TR-Dizin

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14411/21

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Citation - WoS: 4
Citation - Scopus: 5
16s Bacterial Metagenomic Analysis of Herby Cheese (otlu Peynir) Microbiota
(Istanbul Univ-cerrahpasa, 2021) Sudağıdan, Mert; Yurt, Mediha Nur Zafer; Taşbaşı, Behiye Büşra; Acar, Elif Esma; Ömeroğlu, Esra Ersoy; Uçak, Samet; Aydın, Ali; Ozalp, Cengiz; Ersoy Omeroglu, Esra; Mediha Nur, Zafer YURT
Cheese microbiota may contain various bacterial species due to the use of different types of milk, rennet, and herbs. In this study, the distribution of the dominant bacteria present in the microbiota of herby cheese samples (n = 13) were examined by the next generation sequencing (NGS) technique. DNA was extracted both directly from cheese samples and after pre-enrichment. The metagenomic analysis of the NGS results revealed that Firmicutes were dominant both in DNA directly extracted from herby cheese (KOP), and pre-enriched samples (OP), at the phylum level. At the genus level, Lactobacillus, Lactococcus, and Streptococcus were dominant in the KOP samples, whereas in the OP samples, Enterococcus, Streptococcus, and Bacillus were determined as the dominant bacterial genera. Although Lactococcus raffinolactis and Streptococcus salivarius were dominant in the KOP samples, Enterococcus faecalis and S. salivarius were dominant in the OP samples. The Shannon species diversity index and principal coordinates analysis (PCoA) were used to determine the distribution in KOP and OP samples at the genus level. The PCoA of KOP-10, KOP-11, KOP-2, and KOP-7, KOP-3, and KOP-6 samples showed the wide distribution, whereas KOP-5, KOP-8, KOP-9, and KOP-14 herby cheese samples were closely related. The OP samples, especially OP-7 and OP-14, showed wide distribution in comparison to other OP samples. Finally, the dominant bacterial communities were identified by DNAbased metagenomic analysis, and this is the first report to elucidate the microbiota of herby cheese produced in Turkey using the NGS technique.
Citation - WoS: 3
Citation - Scopus: 4
Akciğer Kanserinde İmmünoterapi ve Tedavide Multidisipliner Yaklaşım
(Turkish Assoc Tuberculosis & Thorax, 2020) Karadurmuş, Nuri; Kaya, Akın; Göksel, Tuncay; Yılmaz, Ülkü; Tülek, Necla
Akciğer kanseri dünya genelinde kanserle ilişkili ölümlerin başlıca nedeniolmaya devam etmektedir. Son 20 yılda kanser biyolojisi ve patogenezi hakkındaki bilgiler artmış, immün kontrol noktası inhibitörleri (İKNİ) kullanımasunulmuş ve böylece solid kanserlerin tedavisinde önemli bir dönem başlamıştır. Bu derlemede; tedavide yenilikler, immünoterapi ve tedavide multidisipliner yaklaşım çerçevesinde akciğer kanseri ele alınmıştır. Küçük hücreli dışıakciğer kanseri (KHDAK) en sık görülen ve özellikleri nedeniyle İKNİ tedavisinden ideal olarak yararlanabilecek akciğer kanseri türü olması nedeniyleyazının odak noktasını oluşturmuştur. Bu derleme, akciğer kanseri tedavisindeimmünoterapi yaklaşımının göğüs hastalıkları başta olmak üzere tüm branşlarda multidisipliner farkındalığını artırmayı ve yönetimi hakkında bilgi sağlamayıamaçlayan ilk Türkçe derlemedir. Ayrıca bu derleme, KHDAK tedavisinde İKNİkullanımına ilişkin son klinik çalışmaların dikkat çekici sonuçlarını sunmasıaçısından önem teşkil etmektedir. İmmünoterapi kanser tedavisinde yeni bir dönem başlatmıştır ve İKNİ tedavisinin kendine özgü etki mekanizması yeni bazı advers olay grubunun ortaya çıkmasına nedenolmuştur, bunlar arasında pnömonitis özellikle önemlidir ve advers olaylar konusunda gerektiğinde hastaların ilgili uzmanlık dalları ilekonsülte edilmesi gerekmektedir. Akciğer kanserinde tedavi, hastanın özellikleri, histolojik özellikler, genetik durum göz önünde bulundurularak her bir hastaya özel planlanmalı ve akciğer kanserli bir hastanın tanısal değerlendirilmesi ve en uygun şekilde tedavisi içingöğüs hastalıkları, göğüs cerrahisi, tıbbi onkoloji, radyasyon onkolojisi, patoloji ve radyoloji uzmanlık dalları arasında işbirliği sağlanmalıdır. Bununla birlikte, aile hekimleri de akciğer kanserinin erken tanınmasında ve ayrıca hastalarını tütün bırakmayı teşvik ederekkanserin önlenmesinde önemli rol oynayabilirler. Ayrıca, toplumda farkındalık yaratmak ve erken tanı için akciğer kanseri yönündentarama çalışmaları yapmak hedeflenmelidir
Citation - WoS: 5
Citation - Scopus: 6
Analysis of the Effect of Propellant Temperature on Interior Ballistics Problem
(Yildiz Technical Univ, 2018) Evci, C.; Isik, H.
This study investigates the effect of conditioning temperature of double base propellants on the interior ballistic parameters such as burning gas temperature, barrel wall temperature, pressure and stresses generated in the barrel. Interior ballistic problem was solved employing experimental, numerical and analytical methods with a thermo-mechanical approach. Double base propellants were conditioned at different temperatures ( 52, 35, 21, 0, -20, -35, -54 degrees C). The maximum pressure in the barrel and projectile muzzle velocity were measured for all the propellants by conducting shooting tests with a special test barrel using 7.62x51 mm NATO ammunition. Vallier-Heydenreich method was employed to determine the transient pressure distribution along the barrel. The temperature of burnt gases was calculated by using Noble-Abel equation. The heat transfer analysis was done using the commercial software ANSYS to get the transient temperature and stress distributions. Temperature distribution through the barrel wall thickness was validated using a FLIR thermal imager. Radial, circumferential and axial stresses and corresponding equivalent Von Misses stresses were determined numerically and analytically. The results of the analytical solution for stress analysis validated the finite element solution of interior ballistic problem. Increasing the initial temperature of the propellant resulted in higher temperature and pressure inside the barrel which in turn increased the stresses in the barrel.
Citation - WoS: 7
Citation - Scopus: 10
Ann-Assisted Forecasting of Adsorption Efficiency To Remove Heavy Metals
(Tubitak Scientific & Technological Research Council Turkey, 2019) Buaısha, Magdi; Balku, Şaziye; Yaman, Şeniz Özalp; Özalp Yaman, Şeniz
In wastewater treatment, scientific and practical models utilizing numerical computational techniques suchas artificial neural networks (ANNs) can significantly help to improve the process as a whole through adsorption systems.In the modeling of the adsorption efficiency for heavy metals from wastewater, some kinetic models have been used such as pseudo first-order and second-order. The present work develops an ANN model to forecast the adsorption efficiency of heavy metals such as zinc, nickel, and copper by extracting experimental data from three case studies. To do this, we apply trial-and-error to find the most ideal ANN settings, the efficiency of which is determined by mean square error (MSE) and coefficient of determination (R2). According to the results, the model can forecast adsorption efficiency percent (AE%) with a tangent sigmoid transfer function (tansig) in the hidden layer with 10 neurons and a linear transferfunction (purelin) in the output layer. Furthermore, the Levenberg–Marquardt algorithm is seen to be most ideal for training the algorithm for the case studies, with the lowest MSE and high R2 . In addition, the experimental results and the results predicted by the model with the ANN were found to be highly compatible with each other.
Citation - WoS: 1
Citation - Scopus: 1
Anticipatory Effect of Execution on Observation: an Approach Using Exopinch Finger Robot
(Tubitak Scientific & Technological Research Council Turkey, 2019) Arıkan, Kutluk Bilge; Zadeh, Hassan Gol Mohammad; Turgut, Ali Emre; Zinnuroğlu, Murat; Bayer, Gözde; Günendi, Zafer; Cengiz, Bülent
Background/aim: This study aims to explore the mirror neuron system (MNS) involvement using mu (8–12 Hz)/beta (15–25 Hz) bandsuppression in an action observation-execution paradigm.Materials and methods: Electrophysiological (EEG) data from 16 electrodes were recorded while 8 participants observed video clips ofa hand squeezing a spring. Specifically, the effect of anticipated execution on observation was studied. For this purpose, a fully actuatedfinger exoskeleton robot was utilized to synchronize observation and execution and to control the execution condition for the participants. Anticipatory effect was created with a randomized robot accompany session.Results: The results showed that the observational condition (with or without anticipation) interacted with hemisphere at central channels near somatosensory cortex. Additionally, we explored the response of MNS on the kinetics features of visual stimuli (hard or softspring).Conclusion: The results showed an interaction effect of kinetics features and hemisphere at frontal channels corresponding nearly tothe ventral premotor cortex area of the brain. The activation of mirror neurons in this area plays a crucial role in observational learning.Based on our results, we propose that specific type of visual stimuli can be combined with the functional abilities of the MNS in the action observation based treatment of hand motor dysfunction of stroke patients to have a positive additional impact.
Citation - Scopus: 2
An Approach for Performance Prediction of Saturated Brushed Permanent Magnet\rdirect Current (dc) Motor From Physical Dimensions
(Tubitak Scientific & Technological Research Council Turkey, 2022) Asl, Rasul Tarvirdilu; Zeinali, Reza; Ertan, Hulusi Bulent; Tarvirdilu-Asl, Rasul; Tarvirdilu–Asl, Rasul
An analytical approach for performance prediction of saturated brushed permanent magnet direct current\r(DC) motors is proposed in this paper. In case of a heavy saturation in the stator back core of electrical machines, some\rflux completes its path through the surrounding air, and the conventional equivalent circuit cannot be used anymore.\rThis issue has not been addressed in the literature. The importance of considering the effect of the flux penetrating\rthe surrounding air is shown in this paper using finite element simulations and experimental results, and an analytical\rapproach is proposed to consider this effect on magnet operating point determination and performance prediction of\rsaturated brushed permanent magnet DC motors. An analytical method is also presented to determine the boundary\rradius of the surrounding air for obtaining accurate results in finite element (FE) solutions and analytical calculations.\rAn analytical approach based on Carter’s coefficient is also proposed to calculate the effective length of the magnet when\rthe length of the magnet and rotor length are not the same. The accuracy of the proposed analytical model is illustrated\rusing finite element simulations and experimental results. With this accuracy, this analytical model is very suitable to\rbe used for reliable and quick mathematical design optimization.
Citation - WoS: 13
Citation - Scopus: 13
Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid\raortic valve degeneration
(Tubitak Scientific & Technological Research Council Turkey, 2020) Karaduman, Bilge Duran; Ayhan, Hüseyin; Keles, Telat; Bozkurt, Engin; Duran Karaduman, Bilge
Background/aim: From a pathophysiological point of view, inflammation is thought to be more dominant in bicuspid aortic valve\r(BAV) stenosis than tricuspid aortic valve (TAV) stenosis. Our study aimed to determine the association between monocyte to highdensity lipoprotein cholesterol (HDL-C) ratio (MHR), a new inflammatory marker, and the speed of progression of stenosis and\rpathophysiology of BAV stenosis.\rMaterials and methods: A total of 210 severe aortic stenosis patients (70 consecutive BAV patients, 140 matched TAV patients) were\rretrospectively enrolled in the study. Clinical and echocardiographic data and laboratory results related to our research were collected\rretrospectively from the patients’ records. MHR was measured as the ratio of the absolute monocyte count to the HDL-C value.\rResults: Seventy BAV (mean age: 72.0 ± 9.1 years, 42.9% female) and 140 TAV patients (mean age: 77.9 ± 8.3 years, 51.4% female)\rwith severe aortic stenosis were enrolled in this study. There was no difference between the two groups in terms of another baseline\rdemographic or clinic findings except age (P < 0.001). Monocyte count, hemoglobin level, mean platelet volume was significantly\rhigher, and HDL-C level was significantly lower in the BAV group, while other lipid and CBC parameters were found to be similar. In\rthe multivariate analysis, MHR (P = 0.005, 95% CI: 0.90–0.98) and, as expected, age (P = 0.001, 95% CI: 1.02–1.11) were found to be\rsignificant as the independent predictor of BAV, after adjusting for other risk factors.\rConclusion: Our study showed a significant correlation between increased MHR and BAV. MHR was determined as a significant\rindependent predictor for the speed of progression and diagnosis of severe BAV stenosis in multivariate analysis.
Citation - WoS: 12
Citation - Scopus: 16
Biomaterials and Tissue Engineering for Regenerative Repair of Articular Cartilage Defects
(Turkish League Against Rheumatism, 2009) Tur, Kazim; Department of Metallurgical and Materials Engineering
Articular cartilage defects heal very poorly and lead to degenerative arthritis. Existing medications cannot promote healing process; cartilage defects eventually require surgical replacements with autografts. As there is not enough source of articular cartilage that can be donated for autografting, materials that promote cartilage regeneration are important in both research and clinical applications. Tissue engineering involves cell growth on biomaterial scaffolds in vitro. These cells are then injected into cartilage defects for biological in vivo regeneration of the cartilage tissue. This review aims first to provide a brief introduction to the types of materials in medicine (biomaterials), to their roles in treatment of diseases, and to design factors and general requirements of biomaterials. Then, it attempts to sum up the recent advances in engineering articular cartilage; one of the most challenging area of study in biomaterials based tissue engineering, as an example to the research on regenerative solutions to musculoskeletal problems with an emphasis on the biomaterials that have been developed as scaffolds for cartilage tissue engineering. The definitive goal on cartilage regeneration is to develop a system using biomimetic approach to produce cartilage tissue that mimics native tissue properties, provides rapid restoration of tissue function, and is clinically translatable. This is obviously an ambitious goal; however, significant progress have been made in recent years; and further advances in materials design and technology will pave the way for creating significantly custom-made cellular environment for cartilage regeneration. (Turk J Rheumatol 2009; 24: 206-17)
Borulu Sulama Şebekeleri Optimizasyonu
(Turkish Chamber Civil Engineers, 2018) Marım, Gökhan; Darama, Yakup; Bozkuş, Zafer
Borulu sulama şebekeleri ülkelerin tarımsal ürün yetiştirmesinde ve su tasarrufunda enönemli sistemlerdir. Günümüzde tarımsal amaçlı sulama, su tüketiminin en yüksek olduğusektördür. Ülkemizde tarım sektörünün kullandığı su miktarı su potansiyelimizin %73oranındadır. Ülkemizde ve genelde Dünyada nüfus artışı nedeniyle tarımsal üretimde sutalebinin artması ve su kaynaklarımızın sınırlı olması nedeniyle sürdürülebilir su kaynaklarıyönetimi zorunlu olmaktadır. Son yıllarda ülkemizde yapılan sulama sistemleri yatırımlarınınbüyük bir çoğunluğunu, su kaybını ve tarımsal su kullanımını azaltan modern borulu sulamaşebekeleri yatırımları oluşturmaktadır. Bu çalışma borulu sulama şebekelerinintasarımlarının maliyet ve istenen işletme basınçları açısından optimum koşullara ulaşmasınaodaklanmıştır. Optimizasyon problemi çözümünde heuristik tabanlı dinamik programlamaile birlikte doğrusal programlama yöntemi olan “Simplex” metodu kullanılmış olup, buoptimizasyon yazılımı DSİ borulu sulama şebekeleri için uygulanmıştır.
Citation - WoS: 1
Citation - Scopus: 1
Bozucu Torklar Altında İzdüşümsel Doğru Akım Motoru Kontrolü
(Gazi Univ, Fac Engineering Architecture, 2018) Doruk, Reşat Özgür; Zuglam, İsmail; Doruk, Ozgur
Bu çalışmada, izdüşümsel doğrusal kareselservo geri beslemesi (P-LQSF) yöntemiyle tasarlanmış bir birdoğru akım (DC) motoru denetim yaklaşımı sunulmaktadır. Tasarlanan denetleyicinin kararlılığı girdidenhale-kararlılıkyaklaşımından yola çıkarak incelenmektedir. İzdüşümsel kontrol yöntemi, tam durumdeğişkeni geri beslemeli bir denetleyicinin özdeğer spektrumunu çıktı geri beslemesi kullanarak yaklaşıkolarak elde etmeyi amaçlar. Tasarlanan denetleyicilerin kararlılık analizi hem teorik hem de sayısalbenzetim yoluyla incelenecektir. Temel doğrusal kararlılığın yanı sıra, bozucu etkilerin kapalı döngüyü birdış girdi olarak etkilemesinden yola çıkarak girdiden-çıktıya-kararlılık kavramından yararlanılması olanaklıolabilmektedir. Sonuç olarak bir bozucu etkiden-hale-kararlılık yaklaşımı ortaya çıkmaktadır. Tasarımlar,elde edilen bu yaklaşımla incelenecektir. Performanslar ise sayısal benzetimler yoluyla görülecektir.
Citation - WoS: 1
Citation - Scopus: 2
Cannabinoid Receptor Ligands Modulate Fibrosis and Inflammation in Idiopathic Pulmonary Fibrosis: a Preliminary Study
(Tubitak Scientific & Technological Research Council Turkey, 2024) Kose, Sevil; Onen, Selin; Gizer, Merve; Boduroglu, Esin; Gonullu, Ugur; Korkusuz, Petek
Background/aim: No specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF) exists. Therefore, new antiinflammatory therapeutic strategies are needed. Cannabinoids (CBs), known for their inflammation-modulating and antifibrotic effects, may be potential medication candidates for treating IPF. We aim to evaluate the inflammation-modulating and antifibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide-stimulated normal human lung fibroblast, epithelial cells, IPF fibroblast cells, and monocytes. Materials and methods: We detected CBRs in normal human lung fibroblasts (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry. We determined TGF-(31, IL-8, and TNF-alpha inflammatory cytokines in the LL24, LL29, A549, and THP-1 cell culture supernatants on days 1 and 5 by ELISA. We evaluated the cell viability in LL24, LL29, and A549 cells on days 1, 3, and 5 spectrophotometrically and detected collagen Type I (ColI) production in the LL24 and LL29 cell culture supernatants on days 1, 3, and 5 by ELISA. Results: LL24, LL29, A549, and THP-1 cells exhibited CB1 (CB1R) and CB2 (CB2R) receptors. CB1R and CB2R agonists WIN55,2122 and JWH015 inhibited fibroblastic and epithelial cell proliferation on day 5. TGF-(31 and TNF-alpha release increased, while IL-8 release decreased in LL24, LL29, A549, and THP-1 cells in response to the administration of WIN55,212-2 and JWH015 at a 10-2 mM concentration. CB1R and CB2R antagonists AM251 and AM630 did not block agonistic responses, suggesting a nonclassical CBRmediated pathway. CB2R agonist JWH015 decreased ColI expression in IPF lung fibroblasts LL29 on day 3. Conclusion: These results suggest that CB signaling regulates the progression of pulmonary inflammation and fibrosis via CBR activation. This may offer a potential pharmacological tool for developing antifibrosis therapies.
Citation - WoS: 11
Citation - Scopus: 14
Card Spending Dynamics in Turkey During the Covid-19 Pandemic
(Central Bank Republic Turkey, 2021) Kantur, Zeynep; Özcan, Gülserim
This paper provides an extensive analysis of card spending during the COVID-19 pandemic in Turkey by using weekly aggregated and sectoral credit and debit card spending data from March 2014 to December 2020. At an aggregated level, we show that aggregate demand decreases significantly at the early stages of COVID-19 and seems to reinstate its pre-COVID trend. However, when we include the pre-existing conditions of Turkey, the 2018 currency crisis, we observe that the recovery in demand is not that strong. To highlight the underlying reasons for structural change in aggregate demand, we estimate the model with stringency index and unemployment-related search index. The estimated model indicates that containment measures and restrictions and fear of job/income loss mainly explain the overall impact of COVID-19 on aggregate demand. We also examined sectoral data to understand aggregate demand dynamics better. Only stable and delayable sector groups have reached a trend above their pre-pandemic trajectories. However, the social and work-related sectors are far from their respective pre-pandemic trend.
Citation - WoS: 3
Citation - Scopus: 1
Caval Valve Implantation Procedure in 7 Cases of Torrential Tricuspid Regurgitation and Step-By Description of the Procedure
(Kare Publ, 2025) Sarıçam, Ersin; Barcin, Cem; Çelebi, Aksüyek Savaş; Asfour, Mohamed; Bozbas, Huseyin; İlkay, Erdoğan; Cam, Ersin; Celebi, Savas A.
Tricuspid regurgitation (TR) is an increasingly prevalent and clinically significant health problem.1 Due to the growing understanding of the importance of TR, the tricuspid valve has transitioned from being a forgotten valve to one of significant concern. Tricuspid regurgitation is often functional, and as it progresses to moderate or severe stages, hospital admissions increase and prognosis worsens.1,2 There are no effective pharmacological treatments for TR, and the 5-year survival rate with medical management is reported to be less than 50%.3 Therefore, early diagnosis and timely intervention for TR is crucial. Both surgical and percutaneous treatment options are available for severe TR. The mortality rate for isolated TR surgery is generally high.4 In recent years, transcatheter treatments have become feasible for this patient group, and accumulating evidence shows that transcatheter treatment is superior to medical management.5,6 Transcatheter interventions for TR can be performed in 4 ways, 2 involving repair and 2 involving valve We aimed to present our experience with transcatheter caval valve implantation (CAVI) in 7 patients with torrential TR who were not suitable for surgical intervention or transcatheter edge-to-edge repair (T-TEER) due to severe coaptation defects, review the current literature, and provide a step-by-step description of the procedure.
Citation - WoS: 3
Citation - Scopus: 3
Characterization of Mesenchymal Stem Cells in Mucolipidosis Type Ii (i-Cell Disease)
(Tubitak Scientific & Technological Research Council Turkey, 2019) Köse, Sevil; Kaya, Fatima Aerts; Kuşkonmaz, Bülent Barış; Çetinkaya, Duygu Uçkan; Aerts Kaya, Fatima; Uckan Cetinkaya, Duygu
Mucolipidosis type II (ML-II, I-cell disease) is a fatal inherited lysosomal storage disease caused by a deficiency of theenzyme N-acetylglucosamine-1-phosphotransferase. A characteristic skeletal phenotype is one of the many clinical manifestationsof ML-II. Since the mechanisms underlying these skeletal defects in ML-II are not completely understood, we hypothesized that adefect in osteogenic differentiation of ML-II bone marrow mesenchymal stem cells (BM-MSCs) might be responsible for this skeletalphenotype. Here, we assessed and characterized the cellular phenotype of BM-MSCs from a ML-II patient before (BBMT) and afterBM transplantation (ABMT), and we compared the results with BM-MSCs from a carrier and a healthy donor. Morphologically, wedid not observe differences in ML-II BBMT and ABMT or carrier MSCs in terms of size or granularity. Osteogenic differentiation wasnot markedly affected by disease or carrier status. Adipogenic differentiation was increased in BBMT ML-II MSCs, but chondrogenicdifferentiation was decreased in both BBMT and ABMT ML-II MSCs. Immunophenotypically no significant differences were observedbetween the samples. Interestingly, the proliferative capacity of BBMT and ABMT ML-II MSCs was increased in comparison to MSCsfrom age-matched healthy donors. These data suggest that MSCs are not likely to cause the skeletal phenotype observed in ML-II, butthey may contribute to the pathogenesis of ML-II as a result of lysosomal storage-induced pathology.
Characterizations of the Commutators Involving Idempotents in Certain Subrings of $m_{2}(\mathbb{z})$
(Tubitak Scientific & Technological Research Council Turkey, 2023) Ozdin, Tufan; Gumusel, Gunseli
In this paper, we characterize the idempotency, cleanness, and unit-regularity of the commutator [E1, E2] = E1E2 - E2E1 involving idempotents E1, E2 in certain subrings of M2(Z).
Citation - WoS: 1
Citation - Scopus: 3
The Clinical and Demographical Characteristics of Turkish Pediatric Lymphedema Patients: a Multicenter Study
(Tubitak Scientific & Technological Research Council Turkey, 2022) Borman, Pinar; Balcan, Aysegul; Eyigor, Sibel; Coskun, Evrim; Ayhan, Figen; Cakit, Burcu Duyur; Dogan, Sevil Ceyhan; Vural, Secil Pervane; Ayvaz, Deniz Nazire Çağdaş; Vural, Meltem
Background/aim: Reducing lymphedema-associated burden and disability in the pediatric setting requires improved awareness and understanding clinical properties of the lymphedema. The aim of this study was to evaluate the clinical and demographic characteristics of patients with pediatric lymphedema presented to different lymphedema centers in Turkey. Materials and methods: The socio-demographic and clinical characteristics of the children including age, gender, presence of genetic syndromes, duration of edema, site and stage of lymphedema and the received therapies were determined. Parental and children education on self-management techniques were recorded. Results: A total of 122 children (female: 66, male: 56) with a mean age of 120.7 +/- 71.2 months were included from 7 centers. Of them; 92% had primary, 8% had secondary lymphedema mostly due to infection and trauma. Lymphedema was part of a syndrome in 18% of the children. The most common site of involvement was the lower extremity, followed by upper extremity and genital involvement. Lymphedema was complicated in 17 % of children, mainly with a clinical picture of cellulitis, infection, and pain. The median duration of lymphedema was 41 (5-216) months. Although most of the children had stage 2 lymphedema, only 40% of them received treatment. The most commonly received treatment was compression therapy. No family or child was educated for self-care management before. Conclusion: In conclusion, pediatric lymphedema has a comparable gender distribution and usually involves the lower extremities. Although most of the children had advanced disease, more than half of the patients did not receive any treatment indicating the unmet need for management of lymphedema. The education of patients and/or children about self-management methods were lacking. We suggest educational activities for both families of children with lymphedema and health care providers, in order to facilitate early reference to lymphedema units and to receive prompt preventive and therapeutic approaches for this suffering condition.
Citation - WoS: 4
Citation - Scopus: 4
The Clinical, Functional, and Radiological Features of Hand Osteoarthritis: Tlar-Osteoarthritis Multi-Center Cohort Study
(Turkish League Against Rheumatism, 2022) Duruoz, Mehmet Tuncay; Gursoy, Didem Erdem; Tuncer, Tiraje; Altan, Lale; Ayhan, Figen; Bal, Ajda; Ugurlu, Hatice; Çay, Hasan Fatih; Durmaz, Berrin; Gurer, Gülcan; Sarıkaya, Selda; Sezer, Ilhan
Objectives: This study aims to evaluate the clinical, functional, and radiological features of hand osteoarthritis (OA) and to examine their relationships in different geographic samples of the Turkish population. Patients and methods: Between April 2017 and January 2019, a total of 520 patients (49 males, 471 females; mean age: 63.6 +/- 9.8 years) with hand OA were included in the study from 26 centers across Turkiye by the Turkish League Against Rheumatism (TLAR). The demographic characteristics, grip strengths with Jamar dynamometer, duration of hand pain (month), the severity of hand pain (Visual Analog Scale [ VAS]), and morning stiffness were evaluated. The functional disability was evaluated with Duruoz Hand Index (DHI). The Kellgren-Lawrence (KL) OA scoring system was used to assess the radiological stage of hand OA. Results: The DHI had significant correlations with VAS- pain (r= 0.367, p<0.001), duration of pain (r=0.143, p=0.001) and bilateral handgrip strengths (r=-0.228, p=0.001; r=-0.303, p<0.001). Although DHI scores were similar between the groups in terms of the presence of hand deformity (p= 0.125) or Heberden's nodes (p=0.640), the mean DHI scores were significantly higher in patients with Bouchard's nodes (p=0.015). The total number of nodes had no significant correlations with the VAS-pain and DHI score (p>0.05). The differences between the groups of radiological hand OA grades in terms of age (p= 0.007), VAS-pain (p<0.001), duration of pain (p<0.001), and DHI (p<0.001) were significant. There were no significant differences between radiological hand OA grades according to the duration of the stiffness, grip strength, and BMI (p>0.05 for all). Conclusion: In our population, the patients with hand OA had pain, functional disability, and weak grip strength. The functional impairment was significantly correlated with the severity of the pain, and the functional status was worse in high radiological hand OA grades.
Citation - WoS: 16
Citation - Scopus: 20
Common Fixed Point Theorems in Cone Banach Spaces
(Hacettepe Univ, Fac Sci, 2011) Abdeljawad, Thabet; Karapinar, Erdal; Tas, Kenan; Mathematics
Recently, E. Karapinar (Fixed Point Theorems in Cone Banach Spaces, Fixed Point Theory Applications, Article ID 609281, 9 pages, 2009) presented some fixed point theorems for self-mappings satisfying certain contraction principles on a cone Banach space. Here we will give some generalizations of this theorem.
Citation - Scopus: 21
Comparative Analysis of Programming Languages Utilized in Artificial Intelligence Applications: Features, Performance, and Suitability
(Prof.Dr. İskender AKKURT, 2024) Sezen, Arda; Türkmen, Güzin; Şengül, Gökhan
This study presents a detailed comparative analysis of the foremost programming languages employed in Artificial Intelligence (AI) applications: Python, R, Java, and Julia. These languages are analysed for their performance, features, ease of use, scalability, library support, and their applicability to various AI tasks such as machine learning, data analysis, and scientific computing. Each language is evaluated based on syntax and readability, execution speed, library ecosystem, and integration with external tools. The analysis incorporates a use case of code writing for a linear regression task. The aim of this research is to guide AI practitioners, researchers, and developers in choosing the most appropriate programming language for their specific needs, optimizing both the development process and the performance of AI applications. The findings also highlight the ongoing evolution and community support for these languages, influencing long-term sustainability and adaptability in the rapidly advancing field of AI. This comparative assessment contributes to a deeper understanding of how programming languages can enhance or constrain the development and implementation of AI technologies.
Citation - WoS: 7
Citation - Scopus: 10
Comparison of Three Different Learning Methods of Multilayer Perceptron Neural Network for Wind Speed Forecasting
(Gazi Univ, 2021) Bulut, Mehmet; Tora, Hakan; Buaisha, Dr.magdi; Buaisha, Magdi
In the world, electric power is the highest need for high prosperity and comfortable living standards. The security of energy supply is an essential concept in national energy management. Therefore, ensuring the security of electricity supply requires accurate estimates of electricity demand. The share of electricity generation from renewables is significantly growing in the world. This kind of energy types are dependent on weather conditions as the wind and solar energies. There are two vital requirements to locate and measure specific systems to utilize wind power: modelling and forecasting of the wind velocity. To this end, using only 4 years of measured meteorological data, the present research attempts to estimate the related speed of wind within the Libyan Mediterranean coast with the help of ANN (artificial neural networking) with three different learning algorithms, which are Levenberg-Marquardt, Bayesian Regularization and Scaled Conjugate Gradient. Conclusions reached in this study show that wind speed can be estimated within acceptable limits using a limited set of meteorological data. In the results obtained, it was seen that the SCG algorithm gave better results in tests in this study with less data.

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