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Article Citation - WoS: 6Synthesis and Biological Study of Novel Indole-3 Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors(Bentham Science Publ Ltd, 2013) Kurt, Z. Kilic; Aydin, D.; Isgor, Y. G.; Isgor, B. S.; Olgen, S.The aim of this study is to design and synthesize novel dual inhibitors of Src protein tyrosine kinase (PTK) and Glutathione S-transferases (GSTs), as a potential drug lead with therapeutic efficacy on cancer and immune disorders. The biological activity profiling of small molecule inhibitors via miniaturized biochemical techniques compatible with medium throughput screening and focused screening methodologies were performed. To determining the effects of small molecule inhibitors on Src kinase and Phase II detoxification enzyme GST isozymes in liver homogenates used to verify their roles in drug resistance mechanism for cancer chemotherapeutics. In this study, 14 indole-3-imine-2-on and N-benzyl indole-3-imine-2-on derivatives were synthesized for dual activities against Src and GST. The chemical structures and purities of compounds were verified by IR, H-1 NMR, MASS spectroscopy, and elemental analysis. The compounds 2, 3 and 9 are found slightly active against both enzyme Src and GST.Article On a Boundary Value Problem for a Class of Second-Order Complex Partial Differential Equations(Univ Simon Bolivar, 2023) Aksoy, Umit; Celebi, Ahmet OkayIn this article, a boundary value problem for a second-order complex partial differential equation whose main part is the Laplacian, is introduced and its solvability is discussed by reduction of the problem into the Schwarz problem for a first-order equation. The condition for solvability is presented and an estimate for the unique solution is provided.Article Correlation of Clinical Signs and Magnetic Resonance Imaging Findings in Patients With Lumbar Spondylosis(Turkish League Against Rheumatism, 2023) Altan, Lale; Ökmen, Burcu Metin; Tuncer, Tiraje; Sindel, Dilşad; Çay, Hasan Fatih; Hepgüler, Simin; Uğurlu, HaticeObjectives: The purpose of the study was to contribute further to this debated topic by investigating the correlation of magnetic resonance imaging (MRI) findings with the clinical picture in lumbar spondylosis patients. Patients and methods: This multicenter retrospective study (as part of the epidemiological project of the TLAR-OASG [Turkish League Against Rheumatism-Osteoarthritis Study Group]) included 514 patients (101 males, 413 females; mean age: 63.6±10.8 years; range, 40 to 85 years) who were diagnosed as lumbar spondylosis by clinical examination and direct X-ray between December 2016 and June 2018. Demographic characteristics of patients, Visual Analog Scale for pain, presence of radiating pain, Roland-Morris disability questionnaire, straight leg raise test, deep tendon reflexes, neurogenic intermittent claudication symptoms, any decrease of muscle strength, and abnormality of sensation were recorded. Lumbar MRI findings of the patients were recorded as positive or negative in terms of disc herniation, intervertebral disc degeneration, root compression, osteophytes, spinal stenosis. Statistical analysis was done to assess the correlation between the clinical symptoms, physical examination, and MRI findings. Results: Correlation analysis of the MRI results and the clinical findings showed a significant correlation between straight leg raise test and root compression (p<0.001, r=0.328) and a significant correlation between neurogenic intermittent claudication and spinal stenosis (p<0.001, r=0.376). Roland-Morris disability questionnaire had a significant correlation with all MRI findings (p<0.05, r<0.200). Conclusion: The results of this study corroborate the notion that diligent patient history and physical examination are more valuable than MRI findings, even though a higher incidence of abnormal MRI findings have been obtained in patients with disability and dermatomal radiating pain.Article Citation - WoS: 1Citation - Scopus: 1Can Job Crafting Be a Remedy for Struggling With Work Alienation? the Moderator Effect of Perceived Supervisor Support*(Nomos verlagsgesellschaft Mbh & Co Kg, 2022) Aydin, Esra; Cinar, Esra; Basim, H. NejatDrawing on self-determination theory, this study focuses on the relationship between job crafting and work alienation and the moderating effect of perceived supervisor support. Based on theoretical discussions, this study examines (1) whether a negative relationship exists between job crafting and work alienation; (2) whether and how perceived supervisor support moderates that relationship. Findings are based on the data collected from a survey of 203 participants working in Turkey. The results indicate job crafting's negative association with work alienation. Perceived supervisor support is a moderating variable, fostering employee that, in turn, leads to reduced work alienation.Article Citation - WoS: 3Citation - Scopus: 4Structural, Optical and Electrical Properties of Bi1.5zn0.92< Pyrochlore Ceramics(Univ Fed Sao Carlos, dept Engenharia Materials, 2021) Qasrawi, A. F.; Abdalghafour, Mays A.; Mergen, A.Herein, the structural, morphological, compositional, optical, electrical and dielectric properties of Bi1.5Zn0.92Nb1.5-6x/5WxO6.92 (BZN) solid solutions are reported. Tungsten substituted BZN ceramics which are fabricated by the solid state reaction technique exhibited solubility limits at substitution level below x=0.18. Remarkable engineering in the structural, optical, electrical and dielectric properties of the pyrochlore ceramics is achieved via W substitution. Namely, shrinkage in both of the lattice parameters and in the energy band gap accompanied with decrease in the microstrain, in the dielectric constant and in the electrical resistivity is observed upon increasing the W content below the solubility limit. The increase in the W content in the BZN ceramics enhances the densification of the pyrochlore and leads to higher light absorbability and larger crystallites growth. The temperature dependent electrical resistivity measurements has also shown that the pyrochlore exhibit thermal stability below 380 K.Article Citation - WoS: 1Retrospective Evaluation of Potential Rabies Exposure Cases Over Nine Years: Single-Center Experience(Bilimsel Tip Yayinevi, 2024) Demircan, Serife Altun; Kilic, Esra Kaya; Tulek, Necla; Kinikli, Sami; Bulut, CemalIntroduction: T & uuml;rkiye is the only European country where suspected rabies exposure from animal contact is a significant public health concern. In this study, we evaluate cases investigated in our vaccination center, where individuals with suspected rabies exposure have been seeking consultation for many years. The evaluation encompasses demographic characteristics, distribution by years and seasons, the type of animal involved in the contact, the prevalence of stray animals, and the rabies vaccination status of owned animals. Materials and Methods: The study involves cases reported to the Public Health Center from those who sought consultation at our center between January 1, 2011, and December 31, 2019. Demographic characteristics, distribution by years and seasons, the type of animal involved in the contact, the prevalence of stray animals, and the rabies vaccination status of owned animals were retrospectively evaluated. Results: Over the nine years, there were a total of 39.731 cases, resulting in an average of 4414 cases per year. Of these cases, 61% were male, and 68.83% were between the ages of 15 and 64. The most cases occurred in summer and autumn. Of the suspected rabies contacts, 69% involved dogs, and 83.4% of these dogs were unowned. Forty-one point eight percent of the owned dogs were vaccinated. Eighty-nine point six percent of the cats were unowned, and the rate of vaccination among the owned cats was 28.2%. Over the years, there has been a decrease in the use of the 10 -day observation approach, while an increase in the administration of rabies vaccine and/or immunoglobulin has been observed. Conclusion: Seventy percent of all risky rabies contacts involve dogs, with a high rate of 84% of these dogs being unowned. To mitigate contact involving the risk of rabies, addressing the uncontrolled reproduction of stray animals, particularly dogs, and ensuring control and vaccination of the existing animal population appear to be primary measures. Improving the vaccination rate of owned animals, currently at only 30-40%, can prevent people from encountering risky rabies contacts, thereby potentially reducing the need for rabies prophylaxis significantly.Article Citation - WoS: 4Citation - Scopus: 6A Test Bench To Study Bioinspired Control for Robot Walking(Romanian Soc Control Tech informatics, 2011) Arikan, Kutluk B.; Irfanoglu, Bulent; Department of Mechatronics EngineeringTest bench to study robot walking within the predicted structures of biological control systems is discussed. Physical system is briefly presented with components. Kinematic model and evolutionary way of gait generation for the leg structure in test bench is discussed. Different forms of gaits can be found by genetic optimization using patterns formed by central pattern generators.Article Citation - WoS: 6Effectiveness of Proprioceptive Neuromuscular Facilitation and Myofascial Release Techniques in Patients With Subacromial Impingement Syndrome(Taylor & Francis Ltd, 2022) Celik, Merve Sinem; Sonmezer, Emel; Acar, ManolyaPurpose To compare the effectiveness of proprioceptive neuromuscular facilitation and myofascial release technique in patients with subacromial impingement syndrome on pain, range of motion, muscle strength, quality of life, functionality and disability. Methods Thirty patients were randomly divided into two groups: proprioceptive neuromuscular facilitation group (n = 15) and proprioceptive neuromuscular facilitation combined with myofascial release technique group (n = 15). Both treatment methods were performed 3 times a week for 4 weeks. Pain severity was assessed by Visuel Analog Scale, range of motion by a goniometer, muscle strength by digital hand dynamometer, quality of life by Nottingham health profile, functionality by arm, shoulder and hand problems questionnaire, disability by shoulder pain and disability index. All measurements were used before and after treatments. Pain severity, range of motion and muscle strength were also evaluated after the first session. Results After the treatment, shoulder pain, range of motion, muscle strength, functionality and disability were improved in two groups (p < 0.05). Proprioceptive neuromuscular facilitation showed improvement in pain, whereas myofascial release technique improved pain, physical activity, emotional state, sleep and total dimensions of life quality (p < 0.05). Proprioceptive neuromuscular facilitation was more effective in reducing activity pain, whereas myofascial release technique was more effective in increasing flexion, external and internal rotation range of motion, flexion and abduction muscle strength after the first session (p < 0.05). Conclusions The combined application of proprioceptive neuromuscular facilitation and myofascial release technique has a more acute and cumulative positive effect on pain, range of motion, muscle strength, functionality, disability and quality of life in patients with subacromial impingement syndrome.Article Citation - WoS: 12Citation - Scopus: 15Discrete Parameter-Nonlinear Constrained Optimisation of a Gear Train Using Genetic Algorithms(inderscience Enterprises Ltd, 2005) Dolen, M.; Kaplan, H.; Seireg, A.This paper investigates the optimal design of a four-stage gear train using genetic algorithms. Five different genetic encoding schemes, which incorporate various heuristic search techniques, are proposed to deal with the most critical constraints of the problem. The fitness criterion used by all genetic algorithms includes a merit function for minimising the size of the gearbox. The results show improvement in the design merit over previous approaches without reliance on the designer's interaction to avoid geometric constraint violations and facilitate the convergence.Article Analysing the Views of School of Foreignlanguages Instructors About Organizationalculture(Ani Publishing, 2021) Akman, Devrim; Koşar, DidemThis study aims to investigate the views of school of foreignlanguages instructors about organizational culture. The study is designed inqualitative research method and as a case study. The study was conductedwith 15 school of foreign languages instructors who were selected bymaximum variation sampling method during the 2018 and 2019 academicyear in Ankara. Semi structured interviews were conducted to gather dataand content analysis was used to analyse the data. The study emphasisesthat for the powerful school culture, instructors should focus on orientation,social activities, merit, and democratic management style.
