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Article Citation - WoS: 66Citation - Scopus: 89The Potential Medicinal Value of Plants From Asteraceae Family With Antioxidant Defense Enzymes as Biological Targets(Taylor & Francis Ltd, 2015) Koc, Suheda; Isgor, Belgin S.; Isgor, Yasemin G.; Moghaddam, Naznoosh Shomali; Yildirim, OzlemContext: Plants and most of the plant-derived compounds have long been known for their potential pharmaceutical effects. They are well known to play an important role in the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from plant-derived ancestors in the history of medicine. Objective: The aim of this study was to evaluate the free radical scavenging activity and total phenolic and flavonoid contents of methanol, ethanol, and acetone extracts from flowers and leaves of Onopordum acanthium L., Carduus acanthoides L., Cirsium arvense (L.) Scop., and Centaurea solstitialis L., all from the Asteraceae family, for investigating their potential medicinal values of biological targets that are participating in the antioxidant defense system such as catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx). Materials and methods: In this study, free radical scavenging activity and total phenolic and flavonoid contents of the plant samples were assayed by DPPH, Folin-Ciocalteu, and aluminum chloride colorimetric methods. Also, the effects of extracts on CAT, GST, and GPx enzyme activities were investigated. Results and discussion: The highest phenolic and flavonoid contents were detected in the acetone extract of C. acanthoides flowers, with 90.305 mg GAE/L and 185.43 mg Q/L values, respectively. The highest DPPH radical scavenging was observed with the methanol leaf extracts of C. arvense with an IC50 value of 366 ng/mL. The maximum GPx and GST enzyme inhibition activities were observed with acetone extracts from the flower of C. solstitialis with IC50 values of 79 and 232 ng/mL, respectively.Article Citation - WoS: 2Citation - Scopus: 2Cb65 and Novel Cb65 Liposomal System Suppress Mg63 and Saos-2 Osteosarcoma Cell Growth in Vitro(Taylor & Francis Ltd, 2024) Zorba, Basak Isil; Boyacioglu, Oezge; Caglayan, Tugba; Recber, Tuba; Nemutlu, Emirhan; Eroglu, Ipek; Korkusuz, PetekCurable approaches for primary osteosarcoma are inadequate and urge investigation of novel therapeutic formulations. Cannabinoid ligands exert antiproliferative and apoptotic effect on osteosarcoma cells via cannabinoid 2 (CB2) or transient receptor potential vanilloid type (TRPV1) receptors. In this study, we confirmed CB2 receptor expression in MG63 and Saos-2 osteosarcoma cells by qRT-PCR and flow cytometry (FCM), then reported the reduction effect of synthetic specific CB2 receptor agonist CB65 on the proliferation of osteosarcoma cells by WST-1 (water-soluble tetrazolium-1) and RTCA (real-time impedance-based proliferation). CB65 revealed an IC50 (inhibitory concentration) for MG63 and Saos-2 cells as 1.11 x 10(-11) and 4.95 x 10(-11) M, respectively. The specific antiproliferative effect of CB65 on osteosarcoma cells was inhibited by CB2 antagonist AM630. CB65 induced late apoptosis of MG63 and Saos-2 cells at 24 and 48 h, respectively by FCM when applied submaximal concentration. A novel CB65 liposomal system was generated by a thin film hydration method with optimal particle size (141.7 +/- 0.6 nm), polydispersity index (0.451 +/- 0.026), and zeta potential (-10.9 +/- 0.3 mV) values. The encapsulation efficiency (EE%) of the CB65-loaded liposomal formulation was 51.12%. The CB65 and CB65-loaded liposomal formulation releasing IC50 of CB65 reduced proliferation by RTCA and invasion by scratch assay and induced late apoptosis of MG63 and Saos-2 cells, by FCM. Our results demonstrate the CB2 receptor-mediated antiproliferative and apoptotic effect of a new liposomal CB65 delivery system on osteosarcoma cells that can be used as a targeted and intelligent tool for bone tumors to ameliorate pediatric bone cancers following in vivo validation.Review Citation - WoS: 18Citation - Scopus: 24A Literature Review on Mhe Selection Problem: Levels, Contexts, and Approaches(Taylor & Francis Ltd, 2015) Saputro, Thomy Eko; Masudin, Ilyas; Rouyendegh (Babek Erdebilli), Babak DaneshvarThis paper presents a review on selection problem of material handling equipment (MHE) and general equipment used in industry area. The issue on MHE is widely paid attention since MHE has contribution on material, good and product accomplishment. Few methods and softwares have been proposed and developed to select the most appropriate MHE for a complex selection problem. Today's high diverisity of MHE categories and types influence the generation of many possible choices which leads to the complexity. In this paper, a further discussion in terms of MHE and equipment including three major points namely level of selection, the context of selection problem and the approaches are served to highlight the complex MHE selection according to the number of possible choices provided, to analyse the consideration for the problem context, and to reveal the superior method for complex MHE selection. Forty-two papers collected from the past study are presented asscociating each point of the discussion.Review Citation - WoS: 8Citation - Scopus: 9Latest Developments in Engineered Skeletal Muscle Tissues for Drug Discovery and Development(Taylor & Francis Ltd, 2023) Ostrovidov, Serge; Ramalingam, Murugan; Bae, Hojae; Orive, Gorka; Fujie, Toshinori; Shi, Xuetao; Kaji, HirokazuIntroductionWith the advances in skeletal muscle tissue engineering, new platforms have arisen with important applications in biology studies, disease modeling, and drug testing. Current developments highlight the quest for engineering skeletal muscle tissues with higher complexity . These new human skeletal muscle tissue models will be powerful tools for drug discovery and development and disease modeling.Areas coveredThe authors review the latest advances in in vitro models of engineered skeletal muscle tissues used for testing drugs with a focus on the use of four main cell culture techniques: Cell cultures in well plates, in microfluidics, in organoids, and in bioprinted constructs. Additional information is provided on the satellite cell niche.Expert opinionIn recent years, more sophisticated in vitro models of skeletal muscle tissues have been fabricated. Important developments have been made in stem cell research and in the engineering of human skeletal muscle tissue. Some platforms have already started to be used for drug testing, notably those based on the parameters of hypertrophy/atrophy and the contractibility of myotubes. More developments are expected through the use of multicellular types and multi-materials as matrices . The validation and use of these models in drug testing should now increase.Article Citation - WoS: 7Citation - Scopus: 8Analysis of the Two-Unit Cold Standby Repairable System With Damage and Repair Time Dependency Via Matrix-Exponential Distributions(Taylor & Francis Ltd, 2021) Kus, Coskun; Eryilmaz, SerkanIn this paper, two-unit standby repairable system is studied via matrix-exponential distributions. The system under concern consists of one active and one standby components, and fails if either a damage size upon the failure of the active component is larger than a repair limit or the repair time of the failed unit exceeds the lifetime of the active unit, whichever happens first. Under the assumption that the damage size and repair time are statistically dependent, the Laplace transform of the system's lifetime is obtained. The Laplace transform is shown to be rational under particular cases, and the reliability evaluation of the system is performed via well-known distributional properties of the matrix-exponential distributions. The problem of estimating the unknown parameters of the operation time and repair time distributions is also discussed based on system's lifetime data.Article Citation - WoS: 24Citation - Scopus: 42Using Learning Styles Theory in Engineering Education(Taylor & Francis Ltd, 2008) Cagiltay, Nergiz ErcilStudies have shown that, while learning different concepts, people sometimes take different approaches (learning styles). Accordingly, their performance reflected differently in their academic studies. With the effect of globalisation to the educational environments, the influence of individual learning styles on educational performance is getting more significant. In this study, a learning style assessment tool was used to examine the relationship between students' learning styles and their performance in engineering education programmes. At the beginning of the programme, 285 students' learning styles were measured using a learning style assessment tool. Four years after the engineering education, their performance in the programme was compared with their individual learning styles. This study shows that most of the students are assimilators. Divergers and convergers follow the assimilators. The number of accommodators is very limited. The relationship between engineering students' learning styles and their performance is found: assimilators and convergers performed better than the divergers and accommodators. The performance difference between assimilators and divergers is statistically significant. The results of this study show that the learning style theory is a potential tool for guiding the design and improvement of courses and helping students to improve their individual performance.Article Citation - WoS: 3Citation - Scopus: 3On the Fixed Points of Iterative Contractive Mappings Defined Via Implicit Relation(Taylor & Francis Ltd, 2021) Aksoy, Umit; Erhan, Inci M.; Fulga, Andreea; Karapinar, ErdalIn this paper, we consider an implicit relation to generalize iterative fixed point results in the literature in the context of metric spaces. We conclude that several existing results are immediate consequences of our main results.Article Citation - WoS: 8Citation - Scopus: 15Identification of Linear Handling Models for Road Vehicles(Taylor & Francis Ltd, 2008) Arikan, K. B.; Unlusoy, Y. S.; Korkmaz, I.; Celebi, A. O.This study reports the identification of linear handling models for road vehicles starting from structural identifiability analysis, continuing with the experiments to acquire data on a vehicle equipped with a sensor set and data acquisition system, and ending with the estimation of parameters using the collected data. The model structure originates from the well-known linear bicycle model that is frequently used in handling analysis of road vehicles. Physical parameters of the bicycle model structure are selected as the unknown parameter set that is to be identified. Global identifiability of the model structure is analysed, in detail, and concluded according to various available sensor sets. Physical parameters of the bicycle model structure are estimated using prediction error estimation method. Genetic algorithms are used in the optimisation phase of the identification algorithm to overcome the difficulty in the selection of initial values for parameter estimates. Validation analysis of the identified model is also presented. The identified model is shown to track the system response successfully.Article Citation - WoS: 22Citation - Scopus: 25Facile synthesis of CsPbBr3/PbSe composite clusters(Taylor & Francis Ltd, 2018) Thang Phan Nguyen; Ozturk, Abdullah; Park, Jongee; Sohn, Woonbae; Tae Hyung Lee; Jang, Ho Won; Kim, Soo YoungIn this work, CsPbBr3 and PbSe nanocomposites were synthesized to protect perovskite material from self-enlargement during reaction. UV absorption and photoluminescence (PL) spectra indicate that the addition of Se into CsPbBr3 quantum dots modified the electronic structure of CsPbBr3, increasing the band gap from 2.38 to 2.48 eV as the Cs:Se ratio increased to 1:3. Thus, the emission color of CsPbBr3 perovskite quantum dots was modified from green to blue by increasing the Se ratio in composites. According to X-ray diffraction patterns, the structure of CsPbBr3 quantum dots changed from cubic to orthorhombic due to the introduction of PbSe at the surface. Transmission electron microscopy and X-ray photoemission spectroscopy confirmed that the atomic distribution in CsPbBr3/PbSe composite clusters is uniform and the composite materials were well formed. The PL intensity of a CsPbBr3/PbSe sample with a 1:1 Cs: Se ratio maintained 50% of its initial intensity after keeping the sample for 81 h in air, while the PL intensity of CsPbBr3 reduced to 20% of its initial intensity. Therefore, it is considered that low amounts of Se could improve the stability of CsPbBr3 quantum dots.Article Citation - WoS: 15Citation - Scopus: 21Software Engineering Education: Some Important Dimensions(Taylor & Francis Ltd, 2007) Mishra, Alok; Cagiltay, Nergiz Ercil; Kilic, OzkanSoftware engineering education has been emerging as an independent and mature discipline. Accordingly, various studies are being done to provide guidelines for curriculum design. The main focus of these guidelines is around core and foundation courses. This paper summarizes the current problems of software engineering education programs. It also proposes some important dimensions as integral parts of software engineering education: interdisciplinary skills, practice experience, communication, skills on continuing education and professionalism. In the current guidelines and studies these dimensions are not addressed specifically. Although there could be other dimensions to be considered in software engineering education, we believe that the proposed ones are very crucial as software engineering is evolving more rapidly than any other engineering discipline. This study also provides a survey of some major universities' undergraduate software engineering programs to evaluate these dimensions.
