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Article Reinterpreting Architectural Precedents: the Enduring Relevance and Transformative Capacity of Villa Savoye’s Design Principles(Istanbul Teknik Universitesi, Faculty of Architecture, 2025) Cinar, SinemThis paper examines the evolving role of architectural precedents, focusing on Le Corbusier’s Villa Savoye, and emphasizes their continued relevance and transformative capacity within architectural design culture. It illustrates how engagement with precedents influences their reinterpretation and adaptation in changing contexts. Villa Savoye, a defining example of Modern Architecture, gained renewed attention during the COVID-19 pandemic, particularly through its freestanding washbasin at the entrance. This feature suggested a transitional, hygienic space addressing emerging concerns about sanitization upon returning home. Such recognition highlights how precedents can acquire new meaning when viewed through altered perspectives. Building on the idea that precedents like Villa Savoye offer fresh insights as inquiries evolve, this paper extends discourse on precedent and design. It explores the project’s continued relevance to contemporary architecture, emphasizing adaptability of its design principles. The study assesses the lasting impact of these principles—pilotis, open plan, roof garden, horizontal windows, free façade, and architectural promenade— on both Le Corbusier’s later works and contemporary practices. Through an interpretive-historical methodology, the research integrates primary sources and theoretical critiques to illustrate how evolving perspectives shape the relationship between precedent and design. Comparative analyses examine reinterpretations of these principles in Le Corbusier’s later works and contemporary architecture. Ultimately, this study contributes to architectural literature by framing precedents as dynamic resources that facilitate meaningful dialogue between past and present. It emphasizes their capacity to revitalize architectural culture, generating continuous insights in response to evolving challenges. © 2025, Istanbul Teknik Universitesi, Faculty of Architecture. All rights reserved.Article Evaluation of Covid-19 Cases Who Received Immunosuppressive Therapy at a Tertiary Care Hospital(Doc design informatics Co Ltd, 2022) Sayar, Merve Sefa; Acar, Ali; Bulut, Dilek; Celik, Sebahattin; Oguz, EminObjective: Immunosuppressive drugs are included in the treatment protocols of severe COVID-19 cases that may present with cytokine storm. In this study, we aimed to examine the characteristics of COVID-19 patients who received immunosuppressive therapy Methods: Patients diagnosed with COVID-19 and followed in the quarantine wards of our hospital between 01.03.2020-24.05.2020 were included in the study. Patient information was obtained retrospectively from patient files and discharge reports, and 263 COVID-19 patients-aged 18 and over-were included in the study. Results: The median age of the patients who received immunosuppressive therapy was 60.74 +/- 1.96, and 39.6% of them were women. The average symptom duration of the patients examined in the study at the time of admission to the hospital was 4.59 +/- 0.29 days. There was a significant difference in age, lymphocyte count, neutrophil/lymphocyte ratio, C-reactive protein, ferritin, D-Dimer, blood oxygen saturation, fever after antiviral therapy, qSOFA score, and total hospital stay between the two groups that received and did not receive immunosuppressive therapy (p<0.05). The need for immunosuppressive therapy increased 15.9 times over the age of 40, 15.6 times in the presence of diffuse involvement on thoracic CT, 6.6 times in the presence of chronic disease, 2.7 times in the presence of thrombocytopenia, and 1.7 times in the presence of lymphopenia (p <0.05).Conclusions: We observed that patients whose immunosuppressive therapy was added to their treatment protocols were admitted to the hospital later than others, had more prevalent involvement in thorax CT, high acute phase reactants, low SPO2, and more than one underlying disease.
