineering scaffolds, and many other biomedical fields, surface engineering of the biomaterial, especially of polymeric biomaterials, is often required, and the surface is modified physically and/or chemically. This demand is either in the direction of no cell adhesion, as in the case of stents, or in the opposite direction to promote cell adhesion and proliferation, as in tissue engineering applications. This chapter focuses on the principles and practices of surface engineering techniques applied to biomedical polymers and aims to provide an insight to the reader about the field. The physical, chemical, biological, and radiation techniques are discussed as well as some specific modifications to enhance the surface biocompatibility, blood compatibility, and antibacterial properties in an attempt to create a sophisticated, functional surface for specific biointeractions. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA.
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    Article
    Citation - WoS: 7
    Citation - Scopus: 7
    Advanced 3d Printed Bone Scaffolds With Sodium Alginate/Tri-calcium Phosphate/Probiotic Bacterial Hydroxyapatite: Enhanced Mechanical and Biocompatible Properties for Bone Tissue Engineering
    (Elsevier Sci Ltd, 2024) Nouri, Sabereh; Emtiazi, Giti; Ulag, Songul; Gunduz, Oguzhan; Koyuncu, Ayse Ceren Calikoglu; Roghanian, Rasoul; Sasmazel, Hilal Turkoglu
    Introduction: The increasing prevalence of severe bone diseases, such as osteoporosis and critical bone defects, necessitates the development of more effective bone substitutes. This study addresses this need by investigating 3D-printed bone scaffolds composed of sodium alginate and tricalcium phosphate, enhanced with three distinct types of hydroxyapatite (HA): bovine-derived HA, commercially available HA, and HA enriched with probiotic bacteria. We aim to evaluate the performance of these scaffolds in terms of mechanical strength, biocompatibility, and their ability to support bone regeneration. Methods: The scaffolds were analyzed through various tests, including X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) to characterization. Scanning Electron Microscopy (SEM) was used to examine pore structure, while swelling and degradation tests evaluated the scaffold's stability. Compression testing determined mechanical strength, and in vitro cell culture assays assessed cell proliferation, osteogenic differentiation, and biomineralization. Results: SEM results indicated that 3D scaffolds with probiotic bacterial HA had the desired 472 mu m pore size. These scaffolds demonstrated a strain of 29.26 % and a compressive strength of 10 MPa, meeting the mechanical standards of human trabecular bone. Cell culture studies revealed enhanced cell proliferation by 50 %, osteogenic differentiation with 15.3 U/mg ALP activity, and 1.22-fold biomineralization, suggesting they are highly biocompatible and promote bone growth. Conclusion: Probiotic bacterial HA scaffolds exhibit ideal properties and biocompatibility, enhancing bone regeneration and serving as an ideal alternative to chemical types.
  • Thumbnail Image
    Book Part
    Surface Modification of Polymeric Biomaterials
    (Wiley-VCH Verlag, 2013) Guney,A.; Kara,F.; Ozgen,O.; Aksoy,E.A.; Hasirci,V.; Hasirci,N.
    Summary: The effectiveness of a biomaterial placed into the body or in contact with the body is strongly dependent on its interactions with the body fluids and cells. These interactions determine how the body elements accept the material. Thus, depending on the specific application area of the biomaterial, it is necessary to understand cell-material, tissue-material, and blood-material interactions in order to optimize the properties of the material. The response of the host organism to biomaterials at macroscopic, cellular, and molecular levels is especially related with the properties of the surface of the material as that is the part that first comes in contact and reacts. In implants, tissue engineering scaffolds, and many other biomedical fields, surface engineering of the biomaterial, especially of polymeric biomaterials, is often required, and the surface is modified physically and/or chemically. This demand is either in the direction of no cell adhesion, as in the case of stents, or in the opposite direction to promote cell adhesion and proliferation, as in tissue engineering applications. This chapter focuses on the principles and practices of surface engineering techniques applied to biomedical polymers and aims to provide an insight to the reader about the field. The physical, chemical, biological, and radiation techniques are discussed as well as some specific modifications to enhance the surface biocompatibility, blood compatibility, and antibacterial properties in an attempt to create a sophisticated, functional surface for specific biointeractions. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA.