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Article Citation - WoS: 2Citation - Scopus: 2Role of Surveillance Screening in Detecting Tumor Recurrence After Treatment of Childhood Cancers(Aves, 2021) Kısa, Pelin Teke; Emir, Suna; Teke Kısa, PelinObjective: As the survival rates in children with cancer reach up to 80%, this improvement in survival increases the number of patients under follow-up. After cancer treatment is completed, patients are taken to follow-up surveillance to ensure the early detection of recurrence and the late effects of treatments. The frequency and necessity of surveillance screening tests are controversial. This study aimed to assess the efficacy of surveillance screening in the detection of recurrence. Material and methods: The files of 533 children who were diagnosed as having cancer at our pediatric oncology clinic between 2004 and 2013 were retrospectively evaluated. We looked at outcomes after recurrence, the timing and pattern of recurrence, the presence of symptoms during recurrence, physical examination findings, tumor marker levels, laboratory findings, and radiologic tests. Results: Of the 63 patients with recurrence, 23 were symptomatic and 40 were asymptomatic at the time of the recurrence. Tumor location and time of the recurrence did not affect the post recurrence survival. The median post-recurrence survival for patients was 13 (range, 1-98) months. The median post-relapse survival was 10 (range, 1-73) months in patients with symp-tomatic recurrence, and 16 (range, 1-98) months in patients with asymptomatic recurrence. It was determined that patients in whom recurrence was identified with surveillance tests had longer post-relapse survival time. The 5-year survival rate of 23 patients with symptomatic recurrence was 12.2%; this rate was 49.5% in asymptomatic patients (p<0.05).Conclusions: It should be considered that surveillance testing offers the benefit of prolonging post recurrence survival.Article Citation - WoS: 172Mortality Analysis of Covid-19 Infection in Chronic Kidney Disease, Haemodialysis and Renal Transplant Patients Compared With Patients Without Kidney Disease: a Nationwide Analysis From Turkey(Oxford Univ Press, 2020) Ozturk, Savas; Turgutalp, Kenan; Arici, Mustafa; Odabas, Ali Riza; Altiparmak, Mehmet Riza; Aydin, Zeki; Ates, KenanBackground. Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand as one of the established potential risk factors for severe coronavirus disease 2019 (COVID-19). Case morbidity and mortality rates for any type of infection have always been much higher in CKD, haemodialysis (HD) and RT patients than in the general population. A large study comparing COVID-19 outcome in moderate to advanced CKD (Stages 3-5), HD and RT patients with a control group of patients is still lacking. Methods. We conducted a multicentre, retrospective, observational study, involving hospitalized adult patients with COVID-19 from 47 centres in Turkey. Patients with CKD Stages 3-5, chronic HD and RT were compared with patients who had COVID-19 but no kidney disease. Demographics, comorbidities, medications, laboratory tests, COVID-19 treatments and outcome [in-hospital mortality and combined in-hospital outcome mortality or admission to the intensive care unit (ICU)] were compared. Results. A total of 1210 patients were included [median age, 61 (quartile 1-quartile 3 48-71) years, female 551 (45.5%)] composed of four groups: control (n = 450), HD (n = 390), RT (n = 81) and CKD (n = 289). The ICU admission rate was 266/1210 (22.0%). A total of 172/1210 (14.2%) patients died. The ICU admission and in-hospital mortality rates in the CKD group [114/289 (39.4%); 95% confidence interval (CI) 33.9-45.2; and 82/289 (28.4%); 95% CI 23.9-34.5)] were significantly higher than the other groups: HD = 99/390 (25.4%; 95% CI 21.3-29.9; P < 0.001) and 63/390 (16.2%; 95% CI 13.0-20.4; P < 0.001); RT = 17/81 (21.0%; 95% CI 13.2-30.8; P = 0.002) and 9/81 (11.1%; 95% CI 5.7-19.5; P = 0.001); and control = 36/450 (8.0%; 95% CI 5.8-10.8; P < 0.001) and 18/450 (4%; 95% CI 2.5-6.2; P < 0.001). Adjusted mortality and adjusted combined outcomes in CKD group and HD groups were significantly higher than the control group [hazard ratio (HR) (95% CI) CKD: 2.88 (1.52-5.44); P = 0.001; 2.44 (1.35-4.40); P = 0.003; HD: 2.32 (1.21-4.46); P = 0.011; 2.25 (1.23-4.12); P = 0.008), respectively], but these were not significantly different in the RT from in the control group [HR (95% CI) 1.89 (0.76-4.72); P = 0.169; 1.87 (0.81-4.28); P = 0.138, respectively]. Conclusions. Hospitalized COVID-19 patients with CKDs, including Stages 3-5 CKD, HD and RT, have significantly higher mortality than patients without kidney disease. Stages 3-5 CKD patients have an in-hospital mortality rate as much as HD patients, which may be in part because of similar age and comorbidity burden. We were unable to assess if RT patients were or were not at increased risk for in-hospital mortality because of the relatively small sample size of the RT patients in this study.Article Morning Blood Pressure Surge in Renal Transplant Recipients: Its Relation To Graft Function and Arterial Stiffness(Wiley, 2022) Demirci, Bahar Gurlek; Afsar, Baris; Tutal, Emre; Colak, Turan; Sezer, SirenBackground: When the blood pressure rises before awakening in the morning, it is called as morning blood pressure pulse (MBPS). MBPS is considered to be an independent risk factor for cardiovascular disease. The aim of this study was to investigate the associations between MBPS, graft function, arterial stiffness and echocardiographic indices in renal transplant recipients. Methods: Among 600 renal transplant recipients, 122 patients who had a history of hypertension and were taking at least one anti hypertensive medication were enrolled in the study. Arterial stiffness was measured by carotid-femoral pulse wave velocity (PWv), and echocardiographic indices were assessed. 24 h ambulatory blood pressure was monitored for all patients. MBPS was calculated by subtracting morning systolic blood pressure from minimal asleep systolic blood pressure. Results: Mean morning, day time and asleep systolic blood pressure values were 171.2 +/- 23.9, 137.9 +/- 18.1, and 131.7 +/- 18.9, respectively. Nondipper hypertension status was observed in 93 patients. Mean MBPS was 35.6 +/- 19.5 mm Hg, means PWv was 6.5 +/- 2.0 m/s. Patients with MBPS >= 35 mm Hg, had significantly lower eGFR and higher proteinuria, PWv. higher left atrium volume and LVMI. In regression analysis, day time systolic blood pressure, asleep systolic blood pressure, morning blood pressure surge, nondipper status and left ventricular mass index were detected as the predictors of graft function. Conclusions: Increased morning blood pressure surge is associated with graft dysfunction, increased arterial stiffness and LVMI that contribute to cardiovascular mortality and morbidity in renal transplant recipients.Article Citation - WoS: 28Citation - Scopus: 29Nursing Students' Perceived Stress: Interaction With Emotional Intelligence and Self-Leadership(Wiley, 2022) Yildirim-Hamurcu, Sevda; Terzioglu, FusunPurpose The aim of the current study was to determine how emotional intelligence and self-leadership levels could be related to perceived stress. Design and Methods A total of 341 nursing students were enrolled in this descriptive correlational study. Study measures included a sociodemographic form, Emotional Intelligence Evaluation Scale, Revised Self-Leadership Questionnaire, and Perceived Stress Scale for Nursing Students. Findings Results showed that ''assignments and workload'' as well as "taking care of patients" were the highest sources of stress in clinical training. The emotional intelligence and self-leadership levels had a significant negative correlation with the perceived stress. Practice Implications Perceived stress affects students' academic and social success negatively. Therefore, it is important to develop students' emotional intelligence levels, self-leadership perceptions.Article The Mediating Role of Self-Compassion in the Relationship between Postpartum Depression and Breastfeeding Self-Efficacy(Sage Publications Ltd, 2025) Akdag Topal, Cansu; Mert Karadas, Merve; Karakurt, Irem; Boztepe, HandanPostpartum depression (PPD) may adversely affect breastfeeding self-efficacy, yet the underlying mechanisms remain unclear. This study explored whether self-compassion mediates the relationship between PPD and breastfeeding self-efficacy among Turkish women. An expert model was developed based on validated scales: the Self-Compassion Scale, the Edinburgh Postpartum Depression Scale, and the Postnatal Breastfeeding Self-Efficacy Scale-Short Form. In this cross-sectional study, 236 women (mean age: 28.71, SD = 6.16) were surveyed. Results showed that depression was negatively associated with self-compassion (beta = -0.474, p < 0.001), and self-compassion was positively associated with breastfeeding self-efficacy (beta = 0.785, p < 0.001). Mediation analysis indicated that self-compassion partially mediated the link between PPD and breastfeeding self-efficacy, with a significant indirect effect (-0.586, -0.209). Depression also had a direct negative effect on breastfeeding self-efficacy (beta = -0.484, p < 0.001). These findings suggest that fostering self-compassion may enhance maternal mental health and breastfeeding outcomes.Article Measuring the Reusable Quality for Xml Schema Documents(Budapest Tech, 2013) Thaw, Tinzar; Misra, SanjayeXtensible Markup Language (XML) based web applications are widely used for data describing and providing internet services. The design of XML schema document (XSD) needs to be quantified with software with the reusable nature of XSD. This nature of documents helps software developers to produce software at a lower software development cost. This paper proposes a metric Entropy. Measure of Complexity (EMC), which is intended to measure the reusable quality of XML schema documents. A higher EMC value tends to more reusable quality, and as well, a higher EMC value implies that this schema document contains inheritance feature, elements and attributes. For empirical validation, the metric is applied on 70 WSDL schema files. A comparison with similar measures is also performed. The proposed EMC metric is also validated practically and theoretically. Empirical, theoretical and practical validation and a comparative study proves that the EMC metric is a valid metric and capable of measuring the reusable quality of XSD.Article Citation - WoS: 1Citation - Scopus: 1A Retrospective Study of Tracheostomy Care and Decannulation of the Patients in a Palliative Care Center(Sage Publications inc, 2024) Zengin, Hilal; Karahan, Zehra Can; Can Karahan, ZehraBackground: World Health Organization defines palliative care as a multidisciplinary approach to enhancing patients physical, psychological, and emotional well-being. Our study investigated palliative care unit decannulation rates and factors affecting success. Methods: The data of patients hospitalized in the palliative care clinic between 2017 and 2019 were analyzed retrospectively. Demographic data, diagnoses, comorbidities, nutritional status, Norton and Braden Scale scores, day of hospitalization, and discharge direction of the patients were recorded. All patients were evaluated and treated by a multidisciplinary team. Results: One hundred two tracheostomy patients were monitored. Patients in the palliative care clinic had an average stay of 22.19 +/- 13.67 days (median: 21, min: 4, max: 66). Forty-one patients were decannulated. Statistically significant age difference was observed between decannulated and non-cannulated groups, with the decannulated group having a significantly lower mean age (52.10 +/- 20.54, median: 53) compared to the non-decannulated group (61.48 +/- 18.07) (z = -2.516, P = .012). The mean Braden scale score of the decannulated group (14.29 +/- 2.50) was significantly higher than that of the non-decannulated group (12.20 +/- 2.82) (z = 3.823, P < .001), and the mean Norton scale score of the decannulated group (11.34 +/- 2.50) was significantly higher than that of the non-decannulated group (9.46 +/- 2.46) (z = 3.472, P = .001). Conclusion: Patients with tracheostomy can be easily followed and decannulated in palliative care clinics. It is important that a multidisciplinary team is involved in palliative care units. Age, immobility, Norton and Braden scales, and level of consciousness are factors affecting the success of decannulation.Article Citation - WoS: 9Citation - Scopus: 11Human Laryngeal Squamous Cell Carcinoma Cell Line Release of Endogenous Anandamide and 2-Arachidonoylglycerol, and Their Antiproliferative Effect Via Exogenous Supplementation: an in Vitro Study(Springer, 2022) Onay, Ovsen; Kose, Sevil; Suslu, Nilda; Korkusuz, Petek; Nemutlu, Emirhan; Aydin, Canset; Hosal, SefikThe level of the major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are altered in several types of carcinomas, and are known to regulate tumor growth. Thusly, this study hypothesized that the HEp-2 human laryngeal squamous cell carcinoma (LSCC) cell line releases AEA and 2-AG, and aimed to determine if their exogenous supplementation has an anti-proliferative effect in vitro. In this in vitro observational study a commercial human LSCC cell line (HEp-2) was used to test for endogenous AEA and 2-AG release via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The anti-proliferative effect of AEA and 2-AG supplementation was evaluated via WST-1 proliferation assay. It was observed that the HEp-2 LSCC cell line released AEA and 2-AG; the median quantity of AEA released was 15.69 ng mL(-1) (range: 14.55-15.95 ng mL(-1)) and the median quantity of 2-AG released was 2.72 ng (-1) (range: 2.67-2.74 ng mL(-1)). Additionally, both AEA and 2-AG exhibited an anti-proliferative effect. The anti-proliferative effect of 2-AG was stronger than that of AEA. These findings suggest that AEA might function via a CB1 receptor-independent pathway and that 2-AG might function via a CB2-dependent pathway. The present findings show that the HEp-2 LSCC cell line releases the major endocannabinoids AEA and 2-AG, and that their supplementation inhibits tumor cell proliferation in vitro. Thus, cannabinoid ligands might represent novel drug candidates for laryngeal cancers, although functional in vivo studies are required in order to validate their potency.Article Citation - WoS: 3Citation - Scopus: 2Cross-Sectional Determinants of Lactose-Free Food Awareness and Purchase Among Adult Consumers(Cambridge Univ Press, 2023) Yilmaz, Birsen; Agaguenduez, Duygu; Kalyoncu Atasoy, Z. Begum; Yesilyurt, Neslihan; Ergin, Sule; Murat, Naci; Yllmaz, Birsen; Aǧagündüz, DuyguThis research was conducted to evaluate the knowledge and purchasing behaviour of consumers regarding lactose-free foods. Study data were collected from 1882 individuals with the help of a questionnaire form. Attitudes towards animal welfare, healthy nutrition and gastrointestinal symptoms were also evaluated. The majority (86.6%) of the participants reported that they had heard of the concept of lactose-free foods before, but more than half (67.0%) did not report buying them because of their higher costs compared to regular products and lack of sufficient information. Not causing gas/bloating (32.5%) and being healthier (28.3%) were shown to be the most significant motivational factors in purchasing lactose-free foods (P < 0.05). The factors affecting purchase of lactose-free products were education, employment status, history of having a food intolerance test and animal welfare perception together with higher scores from the gastrointestinal symptom rating scale, and attitude scale for healthy nutrition (P < 0.05). Body mass index was not found to be an effective factor determining purchase intention. The results provide a general overview of consumers, however, further studies on other demographic groups are needed.Review Citation - WoS: 29Citation - Scopus: 46Impact of Nanotechnology on Conventional and Artificial Intelligence-Based Biosensing Strategies for the Detection of Viruses(Springer, 2023) Ramalingam, Murugan; Jaisankar, Abinaya; Cheng, Lijia; Krishnan, Sasirekha; Lan, Liang; Hassan, Anwarul; Marrazza, GiovannaRecent years have witnessed the emergence of several viruses and other pathogens. Some of these infectious diseases have spread globally, resulting in pandemics. Although biosensors of various types have been utilized for virus detection, their limited sensitivity remains an issue. Therefore, the development of better diagnostic tools that facilitate the more efficient detection of viruses and other pathogens has become important. Nanotechnology has been recognized as a powerful tool for the detection of viruses, and it is expected to change the landscape of virus detection and analysis. Recently, nanomaterials have gained enormous attention for their value in improving biosensor performance owing to their high surface-to-volume ratio and quantum size effects. This article reviews the impact of nanotechnology on the design, development, and performance of sensors for the detection of viruses. Special attention has been paid to nanoscale materials, various types of nanobiosensors, the internet of medical things, and artificial intelligence-based viral diagnostic techniques.
