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Article Citation - Scopus: 18Pulmonary rehabilitation principles in SARS-COV-2 infection (COVID-19): The revised guideline for the acute, subacute, and post-COVID-19 rehabilitation(Turkish Society of Physical Medicine and Rehabilitation, 2021) Aytür,Y.K.; Köseoglu,B.F.; Taşkıran,Ö.Ö.; Gökkaya,N.K.O.; Delialioğlu,S.Ü.; Tur,B.S.; Tıkız,C.Coronavirus disease 2019 (COVID-19) is a contagious infection disease, which may cause respiratory, physical, psychological, and generalized systemic dysfunction. The severity of disease ranges from an asymptomatic infection or mild illness to mild or severe pneumonia with respiratory failure and/or death. COVID-19 dramatically affects the pulmonary system. This clinical practice guideline includes pulmonary rehabilitation (PR) recommendations for adult COVID-19 patients and has been developed in the light of the guidelines on the diagnosis and treatment of COVID-19 provided by the World Health Organization and Republic of Turkey, Ministry of Health, recently published scientific literature, and PR recommendations for COVID-19 regarding basic principles of PR. This national guideline provides suggestions regarding the PR methods during the clinical stages of COVID-19 and post-COVID-19 with its possible benefits, contraindications, and disadvantages. © 2021 All right reserved by the Turkish Society of Physical Medicine and RehabilitationArticle Breast Cancer Management During the Covid Pandemic(Coll Physicians & Surgeons Pakistan, 2024) Sariyildiz, Gulcin Turkmen; Ayhan, Fikriye FigenObjective: To explore the impact of COVID-19 among both the newly diagnosed patients and patients under follow-up for breast cancer by focusing on patients' accessibility to management and comparing the distribution of them before and during pandemic. Study Design: Single -centric retrospective study. Place and Duration of the Study: Department of General Surgery and Department of Physical Medicine and Rehabilitation, Atilim University, Medicana International Ankara Hospital, Ankara, Turkiye, from March 2018 to 2022. Methodology: The data were collected to analyse numbers and distributions of physician visits regarding breast cancer. Results: The mean age of patients was 55.98 +/- 12.60 years. The percentages of newly diagnosed cases showed similarity (7.37% vs. 9.79%) before and during the pandemic (p = 0.18). The number of imaging studies decreased by 53.33% in patients under follow-up (p = 0.006), despite screening tests showed a similar trend (p = 0.145). General surgery visits marked up (+44.6%), in contrast to plastic surgery visits (-42.04%, p <0.001). Patients' admissions decreased in many COVID-19 related clinics (pulmonology, emergency, internal medicine, and intensive care), but cardiology (+96.59%) and rehabilitation (+75%) admissions increased during the pandemic (p <0.001). The number of medical oncology and radiation oncology visits did not change (p >0.05). Conclusion: Total number of physician visits was similar before and during the pandemic despite the changing distribution. While COVID-19 led to markedly rising trends of surgical, cardiological, and rehabilitative management in patients with breast cancer, falling trends were seen in other specialities except oncology which showed a plateau during two years. The falling trends of visits to pulmonology, emergency, internal medicine, and intensive care clinics may be explained by crowded COVID-19 cases.Article Citation - WoS: 16Pulmonary Rehabilitation Principles in Sars-Cov Infection (covid-19): the Revised Guideline for the Acute, Subacute, and Post-Covid Rehabilitation(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2021) Aytur, Yesim Kurtais; Koseoglu, Belma Fusun; Taskiran, Ozden Ozyemisci; Ordu-Gokkaya, Nilufer Kutay; Delialioglu, Sibel Unsal; Tur, Birkan Sonel; Tikiz, CananCoronavirus disease 2019 (COVID-19) is a contagious infection disease, which may cause respiratory, physical, psychological, and generalized systemic dysfunction. The severity of disease ranges from an asymptomatic infection or mild illness to mild or severe pneumonia with respiratory failure and/or death. COVID-19 dramatically affects the pulmonary system. This clinical practice guideline includes pulmonary rehabilitation (PR) recommendations for adult COVID-19 patients and has been developed in the light of the guidelines on the diagnosis and treatment of COVID-19 provided by the World Health Organization and Republic of Turkey, Ministry of Health, recently published scientific literature, and PR recommendations for COVID-19 regarding basic principles of PR. This national guideline provides suggestions regarding the PR methods during the clinical stages of COVID-19 and post-COVID-19 with its possible benefits, contraindications, and disadvantages.Article Citation - WoS: 40Citation - Scopus: 53Impacts of Covid-19 Pandemic Period on Depression, Anxiety and Stress Levels of the Healthcare Employees in Turkey(Elsevier Ireland Ltd, 2021) Tengilimoglu, Dilaver; Zekioglu, Aysu; Tosun, Nurperihan; Isik, Oguz; Tengilimoglu, OnurThe COVID-19 pandemic has turned into a public health issue since December 2019 and has risen in all countries in the world. The healthcare employees taking part in the pandemic will eventually be affected by the process. The aim of the study is to determine the levels of the anxiety, depression, and stress of the healthcare employees during the COVID-19 pandemic in Turkey. As the data collection tool, an e-survey was used. In the first section, Depression, Anxiety and Stress Scale (DASS-21) was used. In the second section of the survey, the problems experienced by the healthcare employees during the pandemic and their working media were aimed to be defined. In the last section, the socio-demographic features of the employees were investigated. 2076 healthcare employees participated in the study. The results showed that the major cause of the anxiety or stress among healthcare employees comes from the fear to contaminate the COVID-19 virus to their families (86.9%). It was observed that the levels of depression, anxiety and stress of female employees are higher than that of male employees (p < 0.003). The highest depression, anxiety and stress levels of healthcare employees come from the pandemic, emergency, and internal services (p < 0.001). Health managers and policymakers need to make a move immediately to find solutions for the physical and psychological needs of the health employees. On the other hand, in order to minimize the risk, preparation of the work power plans beforehand and inclusion of obligatory referral chain into health services can be suggested.Article Citation - WoS: 3Citation - Scopus: 3Shared 6mer Peptides of Human and Omicron (21k and 21l) at Sars-Cov Mutation Sites(Mdpi, 2022) Adiguzel, Yekbun; Shoenfeld, YehudaWe investigated the short sequences involving Omicron 21K and Omicron 21L variants to reveal any possible molecular mimicry-associated autoimmunity risks and changes in those. We first identified common 6mers of the viral and human protein sequences present for both the mutant (Omicron) and nonmutant (SARS-CoV-2) versions of the same viral sequence and then predicted the binding affinities of those sequences to the HLA supertype representatives. We evaluated change in the potential autoimmunity risk, through comparative assessment of the nonmutant and mutant viral sequences and their similar human peptides with common 6mers and affinities to the same HLA allele. This change is the lost and the new, or de novo, autoimmunity risk, associated with the mutations in the Omicron 21K and Omicron 21L variants. Accordingly, e.g., the affinity of virus-similar sequences of the Ig heavy chain junction regions shifted from the HLA-B*15:01 to the HLA-A*01:01 allele at the mutant sequences. Additionally, peptides of different human proteins sharing 6mers with SARS-CoV-2 proteins at the mutation sites of interest and with affinities to the HLA-B*07:02 allele, such as the respective SARS-CoV-2 sequences, were lost. Among all, any possible molecular mimicry-associated novel risk appeared to be prominent in HLA-A*24:02 and HLA-B*27:05 serotypes upon infection with Omicron 21L. Associated disease, pathway, and tissue expression data supported possible new risks for the HLA-B*27:05 and HLA-A*01:01 serotypes, while the risks for the HLA-B*07:02 serotypes could have been lost or diminished, and those for the HLA-A*03:01 serotypes could have been retained, for the individuals infected with Omicron variants under study. These are likely to affect the complications related to cross-reactions influencing the relevant HLA serotypes upon infection with Omicron 21K and Omicron 21L.Article Citation - WoS: 3Citation - Scopus: 3Online Learning Perceptions Amid Covid-19 Pandemic: the Engineering Undergraduates' Perspective(Tempus Publications, 2022) Eryilmaz, Meltem; Kalem, Guler; Kilic, Hurevren; Tirkes, Guzin; Topalli, Damla; Turhan, Cigdem; Yazici, Ali; Information Systems Engineering; Computer Engineering; Software EngineeringThe COVID-19 pandemic caused face-to-face education in just about all universities worldwide to shift to online education. For most students, this educational model was a compulsory first experience. In this study, the survey results are analyzed and discussed related to a group of students in the Engineering Faculty of a university in Turkey regarding their online education perceptions. Briefly summarized, the findings of the study indicate that: (a) most of the students still prefer face-to-face learning, which is also favored if accompanied by distance learning; (b) the concentration level of the students has dropped due to the concerns about the COVID-19 pandemic which affects their learning negatively; and (c) around half of the students participating in the study feel that the online exams conducted without a secure exam software, is considered unsafe. Additionally, the study's results were further extended to evaluate the questionnaire results and reported along with the suggestions of necessary actions in emergency online learning (EOL).Article Citation - WoS: 8Citation - Scopus: 8Evaluating the Factors (stress, Anxiety and Depression) Affecting the Mental Health Condition of Nurses During the Covid-19 Pandemic(Sage Publications inc, 2022) Isik, Oguz; Tengilimoglu, Dilaver; Tosun, Nurperihan; Zekioglu, Aysu; Tengilimoglu, OnurThis study aimed to determine the depression, anxiety and stress levels that have negatively impacted nurses' mental health during the COVID-19 pandemic. A sample group of 826 nurses working in Turkey were asked to fill in an online questionnaire in order to evaluate their psychological responses and the related factors that have adversely affected their mental health during the COVID-19 pandemic. In total, 696 nurses (84.3%) showed symptoms of depression, 644 (78%) reported anxiety and 543 (65.74%) reported stress. This study also highlighted that the most concerning factor for the nurses was the risk of transmitting the COVID-19 infection to their household members (89.2%). The most important problems faced by the nurses during COVID-19 included equipment shortages (50.7%), administrative problems (38.5%) and issues such as accommodation and nutrition (27.4%). These were found to have a statistically significant correlation with the nurses' levels of depression, anxiety and stress. The fear of losing a household member, the inability to their household's social needs and the fear of death were among the factors that concerned nurses during the COVID-19 pandemic, significantly affecting their levels of depression, anxiety and stress. Taking the necessary measures to deal with the aforementioned problems and fears is important to protect the health, productivity and efficiency of nurses during the pandemic period.Article Evaluation of Covid-19 Cases Who Received Immunosuppressive Therapy at a Tertiary Care Hospital(Doc design informatics Co Ltd, 2022) Sayar, Merve Sefa; Acar, Ali; Bulut, Dilek; Celik, Sebahattin; Oguz, EminObjective: Immunosuppressive drugs are included in the treatment protocols of severe COVID-19 cases that may present with cytokine storm. In this study, we aimed to examine the characteristics of COVID-19 patients who received immunosuppressive therapy Methods: Patients diagnosed with COVID-19 and followed in the quarantine wards of our hospital between 01.03.2020-24.05.2020 were included in the study. Patient information was obtained retrospectively from patient files and discharge reports, and 263 COVID-19 patients-aged 18 and over-were included in the study. Results: The median age of the patients who received immunosuppressive therapy was 60.74 +/- 1.96, and 39.6% of them were women. The average symptom duration of the patients examined in the study at the time of admission to the hospital was 4.59 +/- 0.29 days. There was a significant difference in age, lymphocyte count, neutrophil/lymphocyte ratio, C-reactive protein, ferritin, D-Dimer, blood oxygen saturation, fever after antiviral therapy, qSOFA score, and total hospital stay between the two groups that received and did not receive immunosuppressive therapy (p<0.05). The need for immunosuppressive therapy increased 15.9 times over the age of 40, 15.6 times in the presence of diffuse involvement on thoracic CT, 6.6 times in the presence of chronic disease, 2.7 times in the presence of thrombocytopenia, and 1.7 times in the presence of lymphopenia (p <0.05).Conclusions: We observed that patients whose immunosuppressive therapy was added to their treatment protocols were admitted to the hospital later than others, had more prevalent involvement in thorax CT, high acute phase reactants, low SPO2, and more than one underlying disease.
