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Editorial Citation - WoS: 47Citation - Scopus: 47Emergency Changes in International Guidelines on Treatment for Head and Neck Cancer Patients During the Covid-19 Pandemic(Elsevier, 2020) Chaves, Aline Lauda Freitas; Castro, Ana Ferreira; Marta, Gustavo Nader; Junior, Gilberto Castro; Ferris, Robert L.; Giglio, Raul Eduardo; Kowalski, Luiz Paulo[No Abstract Available]Book Part Clinical Development of Quinone-Based Drugs(Elsevier, 2024) Altuner, E.E.; Issa, G.; Ozalp, V.C.; Aldemir, O.; Torlak, Y.; Dar, U.A.This chapter provides a detailed explanation of the clinical investigations, pharmacological effects, and characteristics of quinone and quinone derivatives, along with references to pertinent sources. Although quinones have an oxygen group in their structure, they are quickly oxidized and interact with reactive oxygen species. This demonstrates how quinones work as drugs. Quinones and their derivatives are used as medications to treat a wide range of diseases, including cancer, lung, kidney, brain, and tumor disorders. Each of the following has effects on a different area of health; lapochols, anthraquinones, naphthoquinone and its derivatives, and other wide range of quinone derivatives are thoroughly explored in this chapter. © 2025 Elsevier Inc. All rights reserved.Article Citation - WoS: 39Citation - Scopus: 44A Novel Treatment Strategy for Preterm Birth: Intra-Vaginal Progesterone-Loaded Fibrous Patches(Elsevier, 2020) Cam, Muhammet Emin; Hazar-Yavuz, Ayse Nur; Cesur, Sumeyye; Ozkan, Ozan; Alenezi, Hussain; Sasmazel, Hilal Turkoglu; Edirisinghe, Mohan; Turkoglu Sasmazel, HilalProgesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for infra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.Article Citation - WoS: 19Citation - Scopus: 19Metagenomic and Chemical Analysis of Tarhana During Traditional Fermentation Process(Elsevier, 2021) Soyucok, Ali; Yurt, Mediha Nur Zafer; Altunbas, Osman; Ozalp, Veli Cengiz; Sudagidan, Mert; Zafer Yurt, Mediha NurTarhana is one of the favourable traditional fermented food consumed as a soup. Different flour, vegetables, spices and yogurt are main constituents and they compose of microbiota of Tarhana. In this study, bacterial communities in each fermentation process and in their constituents were identified by metagenomic analysis. Also, chemical properties (pH, acidity, salt content and dry matter) were analysed in each step. The results showed that in the dough formation, mainly Lactobacillus, Bacillus, Enterococcus and Streptococcus were present and after Day 4, Clostridium and Bacillus became dominant, after drying Clostridium disappeared and in the final product bacterial communities from Bacillus and Streptococcus genus were observed. Chemical analysis showed that pH decreased from 4.94 to 4.46, acidity increased by time at the beginning of fermentation from 7.5% to 22.5% in first 6 days period, then, became stable at 14% in drying process. Salt content increased by time from 1.74 to 3.08 g salt/100 g Tarhana in first 8 days and in drying process salt content was recorded as 2.81-2.90 and dry matter was obtained as 94 g dry matter/100 g Tarhana in the final product. This study elucidated the effects of ingredients, raw materials and how microbiota and chemical properties changes during fermentation steps of home-made traditional Tarhana production and thus preparation methods could be developed to obtain standardized Tarhana products for industrial production in future.Article Citation - WoS: 19Citation - Scopus: 21Lyapunov Type Inequalities for Mixed Nonlinear Riemann-Liouville Fractional Differential Equations With a Forcing Term(Elsevier, 2017) Agarwal, Ravi P.; Ozbekler, AbdullahIn this paper, we present some new Lyapunov and Hartman type inequalities for Riemann-Liouville fractional differential equations of the form ((a)D(alpha)x)(t) + p(t) vertical bar x(t) vertical bar(mu-1) x(t) + q(t) vertical bar x(t) vertical bar(gamma-1) x(t) = f(t), where p, q, f are real-valued functions and 0 < gamma < 1 < mu < 2. No sign restrictions are imposed on the potential functions p, q and the forcing term f. The inequalities obtained generalize and compliment the existing results for the special cases of this equation in the literature. (C) 2016 Elsevier B.V. All rights reserved.Article Citation - WoS: 51Citation - Scopus: 54Recrystallization and Grain Growth Kinetics of In718 Manufactured by Laser Powder Bed Fusion(Elsevier, 2022) Dogu, Merve Nur; Davut, Kemal; Obeidi, Muhannad Ahmed; Yalcin, Mustafa Alp; Gu, Hengfeng; Low, Thaddeus Song En; Brabazon, DermotThe recrystallization and grain growth behaviour of IN718 alloy additively manufactured by laser powder bed fusion (L-PBF) is presented herein. The effects of three different temperatures (1050, 1150 and 1250 degrees C) and holding times (15, 45 and 90 min) were investigated. The texture evolution of the samples was recorded via electron backscatter diffraction (EBSD). The as-built sample is composed of bowl-shaped melt pools, a chessboard-like grain pattern and has a cube texture {100}<001>. Recrystallized grains were observed in the samples treated at 1150 degrees C for 15 min, as well as the samples treated for longer periods and at higher temperatures. Recrystallization was observed to start from high dislocation density regions, including the overlapping melt pools and the borders of the chessboard-like pattern. The initial cube texture transforms into a first-generation cube-twin texture {122}<212> via a twinning-assisted recrystallization mechanism. Then, those recrystallization nuclei sweep through the high defect density matrix; during which almost no new twins are formed. The samples treated at 1250 degrees C are almost completely recrystallized, which forms a weaker cube texture and a stronger P-orientation {011}<112>. However, the growth of recrystallized grains is very limited due to the presence of non-coherent precipitates. (C) 2022 The Author(s). Published by Elsevier B.V.Article Citation - WoS: 25Citation - Scopus: 28Effect of Solution Heat Treatment on the Microstructure and Crystallographic Texture of In939 Fabricated by Powder Bed Fusion-Laser Beam(Elsevier, 2023) Dogu, Merve Nur; Ozer, Seren; Yalcin, Mustafa Alp; Davut, Kemal; Bilgin, Guney Mert; Obeidi, Muhannad Ahmed; Brabazon, DermotThe effect of various solution heat treatment temperatures (i.e., 1120, 1160, 1200 and 1240 & DEG;C) on the microstructure, grain morphology and crystallographic texture of IN939 fabricated by powder bed fusion-laser beam (PBF-LB) was investigated. Microstructural analyses showed that the high-temperature gradient and rapid solidification of the PBF-LB processing caused different resulting microstructures compared to conventionally pro-duced counterparts. The melt pool morphologies and laser scanning paths were examined in the as-fabricated samples in the XZ-and XY-planes, respectively. After the application of solution heat treatment at 1120 & DEG;C, the as-fabricated PBF-LB initial microstructure was still apparent. For solution heat treatments of 1200 & DEG;C and above, the melt pool and scanning path morphologies disappeared and converted into a mixture of columnar grains in the XZ-plane and equiaxed grains in the XY-plane. On the other hand, large equiaxed grains were observed when the samples were solutionized at 1240 & DEG;C. Additionally, g' phase precipitated within the matrix after all solution heat treatment conditions, which led to increase in the microhardness values. According to electron backscatter diffraction (EBSD) analyses, both as-fabricated and solution heat-treated samples had intense texture with {001} plane normal parallel to the building direction. The first recrystallized grains began to appear when the samples were subjected to the solution heat treatment at 1160 & DEG;C and the fraction of the recrystallized grains increased with increasing temperature, as supported by kernel average misorientation (KAM) and grain spread orientation (GOS) analyses.& COPY; 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Article Citation - WoS: 2Geoengineering Properties of the Ertugrul (cayirkoy) District, Nilufer Province, Bursa-Turkey, by Using Geophysical Methods and Borehole Data(Elsevier, 2020) Cetin, Fatma; Kutluk, Hatice; Aydemir, AttilaIn this study, soil classification experiments and geophysical studies are carried out for the evaluation of local ground soil conditions by using the data and samples from the boreholes in the Quaternary sediments in the Ertugrul district of Nilufer, Bursa, then the engineering parameters and index classifications are also investigated with the soil mechanics experiments using the disturbed samples from the drill holes. The grade of swelling (bulking) potential in the ground soil is found medium, high and very high in different parts of the study area. The basement units for the constructions bear very low liquefaction risk. The plasticity index varies between 9 and 25, but active mass movements are not expected. However, engineering problems such as swelling (bulking), soil settlements, bearing capacity reduction may be expected under the seismic forces because of the alluvial composition, 0-5 degree soil inclinations and being located in the 1st degree earthquake hazard risk zone. Therefore, the study area may be classified in the 'precautionary zone' in the urbanization category in terms of engineering problems. (C) 2020 Elsevier B.V. All rights reserved.Article Citation - WoS: 13Citation - Scopus: 19Bifunctional Praseodymium-Doped Sns2 Thin Films for Photocatalytic and Antibacterial Applications(Elsevier, 2024) Ech-Chergui, Abdelkader Nebatti; Bennabi, Farid; Isik, Mehmet; Khane, Yasmina; Garcia, Francisco Jose Garcia; Kadari, Ali Sadek; Amrani, BouhalouaneThis paper introduces a novel application of bifunctional Pr-doped SnS2 thin films, demonstrating their efficacy in both photocatalytic degradation of dye and antibacterial activities. The thin films were fabricated using an eco-friendly spray-coated method, encompassing undoped and Pr-doped SnS2 variations. The study comprehensively examines the structural, morphological, chemical, photocatalytic, and antibacterial characteristics of these films. The crystal structure of both undoped and Pr-doped SnS2 thin films exhibited hexagonal patterns, prominently favouring the growth in (1 0 1) orientation. Notably, an increase in crystallite size was observed with higher levels of Pr-doping. Raman spectroscopy analysis highlighted a distinct peak at 315 cm -1, corresponding to the A1 g vibrational mode associated with Sn-S bonds along the c-axis of the structure. Employing X ray Photoelectron Spectroscopy (XPS), the presence of essential components - Sn, S, and Pr - within the fabricated thin films was confirmed, consistent with experimental values of undoped and Pr -doped SnS2-x compositions. Importantly, the XPS analysis confirmed the integration of the Pr3+ oxidation state within Pr -doped SnS2 films. The photocatalytic degradation and antibacterial activities of the films were investigated. Notably, the photocatalytic potential of the synthesized materials against Congo Red exhibited a direct correlation with the Pr3+ doping percentage, indicating enhanced pollutant degradation with increasing doping levels. Similarly, the antibacterial performance against Escherichia coli displayed improvement with increasing Pr -doping content, highlighting the promising antimicrobial capabilities of the films. This study presents an innovative avenue to address both organic pollutant degradation and microbial control. By harnessing the attributes of Pr -doped SnS2 thin films, this research introduces a promising strategy for sustainable material applications in environmental purification and improvement in public health.Review Citation - WoS: 67Citation - Scopus: 81Software Test Maturity Assessment and Test Process Improvement: a Multivocal Literature Review(Elsevier, 2017) Garousi, Vahid; Felderer, Michael; Hacaloglu, TunaContext: Software testing practices and processes in many companies are far from being mature and are usually conducted in ad-hoc fashions. Such immature practices lead to various negative outcomes, e.g., ineffectiveness of testing practices in detecting all the defects, and cost and schedule overruns of testing activities. To conduct test maturity assessment (TMA) and test process improvement (TPI) in a systematic manner, various TMA/TPI models and approaches have been proposed. Objective: It is important to identify the state-of-the-art and the-practice in this area to consolidate the list of all various test maturity models proposed by practitioners and researchers, the drivers of TMA/TPI, the associated challenges and the benefits and results of TMA/TPI. Our article aims to benefit the readers (both practitioners and researchers) by providing the most comprehensive survey of the area, to this date, in assessing and improving the maturity of test processes. Method: To achieve the above objective, we have performed a Multivocal Literature Review (MLR) study to find out what we know about TMA/TPI. A MLR is a form of a Systematic Literature Review (SLR) which includes the grey literature (e.g., blog posts and white papers) in addition to the published (formal) literature (e.g., journal and conference papers). We searched the academic literature using the Google Scholar and the grey literature using the regular Google search engine. Results: Our MLR and its results are based on 181 sources, 51 (29%) of which were grey literature and 130 (71%) were formally published sources. By summarizing what we know about TMA/TPI, our review identified 58 different test maturity models and a large number of sources with varying degrees of empirical evidence on this topic. We also conducted qualitative analysis (coding) to synthesize the drivers, challenges and benefits of TMA/TPI from the primary sources. Conclusion: We show that current maturity models and techniques in TMA/TPI provides reasonable advice for industry and the research community. We suggest directions for follow-up work, e.g., using the findings of this MLR in industry-academia collaborative projects and empirical evaluation of models and techniques in the area of TMA/TPI as reported in this article. (C) 2017 Elsevier B.V. All rights reserved.
