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Article Citation - WoS: 12Citation - Scopus: 12Mutual Correlation of Nist Statistical Randomness Tests and Comparison of Their Sensitivities on Transformed Sequences(Tubitak Scientific & Technological Research Council Turkey, 2017) Doganaksoy, Ali; Sulak, Fatih; Uguz, Muhiddin; Seker, Okan; Akcengiz, ZiyaRandom sequences are widely used in many cryptographic applications and hence their generation is one of the main research areas in cryptography. Statistical randomness tests are introduced to detect the weaknesses or nonrandom characteristics that a sequence under consideration may have. In the literature, there exist various statistical randomness tests and test suites, defined as a collection of tests. An efficient test suite should consist of a number of uncorrelated statistical tests each of which measures randomness from another point of view. `Being uncorrelated' is not a well-defined or well-understood concept in the literature. In this work, we apply Pearson's correlation test to measure the correlation between the tests. In addition, we define five new methods for transforming a sequence. Our motivation is to detect those tests whose results are invariant under a certain transformation. To observe the correlation, we use two methods. One is the direct correlation between the tests and the other is the correlation between the results of a test on the sequence and its transformed form. In light of the observations, we conclude that some of the tests are correlated with each other. Furthermore, we conclude that in designing a reliable and efficient suite we can avoid overpopulating the list of test functions by employing transformations together with a reasonable number of statistical test functions.Article Citation - WoS: 5Citation - Scopus: 10Quality of Service Assessment: a Case Study on Performance Benchmarking of Cellular Network Operators in Turkey(Tubitak Scientific & Technological Research Council Turkey, 2015) Kadioglu, Rana; Dalveren, Yaser; Dalveren, Yaser; Kara, Ali; Kara, Ali; Dalveren, Yaser; Kara, Ali; Department of Electrical & Electronics Engineering; Department of Electrical & Electronics EngineeringThis paper presents findings on performance benchmarking of cellular network operators in Turkey. Benchmarking is based on measurements of standard key performance indicators (KPIs) in one of the metropolitan cities of Turkey, Ankara. Performance benchmarking is formulated by incorporating customer perception by conducting surveys on how important KPIs are from the user's point of view. KPIs are measured, with standard test equipment, by drive test method on specified routes. According to the performance benchmarking results, the GSM and UMTS network operators achieving the best performance were determined in Ankara. Speech qualities of network operators, as the most popular service, were also evaluated by several statistical methods including pdf/cdf analysis and chi-square and Fisher's exact tests. The network operator providing the highest speech quality in Ankara was determined with the methods applied. Overall, the results and approaches on benchmarking of cellular networks in Turkey are reported for the first time in this paper. The approaches proposed in this paper could be adapted to wide-scale benchmarking of services in cellular networks.Article Neuron Modeling: Estimating the Parameters of a Neuron Model From Neural Spiking Data(Tubitak Scientific & Technological Research Council Turkey, 2018) Doruk, Resat OzgurWe present a modeling study aiming at the estimation of the parameters of a single neuron model from neural spiking data. The model receives a stimulus as input and provides the firing rate of the neuron as output. The neural spiking data will be obtained from point process simulation. The resultant data will be used in parameter estimation based on the inhomogeneous Poisson maximum likelihood method. The model will be stimulated by various forms of stimuli, which are modeled by a Fourier series (FS), exponential functions, and radial basis functions (RBFs). Tabulated results presenting cases with different sample sizes (# of repeated trials), stimulus component sizes (FS and RBF), amplitudes, and frequency ranges (FS) will be presented to validate the approach and provide a means of comparison. The results showed that regardless of the stimulus type, the most effective parameter on the estimation performance appears to be the sample size. In addition, the lowest variance of the estimates is obtained when a Fourier series stimulus is applied in the estimation.Article Citation - WoS: 1Citation - Scopus: 1A Short Note on Some Arithmetical Properties of the Integer Part of Ap(Tubitak Scientific & Technological Research Council Turkey, 2019) Akbal, YıldırımLet $a>0$ be an irrational number. We study some of the arithmetical properties of ${\\{\\lfloor ap\\rfloor\\}}_{p=2}^\\infty$ where pdenotes a prime number and $\\lfloor x\\rfloor$ denotes the largest integer not exceeding x.Article Citation - WoS: 12Citation - Scopus: 12A Polarity Calculation Approach for Lexicon-Based Turkish Sentiment Analysis(Tubitak Scientific & Technological Research Council Turkey, 2019) Yurtalan, Gökhan; Koyuncu, Murat; Turhan, ÇiğdemSentiment analysis attempts to resolve the senses or emotions that a writer or speaker intends to send across tothe people about an object or event. It generally uses natural language processing and/or artificial intelligence techniquesfor processing electronic documents and mining the opinion specified in the content. In recent years, researchers haveconducted many successful sentiment analysis studies for the English language which consider many words and wordgroups that set emotion polarities arising from the English grammar structure, and then use datasets to test theirperformance. However, there are only a limited number of studies for the Turkish language, and these studies have lowerperformance results compared to those studies for English. The reasons for this can be incorrect translation of datasetsfrom English into Turkish and ignoring the special grammar structures in the latter. In this study, special Turkish wordsand linguistic constructs which affect the polarity of a sentence are determined with the aid of a Turkish linguist, and anappropriate lexicon-based polarity determination and calculation approach is introduced for this language. The proposedmethodology is tested using different datasets collected from Twitter, and the test results show that the proposed systemachieves better accuracy than the previously developed lexical-based sentiment analysis systems for Turkish. The authorsconclude that especially analysis of word groups increases the overall performance of the system significantly.Article Citation - WoS: 9Citation - Scopus: 10Impact of Hospital-Acquired Acute Kidney Injury on Covid-19 Outcomes in Patients With and Without Chronic Kidney Disease: a Multicenter Retrospective Cohort Study(Tubitak Scientific & Technological Research Council Turkey, 2021) Ozturk, Savas; Turgutalp, Kenan; Arıcı, Mustafa; Çetinkaya, Hakkı; Altıparmak, Mehmet Rıza; Aydın, Zeki; Ateş, KenanBackground/aim: Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There is little comparative data investigating the effect of HA-AKI on mortality of chronic kidney disease (CKD) patients and a control group of general population suffering from Covid-19. Materials and methods: HA-AKI development was assessed in a group of stage 3–5 CKD patients and control group without CKD among adult patients hospitalized for Covid-19. The role of AKI development on the outcome (in-hospital mortality and admission to the intensive care unit [ICU]) of patients with and without CKD was compared. Results: Among 621 hospitalized patients (age 60 [IQR: 47–73]), women: 44.1%), AKI developed in 32.5% of the patients, as stage 1 in 84.2%, stage 2 in 8.4%, and stage 3 in 7.4%. AKI developed in 48.0 % of CKD patients, whereas it developed in 17.6% of patients without CKD. CKD patients with HA-AKI had the highest mortality rate of 41.1% compared to 14.3% of patients with HA-AKI but no CKD (p < 0.001). However, patients with AKI+non-CKD had similar rates of ICU admission, mechanical ventilation, and death rate to patients with CKD without AKI. Adjusted mortality risks of the AKI+non-CKD group (HR: 9.0, 95% CI: 1.9–44.2) and AKI+CKD group (HR: 7.9, 95% CI: 1.9–33.3) were significantly higher than that of the non-AKI+non-CKD group. Conclusion: AKI frequently develops in hospitalized patients due to Covid-19 and is associated with high mortality. HA-AKI has worse outcomes whether it develops in patients with or without CKD, but the worst outcome was seen in AKI+CKD patients.Key words: Acute kidney injury, chronic kidney disease, Covid-19, hospitalization, mortalityArticle Characterizations of the Commutators Involving Idempotents in Certain Subrings of $m_{2}(\mathbb{z})$(Tubitak Scientific & Technological Research Council Turkey, 2023) Ozdin, Tufan; Gumusel, GunseliIn this paper, we characterize the idempotency, cleanness, and unit-regularity of the commutator [E1, E2] = E1E2 - E2E1 involving idempotents E1, E2 in certain subrings of M2(Z).Article Citation - WoS: 32Citation - Scopus: 32On the Independence of Statistical Randomness Tests Included in the Nist Test Suite(Tubitak Scientific & Technological Research Council Turkey, 2017) Sulak, Fatih; Uguz, Muhiddin; Kocak, Onur; Doganaksoy, AliRandom numbers and random sequences are used to produce vital parts of cryptographic algorithms such as encryption keys and therefore the generation and evaluation of random sequences in terms of randomness are vital. Test suites consisting of a number of statistical randomness tests are used to detect the nonrandom characteristics of the sequences. Construction of a test suite is not an easy task. On one hand, the coverage of a suite should be wide; that is, it should compare the sequence under consideration from many different points of view with true random sequences. On the other hand, an overpopulated suite is expensive in terms of running time and computing power. Unfortunately, this trade-off is not addressed in detail in most of the suites in use. An efficient suite should avoid use of similar tests, while still containing sufficiently many. A single statistical test gives a measure for the randomness of the data. A collection of tests in a suite give a collection of measures. Obtaining a single value from this collection of measures is a difficult task and so far there is no conventional or strongly recommended method for this purpose. This work focuses on the evaluation of the randomness of data to give a unified result that considers all statistical information obtained from different tests in the suite. A natural starting point of research in this direction is to investigate correlations between test results and to study the independences of each from others. It is started with the concept of independence. As it is complicated enough to work even with one test function, theoretical investigation of dependence between many of them in terms of conditional probabilities is a much more difficult task. With this motivation, in this work it is tried to get some experimental results that may lead to theoretical results in future works. As experimental results may reflect properties of the data set under consideration, work is done on various types of large data sets hoping to get results that give clues about the theoretical results. For a collection of statistical randomness tests, the tests in the NIST test suite are considered. Tests in the NIST suite that can be applied to sequences shorter than 38,912 bits are analyzed. Based on the correlation of the tests at extreme values, the dependencies of the tests are found. Depending on the coverage of a test suite, a new concept, the coverage efficiency of a test suite, is defined, and using this concept, the most efficient, the least efficient, and the optimal subsuites of the NIST suite are determined. Moreover, the marginal benefit of each test, which also helps one to understand the contribution of each individual test to the coverage efficiency of the NIST suite, is found. Furthermore, an efficient subsuite that contains five statistical randomness tests is proposed.Article Citation - WoS: 3Citation - Scopus: 5Investigation of the Effect of Hyperthyroidism on Endoplasmic Reticulum Stress and Transient Receptor Potential Canonical 1 Channel in the Kidney(Tubitak Scientific & Technological Research Council Turkey, 2021) Aykanat, Nuriye Ezgi Bektur; Şahin, Erhan; Kaçar, Sedat; Bağcı, Rıdvan; Karakaya, Şerife; Dönmez, Dilek Burukoğlu; Şahintürk, VarolBackground/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in the kidneys of hyperthyroid rats in terms of ER stress markers that are glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), (protein kinase R (PKR)-like endoplasmic reticulum kinase) (PERK), Inositol-requiring enzyme 1 (IRE1). Materials and methods: Twenty male rats were assigned into control and hyperthyroid groups (n = 10). Hyperthyroidism was induced by adding 12 mg/L thyroxine into the drinking water of rats for 4 weeks. The serum-free T3 and T4 (fT3, fT4), TSH, blood urea nitrogen (BUN), and creatinine levels were measured. The histochemical analysis of kidney sections for morphological changes and also immunohistochemical and western blot analysis of kidney sections were performed for GRP78, ATF6, PERK, IRE1, TRPC1 antibodies. Results: TSH, BUN, and creatinine levels decreased while fT3 and fT4 levels increased in the hyperthyroid rat. The morphologic analysis resulted in the capillary basal membrane thickening in glomeruli and also western blot, and immunohistochemical results showed an increase in TRPC1, GRP78, and ATF6 in the hyperthyroid rat (p < 0.05). Conclusion: In conclusion, in our study, we showed for the first time that the relationship between ER stress and TRPC1, and their increased expression caused renal damage in hyperthyroid rats.Key words: Hyperthyroidism, endoplasmic reticulum (ER) stress, transient receptor potential canonical 1 (TRPC1), kidney, ratArticle Fedja’s Proof of Deepti’s Inequality(Tubitak Scientific & Technological Research Council Turkey, 2018) Ostrovska, Sofiya; Turan, MehmetThe paper aims to present, in a systematic way, an elegant proof of Deepti’s inequality. Both the inequalityand various ideas concerning the issue were discussed on the Mathoverflow website by a number of users, but none haveappeared in the literature thus far. In this work, suggestions pertaining to users ‘Deepti’ and ‘fedja’ are traced, whencethe title. The results or the paper are new, and the proof is divided into a series of statements, many of which are ofinterest in themselves.
