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Article Clinicopathological Predictors of Central Lymph Node Metastasis in Clinically Node-Negative Papillary Thyroid Carcinoma: A Retrospective Cohort Analysis(Springer, 2025) Sakiz, Davut; Calapkulu, Murat; Sencar, Muhammed Erkam; Unsal, Ilknur Ozturk; Kartal, Mehmet Zabit; Ucan, Bekir; Cakal, ErmanPurposeThis retrospective cohort study aimed to identify clinicopathological predictors of central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC).MethodsA total of 503 patients with PTC who underwent thyroidectomy with central lymph node dissection were included. Preoperative clinical data, ultrasonographic features, and postoperative histopathological characteristics were analyzed.ResultsCLNM was detected in 209 (41.55%) patients. Male sex (odds ratio [OR] = 3.12, 95% CI: 1.82-5.35), irregular nodule borders (OR = 2.02, 95% CI: 1.25-3.26) and higher risk categories in the American Thyroid Association (ATA) ultrasonographic pattern stratification system (OR = 13.312, 95% CI: 8.623-20.551) were identified as independent preoperative predictors of CLNM. A simplified model incorporating only the ATA ultrasonographic pattern stratification system and male sex achieved 83.5% accuracy in predicting CLNM. Histopathological evaluation revealed lymphovascular invasion (OR = 4.61, 95% CI: 2.81-7.55), extrathyroidal extension (OR = 2.41, 95% CI: 1.52-3.83), and multifocality (OR = 1.58, 95% CI: 1.04-2.40) as independent predictors of CLNM, while lymphocytic thyroiditis (OR = 0.59, 95% CI: 0.39-0.89) was a protective factor.ConclusionThis study establishes that ATA ultrasonographic suspicion patterns combined with the male sex provide an accurate and simplified model for preoperative CLNM prediction in PTC, outperforming complex nomograms. Key independent predictors included male sex, irregular nodule margins, ATA high-risk patterns, lymphovascular invasion, extrathyroidal extension, and multifocality, while lymphocytic thyroiditis was protective. According to the current study, risk assessment and personalized management should favor a holistic approach, rather than focusing solely on individual risk factors.Article Citation - WoS: 6Citation - Scopus: 7A European Survey on the Practice of Nutritional Interventions in Head-Neck Cancer Patients Undergoing Curative Treatment With Radio(chemo)therapy(Springer, 2022) Bozzetti, Federico; Gurizzan, Cristina; Lal, Simon; Van Gossum, Andre; Wanten, Geert; Golusinski, Wojciech; Bossi, PaoloPurpose As the practice of nutritional support in patients with head and neck cancer (HNC) during curative radio(chemo)therapy is quite heterogeneous, we carried out a survey among European specialists. Methods A 19-item questionnaire was drawn up and disseminated via the web by European scientific societies involved in HNC and nutrition. Results Among 220 responses, the first choice was always for the enteral route; naso-enteral tube feeding was preferred to gastrostomy in the short term, while the opposite for period longer than 1 month. Indications were not solely related to the patient's nutritional status, but also to the potential burden of the therapy. Conclusion European HNC specialists contextualize the use of the nutritional support in a comprehensive plan of therapy. There is still uncertainty relating to the role of naso-enteral feeding versus gastrostomy feeding in patients requiring < 1 month nutritional support, an issue that should be further investigated.Article Citation - WoS: 9Citation - Scopus: 11Human Laryngeal Squamous Cell Carcinoma Cell Line Release of Endogenous Anandamide and 2-Arachidonoylglycerol, and Their Antiproliferative Effect Via Exogenous Supplementation: an in Vitro Study(Springer, 2022) Onay, Ovsen; Kose, Sevil; Suslu, Nilda; Korkusuz, Petek; Nemutlu, Emirhan; Aydin, Canset; Hosal, SefikThe level of the major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are altered in several types of carcinomas, and are known to regulate tumor growth. Thusly, this study hypothesized that the HEp-2 human laryngeal squamous cell carcinoma (LSCC) cell line releases AEA and 2-AG, and aimed to determine if their exogenous supplementation has an anti-proliferative effect in vitro. In this in vitro observational study a commercial human LSCC cell line (HEp-2) was used to test for endogenous AEA and 2-AG release via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The anti-proliferative effect of AEA and 2-AG supplementation was evaluated via WST-1 proliferation assay. It was observed that the HEp-2 LSCC cell line released AEA and 2-AG; the median quantity of AEA released was 15.69 ng mL(-1) (range: 14.55-15.95 ng mL(-1)) and the median quantity of 2-AG released was 2.72 ng (-1) (range: 2.67-2.74 ng mL(-1)). Additionally, both AEA and 2-AG exhibited an anti-proliferative effect. The anti-proliferative effect of 2-AG was stronger than that of AEA. These findings suggest that AEA might function via a CB1 receptor-independent pathway and that 2-AG might function via a CB2-dependent pathway. The present findings show that the HEp-2 LSCC cell line releases the major endocannabinoids AEA and 2-AG, and that their supplementation inhibits tumor cell proliferation in vitro. Thus, cannabinoid ligands might represent novel drug candidates for laryngeal cancers, although functional in vivo studies are required in order to validate their potency.Review Citation - WoS: 29Citation - Scopus: 46Impact of Nanotechnology on Conventional and Artificial Intelligence-Based Biosensing Strategies for the Detection of Viruses(Springer, 2023) Ramalingam, Murugan; Jaisankar, Abinaya; Cheng, Lijia; Krishnan, Sasirekha; Lan, Liang; Hassan, Anwarul; Marrazza, GiovannaRecent years have witnessed the emergence of several viruses and other pathogens. Some of these infectious diseases have spread globally, resulting in pandemics. Although biosensors of various types have been utilized for virus detection, their limited sensitivity remains an issue. Therefore, the development of better diagnostic tools that facilitate the more efficient detection of viruses and other pathogens has become important. Nanotechnology has been recognized as a powerful tool for the detection of viruses, and it is expected to change the landscape of virus detection and analysis. Recently, nanomaterials have gained enormous attention for their value in improving biosensor performance owing to their high surface-to-volume ratio and quantum size effects. This article reviews the impact of nanotechnology on the design, development, and performance of sensors for the detection of viruses. Special attention has been paid to nanoscale materials, various types of nanobiosensors, the internet of medical things, and artificial intelligence-based viral diagnostic techniques.Book Part A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung(Springer, 2025) Boyacıoğlu, Özge; Kalali, Berfin Deniz; Tongün, Ege; Korkusuz, PetekLungs carry the principle function for the conduction and exchange of air through the primary, secondary, tertiary bronchi, bronchioles, and alveoli, resulting in the exchange of oxygen to carbon dioxide within the human tissues. Lung stem and progenitor cells enable differentiation of parenchymal and stromal elements and provide homeostasis and regeneration in the microenvironment against pulmonary diseases. Tumor-initiating cancer cells (TICs) refer to a subpopulation named as cancer stem cells (CSCs) of lung cancer exhibiting high self-renewal and proliferation capacity by Notch, Hippo, Hedgehog, and Wnt signaling pathways that leads to tumor development or recurrence. Lung cancer stem cells (LCSCs) are characterized by distinct genotypic or phenotypic alterations compared to healthy lung stem cells (LSCs) that provide a potential target to treat lung cancer. Therefore, understanding the cascades responsible for the transformation of healthy to CSCs is essential to develop new targeted therapy approaches. In this chapter, we precisely highlight the latest researches on LSCs and CSCs, key signaling mechanisms within the perspective of novel targeted therapy strategies. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 7Citation - Scopus: 7Which Is Better To Predict Erectile Dysfunction and Male Sexual Function in the Context of Metabolic Syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index?: a Retrospective Cross-Sectional Study(Springer, 2024) Bolat, Mustafa Suat; Bolat, Ipek Akalin; Dundar, Cihad; Asci, RamazanPurposeMany factors influence male sexual function, including metabolic disorders such as metabolic syndrome (MetS). We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on male sexual function.MethodsA total of 400 men having sexual dysfunction were included. Anthropological data, comorbidities were recorded. Serum total testosterone, prolactin, and estradiol levels were recorded. Sex-specific VAI was calculated using the [(WC/39.68) + (1.88xMI)] x (TG/1.03) x (1.31/HDL) formula and using Ln (fasting triglycerides) x (fasting glucose)/2] formula, TyG index was calculated. Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire and male sexual health questionnaire (MSHQ) were used for erectile function and ejaculatory function, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk.ResultsA higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI showed similar predictive abilities for ED. Patients with MetS had worse ejaculation quality compared to those without MetS.ConclusionsThese findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help to mitigate their negative impact on male sexual function.Article Evaluating Anterior Segment Stability and Corneal Endothelium After Prolene Gonioscopy Assisted Transluminal Trabeculotomy (gatt) in Open-Angle Glaucoma(Springer, 2024) Aribas, Yavuz Kemal; Aktas, Zeynep; Ertop, MestanIntroduction This study investigates the short-term effects of prolene gonioscopy-assisted transluminal trabeculotomy (GATT) on anterior segment parameters and corneal endothelium in patients with open-angle glaucoma. Methods This retrospective study included 30 eyes from 30 patients who underwent GATT surgery. Demographic data, ophthalmological examination findings, and intraocular pressure (IOP) measurements using a Goldman applanation tonometer were recorded. Scheimpflug images were acquired at the pre-operative stage, as well as on the 1st day, 1st week, and 1st month postoperatively. Corneal endothelial cell counts were obtained via specular microscopy. Results The mean age of patients was 60.3 +/- 15.5 years. Anterior chamber depth and central corneal thickness increased on the 1st postoperative day (p:0.002, p < 0.001, respectively). Changes in anterior chamber depth values at the postoperative 1st week and 1st month compared to baseline were not statistically significant. Central corneal thickness decreased significantly at the 1st postoperative month compared to baseline (p:0.007). Corneal endothelial cell counts at the 1st month were comparable to baseline values (p:0.936). Conclusion Our findings reveal that prolene gonioscopy-assisted transluminal trabeculotomy induces temporary changes in anterior segment parameters but preserves corneal endothelial cell count within the first month, suggesting a promising profile for GATT in glaucoma management.Article Citation - WoS: 30Citation - Scopus: 35Cyberloafing Behaviors Among University Students: Their Relationships With Positive and Negative Affect(Springer, 2023) Metin-Orta, Irem; Demirtepe-Saygili, DilekWith the technological advances, the use of digital devices, such as laptops, tablets, or smartphones in the educational setting has become prevalent among young people. Accordingly, there has been an increased concern among scholars on students' in-class Internet use for personal purposes; namely, 'cyberloafing'. Considerable research has demonstrated the adverse effects of in-class Internet use on students' learning environment and academic performance. The present study particularly investigates the relationship between cyberloafing behaviors and positive and negative affect among university students. It examines five different online activities including sharing, shopping, real-time updating, accessing online content, and gaming/gambling separately to gain greater insight into students' cyberloafing behaviors. The sample consisted of 267 undergraduate students who filled out questionnaires measuring cyberloafing behaviors, positive and negative affect, and demographical information including the use of the Internet and mobile technologies. The initial analyses showed that male students had higher scores in shopping, accessing online content, and gaming/gambling than females. The latent variable analysis revealed that among different activities of cyberloafing, accessing online content and gaming/gambling were positively correlated with positive affect, while sharing was positively associated with negative affect among students. The findings emphasize the importance of evaluating cyberloafing as a part of students' psychological well-being rather than a variable merely related to academic achievement. The findings of the study also enlighten researchers and educators in developing appropriate policies and interventions to manage misuse of the Internet in class.Article Citation - WoS: 6Citation - Scopus: 7The Effect of Social Media Usage, Appearance-Related Social Media Pressure and Body Mass Index on Body Appreciation of Cosmetic Procedure Patients(Springer, 2023) Sonmez, Mehmet; Esiyok, ElifBackground The number of cosmetic procedures has increased in recent years. Social media use and its effects on plastic surgery decisions are among the most widely discussed topics. This study aimed to test a research model that explores the relationship between social media usage frequency, appearance-related social media pressure, and body mass index (BMI) on the body appreciation of patients undergoing cosmetic procedures, and to evaluate their clinical impacts. Methods In total, 136 participants were included in this study, which met and exceeded the sample size requirement. The questionnaire was designed by using reliable scales and demographic data. Partial least squares structural equation modeling was used to test the hypothesized research model. Results The mean age of the participants was 35 years, and 70% had normal BMI scores. Among them, 59.6% underwent invasive procedures and 40.4% underwent minimally invasive procedures. BMI negatively affected body appreciation (beta = 0.199, p < 0.05). Social media did not have a significant effect on appearance-related social media pressure (beta = 0.001, p > 0.05). Appearance-related social media pressure negatively affected body appreciation (beta = - 0.280. p > 0.05). Conclusion Social media is not only an information source but also creates pressure on appearance. Therefore, plastic surgeons should use social media and consider the psychology of patients during their communication.Article Citation - WoS: 16Citation - Scopus: 18Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions(Springer, 2025) Dehghani, Sam; Ocakci, Ozgecan; Hatipoglu, Pars Tan; Ozalp, Veli Cengiz; Tevlek, AtakanNeurodegenerative diseases (NDs) like Alzheimer's, Parkinson's, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis and effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity and specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability and insufficient blood-brain barrier (BBB) permeability. Recently, exosomes-nanoscale vesicles packed with proteins, RNAs, and lipids-have emerged as promising agents with the potential to reshape diagnostic and therapeutic approaches to these diseases. Unlike conventional drug carriers, they naturally traverse the BBB and can deliver bioactive molecules to affected neural cells. Their molecular cargo can influence cell signaling, reduce neuroinflammation, and potentially slow neurodegenerative progression. Moreover, exosomes serve as non-invasive biomarkers, enabling early and precise diagnosis while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded with therapeutic molecules, enhance this capability by targeting diseased neurons and overcoming conventional treatment barriers. By offering enhanced specificity, reduced immunogenicity, and an ability to bypass physiological limitations, exosome-based strategies present a transformative advantage over existing diagnostic and therapeutic approaches. This review examines the multifaceted role of exosomes in NDDs, emphasizing their diagnostic capabilities, intrinsic therapeutic functions, and transformative potential as advanced treatment vehicles.
