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Article Citation - Scopus: 5Real-World Data From Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?(AVES, 2021) Demirtürk,N.; Aygen,B.; Çelik,İ.; Mıstık,R.; Akhan,S.; Barut,Ş.; Doğan,N.; Karakeçili, Faruk; Asan, Ali; Özel, Selcan Arslan; Ersöz, Gülden; Yıldız, Orhan; Şimşek, Sümeyra; Tarakçı, HüseyinBackground: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice. Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 ± 14.2, and 293 (55.8%) were female. The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at baseline in 381 patients (72.6%). SOF/LDV ± RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes. All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect. Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV ± RBV treatment in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment. © Copyright 2021 by The Turkish Society of Gastroenterology • Available online at turkjgastroenterol.orgArticle Factors Affecting the Burden and Quality of Life of Caregivers For\rgynecological Cancer Patients(AVES, 2022) Yaşar, Beril Nisa; Terzioğlu, FüsunObjective: The aim of this study is to evaluate the care burden and quality of life of caregivers of patients with gynecologic cancer.\rMaterial and Methods: This descriptive study was conducted with 251 individuals who provided care to patients with gynecologic cancer in gynecologic oncology\rservices of a university hospital and a state oncology hospital. The data were collected by a semi-structured questionnaire form, Caregiver Burden Inventory (CBI),\rand Quality of Life Family Version.\rResults: The mean age of the participants was 39.76 ± 14.20; 79.3% of them were female, 65.3% were married, 28.7% were high school graduates, 57.4% were\remployed and 56.2% were unemployed before starting care, 91.2% had health insurance, 58.6% perceived their income as moderate, and 57% had relatives of the\rpatient receiving care. Care burden was statistically significant in terms of gender, marital status, educational level, and degree of affinity with the patient (P < .005).\rThe correlation between caregivers’ quality of life, gender, health insurance, income status, and the degree of affinity with the patient was statistically significant\r(P < .005).\rConclusion: As a result of this study, it was determined that some socio-demographic characteristics of the caregivers of patients with gynecologic cancer affected\rthe care burden and quality of life.
