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Article Citation - WoS: 1Citation - Scopus: 1Adaptive Stimulus Design for Dynamic Recurrent Neural Network Models(Frontiers Media Sa, 2019) Doruk, R. Ozgur; Zhang, Kechen; Electrical-Electronics Engineering; 06. School Of Engineering; 01. Atılım UniversityWe present an adaptive stimulus design method for efficiently estimating the parameters of a dynamic recurrent network model with interacting excitatory and inhibitory neuronal populations. Although stimuli that are optimized for model parameter estimation should, in theory, have advantages over nonadaptive random stimuli, in practice it remains unclear in what way and to what extent an optimal design of time-varying stimuli may actually improve parameter estimation for this common type of recurrent network models. Here we specified the time course of each stimulus by a Fourier series whose amplitudes and phases were determined by maximizing a utility function based on the Fisher information matrix. To facilitate the optimization process, we have derived differential equations that govern the time evolution of the gradients of the utility function with respect to the stimulus parameters. The network parameters were estimated by maximum likelihood from the spike train data generated by an inhomogeneous Poisson process from the continuous network state. The adaptive design process was repeated in a closed loop, alternating between optimal stimulus design and parameter estimation from the updated stimulus-response data. Our results confirmed that, compared with random stimuli, optimally designed stimuli elicited responses with significantly better likelihood values for parameter estimation. Furthermore, all individual parameters, including the time constants and the connection weights, were recovered more accurately by the optimal design method. We also examined how the errors of different parameter estimates were correlated, and proposed heuristic formulas to account for the correlation patterns by an approximate parameter-confounding theory. Our results suggest that although adaptive optimal stimulus design incurs considerable computational cost even for the simplest excitatory-inhibitory recurrent network model, it may potentially help save time in experiments by reducing the number of stimuli needed for network parameter estimation.Article Citation - WoS: 7Citation - Scopus: 7Antibiotic administration in targeted nanoparticles protects the faecal microbiota of mice(Royal Soc Chemistry, 2021) Borsa, Baris A.; Sudagidan, Mert; Aldag, Mehmet E.; Baris, Isik I.; Acar, Elif E.; Acuner, Cagatay; Ozalp, Veli C.; Basic Sciences; 08. Medical School; 01. Atılım UniversityAntibiotic therapy comes with disturbances on human microbiota, resulting in changes of bacterial communities and thus leading to well-established health problems. In this study, we demonstrated that targeted teicoplanin administration maintains the faecal microbiota composition undisturbed in a mouse model while reaching therapeutic improvements for S. aureus infection.Article Citation - WoS: 1Citation - Scopus: 1Assessment of Anticancer Effects of Aloe Vera on 3D Liver Tumor Spheroids in a Microfluidic Platform(Wiley, 2025) Tevlek, Atakan; Kibar, Gunes; Cetin, Barbaros; Basic Sciences; 08. Medical School; 01. Atılım UniversityThe search for effective anticancer therapies has increasingly focused on natural compounds like Aloe vera, renowned for its therapeutic properties. This study investigates the anticancer properties of Aloe vera on 3D liver tumor spheroids via a PDMS-based microfluidic device, providing a more physiologically realistic model compared to traditional 2D cultures. HepG2 cells were cultivated to generate 3D spheroids on-chip, thereafter subjected to different concentrations of Aloe vera and the chemotherapeutic drug Doxorubicin to evaluate cytotoxic effects. The microfluidic system, validated by COMSOL simulations, facilitated continuous perfusion and real-time assessment of cell viability over a duration of 10 days. The results indicated that Aloe vera markedly diminished cell viability by triggering apoptosis at concentrations over 12.5 mg/mL. IC50 values were determined at 72 h: 25 +/- 0.10 mg/mL for Aloe vera and 5.47 +/- 0.03 mu g/mL for Doxorubicin in 2D cultures, but in 3D cultures, the IC50 values were 31.25 +/- 0.14 mg/mL for Aloe vera and 8.33 +/- 0.05 mu g/mL for Doxorubicin. This study underscores the promise of Aloe vera as a natural anticancer agent and illustrates the efficacy of microfluidic platforms for enhanced drug screening and customized medicine applications.Article Citation - WoS: 19Citation - Scopus: 20Assessment of Depression, Anxiety, and Social Support in the Context of Therapeutic Abortion(Wiley, 2019) Topal, Cansu Akdag; Terzioglu, Fusun; Nursing; 07. School of Health Sciences; 01. Atılım UniversityPurpose The purpose of this study is to determine the levels of anxiety, depression, social support, and nursing care needed by women undergoing therapeutic abortion. Designs and Methods Sixty women were administered a sociodemographic form, the Hospital Anxiety Depression Scale and the Multidimensional Perceived Social Support Scale. Results More than half of the women experienced anxiety (61.7%). Anxiety scores were high (10.8 +/- 3.7), and most of the women had depression (85.0%). Social support from family and friends of the women decreased the women's anxiety and depression levels significantly; social support from their partners also decreased the women's anxiety levels (P < 0.05). Practice Implications Support from family and friends after therapeutic abortion is a fundamental affective variable on anxiety scores.Conference Object Citation - WoS: 5Citation - Scopus: 5Assessment of Nitrogen Excess in an Agricultural Area Using a Nitrogen Balance Approach(I W A Publishing, 2005) Muhammetoglu, H; Muhammetoglu, A; Soyupak, S; 01. Atılım UniversityA pilot study has been initiated to develop an approach for quantification of nitrogen excesses from agricultural activities that involve greenhouse farming in Kumluca Plain, Turkey. Detailed calculations utilizing the nitrogen balance method (NBM) were carried out at nine different locations within the plain over a time period of one year. The major contributing factors and governing operative mechanisms taken into consideration were nitrogen application rates both as organic and chemical fertilizers, irrigation water to application practices, and nitrogen uptake by plants. The adopted approach yielded valuable information such as plant nitrogen uptake efficiencies, excess nitrogen, leaching rates and leachate nitrogen concentrations. Further, a site specific multiple linear regression model has been developed to estimate the ratio (N-leachate/N-groundwater) as a function of independent variables: farming age, excess nitrogen application and SEEPAGE Index Number. The negative sign of the model parameters implies that the ratio (N-leachate/N-groundwater) decreases as values of the independent variables increase. The adopted approach and the obtained results can beneficially be applied to similar sites to establish basic parameters of irrigation and fertilizer application operations.Article The Association Between Digital Device Usage Behaviors and the Incidence of De Quervain’s Tenosynovitis Among University Students(Taylor and Francis Ltd., 2025) Jamil, Y.; Öktem, H.; Sever, S.N.; Basic Sciences; 08. Medical School; 01. Atılım UniversityBackground: The extensive use of mobile and digital devices has been implicated in various musculoskeletal disorders, including de Quervain’s tenosynovitis (dQD), a condition affecting the thumb. Purpose: The present study investigates the relationship between digital device usage patterns and the prevalence of dQD among university students. Methods: A cross-sectional study was conducted with 508 participants (255 females and 253 males), collecting data on daily device use time, wrist positions, hand dominance, and stretching practices via a questionnaire. Data collection was carried out through a supervised, face-to-face survey. Diagnosis of dQD was determined using Finkelstein’s test, all data were analyzed using SPSS software. Results: Out of 508 participants, 187 (36.8%) tested positive for dQD, with 152 (95.6)% occurring in the dominant hand (p =.006, Cramér’s (Formula presented.) = 0.121). 250 participants used their devices with wrists in ulnar deviation (49.2%), which was strongly linked to a positive Finkelstein test result (p =.004, Cramér’s (Formula presented.) = 0.175). Finkelstein’s test showed increasing positivity with device use, ranging from 12.5% for < 2 hours to 46.2% for ≥ 8 hours, with a statistically significant association (p <.001, Cramér’s (Formula presented.) = 0.234). Device usage varied, with the highest test positivity rates among those using devices 6–8 hours per day suggesting a significant association with dQD (p =.001). No significant relationship was found between dQD and the practice of stretching or relieving movements (p =.146). Conclusion: The findings indicate that prolonged digital device usage, specific wrist positions such as ulnar deviation, and dominant-hand use are significantly associated with an increased risk of de Quervain’s tenosynovitis among college students. © 2025 Taylor & Francis Group, LLC.Article Citation - Scopus: 1Association Between Fragmented Qrs and Postprocedural Rhythm Disturbances in Patients Who Underwent Transcatheter Aortic Valve Implantation(Assoc Medica Brasileira, 2021) Duran, Mustafa; Ziyrek, Murat; Alsancak, Yakup; Ayhan, Huseyin; 01. Atılım UniversityINTRODUCTION: According to recent studies, the rate of atrioventricular block requiring permanent pacing in patients following transcatheter aortic valve implantation varied between 5.7% and 42.5%. Fragmented QRS is a useful marker of myocardial scar and can predict adverse cardiac events. In this study, we examined association between fragmented QRS and postprocedural rhythm disturbances and the need for permanent pacing in patients who underwent transcatheter aortic valve implantation. OBJECTIVE: In this study, we examined association between fragmented QRS and postprocedural rhythm disturbances and the need for permanent pacing in patients who underwent transcatheter aortic valve implantation' sentence is enough for it. METHODS: We retrospectively analyzed standard 12-lead electrocardiographic recordings of 124 consecutive patients in whom a CoreValve prosthesis was implanted. We examined 12-lead electrocardiogram before and after procedure along with one- and six-month follow-up. We documented QRS fragmentation and postprocedural rhythm disturbances. RESULTS: There was a significant increase in the frequency of left bundle branch block, (21.1 versus 0%, p<0.05) and the incidence of atrioventricular blocks requiring permanent pacing (21.1 versus 0%, p<0.05) following transcatheter aortic valve implantation in patients whose preprocedural electrocardiogram recordings revealed fragmented QRS compared to those without fragmented QRS. Based our collected data, the presence of QRS fragmentation in anterior derivations was the only independent factor associated with postprocedural rhythm disturbances (B-value 0.217; OR 0.805; 95%CI 0.136-4.78; p=0.004). CONCLUSION: Our data showed an increased risk for the development of new-onset left bundle branch block and atrioventricular blocks following transcatheter aortic valve implantation in patients whose baseline electrocardiogram recordings demonstrated QRS fragmentation.Article Citation - WoS: 1Citation - Scopus: 1The Association Between Respiratory Functions, Pain Tolerance and Body Awareness in Obstructive Lung Diseases(Elsevier Science Inc, 2025) Vardar-Yagli, Naciye; Saglam, Melda; Firat, Merve; Inal-Ince, Deniz; Calik-Kutukcu, Ebru; Kilic, Kubra; Coplu, Lutfi; 01. Atılım UniversityPurpose: There are only a limited number of studies in the literature evaluating body awareness, pain perception, and the relationship between clinical parameters and respiratory functions in patients with obstructive lung disease (OLD) and compared with healthy individuals. Therefore, this study aimed to evaluate respiratory functions, pain tolerance, and body awareness in patients with OLD and compare these findings with those of healthy individuals. Methods: The study included 33 patients and 30 healthy individuals. The respiratory function (spirometer), respiratory muscle strength (mouth pressure device), endurance (threshold loading device), pain level and tolerance (short-form McGill Pain Questionnaire and algometer), posture, and body awareness (Body Awareness Questionnaire-BAQ) were evaluated. Results: The pain threshold and tolerance of the biceps, triceps, trapezius, and quadriceps muscles were significantly lower and BAQ scores were higher in patients with OLD compared with healthy individuals (p < .05). There was a significant relationship between FEV1 (%) and pain tolerance of the triceps (r = 0.371, p = .047) and gastrocnemius muscles (r = 0.419, p = .024); FVC (%) and pain threshold of the gastrocnemius (r = 0.413, p = .023), triceps muscles (r = 0.394, p = .034), and pain tolerance of the gastrocnemius muscle (r = 0.549, p = .002). Conclusions: Patients with OLD have a marked increase in pain perception and body awareness levels and a decrease in pain threshold and tolerance compared with healthy controls. Future studies should assess the effectiveness of pain management interventions as a part of pulmonary rehabilitation for patients with chronic respiratory diseases. Clinical Implications: Pain management is important for planning pulmonary rehabilitation programmes. (c) 2024 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Review Citation - WoS: 58Citation - Scopus: 70Atmospheric Pressure Plasma Surface Treatment of Polymers and Influence on Cell Cultivation(Mdpi, 2021) Sasmazel, Hilal Turkoglu; Alazzawi, Marwa; Alsahib, Nabeel Kadim Abid; Metallurgical and Materials Engineering; 06. School Of Engineering; 01. Atılım UniversityAtmospheric plasma treatment is an effective and economical surface treatment technique. The main advantage of this technique is that the bulk properties of the material remain unchanged while the surface properties and biocompatibility are enhanced. Polymers are used in many biomedical applications; such as implants, because of their variable bulk properties. On the other hand, their surface properties are inadequate which demands certain surface treatments including atmospheric pressure plasma treatment. In biomedical applications, surface treatment is important to promote good cell adhesion, proliferation, and growth. This article aim is to give an overview of different atmospheric pressure plasma treatments of polymer surface, and their influence on cell-material interaction with different cell lines.Article Citation - WoS: 5Citation - Scopus: 4Avoiding Contingent Incidents by Quadrotors Due To One or Two Propellers Failure(Public Library Science, 2023) Altinuc, Kemal Orcun; Khan, Muhammad Umer; Iqbal, Jamshed; Mechatronics Engineering; 15. Graduate School of Natural and Applied Sciences; 06. School Of Engineering; 01. Atılım UniversityWith the increasing impact of drones in our daily lives, safety issues have become a primary concern. In this study, a novel supervisor-based active fault-tolerant (FT) control system is presented for a rotary-wing quadrotor to maintain its pose in 3D space upon losing one or two propellers. Our approach allows the quadrotor to make controlled movements about a primary axis attached to the body-fixed frame. A multi-loop cascaded control architecture is designed to ensure robustness, stability, reference tracking, and safe landing. The altitude control is performed using a proportional-integral-derivative (PID) controller, whereas linear-quadratic-integral (LQI) and model-predictive-control (MPC) have been investigated for reduced attitude control and their performance is compared based on absolute and mean-squared error. The simulation results affirm that the quadrotor remains in a stable region, successfully performs the reference tracking, and ensures a safe landing while counteracting the effects of propeller(s) failures.Article Citation - WoS: 10Citation - Scopus: 7Beyond expectations: disease duration and psychological burden in psoriatic arthritis(Springer Heidelberg, 2023) Kilic, Gamze; Kilic, Erkan; Tekeoglu, Ibrahim; Sargin, Betul; Cengiz, Gizem; Balta, Nihan Cuzdan; Nas, Kemal; 01. Atılım UniversityThis study aims to investigate the relationship between disease duration and psychological burden in PsA and to identify the risk factors associated with psychological distress. Patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network. Patients were categorized into three groups based on disease duration: early stage (< 5 years), middle stage (& GE; 5, < 10 years), and late stage (& GE; 10 years). All patients underwent clinical and laboratory assessment using standardized protocol and case report forms. The associations between psychological variables and clinical parameters were assessed by a multivariate analysis. Of the 1113 patients with PsA (63.9% female), 564 (%50.7) had high risk for depression and 263 (%23.6) for anxiety. The risk of psychological burden was similar across all PsA groups, and patients with a higher risk of depression and anxiety also experienced greater disease activity, poorer quality of life, and physical disability. Multivariate logistic regression revealed that female gender (OR = 1.52), PsAQoL (OR = 1.13), HAQ (OR = 1.99), FiRST score (OR = 1.14), unemployment/retired (OR = 1.48) and PASI head score (OR = 1.41) were factors that influenced the risk of depression, whereas the current or past enthesitis (OR = 1.45), PsAQoL (OR = 1.19), and FiRST score (OR = 1.26) were factors that influenced the risk of anxiety. PsA patients can experience a comparable level of psychological burden throughout the course of their disease. Several socio-demographic and disease-related factors may contribute to mental disorders in PsA. In the present era of personalized treatment for PsA, evaluating psychiatric distress can guide tailored interventions that improve overall well-being and reduce disease burden.Article Citation - WoS: 54Biomechanical Comparison of Implant Retained Fixed Partial Dentures With Fiber Reinforced Composite Versus Conventional Metal Frameworks: a 3d Fea Study(Elsevier, 2011) Erkmen, Erkan; Meric, Gokce; Kurt, Ahmet; Tunc, Yahya; Eser, Atilim; 01. Atılım UniversityFiber reinforced composite (FRC) materials have been successfully used in a variety of commercial applications. These materials have also been widely used in dentistry. The use of fiber composite technology in implant prostheses has been previously presented, since they may solve many problems associated with metal alloy frameworks such as corrosion, complexity of fabrication and high cost. The hypothesis of this study was that an FRC framework with lower flexural modulus provides more even stress distribution throughout the implant retained fixed partial dentures (FPDs) than a metal framework does. A 3-dimensional finite element analysis was conducted to evaluate the stress distribution in bone, implant-abutment complex and prosthetic structures. Hence, two distinctly different models of implant retained 3-unit fixed partial dentures, composed of Cr-Co and porcelain (M-FPD model) or FRC and particulate composite (FRC-FPD model) were utilized. In separate load cases, 300 N vertical, 150 N oblique and 60 N horizontal forces were simulated. When the FRC-FPD and M-FPD models were compared, it was found that all investigated stress values in the M-FPD model were higher than the values in the FRC-FPD model except for the stress values in the implant-abutment complex. It can be concluded that the implant supported FRC-FPD could eliminate the excessive stresses in the bone-implant interface and maintain normal physiological loading of the surrounding bone, therefore minimizing the risk of peri-implant bone loss due to stress-shielding. (C) 2010 Elsevier Ltd. All rights reserved.Article Citation - WoS: 8Citation - Scopus: 10Biomechanical Effects of Two Different Collar Implant Structures on Stress Distribution Under Cantilever Fixed Partial Dentures(Taylor & Francis Ltd, 2011) Meric, Gokce; Erkmen, Erkan; Kurt, Ahmet; Eser, Atilim; Ozden, Ahmet Utku; 01. Atılım UniversityObjective. The purpose of the study was to compare the effects of two distinct collar geometries of implants on stress distribution in the bone around the implants supporting cantilever fixed partial dentures (CFPDs) as well as in the implant-abutment complex and superstructures. Materials and methods. The three-dimensional finite element method was selected to evaluate the stress distribution. CFPDs which was supported by microthread collar structured (MCS) and non-microthread collar structured (NMCS) implants was modeled; 300 N vertical, 150 N oblique and 60 N horizontal forces were applied to the models separately. The stress values in the bone, implant-abutment complex and superstructures were calculated. Results. In the MCS model, higher stresses were located in the cortical bone and implant-abutment complex in the case of vertical load while decreased stresses in cortical bone and implant-abutment complex were noted within horizontal and oblique loading. In the case of vertical load, decreased stresses have been noted in cancellous bone and framework. Upon horizontal and oblique loading, a MCS model had higher stress in cancellous bone and framework than the NMCS model. Higher von Mises stresses have been noted in veneering material for NMCS models. Conclusion. It has been concluded that stress distribution in implant-supported CFPDs correlated with the macro design of the implant collar and the direction of applied force.Article Citation - WoS: 1Citation - Scopus: 1Biosorption of Reactive Dyes by Novel Bacterium Leclercia Adecarboxylata: Complete Removal of Reactive Black 5 and Molecular Insights Into the Adsorption Mechanism(Wiley, 2025) Sen, Seda; Korkmaz, Filiz; Kilic, Nur Kocberber; Physics Group; 06. School Of Engineering; 01. Atılım UniversityLeclercia adecarboxylata isolated from the D & uuml;den Waterfall (Turkey) was utilized as a biosorbent for the removal of Reactive Black 5 (RB5), Setazol Blue BRF-X (BRF-X), Setazol Navy Blue SBG (SNB), and Setazol Turquoise Blue G (STBG). Of the dyes, RB5 was removed with the highest efficiency, 97.4% after 60 min. The effect of parameters such as pH (3-9), initial biosorbent dose (0.1-2.0 g/L), and initial dye concentration (25-1200 mg/L) on the biosorption of RB5 was investigated. Increasing the biosorbent dosage from 0.1 to 2.0 g/L enhanced the RB5 removal from 55.3% to 100% within 10 min. The complete removal (100%) of RB5 was achieved in media with 2.0 g/L biosorbent and 25 mg/L RB5 at pH 3 after 10 min. Additionally, the soluble extracellular polymeric substances (EPS) of L. adecarboxylata were found to consist of proteins, lipids, nucleic acids, and polysaccharides according to Fourier transform infrared spectroscopy (FTIR) analysis. The EPS was found to play a crucial role in dye removal, forming chemical interactions with dye molecules. Zeta potential analysis was used to evaluate the charge distribution on the biosorbent surface (-12.6 +/- 1.1 mV) and its interactions in the biosorption process. Kinetic and isotherm models suggested a complex interaction mechanism between the biomass and the dye. Adsorption isotherm data were analyzed via nine isotherm models. Among them, the Hill model was found to be the best fit for describing the equilibrium adsorption process of the RB5 (R2 = 0.9993). Overall, the applied models elucidated the influence of both physical and chemical interactions on the mechanism. Kinetic studies revealed that the adsorption of RB5 fit a pseudo-second-order kinetic model. The unique biochemical composition of the indigenous L. adecarboxylata biosorbent provided a high affinity for RB5, offering a sustainable, rapid, and economical solution for the treatment of dye-polluted water.Article Calcium Phosphate Honeycomb Scaffolds With Tailored Microporous Walls Using Phase Separation-Assisted Digital Light Processing(MDPI, 2025) Kim, Gyu-Nam; Park, Jae-Hyung; Song, Jae-Uk; Koh, Young-Hag; Park, Jongee; Metallurgical and Materials Engineering; 06. School Of Engineering; 01. Atılım UniversityThe present study reports on the manufacturing of biphasic calcium phosphate (BCP) honeycomb scaffolds with tailored microporous walls using phase separation-assisted digital light processing (PS-DLP). To create micropores in BCP walls, camphene was used as the pore-forming agent for preparing BCP suspensions, since it could be completely dissolved in photopolymerizable monomers composed of triethylene glycol dimethacrylate (TEGDMA) and polyethylene glycol diacrylate (PEGDA) and then undergo phase separation when placed at 5 degrees C. Therefore, solid camphene crystals could be formed in phase-separated BCP layers and then readily removed via sublimation after the photopolymerization of monomer networks embedding BCP particles by DLP. This approach allowed for tight control over the microporosity of BCP walls by adjusting the camphene content. As the camphene content increased from 40 to 60 vol%, the microporosity increased from similar to 38 to similar to 59 vol%. Consequently, the overall porosity of dual-scale porosity scaffolds increased from similar to 51 to similar to 67 vol%, while their compressive strength decreased from similar to 70.4 to similar to 13.7 MPa. The mass transport ability increased remarkably with an increase in microporosity.Article Citation - WoS: 5Citation - Scopus: 6Characteristic Features of Thermoluminescence in Neodymium-Doped Gallium Sulfide(Wiley, 2018) Guler, I.; Isik, M.; Ahmedova, F.; Guseinov, A.; Gasanly, N.; Department of Electrical & Electronics Engineering; 15. Graduate School of Natural and Applied Sciences; 01. Atılım UniversityThe thermoluminescence (TL) of neodymium-doped gallium sulfide (GaS:Nd) single crystals was measured from 10 K to room temperature with various heating rates between 0.2 and 1.0 K/sec. Two peaks centered at 70.9 K and 116.0 K were observed when using a heating rate of 0.8 K/sec. Initial rise and curve fitting methods were used to obtain information on trap activation energies. Activation energies of 94 and 216 meV were found for two analyzable peaks. The heating rate dependencies of TL intensities revealed that one of the observed peaks showed normal behavior according to the one trap-one recombination model, whereas the other model showed anomalous heating rate behavior. TL experiments were also carried out at different illumination temperatures from 10 to 32 K; maximum peak temperature remained almost the same at various illumination temperatures. This behavior indicated that the revealed trapping centers are single, discrete levels. The TL glow curves of undoped GaS crystals were also investigated and the effect of Nd doping on the TL characteristics of crystals is discussed in the manuscript.Article Citation - WoS: 35Citation - Scopus: 35Characteristics and Outcomes of Carbapenemase Harbouring Carbapenem-Resistant klebsiella Spp. Bloodstream Infections: a Multicentre Prospective Cohort Study in an Oxa-48 Endemic Setting(Springer, 2022) Isler, Burcu; Ozer, Berna; Cinar, Gule; Aslan, Abdullah Tarik; Vatansever, Cansel; Falconer, Caitlin; Ergonul, Onder; 01. Atılım UniversityA prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.Article Citation - WoS: 2Citation - Scopus: 2Chronic Pregabalin Treatment Reduced Anxiety, and Acute Pregabalin Treatment Increased Depression-Like Behaviors in Rats(Bmc, 2024) Caliskan, Hasan; Akat, Firat; Dursun, Ali Dogan; Zaloglu, Nezahet; Basic Sciences; 08. Medical School; 01. Atılım UniversityBackgroundPregabalin is an antiepileptic drug that binds to the alpha-2/delta unit at presynaptic voltage-dependent calcium channels. We aimed to investigate the effect of acute and chronic pregabalin administration on anxiety and depression-like behaviors.MethodsFifty-six male Wistar albino rats were divided into seven groups: control, vehicle, and five different dose groups (5, 10, 30, 60, and 100 mg/kg). Pregabalin was administered for two weeks. Depression-like behaviors were evaluated by Forced swimming test. Anxiety-like behavior (ALB) was evaluated by Open field test (OFT), Elevated Plus Maze (EPM), and light-dark box. Subjects underwent the forced swimming test (FST) after the first dose, while the open field test (OFT), elevated plus maze (EPM), and light-dark box (LDB) were performed after two weeks of treatment. Further sucrose preference test was conducted to evaluate anhedonia until the end of the experiment.ResultsIn the forced swimming test, depression-like behaviors increased after acute single-dose administration of 10, 30, 60, 100 mg/kg pregabalin. According to OFT results, chronic 100 mg/kg pregabalin showed anxiolytic effects by decreasing grooming, and freezing behaviors. In addition, 100 mg/kg chronic pregabalin administration significantly increased the time spent in the central region, the number of entries to the center, and the unsupported rearing number without causing any change in locomotor activity. According to EPM results, both chronic 60 and 100 mg/kg pregabalin treatments showed anxiolytic effects by increasing open arm time and head dipping behavior. In addition, 60 and 100 mg/kg chronic pregabalin administration significantly decreased stretch attend posture. All pregabalin administrations between 5 and 100 mg/kg displayed anxiolytic effects in the LDB. Sucrose preference was above 65% for the duration of all experiments and subjects did not show anhedonia.ConclusionAcute pregabalin treatment triggered depression-like behaviors. Anhedonia, which may be associated with depression, was not observed during chronic treatment. Moreover, chronic treatment with pregabalin revealed potent anxiolytic effects in different behavior patterns and doses for all tests of unconditional anxiety. In particular, 100 mg/kg chronic pregabalin administration decreased anxiety-like behaviors in all experiment setups. Although the anxiolytic effect was demonstrated in chronic treatment, acute treatment of pregabalin induced depression-like behaviors, and thus in clinical practice should be done with caution, especially in patients with anxiety-depression comorbidity.Article Citation - WoS: 7Citation - Scopus: 7Colorimetric Detection of Ultrathin Dielectrics on Strong Interference Coatings(Optical Soc Amer, 2018) Ayas, Sencer; Bakan, Gokhan; Ozgur, Erol; Celebi, Kemal; Torunoglu, Gamze; Dana, Aykutlu; Department of Electrical & Electronics Engineering; 15. Graduate School of Natural and Applied Sciences; 01. Atılım UniversityMetal films covered with ultrathin lossy dielectrics can exhibit strong interference effects manifested as the broad absorption of the incident light resulting in distinct surface colors. Despite their simple bilayer structures, such surfaces have only recently been scrutinized and applied mainly to color printing. Here, we report the use of such surfaces for colorimetric detection of ultrathin dielectrics. Upon deposition of a nanometer-thick dielectric on the surface, the absorption peak red shifts, changing the surface color. The color contrast between the bare and dielectric- coated surfaces can be detected by the naked eye. The optical responses of the surfaces are characterized for nanometerthick SiO2, Al2O3, and bovine serum albumin molecules. The results suggest that strong interference surfaces can be employed as biosensors. (C) 2018 Optical Society of AmericaArticle Citation - WoS: 13Citation - Scopus: 13Comparison of Physicochemical Properties of Two Types of Polyepichlorohydrin-Based Anion Exchange Membranes for Reverse Electrodialysis(Mdpi, 2022) Karakoc, Ezgi; Guler, Enver; Chemical Engineering; 06. School Of Engineering; 01. Atılım UniversityThe development of the most effective, suitable and economic ion-exchange membranes is crucial for reverse electrodialysis (RED)-the most widely studied process to harvest salinity gradient energy from mixing seawater and river water. RED utilizes two types of membranes as core elements, namely cation exchange membranes (CEM) and anion exchange membranes (AEM). Since the preparation of AEMs is more complex compared to CEMs, the design and development of anion exchange membranes have been the focus in this study. Homogeneous AEMs based on two types of polyepichlorohydrin (PECH) with different chlorine amounts (PECH-H, 37 wt% and PECH-C, 25 wt%) were synthesized, and first-time benchmarking of the membrane properties was conducted. In addition to physicochemical membrane properties, some instrumental analyses such as SEM, FTIR and DSC were investigated to characterize these anion-exchange membranes. Based on the results, although the PECH-H-type membrane had enhanced ion-exchange properties, PECH-C-based anion-exchange membranes exhibited a higher power density of 0.316 W/m(2) in a lab-scale RED system. Evidently, there is room for the development of new types of PECH-C-based AEMs with great potential for energy generation in the RED process.
