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Article Citation - WoS: 9Citation - Scopus: 15Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats With Experimental Alzheimer's Disease(Dove Medical Press Ltd, 2023) Ozdemir, Cagri; Arslan, Mustafa; Kucuk, Aysegul; Yigman, Zeynep; Dursun, Ali DoganIntroduction: Oxidative stress has an important role in the pathophysiology of Alzheimer's disease (AD), the most common type of dementia. Boric acid (BA) contributes significantly to the protection of the brain by reducing lipid peroxidation and supporting antioxidant defense. We aimed to evaluate the therapeutic potential of BA treatment in AD rats. Materials and Methods: Four groups were formed as Control (C), Alzheimer's (A), Alzheimer's + Boric acid (ABA), Boric acid (BA). Intracerebroventricular injection of Streptozotocin (STZ) was preferred to create an AD. After 4 weeks, BA was applied 3 times every other day. The Radial Arm Maze Test (RAMT) was used to evaluate memory and learning abilities. Biochemical and histopathological evaluations were made in the hippocampus. Results: Initial RAMT inlet/outlet (I/O) numbers were similar. Two weeks after STZ injection, I/O numbers decreased in group A and ABA compared to group C and BA (p<0.05). After the second BA application, I/O numbers increased in the ABA group compared to the A group (p<0.05). In group A, PON-1, TOS and OSI levels were higher and TAS levels were lower than in groups BA and C. After BA treatment, PON-1 and OSI levels were lower in the ABA group than in the A group (p<0.05). Although there was an increase in TAS value and a decrease in TOS, this did not make a statistical difference. The thickness of the pyramidal cell in CA1 and the granular cell layers in the dentate gyrus, and the number of intact and degenerated neurons in the pyramidal cell layer were similar between the groups. Discussion: Significant improvement in learning and memory abilities after BA application is promising for AD. Conclusion: These results show that BA application positively affects learning and memory abilities, and reduces oxidative stress. More extensive studies are required to evaluate histopathological efficacy.Article Use of Boric Acid as a Binder for Briquetting Some Boron Mine Wastes and Their Calcined Products(Parlar Scientific Publications (p S P), 2010) Sener, Savas; Özbayoğlu, Gülhan; Ozbayoglu, Gulhan; Ozdemir, Zeynep; Özbayoğlu, Gülhan; Energy Systems Engineering; Energy Systems EngineeringIn this study, boric acid as a binder for briquetting some boron mine wastes, such as colemanite and ulexite fines and calcined products, which do not meet the market specifications with respect to particle size, were investigated. Effects of water and binder contents, applied pressure, and curing and drying conditions on the briquette quality were evaluated in terms of mechanical strength, water-proofing characteristics and wearing resistance. The best briquettes were obtained at 62.4 MPa pressure (cured at ambient temperature for 24 h and dried at 105 C for 2 h). Only binder free briquettes of uncalcined ulexite gave satisfactory result. The briquette strength increased with an increase in the percentage of binder. The optimum binder content was found to be 5 % by weight for uncalcined ulexite and colemanite as well as calcined colemanite, but 10 To by weight for calcined ulexite. The water-proof briquettes of ulexite and calcined products of ulexite and colemanite fines could be produced. According to wearing resistance, ulexite and colemanite fines as well as calcined product of colemanite showed resistance to abrasion action during transportation and loading.
