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Article Citation - WoS: 32Electrospun Essential Oil-Polycaprolactone Nanofibers as Antibiofilm Surfaces Against Clinical Candida Tropicalis Isolates(Springer, 2019) Sahal, Gulcan; Nasseri, Behzad; Ebrahimi, Aliakbar; Bilkay, Isil SeyisObjectiveAs an approach to prevent biofilm infections caused by Candida tropicalis on various surfaces, determination of effect of biodegradable polycaprolactone nanofibers (PCLNFs) with different concentrations of two different essential oils were tested in this study.ResultsBoth of the tested essential oils exhibited antifungal effect (minimal inhibitory concentration; 0.25-0.49 mu L/mL, minimal fungicidal concentration; 0.25-0.49 mu L/mL, depending on the C. tropicalis strain) (Zone of inhibition caused by 500 L/mL concentration of oils; 28-56mm). 0, 2, 4% clove oil PCLNFs and 0, 2, 4% red thyme oil-PCLNFs were free from bead formation and uniform in diameter. Diameters of all essential oil containing PCLNFs were ranged from 760 to 1100nm and were significantly different from 0% essential oil-PCLNF (P<0.05). 0, 2, 4% clove oil-PCLNFs were significantly more hydrophobic compared to 8% clove oil-PCLNF (P<0.01), whereas 0% and 2% red thyme oil-PCLNFs were significantly more hydrophobic compared to 4% and 8% red thyme oil PCLNFs (P<0.01). Highest amount of biofilm inhibition was observed by 4% clove oil-PCLNF and by 4% red thyme oil-PCLNF.ConclusionsClove and red thyme oils may be used not only as antifungals but also as biofilm inhibitive agents on surfaces of biomaterials that are frequently contaminated by C. tropicalis, when they are incorporated into PCLNFs.Article Multifunctional POSS-Based Nanoparticles Functionalized with Silver, SPIONs, and Rhamnolipid for Antibacterial Applications(Elsevier Ltd, 2026) Kibar, G.; Kafali, M.; Ozonuk, O.C.; Öztaş, M.; Usta, B.; Ercan, B.Nano-engineered materials, particularly those featuring bio-based surface modifications, are emerging as effective tools in combating bacterial infections. In this study, polyhedral oligomeric silsesquioxane (POSS) nanoparticles were functionalized with silver nanoparticles (Ag), superparamagnetic iron oxide nanoparticles (SPIONs), and the biosurfactant rhamnolipid (RL)—either individually or in combination—to evaluate their antibacterial and antibiofilm activities against Staphylococcus aureus ( S. aureus ) and Pseudomonas aeruginosa ( P. aeruginosa ). The modified nanoparticles exhibited sizes ranging from 127 to 227 nm and demonstrated superparamagnetic behavior, offering potential for magnetic targeting. Among the various formulations, the RL-coated, silver- and SPION-decorated POSS nanoparticles (RSMP) exhibited the highest antibacterial efficacy, reducing S. aureus and P. aeruginosa colony growth by approximately 90 % and 66 %, respectively, at a concentration of 0.01 g/L. RSMP nanoparticles also showed strong biofilm inhibition and had the lowest MIC₅₀ values. Notably, these nanoparticles supported the proliferation of human osteoblasts at concentrations up to 0.05 g/L, indicating favorable cytocompatibility. Overall, RSMP nanoparticles present a promising platform for magnetically targetable antibacterial agents, with potential applications in biomedical fields, particularly for managing orthopedic infections. © 2025 Elsevier B.V.
