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Article Citation - WoS: 6Synthesis and Biological Study of Novel Indole-3 Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors(Bentham Science Publ Ltd, 2013) Kurt, Z. Kilic; Aydin, D.; Isgor, Y. G.; Isgor, B. S.; Olgen, S.The aim of this study is to design and synthesize novel dual inhibitors of Src protein tyrosine kinase (PTK) and Glutathione S-transferases (GSTs), as a potential drug lead with therapeutic efficacy on cancer and immune disorders. The biological activity profiling of small molecule inhibitors via miniaturized biochemical techniques compatible with medium throughput screening and focused screening methodologies were performed. To determining the effects of small molecule inhibitors on Src kinase and Phase II detoxification enzyme GST isozymes in liver homogenates used to verify their roles in drug resistance mechanism for cancer chemotherapeutics. In this study, 14 indole-3-imine-2-on and N-benzyl indole-3-imine-2-on derivatives were synthesized for dual activities against Src and GST. The chemical structures and purities of compounds were verified by IR, H-1 NMR, MASS spectroscopy, and elemental analysis. The compounds 2, 3 and 9 are found slightly active against both enzyme Src and GST.Conference Object Effect of Synthesis Methods, Doping Methods, Metals and Metal Contents on the Dosimetric Properties of Lithium Tetraborate(RAD Association, 2012) Yilmaz,A.; Ozbayoǧlu,G.Thermoluminescent dosimeter (TLD) needs to have some features such as; a simple glow curve structure, a high gamma ray sensitivity, low fading of TL signal, linear dose-response relationship, simple annealing procedure for reuse, chemical stability and inertness to extreme climatic variations, insensitive to daylight, suitable effective atomic number (Zeff), close to that of soft tissue which is 7.42. The effective atomic number of lithium tetraborate is (7.42), which is almost the same as that of the biological tissue. Due to that reason, in this research, Lithium tetraborate: Li2B4O7, has been synthesized by different methods, such as, high temperature solid state synthesis and solution assisted synthesis methods. After preparing the host material, Cu and Mn were doped with different concentrations. TL glow curves of Mn and Cu doped LTB samples produced by using different synthesis and doping methods and Ag, P and Mg co-doped samples were investigated for comparison. All samples prepared displayed TL response and the best TL signal was obtained from the sample produced by solid state synthesis and doped by solution assisted method with 0.1% Cu and 0.004% Ag. High temperature solid-state synthesis of LTB and high temperature solid-state doping of Mn gave better glow curves with 1 wt% Mn content than other products with different synthesis and doping methods and than other percentages of Mn in LTB with two separable glow peak at 77 °C and 280 °C with high intensity. The addition of Ag as co-dopant shifted the main glow peak to 200 °C. P increased the intensity of glow peak at 280 °C. Mg increased the glow curve complexity. © 2012 RAD Conference Proceedings. All rights reserved.Article Citation - Scopus: 6Synthesis and Biological Study of Novel Indole-3 Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors(Bentham Science Publishers, 2013) Kurt,Z.K.; Aydin,D.; Işgör,Y.G.; Işgör,B.S.; Olgen,S.The aim of this study is to design and synthesize novel dual inhibitors of Src protein tyrosine kinase (PTK) and Glutathione S-transferases (GSTs), as a potential drug lead with therapeutic efficacy on cancer and immune disorders. The biological activity profiling of small molecule inhibitors via miniaturized biochemical techniques compatible with medium throughput screening and focused screening methodologies were performed. To determining the effects of small molecule inhibitors on Src kinase and Phase II detoxification enzyme GST isozymes in liver homogenates used to verify their roles in drug resistance mechanism for cancer chemotherapeutics. In this study, 14 indole-3-imine-2-on and N-benzyl indole-3-imine-2-on derivatives were synthesized for dual activities against Src and GST. The chemical structures and purities of compounds were verified by IR, 1H NMR, MASS spectroscopy, and elemental analysis. The compounds 2, 3 and 9 are found slightly active against both enzyme Src and GST. © 2013 Bentham Science Publishers.Article Citation - WoS: 50Citation - Scopus: 54The Effect of Synthesis and Doping Procedures on Thermoluminescent Response of Lithium Tetraborate(Elsevier Science Sa, 2011) Pekpak, E.; Yilmaz, A.; Ozbayoglu, G.Lithium tetraborate has been a scientific focus since 1960s by the courtesy of the thermoluminescence property it possesses. Moreover, it is utilized in surface acoustic wave apparatuses, in sensor sector and in laser technology owing to its non-linear optical characteristics. For the uses in thermoluminescence dosimetry lithium tetraborate is activated by addition of a variety of metals as dopants. This study includes the synthesis of lithium tetraborate by two methods (high temperature solid state synthesis and water/solution assisted synthesis), doping of activators into the matrix material synthesized and characterization of the products. Lithium tetraborate is readily commercially available in TL (Themoluminescence) dosimetry; hence, the main aim in this study was to specify the effect of synthesis and doping methods on the TL response. The heating temperature for the synthesis was 750 degrees C and the retention time as selected as 4 h for both methods. The synthesis stages were followed by doping step where the compounds of Cu, Ag and In in different proportions were doped in lithium tetraborate by solid state and solution assisted doping techniques. Characterization of the product was achieved by X-ray diffraction (XRD). Fourier transform Infra Red Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) techniques. All samples prepared displayed TL response and the best TL signal was obtained from the sample produced by solid state synthesis and doped by solution assisted method with 0.1% Cu and 0.004% Ag. (C) 2010 Elsevier B.V. All rights reserved.Article Citation - WoS: 18Citation - Scopus: 19Synthesis and Enhanced Photocatalytic Activity of Molybdenum, Iron, and Nitrogen Triple-Doped Titania Nanopowders(Elsevier Sci Ltd, 2016) Erdogan, Nursev; Park, Jongee; Ozturk, AbdullahA novel Mo, Fe, and N triple-doped rutile TiO2 nanopowder was synthesized with simple HNO3 assisted hydrothermal treatment. Powders synthesized were characterized by using x-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS), inductively coupled plasma mass spectrometry (ICP-MS), scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM), and Brunauer-Emmett-Teller (BET) surface area analysis techniques. Mo doping initiated the formation of a structure composed of a mixture of anatase and rutile with some modifications in morphology; but Mo, Fe, and N triple-doped titania powders are composed of entirely rutile structures. XPS analysis confirmed that Mo dissolved in the structure, replacing Ti atoms and forming some MoO3 partially crystallized nano regions on the surface. Existence of Fe in the TiO2 crystal lattice was confirmed by ICP analysis. Fe doping had an influence on the crystal structure and morphology. N was found to be dissolved in the co-doped structure by HNO3 catalyzer autogenously. Methylene blue degradation testing and band gap measurements were performed by using UV-vis photospectroscopy and diffuse reflector apparatus in order to evaluate the photocatalytic performance of the powders. Dopant elements decreased band gap energy steadily. An enhanced photoactivity was reached by Mo, Fe, and N triple-doping as compared with that of undoped, and mono doped TiO2 powders under UV-light irradiation. Possible reasons for the enhancement in photocatalytic activity are outlined. (C) 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
