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Other Current Induction Therapy Strategies and Anti-T Lymphocyte Globulin Usage in Kidney Transplantation: Consensus-Based Recommendations by a Turkish Expert Panel(Aves, 2024) Çakır, Ülkem; Dinçkan, Ayhan; Karadoğan, Nayim; Keven, Kenan; Koçak, Hüseyin; Koç, Serkan Kubilay; Yıldız, Alaattin; Turkmen, Aydin; Töz, Hüseyin; Sezer, SirenThis advisory committee convened to review national and global kidney transplantation dynamics and provide recom- mendations on the use of anti-T lymphocyte globulin (ATLG) for prevention and treatment of rejection after allogeneic kidney transplantation. A critical evaluation of 6 relevant articles released up to October 2022 was performed to reveal their importance in clinical practice. Additionally, 27 key questions on the indication, dosage of ATLG, and risk stratification were used for the Delphi technique with 8 members of the Turkish Society of Nephrology including 5 kidney transplanta- tion (KTx) subcommittee members and a surgeon experienced in solid organ transplantation. The committee declared that Türkiye had great potential in KTx; however, increase in transplantation would be possible in the case of raise in the deceased donor transplantation. As a consensus, ATLG was strongly recommended for induction and rejection treatment. Also, committee members recommended the safe dosage range in steroid resistant acute rejection as 2.5-3 mg/kg daily for 5-7 days, and the median of preferred dosage in induction sounded as 2-2.5 mg/kg daily for 3 days in intermediate risk state. Additionally, post-transplant infection and malignancy cases due to immunosuppression were much rarely encoun- tered than they were in the past.Article Pankreas Cerrahisi Sonrası Histopatolojik Değerlendirme: Hpb’ye Özgü Patologlar ile Spesifik Olmayan Patologların Sonuçlarının Karşılaştırılması(Turkish Surgical Assoc, 2023) Emral, Ahmet Cihangir; Dikmen, Kürşat; Tahernejad, Maryam; Sardari, Khotan; Pour, Ali Rahman; Ekinci, Özgür; Kerem, MustafaGiriş ve Amaç: Bu çalışmanın amacı, aynı cerrahi ekip tarafından pankreatikoduodenektomi yapılan hastaların spesmenlerinin HPB-spesifik pato- loglar ve genel patologların değerlendirme sonuçlarını karşılaştırmaktır. Gereç ve Yöntem: Periampuller bölgede pankreatikoduodenektomi (PD) uygulanan 159 hastanın patoloji sonuçları retrospektif olarak incelendi. HPB-spesifik patologlar (S grubu) ve diğer patologların (NS grubu) histopatolojik değerlendirme sonuçları karşılaştırıldı. Patoloji spesmenleri değerlendirilerek, tümör boyutu (mm), total lenf nodu, metastatik lenf nodu, cerrahi sınır pozitif/negatifliği (RO/R1/R2 rezeksiyonu) ve vasküler rezeksiyon yapılan hastaların verileri gruplar karşılaştırılarak değerlendirildi. Bulgular: HPB-spesifik patologlar (S grubu) tarafından 91 hastanın, non-spesifik grupta (NS grubu) ise 68 hastanın spesmen sonuçları incelendi. Ortalama toplam lenf nodu sayısı ve diseke edilen metastatik lenf nodu sayısı açısından karşılaştırıldığında istatistiksel olarak anlamlı sonuç göz- lendi (sırasıyla p= 0,04, p< 0,01). Ayrıca cerrahi sınır pozitifliği (R1) S grubunda istatistiksel olarak daha yüksek bulundu (p= 0,02). Sonuç: HPB ameliyatlarının başarısının kliniğe yansıyabilmesi için patoloji spesmenlerinin HPB-spesifik patologlar tarafından incelenmesi önem taşımaktadır.Article Identification of Bacterial Vaginal Microbiota Via Metagenomic Approach(Galenos Publ House, 2022) Ucak, Samet; Sudagidan, Mert; Yurt, Mediha Nur Zafer; Tasbasi, Behiye Busra; Acar, Elif Esma; Tuna, Bilge Guvenc; Ozalp, Veli Cengiz; Ozalp, Cengiz; Dogan, SonerAim: The aim of the current study was to identify vaginal bacterial microbiota of 38 Turkish women using the high -throughput next -generation sequencing and metagenomic approach at different taxonomic levels from the kingdom to the species level. Materials and Methods: Vaginal swab samples (n=38) were collected in the DNA/RNA shield collection tubes at Yeditepe University Hospital, Department of Obstetrics and Gynecology in June 2021 and DNA extraction was performed by ZymoBIOMICS DNA miniprep kit. The information related to age, marital status, preliminary diagnosis and anamnesis status of patients were collected. To determine the vaginal microbiota, a metagenomic approach was applied using 16S rRNA amplicon sequencing. Results: The dominant phylum Firmicutes was followed by Proteobacteria, Actinobacteria, Tenericutes, Fusobacteria, and Synergistetes in the vaginal samples. Lactobacillus was the most abundant genus followed by Prevotella, Enterobacter, Gardnerella, and Dialister. Lactobacillus iners was dominant at the species level in vaginal swab samples, followed by Gardnerella vaginalis, Enterobacter tabaci, Prevotella timonensis, Prevotella bivia, and Lactobacillus jensenii. Canonical correspondence analysis (CCA) showed that Proteobacteria and Fusobacteria were mainly related to married/single variable with the highest percentages, whereas Actinobacteria and Tenericutes were related to age variable at the phylum level. Campylobacter , Atopobium , Enterobacter , and Lactococcus were mainly found in married/single variable with the highest percentages, whereas Anaerococcus, Streptococcus, Sutterella , and Veillonella were related to age. Moreover, CCA showed that Campylobacter ureolyticus, Lb. jensenii , and Atopobium vaginae were associated with married/single variable, whereas Lactobacillus johnsonii and G. vaginalis were found in age variable with the highest percentages at the species level. Conclusion: Vaginal diseases are still a major public health concern. The vaginal microbiota, which has been studied in more depth in recent years, has been discovered to be more complicated than previously imagined thanks to technological developments. More patient investigations are needed to confirm and develop these findings.Article Investigation of the Anti-Inflammatory Effects of Astaxanthin on Liver Tissue in Lipopolysaccharide-Induced Sepsis in Rats(Galenos Yayincilik, 2022) Cobaner, Nurdan; Yelken, Birgul; Erkasap, Nilufer; Ozkurt, Mete; Bektur, EzgiObjective: Corticosteroids are one of the treatment methods used to prevent inflammation in sepsis. This study aimed to determine the anti-inflammatory activity of astaxanthin in sepsis and compare it with dexamethasone. Materials and Methods: After approval of the local ethics committee, 40 Sprague-Dawley male rats were randomly assigned to the control group (n=8), lipopolysaccharide group (n=8), astaxanthin group (n=8), astaxanthin + lipopolysaccharide group (n=8) and dexamethasone + lipopolysaccharide group (n=8). On day 1, these groups were given dimethyl sulfoxide, Salmonella typhimurium lipopolysaccharide, astaxanthin dissolved in dimethyl sulfoxide, astaxanthin and lipopolysaccharide and dexamethasone and lipopolysaccharide, respectively. After 24 hours, rats underwent laparotomy, and liver and blood samples were taken. GraphPad Prism 6 was used for statistical analysis. P values less than 0.05 were considered significant. Results: Nuclear factor-kappa B levels in both treatment groups significantly decreased when compared with the lipopolysaccharide group. Apoptotic cells and reaction severity decreased significantly in the treatment groups compared with the lipopolysaccharide group. Conclusion: This study revealed that the use of astaxanthin had a positive effect on liver tissue undergoing treatment for sepsis. Moreover, despite some differences, measurement values were comparable when dexamethasone was administered.
