2 results
Search Results
Now showing 1 - 2 of 2
Article Citation - WoS: 1Citation - Scopus: 1Dietary Total Antioxidant Capacity and Oxidative Stress in Patients With Type-2 Diabetes(Mattioli 1885, 2021) Cetiner, Ozlem; Sendur, Suleyman Nahit; Yalcin, Tuba; Bayraktar, Miyase; Rakicioglu, NeslisahBackground: Reactive oxygen species can disrupt normal cellular functions by damaging DNA, protein, and lipid structures of the cell. Some antioxidant molecules may protect the body against reactive oxygen species. We aimed to investigate the relationship between the dietary intake of antioxidants and oxidative DNA damage in diabetic patients. Material and Methods: A total of 85 individuals were included in the study, of which 30 were newly diagnosed with type-2 diabetes, 30 were formerly diagnosed with type-2 diabetes, and 25 were healthy individuals. Twenty-four-hour dietary recalls were recorded for 3 consecutive days. Dietary total antioxidant capacity and dietary oxidative balance scores were calculated according to these records. Spot urine samples were collected and analyzed for 8-hydroxy-2' deoxyguanosine/creatinine. Results: Dietary total antioxidant capacity, estimated via different methods, was higher in the controls than that in patients with type-2 diabetes (p<0.05). The urinary 8-hydroxy-2'-deoxyguanosine/creatinine ratio, a reliable predictor of oxidative DNA damage, was also higher in non-diabetic patients (p<0.05). The urinary 8-hydroxy-2'-deoxyguanosine/creatinine ratio was not related to dietary antioxidant intake (p>0.05). Conclusion: Urinary 8-hydroxy-2'-deoxyguanosine/creatinine concentration may not always reflect the current oxidative status of the body.Article Clinical and Laboratory Evaluation of Acute Pericarditis Associated With Antinuclear Antibodies Positivity(Bentham Science Publ Ltd, 2023) Dursun, Ali Dogan; Saricam, Ersin; Erdem, Hakan; Sariyildiz, Gulcin Turkmen; Ozyer, Esref Umut; Bozkurt, Engin; Cantekin, Omer FarukBackground Up to 30% of patients with acute pericarditis develop recurrent pericarditis. Acute pericarditis may be a manifestation of an underlying systemic autoimmune disease. Therefore, we evaluated the characteristics of patients with acute pericarditis according to antinuclear antibodies (ANA) positivity/negativity. Methods Participants with acute pericarditis and negative ANA (n=29), recurrent pericarditis with positive ANA (n=30) and healthy controls (n=11) were examined. The groups were compared using serum parameters (ANA, C-reactive protein, leucocyte count, erythrocyte sedimentation rate, total antioxidant status, nitric oxide (NO), and oxidative stress index (OSI)) and imaging techniques (electrocardiogram, echocardiography, cardiovascular magnetic resonance, and venous Doppler ultrasound). Results In females, acute pericarditis associated with ANA occurred more frequently (p<0.001). ANA-positive acute pericarditis had significantly lower NO and OSI (p<0.05 and p<0.001, respectively) and pericardial inflammation on magnetic resonance. We found a pulmonary embolism in one patient with positive ANA. Slow venous flow (SVF) occurred more often in acute pericarditis associated with ANA than in the ANA-negative group on venous ultrasound (p<0.05). The prevalence of positive ANAs was 1.6 times higher among SVF patients than in controls. Conclusion This study suggests that acute pericarditis associated with ANA is more common in middle-aged females. SVF and lower oxidative stress tests were more common in patients with ANA-associated acute pericarditis. Acute pericarditis associated with ANA could be considered as a hypercoagulable state. Therefore, all newly diagnosed pericarditis patients (especially females) should be checked for ANA positivity. Awareness of this coexistence should be promptly addressed to establish management strategies.
