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Article Citation - WoS: 2Citation - Scopus: 2The Relationship Between Lung Function, Exercise Capacity, Oxidant and Antioxidant Response in Primary Ciliary Dyskinesia and Cystic Fibrosis(Turkish J Pediatrics, 2024) Kartal, Yasemin; Ozel, Cemile Bozdemir; Cakmak, Aslihan; Ulu, Hazal Sonbahar; Ince, Deniz Inal; Tural, Dilber Ademhan; Sabuncuoglu, Suna; Özçelik, Uğur; Inal-ınce, Deniz; Budak, Murat; Arıkan, HülyaBackground. There is a need to identify the complex interplay between various physiological mechanisms in primary ciliary dyskinesia (PCD) and cystic fibrosis (CF). The study investigated the interaction between respiratory function, exercise capacity, muscle strength, and inflammatory and oxidant/antioxidant responses in patients with PCD and CF. Methods. The study included 30 PCD patients, 30 CF patients, and 29 age and sex-matched healthy subjects. Exercise capacity was assessed using the modified shuttle walk test (MSWT). Handgrip strength (HGS) was used to evaluate general muscle strength. Oxidative stress-inflammatory parameters were also assessed. Pulmonary function test was performed by spirometry. Regarding the forced expiratory volume in 1 second (FEV1) 1 ) z-score, patients with PCD and CF were subdivided into normal, mild, and severe/moderate groups. Results. Forced vital capacity (FVC) z-scores were lower in PCD and CF patients than controls. FEV1, 1 , FEV1/ 1 / FVC, peak expiratory flow (PEF), and forced mid expiratory flow (FEF 25-75% ) z-scores were lower in PCD than in the other groups. HGS was lower in both mild PCD and normal CF patients relative to the controls. MSWT distance was lower in severe/moderate PCD patients than controls. Catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), and malondialdehyde (MDA) levels did not differ significantly among the study groups, but superoxide dismutase (SOD) level in severe/moderate PCD, and glutathione (GSH) level in normal CF were higher than in controls. Interleukin-6 (IL-6) level was higher in patients with normal PCD and CF compared to the controls. IL-1 beta level was higher in PCD compared to controls. Additionally, correlations among these parameters were also determined in some patient groups. Conclusion. Homeostasis related to respiratory function, aerobic performance, muscle strength, inflammatory response, and oxidant/antioxidant balance were affected in PCD and CF. Evaluating these mechanisms together may contribute to elucidating the pathophysiology of these rare diseases.Article Citation - Scopus: 5Real-World Data From Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?(AVES, 2021) Demirtürk,N.; Aygen,B.; Çelik,İ.; Mıstık,R.; Akhan,S.; Barut,Ş.; Doğan,N.; Karakeçili, Faruk; Asan, Ali; Özel, Selcan Arslan; Ersöz, Gülden; Yıldız, Orhan; Şimşek, Sümeyra; Tarakçı, HüseyinBackground: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice. Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 ± 14.2, and 293 (55.8%) were female. The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at baseline in 381 patients (72.6%). SOF/LDV ± RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes. All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect. Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV ± RBV treatment in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment. © Copyright 2021 by The Turkish Society of Gastroenterology • Available online at turkjgastroenterol.orgArticle Citation - WoS: 3Citation - Scopus: 4Identification of Bacterial Diversity of Bee Collected Pollen and Bee Bread Microbiota by Metagenomic Analysis(Aves, 2022) Arserim Ucar, Dilhun Keriman; Yurt, Mediha Nur Zafer; Tasbasi, Behiye Busra; Acar, Elif Esma; Yegin, Zeynep; Ozalp, Veli Cengiz; Sudagidan, Mert; Uçar, Dilhun Keriman Arserim; Ozalp, Cengiz; Arserim-uçar, Dılhun KerimanThis study investigated the bacterial diversities of bee-collected pollen and bee bread of Apis mellifera in Turkey. The bacterial community structure of 14 bee pollen from Bingol, Konya, and Hakkari and 11 bee bread samples from Bingol were studied using 16 S rRNA amplicon sequencing and metagenomic analysis. The dominant bacterial phylum in pollen and bee bread samples was Firmicutes, followed by Proteobacteria. In pollen and bee bread samples, Bacillaceae, Clostridiaceae, Enterococcaceae, and Enterobacteriaceae were identified as dominant bacterial families. At the genus level, Bacillus, Clostridium sensu stricto, and Enterococcus were dominant bacteria in both pollen and bee bread samples. The most abundant species was Clostridium perfringens in both pollen and bee bread samples. Escherichia vulneris, Enterococcus faecalis, Bacillus cereus, Enterococcus casseliflavus, and Cronobacter malonaticus were identified with high reads in pollen samples. In bee bread samples, E. faecalis, Clostridium bifermentans, and Pantoea calida were abundant bacterial species. Alpha diversity showed that pol-3 sample had the highest diversity. Beta-diversity plots separated the pollen samples into four main groups and bee bread samples into three main groups. Our results indicated that the culture-independent metagenomic analysis will be a valuable tool for determining the microbial diversity of bee products produced in Bingol-Turkey one of the important centers of apiculture.Article Gold-Assembled Silica-Coated Cobalt Nanoparticles as Efficient Magnetic Separation Units and Surface-Enhanced Raman Scattering Substrate Lütfiye Sezen Yildirim1,, Murat Kaya2,∗,, Mürvet Volkan(Tubitak Scientific & Technological Research Council Turkey, 2019) Yıldırım, Lütfiye Sezen; Kaya, Murat; Volkan, MürvetMagnetic and optical bifunctional nanoparticles that combine easy separation, preconcentration, and efficientSERS capabilities have been fabricated with high sensitivity and reproducibility through a low-cost method. Thesegold nanoparticles attached on magnetic silica-coated cobalt nanospheres (Co@SiO2 /AuNPs) display the advantageof strong resonance absorption due to gaps at nanoscale between neighboring metal nanoparticles bringing large fieldenhancements, known as “hot spots”. The prepared particles can be controlled by using an external magnetic field,which makes them very promising candidates in biological applications and Raman spectroscopic analysis of dissolvedorganic species. The magnetic property of the prepared particles lowers the detection limits through preconcentrationwith solid-phase extraction in SERS analysis. The performance of the prepared nanostructures was evaluated as a SERSsubstrate using brilliant cresyl blue (BCB) and rhodamine 6G (R6G) as model compounds. The solid-phase affinityextraction of 4-mercapto benzoic acid (4-MBA) using bifunctional Co@SiO2 /AuNPs nanoparticles followed by magneticseparation and the measurement of the SERS signal on the same magnetic particles without elution were investigated.Approximately 50-fold increase in SERS intensity was achieved through solid-phase extraction of 8.3 × 10 −6 M 4-MBAin 10 min.Article Citation - Scopus: 1Determination of the Knowledge Levels of Nurses Regarding Central Venous Catheter Care(Galenos Publ House, 2022) Turkkan, Hicran; Ayyildiz, Tulay Kuzlu; Sonmez, MunevverIntroduction: It is important that pediatric nurses have sufficient knowledge in the prevention of central catheter-related blood circulation infections. This study was carried out to determine knowledge levels of the nurses, who were working in pediatric clinics, regarding central venous catheter care.Methods: The universe of the study was composed of 118 nurses, who were working in pediatric clinic of a public hospital (n=50) and a training hospital (n=68) between May-June 2019. No sample was selected; and 88 nurses, who were eligible for the sample and study criteria and approved to participate during the dates of data collection (May-June 2019) were included in the study. 75% of the universe was reached. Personal information form for the identification of demographic characteristics and working lives of the nurses and the form for the knowledge levels of the nurses regarding central venous catheter care were used to collect data.Results: At the end of statistical assessment, central venous catheter care mean score of nurses was found to be 8.35+2.36 (0-12). In addition, it was determined that no significant differences were found between central venous catheter scores of the nurses based on age, sex, marital status, working institution, working department, working year and their states of providing central venous catheter care (p>0.05). A significant difference was detected between nurses' states of having knowledge and education regarding central venous catheter and their central venous catheter scores (p<0.05). Conclusion: It was found that the knowledge points of the nurses for central venous catheter care were insufficient. It is recommended to increase in-service training in line with the protocol/procedure/ instructions regarding central venous catheter care.Article Citation - WoS: 4Citation - Scopus: 3Management of Chronic Hepatitis B in Special Patient Groups: a Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases-2023(Doc design informatics Co Ltd, 2023) Tekin, Sueda; Karakecili, Faruk; Binay, Umut Devrim; Celik, Ilhami; Tulek, Necla; Tutuncue, Ediz; Demirturk, Nese; Tütüncü, Ediz; Yılmaz, EmelTurkish Society of Clinical Microbiology and Infectious Diseases Viral Hepatitis Working Group updated the consensus report on the management of chronic hepatitis B (CHB) in private hosts and special situations. Relevant literature and international guidelines are reviewed, and agreed recommendations are presented at the end of each chapter. In the report, treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection, management of HBV and hepatitis C virus (HCV) coinfection, management of CHB in severe COVID-19 patients, non-transplant immunocompromised patients.Article Herpes Zoster Hastalarının Demografik ve Klinik Özelliklerinin Değerlendirilmesi(Selcuk University, 2023) Demirci Saadet, E.; Hasanbeyzade, S.; Hasanbeyzade, Sabir; Saadet, Elif DemırcıBackground: Herpes zoster is a disease that is more frequently seen in people aged over 50 years and negatively affects the quality of life due to the development of post-herpetic neuralgia. This study aimed to investigate the demographic and clinical characteristics of patients diagnosed with herpes zoster. Methods: In this cross-sectional study, the data of patients who were followed up with a diagnosis of herpes zoster at the dermatology department between 2013 and 2020 were retrospectively examined. Results: Of 440 patients, 252 (57.3%) were female and 188 (42.7%) were male. The mean age was 48.9±18 (4-94) years. The most common localization was the thoracic region at a rate of 35.5% and the lumbar region at a rate of 21.4%. Disseminated and ophthalmic zoster were more common in elderly patients (p<0.001). The most common comorbidities were hypertension (HT)+coronary artery disease (CAD) (12.6%), cancer (10.3%), and diabetes+HT (5.9%). Severe pain was observed in 19.7% of the patients and was more common in women (p=0.016). The rate of moderate and severe pain was high in the patients with HT+CAD and cancer (p˂0.001). Post-herpetic neuralgia was observed in 15.3% of the patients aged over 50. Conclusions: Herpes zoster is especially common in adults. Since it causes acute pain and can lead to postherpetic neuralgia development, risky patient groups should be more carefully followed up and treated. © 2023, Selcuk University. All rights reserved.Article Citation - WoS: 6Citation - Scopus: 6Covid-19 Infection in Peritoneal Dialysis Patients: \ra Comparative Outcome Study With Patients on \rhemodialysis and Patients Without Kidney Disease(Aves, 2022) Kazancıoğlu, Rümeyza; Ozturk, Savas; Turgutalp, Kenan; Gürsu, Meltem; Arıcı, Mustafa; Oruç, Ayşegül; Ateş, Kenan; Odabas, Ali Riza; Bek, Sibel GökçayObjectives: There is limited data about coronavirus disease-19 (COVID-19) characteristics and results in peritoneal dialysis \r(PD) patients. This study aimed to investigate the characteristics and outcomes among PD patients and compare them with \rmatched hemodialysis (HD) patients and a control group without kidney disease.\rMethods: We included 18 PD patients and consecutive age- and gender-matched 18 HD and 18 patients without kidney \rdisease (control group) registered into the Turkish Society of Nephrology database including 1301 COVID-19 patients. We \rcompared demographic, clinical, radiological, laboratory data, and outcomes namely intensive care unit (ICU) admission, \rmechanical ventilation, mortality, and composite outcome (death and/or ICU admission).\rResults: ICU admission, mechanical ventilation, and mortality rates in PD patients (27.8%, 22.2%, and 22.2%, respectively) \rand the HD group (16.7%, 11.1%, and 16.7%, respectively) were higher than the control group (11.1%, 11.1%, and 5.6%, \rrespectively), but intergroup comparison did not reveal difference. A total of 11 (20.3%) patients had composite outcome \r(6 PD patients, 3 HD patients, and 2 patients in the control group). In Cox regression analysis, higher age and higher CRP level were related to increased risk of composite outcome. Adjusted rate of composite outcome in PD group was significantly higher than \rthe control group (P = .050). This rate was similar in HD and control groups (P = .30).\rConclusions: Combined in-hospital mortality and/or ICU admission of PD patients with COVID-19 was significantly higher than the control \rpatients. There is a need for careful surveillance of PD patients for infection signs and prompt treatment of COVID-19.Article Evaluation of Covid-19 Cases Who Received Immunosuppressive Therapy at a Tertiary Care Hospital(Doc design informatics Co Ltd, 2022) Sayar, Merve Sefa; Acar, Ali; Bulut, Dilek; Celik, Sebahattin; Oguz, EminObjective: Immunosuppressive drugs are included in the treatment protocols of severe COVID-19 cases that may present with cytokine storm. In this study, we aimed to examine the characteristics of COVID-19 patients who received immunosuppressive therapy Methods: Patients diagnosed with COVID-19 and followed in the quarantine wards of our hospital between 01.03.2020-24.05.2020 were included in the study. Patient information was obtained retrospectively from patient files and discharge reports, and 263 COVID-19 patients-aged 18 and over-were included in the study. Results: The median age of the patients who received immunosuppressive therapy was 60.74 +/- 1.96, and 39.6% of them were women. The average symptom duration of the patients examined in the study at the time of admission to the hospital was 4.59 +/- 0.29 days. There was a significant difference in age, lymphocyte count, neutrophil/lymphocyte ratio, C-reactive protein, ferritin, D-Dimer, blood oxygen saturation, fever after antiviral therapy, qSOFA score, and total hospital stay between the two groups that received and did not receive immunosuppressive therapy (p<0.05). The need for immunosuppressive therapy increased 15.9 times over the age of 40, 15.6 times in the presence of diffuse involvement on thoracic CT, 6.6 times in the presence of chronic disease, 2.7 times in the presence of thrombocytopenia, and 1.7 times in the presence of lymphopenia (p <0.05).Conclusions: We observed that patients whose immunosuppressive therapy was added to their treatment protocols were admitted to the hospital later than others, had more prevalent involvement in thorax CT, high acute phase reactants, low SPO2, and more than one underlying disease.Article Tedavi Alan Kronik Hepatit B Hastalarında Serum Kantitatif Hbsag Düzeyi ile Viral Yük Arasındaki İlişkinin Araştırılması(Pamukkale University, 2020) Demirelli, Meryem; Tülek, Necla; Temoçin, Fatih; Yücel, Doğan; Erdinç, Fatma Şebnem; Ertem, Günay; Erdinc, SebnemAmaç: Yakın geçmişe kadar HBsAg sadece hepatit B enfeksiyonun tanısında kullanılırken, günümüzde serum HBsAg kantitasyonu (qHBsAg)’nun, hepatit B virüsü (HBV) enfeksiyonunun viral monitörizasyonunda kullanılabileceğine dair veriler artmaya başlamıştır. Bu çalışmada inaktif hepatit B taşıyıcıları ile kronik aktif hepatit B hastaları arasındaki qHBsAg ile HBV DNA düzeyleri karşılaştırılmış ve tedavi başlanmış hastalarda tedavi süresince qHBsAg ile HBVDNA seyri izlenerek aralarındaki ilişki değerlendirilmiştir. Gereç ve yöntem: Çalışma Ankara Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği’nde yapılmıştır. Kronik hepatit B (KHB) tanısıyla tedavi alan 71 hasta ve inaktif HBsAg taşıyıcısı 74 hasta çalışmaya dahil edildi. Bu hastalarda serum qHBsAg düzeyleri Elecsys HBsAg II cihazı ile çalışıldı. Bulgular: Nükleoz(t)id analoğu ile tedavi edilen hastalarda 6. ve 12. aydaki serum qHBsAg düzeyi ile HBVDNA arasında pozitif yönde bir korelasyon görüldü ve her iki parametrenin altı ay ve bir yıllık izlemindeki düşüş istatiksel olarak anlamlı bulundu (qHBsAg 6ay p=0,03, qHBsAg 12 ay p=0,001, HBV DNA 6 ay p=0,001, HBV DNA 12 ay p=0,001). Peg-IFN tedavisi alan kronik hepatit B hastalarında ise serum qHBsAg düzeyi ile HBVDNA arasında tedavi başlangıcı ve 6. ayında anlamlı bir ilişki olmayıp tedavi sonunda pozitif yönde korelasyon görüldü. PEG-IFN tedavisi alan hasta grubunda ise qHBsAg seviyeleri ile HBV DNA arasındaki korelasyon tedavi sonunda anlamlı (p=0,01) olarak saptandı.
