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Article Citation - WoS: 36Citation - Scopus: 45Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering(Elsevier, 2021) Topsakal, Aysenur; Midha, Swati; Yuca, Esra; Tukay, Ari; Sasmazel, Hilal Turkoglu; Kalaskar, Deepak M.; Gunduz, OguzhanOver the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.Book Non-Discrimination in Turkey(Springer International Publishing, 2022) Yilmaz,G.The book “Non-discrimination in Turkey” focuses on issue areas within the broader non-discrimination framework in Turkey. It looks domestic change in Turkey regarding non-discrimination across time. The book unpacks the principle of non-discrimination and provides analysis in many issue areas like LGBTI rights, disability rights or age discrimination that rely under the framework of non-discrimination. Adopting a comprehensive approach including many areas within non-discrimination, the book will be useful for the students, scholars and researchers of international relations, political science, Middle East and Turkish studies and those interested in human rights. © The Editor(s)(if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.Editorial Citation - WoS: 5Citation - Scopus: 5Transcatheter Treatment Tricuspid Regurgitation by Valve-In Implantation With a Novel Balloon-Expandable Myval® Thv(Polish Cardiac Soc-polskie Towarzystwo Kardiologiczne, 2022) Ayhan, Huseyin; Karaduman, Bilge Duran; Keles, Telat; Bozkurt, Engin[No Abstract Available]Article Citation - WoS: 2Citation - Scopus: 22-Ag and Bone Marrow-Targeted Pcl Nanoparticles as Nanoplatforms for Hematopoietic Cell Line Mobilization(Bmc, 2024) Kose, Sevil; Varan, Cem; Onen, Selin; Nemutlu, Emirhan; Bilensoy, Erem; Korkusuz, PetekBackgroundThe use of mobilizing agents for hematopoietic stem cell (HSC) transplantation is insufficient for an increasing number of patients. We previously reported lipid made endocannabinoid (eCB) ligands act on the human bone marrow (hBM) HSC migration in vitro, lacking long term stability to be therapeutic candidate. In this study, we hypothesized if a novel 2-AG-loaded polycaprolactone (PCL)-based nanoparticle delivery system that actively targets BM via phosphatidylserine (Ps) can be generated and validated.MethodsPCL nanoparticles were prepared by using the emulsion evaporation method and characterized by Zetasizer and scanning electron microscopy (SEM). The encapsulation efficiency and release profile of 2-AG were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The presence of cannabinoid receptors (CBRs) in HSCs and monocytes was detected by flow cytometry. Cell morphology and viability were assessed using transmission electron microscopy (TEM), SEM, and the WST-1 viability assay. The migration efficacy of the 2-AG and 2-AG-loaded nanoparticle delivery system on HSCs and HPSCs (TF-1a and TF-1) and monocytes (THP-1) was evaluated using a transwell migration assay.ResultsThe 140-225 nm PCL nanoparticles exhibited an increasing polydispersity index (PDI) after the addition of Ps and 2-AG, with a surface charge ranging from - 25 to -50 mV. The nanoparticles released up to 36% of 2-AG within the first 8 h. The 2-AG-Ps-PCL did not affect cellular viability compared to control on days 5 and 10. The HSCs and monocytes expressed CB1R and CB2R and revealed increased migration to media containing 1 mu M 2-AG-Ps-PCL compared to control. The migration rate of the HSCs toward monocytes incubated with 1 mu M 2-AG-Ps-PCL was higher than that of the monocytes of control. The 2-AG-Ps-PCL formulation provided a real time mobilization efficacy at 1 mu M dose and 8 h time window via a specific CBR agonism.ConclusionThe newly generated and validated 2-AG-loaded PCL nanoparticle delivery system can serve as a stable, long lasting, targeted mobilization agent for HSCs and as a candidate therapeutic to be included in HSC transplantation (HSCT) protocols following scale-up in vivo preclinical and subsequent clinical trials.Article Citation - WoS: 29Citation - Scopus: 36Massive Mimo Systems for 5g: a Systematic Mapping Study on Antenna Design Challenges and Channel Estimation Open Issues(inst Engineering Technology-iet, 2021) Benzaghta, Mohamed; Rabie, Khaled M.The next generation of mobile networks (5G) is expected to achieve high data rates, reduce latency, as well as improve the spectral and energy efficiency of wireless communication systems. Several technologies are being explored to be used in 5G systems. One of the main promising technologies that is seen to be the enabler of 5G is massive multiple-input multiple-output (mMIMO) systems. Numerous studies have indicated the utility of mMIMO in upcoming wireless networks. However, there are several challenges that needs to be unravelled. In this paper, the latest progress of research on challenges in mMIMO systems is tracked, in the context of mutual coupling, antenna selection, pilot contamination and feedback overhead. The results of a systematic mapping study performed on 63 selected primary studies, published between the year 2017 till the second quarter of 2020, are presented. The main objective of this secondary study is to identify the challenges regarding antenna design and channel estimation, give an overview on the state-of-the-art solutions proposed in the literature, and finally, discuss emerging open research issues that need to be considered before the implementation of mMIMO systems in 5G networks.Article Citation - WoS: 32Citation - Scopus: 45Fixed Point Theorems for a Class of Α-Admissible Contractions and Applications To Boundary Value Problem(Hindawi Publishing Corporation, 2014) Alsulami, Hamed H.; Gulyaz, Selma; Karapinar, Erdal; Erhan, Inci M.A class of alpha-admissible contractions defined via altering distance functions is introduced. The existence and uniqueness conditions for fixed points of such maps on complete metric spaces are investigated and related fixed point theorems are presented. The results are reconsidered in the context of partially ordered metric spaces and applied to boundary value problems for differential equations with periodic boundary conditions.Conference Object Citation - Scopus: 12Design and Implementation of a Mobile Webcast Application With Google Analytics and Cloud Messaging Functionality(Institute of Physics Publishing, 2019) Jonathan,O.; Misra,S.; Ibanga,E.; Maskeliunas,R.; Damasevicius,R.; Ahuja,R.Church cast is an application developed to bring the messages of ministries closer to their members by harnessing the Internet and mobile devices. Due to the very busy schedules of people and religious restrictions in some countries, people are not usually able to be physically present at their locations of worship to listen to or watch their ministers. Existing applications developed in the past like DOMI radio and Redemption TV Media were limited to only audio, poor and unintuitive user interfaces and not providing the administrator any interactions with the users of the application. In this work, we develop an Android-based application that makes it possible for users to watch live streams and on-demand videos from their ministries using their mobile devices. The application also incorporates sharing and analytics functionalities to enable users to share videos messages with loved ones and help the administrator monitor users' activities on the application respectively. The cloud messaging functionality enables the administrator to send messages such as announcements to user devices as push notifications. This would eventually increase user knowledge and interaction with the activities going on in their respective places of worship. © 2019 Published under licence by IOP Publishing Ltd.Article Citation - WoS: 38Citation - Scopus: 48Fixed Points of Modified f-contractive Mappings in Complete Metric-Like Spaces(Hindawi Ltd, 2015) Alsulami, Hamed H.; Karapinar, Erdal; Piri, HosseinWe introduce the notion of modified F-contractive mappings in the setting of complete metric-like spaces and we investigate the existence and uniqueness of fixed point of such mappings. The presented results unify, extend, and improve several results in the related literature.Review Citation - WoS: 73Citation - Scopus: 118Hybrid Blockchain Platforms for the Internet of Things (iot): a Systematic Literature Review(Mdpi, 2022) Alkhateeb, Ahmed; Catal, Cagatay; Kar, Gorkem; Mishra, AlokIn recent years, research into blockchain technology and the Internet of Things (IoT) has grown rapidly due to an increase in media coverage. Many different blockchain applications and platforms have been developed for different purposes, such as food safety monitoring, cryptocurrency exchange, and secure medical data sharing. However, blockchain platforms cannot store all the generated data. Therefore, they are supported with data warehouses, which in turn is called a hybrid blockchain platform. While several systems have been developed based on this idea, a current state-of-the-art systematic overview on the use of hybrid blockchain platforms is lacking. Therefore, a systematic literature review (SLR) study has been carried out by us to investigate the motivations for adopting them, the domains at which they were used, the adopted technologies that made this integration effective, and, finally, the challenges and possible solutions. This study shows that security, transparency, and efficiency are the top three motivations for adopting these platforms. The energy, agriculture, health, construction, manufacturing, and supply chain domains are the top domains. The most adopted technologies are cloud computing, fog computing, telecommunications, and edge computing. While there are several benefits of using hybrid blockchains, there are also several challenges reported in this study.Article Correlation of Clinical Signs and Magnetic Resonance Imaging Findings in Patients With Lumbar Spondylosis(Turkish League Against Rheumatism, 2023) Altan, Lale; Ökmen, Burcu Metin; Tuncer, Tiraje; Sindel, Dilşad; Çay, Hasan Fatih; Hepgüler, Simin; Uğurlu, HaticeObjectives: The purpose of the study was to contribute further to this debated topic by investigating the correlation of magnetic resonance imaging (MRI) findings with the clinical picture in lumbar spondylosis patients. Patients and methods: This multicenter retrospective study (as part of the epidemiological project of the TLAR-OASG [Turkish League Against Rheumatism-Osteoarthritis Study Group]) included 514 patients (101 males, 413 females; mean age: 63.6±10.8 years; range, 40 to 85 years) who were diagnosed as lumbar spondylosis by clinical examination and direct X-ray between December 2016 and June 2018. Demographic characteristics of patients, Visual Analog Scale for pain, presence of radiating pain, Roland-Morris disability questionnaire, straight leg raise test, deep tendon reflexes, neurogenic intermittent claudication symptoms, any decrease of muscle strength, and abnormality of sensation were recorded. Lumbar MRI findings of the patients were recorded as positive or negative in terms of disc herniation, intervertebral disc degeneration, root compression, osteophytes, spinal stenosis. Statistical analysis was done to assess the correlation between the clinical symptoms, physical examination, and MRI findings. Results: Correlation analysis of the MRI results and the clinical findings showed a significant correlation between straight leg raise test and root compression (p<0.001, r=0.328) and a significant correlation between neurogenic intermittent claudication and spinal stenosis (p<0.001, r=0.376). Roland-Morris disability questionnaire had a significant correlation with all MRI findings (p<0.05, r<0.200). Conclusion: The results of this study corroborate the notion that diligent patient history and physical examination are more valuable than MRI findings, even though a higher incidence of abnormal MRI findings have been obtained in patients with disability and dermatomal radiating pain.
