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Article Serum Asporin Levels in Maintenance Hemodialysis Patients Without Osteoarthritis(Galenos Publishing House, 2023) Dursun, Ali Doğan; Dursun, Ali Doğan; Demir, Canan; Demir, Canan; Dursun, Ali Doğan; Demir, Canan; Basic Sciences; Basic SciencesAims: Several human and experimental studies have shown that small leucine-rich proteoglycans might play a significant role in inflammation and fibrosis in various renal diseases. However, as far as we know, no study has reported asporin levels in patients with advanced renal disease. The primary aim of this study was to determine serum asporin levels in hemodialysis (HD) patients without symptomatic osteoarthritis. Methods: This single-center, cross-sectional study prospectively enrolled maintenance HD patients and healthy control subjects. Subjects with clinically clear osteoarthritis were excluded. Serum asporin level was measured via Human ASPN (Asporin) ELISA Kit (Elabscience Biotechnology Inc. Houston, Texas, USA) in fasting blood samples. Results: The study included 25 (mean age: 43.3±13.5 years, 60% were females) patients and 29 control subjects (mean age: 38.0±8.8 years, 37.9% were females). Patients and controls were similar in age and sex. Serum asporin levels were significantly higher in HD patients compared with the controls 2.4 (0.9-4.8) ng/mL vs. 0.3 (0.2-0.6) ng/mL, respectively, p<0.001). Asporin levels were not correlated with age (r=0.344, p=0.092) and the duration of HD (r=0.385, p=0.077). Among HD patients, asporin level was not significantly correlated with C-reactive protein, parathyroid hormone, calcium, or phosphorus levels. Conclusions: This study showed that serum asporin levels were significantly elevated in patients undergoing HD. Further studies must elucidate the possible origins of increased asporin in these patients.Article Relationship of Lumbar Spinal Anatomical Structures With Lumbar Disc Hernia and Spinal Stenosis(Galenos Publishing House, 2024) Küçükyıldız, Halil Can; Koç, Fatih; Kıymaz, Eren; Özüm, ÜnalObjective: We aimed to radiologically evaluate the clinical and demographic features accompanying ligamentum flavum hypertrophy and possible accompanying differences in anatomical structures. Materials and Methods: We evaluated vertebral alignment, integrity of neural structures, diameter of the central canal, posterior longitudinal ligament, ligamentum flavum integrity, and position of the facet joints in patients with lumbar disk herniation and lumbar spinal canal stenosis using magnetic resonance imaging (MRI). Furthermore, we examined the age, body mass index (BMI), and employment status of the patients and the status of the vertebral and paravertebral anatomical structures using MRI. Age, BMI, employment status, ligamentum flavum thickness at the L4–L5 level, interspinous ligament thickness, facet joint diameter, posterior longitudinal ligament integrity, psoas muscle diameter, erector spina muscle diameter, and mean multifidus muscle diameter were also analyzed. Results: Significant differences were found in age, BMI, employment status, ligamentum flavum thickness, interspinous ligament thickness, mean facet diameter, mean multifidus muscle diameter, mean erector spina muscle diameter, and mean psoas muscle diameter. In addition, separate statistical analyses were conducted between sex, age, employment status, BMI, and lumbar anatomical parameters. Significant correlations were found between lumbar disk herniation and spinal stenosis pathologies based on radiological measurements of lumbar structures, such as the ligamentum flavum, interspinous ligament, and facet diameter, and demographic parameters, such as age, sex, employment status, and BMI. Conclusion: We examined changes in the anatomical structures accompanying the vertebral column and existing discal or stenotic pathologies. In addition to the demographic characteristics of the patients, changes in the accompanying lumbar spinal anatomical structures, such as degeneration, hypertrophy, and atrophy, may be important. These factors and changes will help plan the treatment process and guide the results.
