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Article Citation - WoS: 75Citation - Scopus: 80Unique Ligand-Based Oxidative Dna Cleavage by Zinc(ii) Complexes of Hpyramol and Hpyrimol(Wiley-v C H verlag Gmbh, 2007) Maheswari, Palanisamy Uma; Barends, Sharief; Oezalp-Yaman, Seniz; de Hoog, Paul; Casellas, Helene; Teat, Simon J.; Reedijk, JanThe zinc(II) complexes reported here have been synthesised from the ligand 4-methyl-2-N-(2-pyridylmethyl)aminophenol (Hpyramol) with chloride or acetate counterions. All the five complexes have been structurally characterised, and the crystal structures reveal that the ligand Hpyramol gradually undergoes an oxidative dehydrogenation to form the ligand 4-methyl-2-N-(2-pyridylmethylene)aminophenol (Hpyrimol), upon coordination to Zn-II. All the five complexes cleave the phi X174 phage DNA oxidatively and the complexes with fully dehydrogenated pyrimol ligands were found to be more efficient than the complexes with non-dehydrogenated Hpyramol ligands. The DNA cleavage is suggested to be ligand-based, whereas the pure ligands alone do not cleave DNA. The DNA cleavage is strongly suggested to be oxidative, possibly due to the involvement of a non-diffusible phenoxyl radical mechanism. ne enzymatic religation experiments and DNA cleavage in the presence of different radical scavengers further support the oxidative DNA cleavage by the zinc(II) complexes.Article Citation - WoS: 2Citation - Scopus: 2Synthesis, Properties, and Electrochemistry of a Photochromic Compound Based on Dithienylethene and Prodot(Tubitak Scientific & Technological Research Council Turkey, 2015) Algi, Melek Pamuk; Cihaner, Atilla; Algi, FatihThe synthesis, photochromic features, and electrochemistry of a novel material based on dithienylethene (DTE) and 3,3-didecyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine (didecyl-ProDOT) units are described. It is noteworthy that 1,2-bis (5-(3,3-didecyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-6-yl)-2-methylthiophen-3-yl)cyclopent-1-ene can be efficiently switched between open and closed states by light in both solution and in the solid poly(methyl metacrylate) (PMMA) matrix. It is also found that the emission of this novel compound can be switched on and off upon irradiation.
