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Book Part A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung(Springer, 2025) Boyacıoğlu, Özge; Kalali, Berfin Deniz; Tongün, Ege; Korkusuz, PetekLungs carry the principle function for the conduction and exchange of air through the primary, secondary, tertiary bronchi, bronchioles, and alveoli, resulting in the exchange of oxygen to carbon dioxide within the human tissues. Lung stem and progenitor cells enable differentiation of parenchymal and stromal elements and provide homeostasis and regeneration in the microenvironment against pulmonary diseases. Tumor-initiating cancer cells (TICs) refer to a subpopulation named as cancer stem cells (CSCs) of lung cancer exhibiting high self-renewal and proliferation capacity by Notch, Hippo, Hedgehog, and Wnt signaling pathways that leads to tumor development or recurrence. Lung cancer stem cells (LCSCs) are characterized by distinct genotypic or phenotypic alterations compared to healthy lung stem cells (LSCs) that provide a potential target to treat lung cancer. Therefore, understanding the cascades responsible for the transformation of healthy to CSCs is essential to develop new targeted therapy approaches. In this chapter, we precisely highlight the latest researches on LSCs and CSCs, key signaling mechanisms within the perspective of novel targeted therapy strategies. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 39Citation - Scopus: 46Inhibitory Effects of Aptamer Targeted Teicoplanin Encapsulated Plga Nanoparticles for staphylococcus Aureus Strains(Springer, 2020) Ucak, Samet; Özalp, Veli Cengiz; Sudagidan, Mert; Borsa, Baris A.; Mansuroglu, Banu; Ozalp, Veli C.; Özalp, Veli Cengiz; Basic Sciences; Basic SciencesEmergence of resistance to traditional antibiotic treatments necessitates alternative delivery systems. Teicoplanin is a glycopeptide antibiotic used in the treatments of serious infections caused by Gram-positive bacteria, including Methicillin Resistant Staphylococcus aureus (MRSA). One strategy to keep up with antibiotic resistance development is to limit dose and amount during treatments. Targeted delivery systems of antibiotics have been suggested as a mechanism to slow-down the evolution of resistance and to increase efficiency of the antimicrobials on already resistant pathogens. In this study, we report teicoplanin delivery nanoparticles of Poly Lactic-co-Glycolic Acid (PLGA), which are functionalized with S. aureus specific aptamers. A 32-fold decrease in minimum inhibitory concentration (MIC) values of teicoplanin for S. aureus was demonstrated for susceptible strains and about 64-fold decline in MIC value was achieved for moderately resistant clinical isolates of MRSA upon teicoplanin treatment with aptamer-PLGA nanoparticles. Although teicoplanin delivery in PLGA nanoparticles without targeting demonstrated eightfold decrease in MIC of susceptible strains of S. aureus and S. epidermidis and twofold in MIC of resistant strains, the aptamer targeting specifically decreased MIC for S. aureus, but not for S. epidermidis. Therefore, aptamer-targeted PLGA delivery of antibiotic can be an attractive alternative to combat with some of the multi-drug resistant bacterial pathogens.Article Citation - WoS: 16Citation - Scopus: 18Modeling and Forecasting of Monthly Pm2.5 Emission of Paris by Periodogram-Based Time Series Methodology(Springer, 2021) Akdi, Yilmaz; Golveren, Elif; Unlu, Kamil Demirberk; Yucel, Mustafa ErayIn this study, monthly particulate matter (PM2.5) of Paris for the period between January 2000 and December 2019 is investigated by utilizing a periodogram-based time series methodology. The main contribution of the study is modeling the PM2.5 of Paris by extracting the information purely from the examined time series data, where proposed model implicitly captures the effects of other factors, as all their periodic and seasonal effects reside in the air pollution data. Periodicity can be defined as the patterns embedded in the data other than seasonality, and it is crucial to understand the underlying periodic dynamics of air pollutants to better fight pollution. The method we use successfully captures and accounts for the periodicities, which could otherwise be mixed with seasonality under an alternative methodology. Upon the unit root test based on periodograms, it is revealed that the investigated data has periodicities of 1 year and 20 years, so harmonic regression is utilized as an alternative to Box-Jenkins methodology. As the harmonic regression displayed a better performance both in and out-of-sample forecasts, it can be considered as a powerful alternative to model and forecast time series with a periodic structure.Article Citation - WoS: 3Citation - Scopus: 3Impact of Mobile Received Signal Strength (rss) on Roaming and Non-Roaming Mobile Subscribers(Springer, 2023) Karanja, Hinga Simon; Misra, Sanjay; Atayero, A. A. A.Mobile phones have transitioned from voice-centric devices to smart devices supporting functionalities like high-definition video and games, web browsers, radio reception, and video conferencing. Mobile phones are used in telemedicine, health monitoring applications, navigation tools, and gaming devices, among other applications. Given the above, Mobile broadband connectivity affects mobile access to the internet and voice communications. This paper assesses the impact of the Reference Signal Received Power (RSRP) and broadband connectivity around Covenant University. LTE, GSM, and HSPA mobile signal measurement campaigns were conducted around Covenant University in Ota, Ogun state, Nigeria. To investigate the best optimized mobile network for mobile subscribers on roaming services and subscriber's high performance and data rates. After the experiment, exploratory data analysis was used to visualize the best mobile network; GSM proved as stable than LTE and HSPA.Review Citation - WoS: 11Citation - Scopus: 12The Importance of Media on Decision to Undergo Cosmetic Surgery Operation(Springer, 2022) Sonmez, Mehmet; Esiyok, ElifBackground How media disseminates ideal beauty, and its effect on the decision-making process of cosmetic procedures are among the most discussed topics in the literature. This study aimed to investigate the effects of media on patients' decisions to undergo cosmetic surgery. Materials and Methods Between March and September 2021, 82 patients participated in this study and informed consent was obtained from all patients. A questionnaire containing three different parts was developed by a consultant plastic surgeon and a public relations and marketing specialist, according to the literature. All statistical analyses were performed using SPSS version 22.0. Results The majority of patients underwent rhinoplasty (31.7%), breast reduction (25.6%), and breast augmentation (12.2%). Some of the patients underwent two different operations (6%). The correlation analysis results showed that, there was a medium, positive correlation between wanting to be attractive and thinking that media is an important tool in the decision to undergo cosmetic surgery (r=.307, p<.01). Want to look like people on the media and compare themselves with those showing a positive and strong correlation (r=.640, p<.01). The photographs on the magazines affected the patients aged between 40-49 and 50-59 more (chi(2)(4) = 11,378, p<.05); however, the published news on the Internet affected the younger sample (30-39 and 21-29) more than the other age groups (chi(2)(4)= 11,808, p<.05). The participants aged 30-39 and 21-29 tend to compare themselves with people on the Internet. Conclusion The study concludes that media is not only important for disseminating beauty ideals but is also an important source during decision making. However, further studies with more participants and objective scales are needed to verify our results.Article Citation - WoS: 35Citation - Scopus: 43Lyapunov-Type Inequalities for Mixed Non-Linear Forced Differential Equations Within Conformable Derivatives(Springer, 2018) Abdeljawad, Thabet; Agarwal, Ravi P.; Alzabut, Jehad; Jarad, Fahd; Ozbekler, AbdullahWe state and prove new generalized Lyapunov-type and Hartman-type inequalities fora conformable boundary value problem of order alpha is an element of (1,2] with mixed non-linearities of the form ((T alpha X)-X-a)(t) + r(1)(t)vertical bar X(t)vertical bar(eta-1) X(t) + r(2)(t)vertical bar x(t)vertical bar(delta-1) X(t) = g(t), t is an element of (a, b), satisfying the Dirichlet boundary conditions x(a) = x(b) = 0, where r(1), r(2), and g are real-valued integrable functions, and the non-linearities satisfy the conditions 0 < eta < 1 < delta < 2. Moreover, Lyapunov-type and Hartman-type inequalities are obtained when the conformable derivative T-alpha(a) is replaced by a sequential conformable derivative T-alpha(a) circle T-alpha(a), alpha is an element of (1/2,1]. The potential functions r(1), r(2) as well as the forcing term g require no sign restrictions. The obtained inequalities generalize some existing results in the literature.Article Citation - WoS: 6Citation - Scopus: 6Which Is Better To Predict Erectile Dysfunction and Male Sexual Function in the Context of Metabolic Syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index?: a Retrospective Cross-Sectional Study(Springer, 2024) Bolat, Mustafa Suat; Bolat, Ipek Akalin; Dundar, Cihad; Asci, RamazanPurposeMany factors influence male sexual function, including metabolic disorders such as metabolic syndrome (MetS). We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on male sexual function.MethodsA total of 400 men having sexual dysfunction were included. Anthropological data, comorbidities were recorded. Serum total testosterone, prolactin, and estradiol levels were recorded. Sex-specific VAI was calculated using the [(WC/39.68) + (1.88xMI)] x (TG/1.03) x (1.31/HDL) formula and using Ln (fasting triglycerides) x (fasting glucose)/2] formula, TyG index was calculated. Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire and male sexual health questionnaire (MSHQ) were used for erectile function and ejaculatory function, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk.ResultsA higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI showed similar predictive abilities for ED. Patients with MetS had worse ejaculation quality compared to those without MetS.ConclusionsThese findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help to mitigate their negative impact on male sexual function.Article Evaluating Anterior Segment Stability and Corneal Endothelium After Prolene Gonioscopy Assisted Transluminal Trabeculotomy (gatt) in Open-Angle Glaucoma(Springer, 2024) Aribas, Yavuz Kemal; Aktas, Zeynep; Ertop, MestanIntroduction This study investigates the short-term effects of prolene gonioscopy-assisted transluminal trabeculotomy (GATT) on anterior segment parameters and corneal endothelium in patients with open-angle glaucoma. Methods This retrospective study included 30 eyes from 30 patients who underwent GATT surgery. Demographic data, ophthalmological examination findings, and intraocular pressure (IOP) measurements using a Goldman applanation tonometer were recorded. Scheimpflug images were acquired at the pre-operative stage, as well as on the 1st day, 1st week, and 1st month postoperatively. Corneal endothelial cell counts were obtained via specular microscopy. Results The mean age of patients was 60.3 +/- 15.5 years. Anterior chamber depth and central corneal thickness increased on the 1st postoperative day (p:0.002, p < 0.001, respectively). Changes in anterior chamber depth values at the postoperative 1st week and 1st month compared to baseline were not statistically significant. Central corneal thickness decreased significantly at the 1st postoperative month compared to baseline (p:0.007). Corneal endothelial cell counts at the 1st month were comparable to baseline values (p:0.936). Conclusion Our findings reveal that prolene gonioscopy-assisted transluminal trabeculotomy induces temporary changes in anterior segment parameters but preserves corneal endothelial cell count within the first month, suggesting a promising profile for GATT in glaucoma management.Article Citation - WoS: 6Citation - Scopus: 7The Effect of Social Media Usage, Appearance-Related Social Media Pressure and Body Mass Index on Body Appreciation of Cosmetic Procedure Patients(Springer, 2023) Sonmez, Mehmet; Esiyok, ElifBackground The number of cosmetic procedures has increased in recent years. Social media use and its effects on plastic surgery decisions are among the most widely discussed topics. This study aimed to test a research model that explores the relationship between social media usage frequency, appearance-related social media pressure, and body mass index (BMI) on the body appreciation of patients undergoing cosmetic procedures, and to evaluate their clinical impacts. Methods In total, 136 participants were included in this study, which met and exceeded the sample size requirement. The questionnaire was designed by using reliable scales and demographic data. Partial least squares structural equation modeling was used to test the hypothesized research model. Results The mean age of the participants was 35 years, and 70% had normal BMI scores. Among them, 59.6% underwent invasive procedures and 40.4% underwent minimally invasive procedures. BMI negatively affected body appreciation (beta = 0.199, p < 0.05). Social media did not have a significant effect on appearance-related social media pressure (beta = 0.001, p > 0.05). Appearance-related social media pressure negatively affected body appreciation (beta = - 0.280. p > 0.05). Conclusion Social media is not only an information source but also creates pressure on appearance. Therefore, plastic surgeons should use social media and consider the psychology of patients during their communication.Article Citation - WoS: 9Citation - Scopus: 12Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions(Springer, 2025) Dehghani, Sam; Ocakci, Ozgecan; Hatipoglu, Pars Tan; Ozalp, Veli Cengiz; Tevlek, AtakanNeurodegenerative diseases (NDs) like Alzheimer's, Parkinson's, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis and effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity and specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability and insufficient blood-brain barrier (BBB) permeability. Recently, exosomes-nanoscale vesicles packed with proteins, RNAs, and lipids-have emerged as promising agents with the potential to reshape diagnostic and therapeutic approaches to these diseases. Unlike conventional drug carriers, they naturally traverse the BBB and can deliver bioactive molecules to affected neural cells. Their molecular cargo can influence cell signaling, reduce neuroinflammation, and potentially slow neurodegenerative progression. Moreover, exosomes serve as non-invasive biomarkers, enabling early and precise diagnosis while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded with therapeutic molecules, enhance this capability by targeting diseased neurons and overcoming conventional treatment barriers. By offering enhanced specificity, reduced immunogenicity, and an ability to bypass physiological limitations, exosome-based strategies present a transformative advantage over existing diagnostic and therapeutic approaches. This review examines the multifaceted role of exosomes in NDDs, emphasizing their diagnostic capabilities, intrinsic therapeutic functions, and transformative potential as advanced treatment vehicles.
