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Book Part Clinical Development of Quinone-Based Drugs(Elsevier, 2024) Altuner, E.E.; Issa, G.; Ozalp, V.C.; Aldemir, O.; Torlak, Y.; Dar, U.A.This chapter provides a detailed explanation of the clinical investigations, pharmacological effects, and characteristics of quinone and quinone derivatives, along with references to pertinent sources. Although quinones have an oxygen group in their structure, they are quickly oxidized and interact with reactive oxygen species. This demonstrates how quinones work as drugs. Quinones and their derivatives are used as medications to treat a wide range of diseases, including cancer, lung, kidney, brain, and tumor disorders. Each of the following has effects on a different area of health; lapochols, anthraquinones, naphthoquinone and its derivatives, and other wide range of quinone derivatives are thoroughly explored in this chapter. © 2025 Elsevier Inc. All rights reserved.Book Part Drawing a Portrait of Refugee Representation in Turkish Newspapers: A Framing Analysis of Hürriyet and Sabah(Bloomsbury Publishing Plc., 2020) Özoran, Beris Artan; Seyidov, IlgarArticle Catalyst-Free Synthesis of Thiourea-Linked Dumbbell-Shaped POSS for Ultrasensitive Determination of Prilocaine in Human Blood with Computational Insights(Elsevier Inc., 2026) Bilge, S.; Bayraktar, E.N.; Erkmen, C.; Balci, B.; Abofoul, A.; Içli-Özkut, M.I.; Cihaner, A.Although various electrochemical sensors have been reported for the determination of local anesthetic drugs, most existing platforms suffer from limited sensitivity, insufficient surface stability, or inadequate electron-transfer efficiency, particularly when applied to complex biological matrices. Moreover, the potential of hybrid polyhedral oligomeric silsesquioxane (POSS)-based nanostructures combined with metal oxide nanoparticles for improving electroanalytical performance has not yet been thoroughly explored. In this study, a high-sensitivity electrochemical nanosensor was developed for the determination of prilocaine (PC), an amide-type local anesthetic, using a glassy carbon (GC) electrode modified with POSS‑titanium dioxide (TiO2) nanoparticles (Nps). The combination of modifications provided a unique electrode surface by combining the high stability of POSS with the strong adsorption properties of TiO2 Nps, thereby increasing both surface loading and adsorption capacity. To elucidate the structure of the modification combination, 1H and 13C nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopic techniques, as well as Brunauer–Emmett–Teller (BET), X-Ray diffraction (XRD), Electrochemical impedance spectroscopy (EIS), and high-resolution transmission electron microscopy (HRTEM) analysis techniques were used, respectively. The analytical performance of the developed nanosensor was systematically optimized using differential pulse voltammetry (DPV), adsorptive stripping differential pulse voltammetry (AdSDPV), square wave voltammetry (SWV), and adsorptive stripping square wave voltammetry (AdSSWV) techniques. As a result of the optimization studies, the lowest limit of detection (LOD) was 3.66 × 10−8 M with the AdSSWV technique. DFT results corroborated the mechanism, indicating ring-centered electron donation (HOMO) and adsorption-favored N/O regions (MEP). Low LOD values were also recorded with other techniques, demonstrating the method's high sensitivity in analyte detection. In real sample analysis tests, PC recovery value in human blood samples was determined to be 98.69% using the AdSDPV technique. Despite the matrix effect, the nanosensor demonstrated high accuracy and reproducibility. The results indicate that the developed POSS-TiO2 Nps modified GC electrode sensor offers a high-performance, reliable, and good electrochemical detection platform suitable for use in biological and clinical applications. © 2024Conference Object Comparative Analysis Of Patch Antennas With Rectangular Slots For Laminate And Wearable Materials At 5g Networks(Institute of Electrical and Electronics Engineers Inc., 2024) Hakanoglu, B.G.; Agaya, E.; Gulmez, G.; Yalinsu, S.In this study, new multi-band patch antenna design models are proposed for use in 5G networks. The purpose of the designs is to open rectangular slots on rectangular shaped patch antennas and bring them to the desired operating conditions with parametric analyzes. The designs were carried out by following the same procedure steps using five different dielectric laminate substrate materials, such as RO3003, RT6006, FR4, RO3203, RO6010, and one denim fabric base material. The antennas were compared in terms of return loss, gain and radiation characteristics. Except for the antenna designed with RO3203 at certain values of rectangular slots, radiation at multiple frequencies was obtained at 5G frequencies. With the proposed method, improvement was observed for return loss and bandwidth characteristics in the RO3203 based antenna. This study will be a resource for antenna researchers by revealing the responses of different substrate materials to the same design method for 5G bands in patch antennas. © 2024 IEEE.Conference Object Need for a Software Development Methodology for Research-Based Software Projects(Institute of Electrical and Electronics Engineers Inc., 2018) Cereci,I.; Karakaya,Z.Software development is mostly carried by a group of individuals. Software development methodologies are heavily utilized to organize these individuals and keep track of the entire software development process. Although previously proposed software development methodologies meet the needs of the industry and the firms, they are not usually suitable for research-based software projects that are carried by universities and individual researchers. In this paper, we aim to show the necessity of a new software development methodology for research-based problems carried by universities. The literature review will show the differences between industry and university software projects from certain aspects. These findings will be supported by the authors own research on the area. This qualitative research involves collecting data through interviews and applying Grounded Theory to better understand the development process. © 2018 IEEE.Book Part Candidacy Versus Membership: Is Turkey the Greatest Beneficiary of the European Union(Bloomsbury Publishing Plc., 2013) Temel, B.Conference Object Citation - WoS: 1Characterization of Satellite Transponder Impairments Based on Simulations with Test Data(Ieee, 2015) Ulubey, Orhan; Gulgonul, Senol; Kara, AliA satellite transponder simulator based on actual test data of TURKSAT 3A satellite has been developed to analyze degradation in multicarrier scenarios. Communication impairment sources through a transponder are explained in conjunction with a methodology defined to characterize total degradation resulting from them. Several transponder utilization scenarios are studied with respect to total degradation and optimum operation conditions are demonstrated.Article An Investigation Into The AI-Assisted Visualization Of Children’s Songs: The Case Of Ali Baba’s Farm(Nilgun SAZAK, 2025) Südor, S.; İpekçiler, B.This study aims to visualize children’s songs, which are part of primary-level music education, using AI-supported tools. The objectives of the Ministry of National Education’s music course curriculum were examined, and both the themes to be emphasized in song selection and the pedagogical functions of children’s songs were analyzed. In the literature review, the Web of Science and Google Scholar databases were used. The obtained source data were analyzed with the VOSviewer software to generate conceptual maps, through which thematic trends in the field were identified. In the practical part of the study, the children’s song “Old MacDonald’s Farm” was visualized in detail using two different AI-supported tools: RunwayML and WZRD.ai. In RunwayML, prompt-based scenes were generated using the “text-to-video” feature, and visuals compatible with the lyrics of the song were created. On the WZRD.ai platform, visuals were automatically generated in response to sound waves, and the limitations of the platform were examined. Based on the findings, it was concluded that RunwayML offers more effective results for pedagogical content production, while WZRD. ai, despite its technical capabilities, falls short in delivering child-appropriate visual stimuli. The study also provides a theoretical foundation on synesthesia and discusses how AI tools can be integrated into music education in early childhood and primary school levels. The findings indicate that AI-supported visualization tools have the potential to provide engaging and flexible educational materials that support learning at the primary school level. It is recommended that teacher training programs develop hands-on modules for these tools, and that future research focus on how these technologies can be adapted to various songs, age groups, and learning domains. © © 2025 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.Article Multifunctional POSS-Based Nanoparticles Functionalized with Silver, SPIONs, and Rhamnolipid for Antibacterial Applications(Elsevier Ltd, 2026) Kibar, G.; Kafali, M.; Ozonuk, O.C.; Öztaş, M.; Usta, B.; Ercan, B.Nano-engineered materials, particularly those featuring bio-based surface modifications, are emerging as effective tools in combating bacterial infections. In this study, polyhedral oligomeric silsesquioxane (POSS) nanoparticles were functionalized with silver nanoparticles (Ag), superparamagnetic iron oxide nanoparticles (SPIONs), and the biosurfactant rhamnolipid (RL)—either individually or in combination—to evaluate their antibacterial and antibiofilm activities against Staphylococcus aureus ( S. aureus ) and Pseudomonas aeruginosa ( P. aeruginosa ). The modified nanoparticles exhibited sizes ranging from 127 to 227 nm and demonstrated superparamagnetic behavior, offering potential for magnetic targeting. Among the various formulations, the RL-coated, silver- and SPION-decorated POSS nanoparticles (RSMP) exhibited the highest antibacterial efficacy, reducing S. aureus and P. aeruginosa colony growth by approximately 90 % and 66 %, respectively, at a concentration of 0.01 g/L. RSMP nanoparticles also showed strong biofilm inhibition and had the lowest MIC₅₀ values. Notably, these nanoparticles supported the proliferation of human osteoblasts at concentrations up to 0.05 g/L, indicating favorable cytocompatibility. Overall, RSMP nanoparticles present a promising platform for magnetically targetable antibacterial agents, with potential applications in biomedical fields, particularly for managing orthopedic infections. © 2025 Elsevier B.V.Article Citation - WoS: 11Citation - Scopus: 11Supply chain resilience in the tourism and hospitality industry: A comprehensive examination of driving and restraining forces(Elsevier Sci Ltd, 2024) Erol, Ismail; Oztel, Ahmet; Dogru, Tarik; Peker, Iskender; Neuhofer, Irem Onder; Benli, TolgaSupply chain disruptions and a lack of resilient supply chains have adverse impact on the global economy. Particularly, complex nature of the tourism and hospitality industry makes it even more susceptible to failure when supply chain resiliency is rather low or does not exist. However, despite its significance, a comprehensive and systematic examination of building resilience in tourism and hospitality supply chains (THSCs) is lacking in the extant literature. The purpose of this study is to develop a comprehensive framework that outlines the driving and restraining forces for building resilient THSCs. The decision framework proposed in this study integrates rough interval valued neutrosophic (RIVN) force field theory of change with RIVN-ISM-MICMAC methodology. The results showed that the restraining forces, such as lack of effective regulations and incentives and effective organizational and supply chain policies are the primary factors that constrain improving resilience in THSCs. Theoretical and practical implications are discussed.
