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Article Citation - WoS: 1Citation - Scopus: 1Classifying the Who European Countries by Noncommunicable Diseases and Risk Factors(Elsevier Ireland Ltd, 2025) Bulut, TevfikBackground: In the twenty-first century, noncommunicable diseases (NCDs) are a major obstacle to global development and the accomplishment of the Sustainable Development Goals set forth by the United Nations. The WHO (World Health Organization) European Region lacks comprehensive understanding of NCD risk factors, the NCDs they trigger, and the more disadvantaged countries. Objective: This study aims to classify the countries in the European Region at the country level based on NCDs and their key risk factors. Methods: The Ward method, a hierarchical clustering technique based on Manhattan and Euclidean distance measures, was used. The study's dataset comes from the WHO's publicly available NCDs and key risk factors dataset. Results: The European region's countries have been categorized into two clusters based on key NCD risk factors. The second cluster consists of countries with high income levels. On the other hand, in the European Region, countries fall into three clusters based on NCDs. Countries in the third cluster, which consists of low- and upper- middle-income countries, have lower average values in four variables compared to other countries, resulting in lower overall disease prevalence. Counclusions: The prevalence of NCDs varies among clusters, with high-income countries having lower disease prevalence, particularly in diabetes and hypertension. Addressing risk factors and improving healthcare access and infrastructure are crucial in reducing the burden of NCDs in the European region.Article Automatic Control of Hypothalamus-Pituitary Axis Dynamics(Elsevier Ireland Ltd, 2019) Doruk, R. Ozgur; Mohsin, Ahmed H.Background and Objective: In this study, a presentation is made for the automatic control of the hypothalamus-pituitary-adrenal axis which plays an important role in the immune stress responses and the circadian rhythms of mammalian organisms. Methods: Control approaches are implemented on a novel second order nonlinear system which accepts adrenocorticotropin hormone as an input and models the variation of plasma concentrations of adrenocorticotropin and cortisol respectively. The control methods are based on back-stepping and input-output feedback linearization techniques. The controllers adjust the adrenocorticotropin injection to maintain the daily rhythm of the cortisol concentration. In accordance with the periodicity of biological clock mechanism, we provide a sinusoidally varying cortisol reference to the controllers. Results: Numerical simulations are performed (on MATLAB) to demonstrate the closed loop performance of the controllers. Major concerns in the selection of the control gains are chattering and negative concentration in responses. The simulation results showed that one can successfully find gain levels which do not lead to those issues. However, the gains lie in different ranges for back-stepping and feedback linearization based controllers. Conclusion: The results showed that, both back-stepping and feedback linearization based controllers fulfilled their duty of synchronization of the cortisol concentration to a reference daily periodic rhythm. In addition to that, the risk of negative valued adrenocorticotropin injection can be eliminated by properly choosing the controller gains. (C) 2019 Elsevier B.V. All rights reserved.Article Citation - Scopus: 15From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity of Solanum Melongena L. Via in Vivo Experimental Models and Its Major Chemicals(Elsevier Ireland Ltd, 2020) Dönmez,C.; Yalçın,F.N.; Boyacıoğlu,Ö.; Korkusuz,P.; Akkol,E.K.; Nemutlu,E.; Çalışkan,U.K.Ethnopharmacological relevance: Solanum melongena L. (eggplant) is used for treatment of rheumatism, beriberi, itching, toothache, bleeding, asthma, bronchitis, cholera, neuralgia and hemorrhoids in traditional medicine (Turkish, Chinese, and Indian). Hemorrhoids from these diseases, are common illness in all over the world, which are treated with various approaches including ethnobotanicals. Aim of the study: This study aimed to evaluate the anti-hemorrhoidal activity of eggplant, an edible plant, which is commonly utilized around the world. Materials & methods: In vivo anti-hemorrhoidal activity of the methanolic extract prepared from eggplant was evaluated by experimental hemorrhoid model, subsequently histological and biochemical analysis. Hemorrhoid, which was induced by applying croton oil to the anal area of the rats. Furthermore, the extract was screened for anti-inflammatory activity which is based on the inhibition of acetic acid-induced increase in capillary permeability. The healing potential was comparatively assessed with a reference Pilex® tablet and cream. Phytochemical analysis performed by HPLC. The amount of the major phenolic compound (chlorogenic acid) in extract was found by using HPLC method. Results: Histological and biochemical analysis demonstrated that eggplant extract is highly effective against hemorrhoid in comparison to the controls and the commercial preparation. In addition, the methanolic extract demonstrated significant inhibitory effect on acetic acid-induced increase in capillary permeability. The phytochemical studies identified major compound as chlorogenic acid (2.86%) by liquid chromatography. Conclusion: The eggplant calyxes, not edible, are easy to reach, by products/vast from the food sources. This is the first scientific evidence revealing that the eggplant extract has significant anti-hemorrhoidal and anti-inflammatory activity. © 2020 Elsevier B.V.Editorial Citation - Scopus: 1The Playmaker of the Mitral Valve Disease: Mitral Annulus(Elsevier Ireland Ltd, 2020) Karaduman, Bilge Duran; Ayhan, Huseyin; Keles, Telat; Bozkurt, Engin[No Abstract Available]Review Citation - WoS: 7Citation - Scopus: 7A Systematic Review on Classification and Assessment of Surgical Skill Levels for Simulation-Based Training Programs(Elsevier Ireland Ltd, 2023) Tonbul, Gokcen; Topalli, Damla; Cagiltay, Nergiz ErcilBackground: Nowadays, advances in medical informatics have made minimally invasive surgery (MIS) procedures the preferred choice. However, there are several problems with the education programs in terms of surgical skill acquisition. For instance, defining and objectively measuring surgical skill levels is a challenging process. Accordingly, the aim of this study is to conduct a literature review for an investigation of the current approaches for classifying the surgical skill levels and for identifying the skill training tools and measurement methods.Materials and Methods: In this research, a search is conducted and a corpus is created. Exclusion and inclusion criteria are applied by limiting the number of articles based on surgical education, training approximations, hand movements, and endoscopic or laparoscopic operations. To satisfy these criteria, 57 articles are included in the corpus of this study.Results: Currently used surgical skill assessment approaches have been summarized. Results show that various classification approaches for the surgical skill level definitions are being used. Besides, many studies are con-ducted by omitting particularly important skill levels in between. Additionally, some inconsistencies are also identified across the skill level classification studies.Conclusion: In order to improve the benefits of simulation-based training programs, a standardized interdisci-plinary approach should be developed. For this reason, specific to each surgical procedure, the required skills should be identified. Additionally, appropriate measures for assessing these skills, which can be defined in simulation-based MIS training environments, should be refined. Finally, the skill levels gained during the developmental stages of these skills, with their threshold values referencing the identified measures, should be redefined in a standardized manner.Article Citation - WoS: 3Citation - Scopus: 3Angiogenic Inhibition Therapy, a Sliding Mode Control Adventure(Elsevier Ireland Ltd, 2020) Doruk, Resat Ozgur[No Abstract Available]Article Citation - WoS: 1Citation - Scopus: 1Investigation the Effect of Rigid Taping on Knee and Hip Joint Kinematics in Chronic Stroke Patients With Knee Hyperextension Gait(Elsevier Ireland Ltd, 2025) Korkusuz, Suleyman; Fil-Balkan, Ayla; Korkusuz, Busra Seckinogullari; Ozgoren, Nihat; Aritan, Serdar; Ceren, Ali Naim; Topcuoglu, Mehmet AkifBackground: Although stroke patients gain an advantage in gait due to the knee hyperextension that occurs during the stance phase, this situation disrupts the biomechanical structure of the knee and increases the risk of injury to the capsular and ligamentous structures. The aim of this study was to examine the effects of rigid taping on hyperextension control and pelvic kinematics in stroke patients with knee hyperextension during the stance phase of gait. Research question: Does rigid taping have an effect on hyperextension control and pelvic kinematics in stroke patients with knee hyperextension? Methods: Thirty stroke patients aged between 40 and 70 were included in this pre-postintervention study. Kinematic assessment of gait was performed using a motion analysis system (Vicon Ltd, Bilston). Then, the rigid taping was applied to the patients using the hyperextension taping technique, and the kinematic analysis of the gait was repeated with the motion analysis system. Results: It was found that the rigid taping for the knee hyperextension significantly reduced the knee hyperextension (p < 0.05). Additionally, it was observed that the rigid taping significantly reduced the pelvic retraction (p < 0.05). However, no change was observed in the pelvic drop with the rigid taping application. Significance: Our results showed that the rigid taping effectively controlled the knee hyperextension. It was thought that the rigid taping application contributed to reducing knee hyperextension and pelvic retraction because it mechanically gave the knee a flexion moment and provided proprioceptive input.
