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Article Citation - WoS: 2Citation - Scopus: 2Phase and Wave Dependent Analysis of Health Expenditure Efficiency: a Sample of Oecd Evidence(Frontiers Media Sa, 2023) Boduroglu, Elif; Atici, Kazim Baris; Omay, TolgaIntroductionHealth expenditures are a factor that reflects the government's public health policy and contributes to the protection of national health. Therefore, this study focuses on measuring the effectiveness of health expenditures in order to evaluate and improve the public health system and policy during the pandemic period. MethodIn order to examine the effectiveness of health expenditures, the behaviors of the pandemic process were analyzed in two stages. The number of daily cases is analyzed in the first stage by dividing it into waves and phases according to the transmission coefficient (R). For this classification, the discrete cumulative Fourier function estimation is used. In the second stage, the unit root test method was used to estimate the stationarity of the number of cases in order to examine whether the countries made effective health expenditures according to waves and phases. The series being stationary indicates that the cases are predictable and that health expenditure is efficient. Data consists of daily cases from February 2020 to November 2021 for 5 OECD countries. ConclusionThe general results are shown that cases cannot be predicted, especially in the first stage of the pandemic. In the relaxation phase and at the beginning of the second wave, the countries that were seriously affected by the epidemic started to control the number of cas es by taking adequate measures, thus increasing the efficiency of their health systems. The common feature of all the countries we examined is that phase 1, which represents the beginning of the waves, is not stationary. After the waves fade, it can be concluded that the stationary number of health cases cannot be sustainable in preventing new waves' formation. It is seen that countries cannot make effective health expenditures for each wave and stage. According to these findings, the periods in which countries made effective health expenditures during the pandemic are shown. DiscussionThe study aims to help countries make effective short- and long-term decisions about pandemics. The research provides a view of the effectiveness of health expenditures on the number of cases per day in 5 OECD countries during the COVID-19 Pandemic.Article Citation - WoS: 8Citation - Scopus: 9Propagation Measurements for Iqrf Network in an Urban Environment(Mdpi, 2022) Bouzidi, Mohammed; Dalveren, Yaser; Mohamed, Marshed; Dalveren, Yaser; Moldsvor, Arild; Cheikh, Faouzi Alaya; Derawi, Mohammad; Dalveren, Yaser; Department of Electrical & Electronics Engineering; Department of Electrical & Electronics EngineeringRecently, IQRF has emerged as a promising technology for the Internet of Things (IoT), owing to its ability to support short- and medium-range low-power communications. However, real world deployment of IQRF-based wireless sensor networks (WSNs) requires accurate path loss modelling to estimate network coverage and other performances. In the existing literature, extensive research on propagation modelling for IQRF network deployment in urban environments has not been provided yet. Therefore, this study proposes an empirical path loss model for the deployment of IQRF networks in a peer-to-peer configured system where the IQRF sensor nodes operate in the 868 MHz band. For this purpose, extensive measurement campaigns are conducted outdoor in an urban environment for Line-of-Sight (LoS) and Non-Line-of-Sight (NLoS) links. Furthermore, in order to evaluate the prediction accuracy of well-known empirical path loss models for urban environments, the measurements are compared with the predicted path loss values. The results show that the COST-231 Walfisch-Ikegami model has higher prediction accuracy and can be used for IQRF network planning in LoS links, while the COST-231 Hata model has better accuracy in NLoS links. On the other hand, the effects of antennas on the performance of IQRF transceivers (TRs) for LoS and NLoS links are also scrutinized. The use of IQRF TRs with a Straight-Line Dipole Antenna (SLDA) antenna is found to offer more stable results when compared to IQRF (TRs) with Meander Line Antenna (MLA) antenna. Therefore, it is believed that the findings presented in this article could offer useful insights for researchers interested in the development of IoT-based smart city applications.Article Citation - WoS: 76Citation - Scopus: 80Unique Ligand-Based Oxidative Dna Cleavage by Zinc(ii) Complexes of Hpyramol and Hpyrimol(Wiley-v C H verlag Gmbh, 2007) Maheswari, Palanisamy Uma; Barends, Sharief; Oezalp-Yaman, Seniz; de Hoog, Paul; Casellas, Helene; Teat, Simon J.; Reedijk, JanThe zinc(II) complexes reported here have been synthesised from the ligand 4-methyl-2-N-(2-pyridylmethyl)aminophenol (Hpyramol) with chloride or acetate counterions. All the five complexes have been structurally characterised, and the crystal structures reveal that the ligand Hpyramol gradually undergoes an oxidative dehydrogenation to form the ligand 4-methyl-2-N-(2-pyridylmethylene)aminophenol (Hpyrimol), upon coordination to Zn-II. All the five complexes cleave the phi X174 phage DNA oxidatively and the complexes with fully dehydrogenated pyrimol ligands were found to be more efficient than the complexes with non-dehydrogenated Hpyramol ligands. The DNA cleavage is suggested to be ligand-based, whereas the pure ligands alone do not cleave DNA. The DNA cleavage is strongly suggested to be oxidative, possibly due to the involvement of a non-diffusible phenoxyl radical mechanism. ne enzymatic religation experiments and DNA cleavage in the presence of different radical scavengers further support the oxidative DNA cleavage by the zinc(II) complexes.Article The Relationship between Perinatal Grief and Spiritual Well-Being in Women Experiencing Termination due to Fetal Anomaly in Türkiye(Springer, 2025) Sari, Tugba; Gemicioglu, Sirin HarkinPregnancy termination is a significant event in women's lives and can be considered a traumatic experience that can assess grief reactions. Couples who accept the decision to have a medical termination due to fetal anomaly face not only anxiety and feelings of loss, but also difficulties adapting to and coping with the termination process. This study aims to examine the relationship between perinatal grief and spiritual well-being in women who experience termination due to fetal anomaly. The study sample consisted of 256 women who had undergone termination during pregnancy. Data were analyzed using descriptive statistics (percentage, mean, standard deviation), the Mann-Whitney U test for independent samples, the Kruskal-Wallis test, Spearman correlation, and multiple linear regression analyses. The participants' mean score on the Perinatal Grief Scale was 112.87 +/- 15.04. The spiritual well-being scale subscale scores were 56.13 +/- 8.69 for the transcendence subscale, 25.27 +/- 2.94 for the harmony with nature subscale, and 26.58 +/- 3.18 for the anomie subscale. The correlation between the mean scores of the scales indicated that perinatal grief level was positively and significantly related to both the transcendence (r = 0.454; p < .001) and harmony with nature (r = 0.571; p < .001) subscales, while there was a strong negative correlation between perinatal grief and the anomie subscale (r = -0.762; p < .001). In conclusion, the study results indicate that perinatal grief is significantly related to various dimensions of spiritual well-being. These findings support the idea that supporting spiritual well-being in individuals experiencing perinatal grief can strengthen psychosocial adjustment.Review Citation - WoS: 23Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches(Amer Scientific Publishers, 2020) Ahmadi, Sepideh; Rabiee, Navid; Fatahi, Yousef; Bagherzadeh, Mojtaba; Gachpazan, Meysam; Baheiraei, Nafiseh; Hamblin, Michael R.Successful gene therapy depends on the design of effective gene delivery systems. A gene delivery system is considered a powerful tool for the release of genetic material within cells resulting in a change in cell functions and protein production. The release of genes in a controlled manner by using appropriate carriers facilitates their release without side effects and increases the expression of genes at the released site. It is expected that significant changes in the combination of several genes and drugs can be provided by developing treatment systems sensitive to different stimuli such as redox potential, pH variations, temperature gradients, light irradiation, and enzyme activity. The most important advantages for the release of genes and stimuli-responsive therapeutics include delivering vectors locally, reducing side effects and causing no toxicity to distant tissues while at the same time reducing the immune response to the vectors. In this review, we aim to discuss different types of gene carriers involved in the controlled transfer of nucleic acids (non-viral inorganic and organic nanoparticles (NPs) and virus-like particles (VLPs)) as well as the simultaneous transfer of several genes and/or drugs into cells or different tissues, providing for an efficient and safe treatment of numerous diseases.Article Fistulectomy and Primary Sphincteroplasty for Transsphincteric Fistula(Coll Physicians & Surgeons Pakistan, 2025) Emral, Ahmet Cihangir; Gulen, Merter; Ege, BahadirObjective: To evaluate the results of patients treated with fistulectomy and primary sphincteroplasty for uncomplicated perianal fistula. Study Design: Observational study. Place and Duration of the Study: Medicana International Hospital affiliated with Atilim University, Faculty of Medicine, Ankara, Turkiye, from January 2020 to September 2023. Methodology: In this study, patients who were operated on for perianal fistula between 2020 and 2023 were retrospectively examined. Data were obtained retrospectively. All patients underwent preoperative perianal MRI. Clinical notes were evaluated with the Cleveland Clinic Incontinence Score (CCIS) by physical examination. All patients were followed up on the first postoperative day, 1st week, 1st and 3rd postoperative months. Results: A total of 44 patients who underwent fistulectomy with primary sphincteroplasty were included in the study. Twenty-six patients (59.1%) had a history of perianal abscesses. It was observed that 34 (77.3%) of the patients had posterior, 7 (15.9%) anterior, and 3 (6.8%) lateral fistulas. A total of 3 patients (6.8%) were observed to have minor worsening in their incontinence scores. There was no statistically significant difference between the preoperative and postoperative 3rd month Cleveland Clinic Incontinence Score values of the patients (CCIS mean 1.6 vs. 1.7, respectively, p >0.05). Recurrence was observed in 1 patient (2.3%) during follow-ups. Conclusion: Fistulectomy with primary sphincteroplasty is an effective and reliable method to preserve anal continence and improve quality of life.Article Citation - Scopus: 18From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity of Solanum Melongena L. Via in Vivo Experimental Models and Its Major Chemicals(Elsevier Ireland Ltd, 2020) Dönmez,C.; Yalçın,F.N.; Boyacıoğlu,Ö.; Korkusuz,P.; Akkol,E.K.; Nemutlu,E.; Çalışkan,U.K.Ethnopharmacological relevance: Solanum melongena L. (eggplant) is used for treatment of rheumatism, beriberi, itching, toothache, bleeding, asthma, bronchitis, cholera, neuralgia and hemorrhoids in traditional medicine (Turkish, Chinese, and Indian). Hemorrhoids from these diseases, are common illness in all over the world, which are treated with various approaches including ethnobotanicals. Aim of the study: This study aimed to evaluate the anti-hemorrhoidal activity of eggplant, an edible plant, which is commonly utilized around the world. Materials & methods: In vivo anti-hemorrhoidal activity of the methanolic extract prepared from eggplant was evaluated by experimental hemorrhoid model, subsequently histological and biochemical analysis. Hemorrhoid, which was induced by applying croton oil to the anal area of the rats. Furthermore, the extract was screened for anti-inflammatory activity which is based on the inhibition of acetic acid-induced increase in capillary permeability. The healing potential was comparatively assessed with a reference Pilex® tablet and cream. Phytochemical analysis performed by HPLC. The amount of the major phenolic compound (chlorogenic acid) in extract was found by using HPLC method. Results: Histological and biochemical analysis demonstrated that eggplant extract is highly effective against hemorrhoid in comparison to the controls and the commercial preparation. In addition, the methanolic extract demonstrated significant inhibitory effect on acetic acid-induced increase in capillary permeability. The phytochemical studies identified major compound as chlorogenic acid (2.86%) by liquid chromatography. Conclusion: The eggplant calyxes, not edible, are easy to reach, by products/vast from the food sources. This is the first scientific evidence revealing that the eggplant extract has significant anti-hemorrhoidal and anti-inflammatory activity. © 2020 Elsevier B.V.Article Citation - WoS: 4Citation - Scopus: 7Real-Time Learning and Monitoring System in Fighting Against Sars-Cov in a Private Indoor Environment(Mdpi, 2022) Erisen, SerdarThe SARS-CoV-2 virus has posed formidable challenges that must be tackled through scientific and technological investigations on each environmental scale. This research aims to learn and report about the current state of user activities, in real-time, in a specially designed private indoor environment with sensors in infection transmission control of SARS-CoV-2. Thus, a real-time learning system that evolves and updates with each incoming piece of data from the environment is developed to predict user activities categorized for remote monitoring. Accordingly, various experiments are conducted in the private indoor space. Multiple sensors, with their inputs, are analyzed through the experiments. The experiment environment, installed with microgrids and Internet of Things (IoT) devices, has provided correlating data of various sensors from that special care context during the pandemic. The data is applied to classify user activities and develop a real-time learning and monitoring system to predict the IoT data. The microgrids were operated with the real-time learning system developed by comprehensive experiments on classification learning, regression learning, Error-Correcting Output Codes (ECOC), and deep learning models. With the help of machine learning experiments, data optimization, and the multilayered-tandem organization of the developed neural networks, the efficiency of this real-time monitoring system increases in learning the activity of users and predicting their actions, which are reported as feedback on the monitoring interfaces. The developed learning system predicts the real-time IoT data, accurately, in less than 5 milliseconds and generates big data that can be deployed for different usages in larger-scale facilities, networks, and e-health services.Article Citation - WoS: 3Citation - Scopus: 4A Simple Method To Set the Spray Properties for Flame Spray Pyrolysis Production of Nanoparticles(Elsevier Sci Ltd, 2020) Alhaleeb, Mustafi A.; Machin, Nesrin E.The most critical part of the flame spray pyrolysis (FSP) process is the nozzle, since it plays a key role in setting the spray properties. In this study, we developed an approach to adjust the nozzle throat gap size for a desired dispersion gas flow rate and upstream pressure, based on the external size and shape of a two phase external mixing nozzle. An equation was derived and validated by comparing the predicted gas flow rates with the data provided in a commercial nozzle supplier chart. Experiments were also conducted in our lab-scale FSP reactor to test the validity of the predictions. The approach developed here was found to closely predict the gap size necessary to pass the required dispersion gas flow at a desired pressure drop. Error in predictions was found to be less than 3% at an upstream pressure range of 3-10 bars. The isentropic flow assumption for perfect gases across the convergent-divergent nozzle was found to fail below 2 bars, consistent with the theory applied. By using the method here, the nozzle setting for a desired operation in an FSP process can be easily done, minimizing the time-consuming trial and error steps needed otherwise.Article Citation - WoS: 32Citation - Scopus: 32Urine Analysis Using Ftir Spectroscopy: a Study on Healthy Adults and Children(Wiley-v C H verlag Gmbh, 2021) Sarigul, Neslihan; Kurultak, Ilhan; Gokceoglu, Arife Uslu; Korkmaz, FilizUrine spectra from 108 healthy volunteers are studied by attenuated total refraction-Fourier transform infrared (ATR-FTIR) spectroscopy. The spectral features are correlated with observable urine components. The variation of spectra within a healthy population is quantified and a library of reference spectra is constructed. Using the band assignments, these spectra are compared with both age-wise and gender-wise. Children show the least intensity variations compared to both adult groups. Young adults show the highest variation, particularly in the 1650 to 1400 cm(-1) and 1200 to 900 cm(-1) regions. These results indicate the importance of the size of the control group in comparative studies utilizing FTIR. Age-wise comparisons reveal that phosphate and sulfate excretion decreases with age, and that the variance of phosphate among individuals is higher with adults. As for gender-wise comparisons, females show a slightly higher citrate content at 1390 cm(-1) regardless of the age and they show a higher variance in the 1200 to 1000 cm(-1) region when compared to men.
