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Article Citation - WoS: 1Citation - Scopus: 1Topical Intranasal Insulin Enhances Healing of Nasal Mucosa: an Experimental Animal Study(Sage Publications inc, 2023) Kulekci, Cagri; Ozer, Serdar; Onen, Selin; Korkusuz, Petek; Yilmaz, TanerObjective Aim of this study was to evaluate the effect of topical intranasal insulin on healing of nasal mucosa in a rat model. Methods Forty-eight Wistar rats, weighing between 250 and 300 g and aged 10-12 weeks were used and randomized into two equal groups. 1.9 mm curette was introduced through the left nostril and 1.9 mm mucosa from the left nasal septum was curetted. Postoperatively, animals in the control group received 1 mL of physiologic saline, 3 times a day in a nasal irrigation fashion. Animals in the experimental group received 1 mL of 5 IU/mL regular insulin in saline solution. Subjects were sacrificed after 5, 10, and 15 days and macroscopic and histomorphometric evaluations were performed. Results There were no mucosal synechiae and septal perforation macroscopically. Histological examination revealed that the defect size reduction was 21% in the saline group versus 56% in the insulin group on the fifth day (p = 0.006). There was 62% defect reduction in the saline group versus 79% in the insulin group on the 10th day (p = 0.034). On the 15th day, only 67% of saline group animals had complete defect closure, whereas 100% of animals treated with insulin had complete closure (92% vs 100% mucosal defect reduction, p = 0.036). Both edema and inflammation were less in the insulin group on 15th day (p = 0.006; p = 0.023, respectively). Conclusion The results from this study support the safety and efficacy of topical insulin on wound healing in the literature. This study could guide further experimental studies that examine human sinonasal wound healing.Article Citation - WoS: 2Citation - Scopus: 4Evaluation of Wound Healing in Patients With Hip Prosthesis According To Nursing Outcome Classification(Wiley, 2022) Seyhan Ak, Ezgi; Kilinc Akman, Esra; Gencbas, DercanPurpose The purpose of this study is to perform Turkish adaptation and validation of NOC (1102) Wound Healing: Primary Intent and examine wound healing in patients with hip prosthesis diagnosed with impaired tissue integrity. Method The study was carried out in methodological and descriptive design, and the sample of the study consisted of 55 patients. Introductory Characteristics Form and Wound Healing: Primary Intention NOC Form were used for data collection. Ethical consent was obtained before initiating the study. Findings In the study, content validity index value of the NOC scale was calculated was 95.71%. Looking at NOC scale indicators for postoperative day 1, 2, and 7 and the distribution of the total mean scores, it was determined that there was a statistically significant difference between the mean scores over time (p = 0.000). It was found that patients with chronic disease had lower NOC scale scores and wound healing was slower on the postoperative first day compared to the patients with no chronic diseases (p < 0.05). Conclusions As a result of the study, it was concluded that the Turkish version of the Wound Healing: Primary Intention NOC (1102) scale was a valid tool for evaluating the location of the wound in patients with hip prosthesis, the presence of chronic diseases affected wound healing, and mean scores obtained by the patients in NOC scale increased over time with a good progress in terms of wound healing. Implications of Nursing Practice With the use of Wound Healing: Primary Intention NOC (1102) scale, a common language will be formed in the evaluation of the wound site of patients undergoing hip prosthesis.
