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COAR Access Rights: metadata only accessSubject: biomaterials

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    Article
    Citation - WoS: 13
    Citation - Scopus: 13
    In Vitro and in Vivo Bacterial Antifouling Properties of Phosphite of Plasma-Treated Silicone
    (Ice Publishing, 2019) Akdogan, Ebru; Demirbilek, Murat; Sen, Yasin; Onur, Mehmet Ali; Azap, Ozlem Kurt; Sonmez, Erkin; Mutlu, Mehmet
    In order to improve their bacterial antifouling property, silicone surfaces were functionalized through the plasma polymerization (PP) technique using diethyl phosphite as the precursor. The functionalized surfaces were characterized using contact angle measurements, contact angle titration, Fourier transform infrared-attenuated total reflection spectroscopy and in vitro cytotoxicity assay. The amount of non-specific protein adsorption and the conformational changes of surface-adsorbed proteins were investigated. Antifouling properties of the surfaces were evaluated in vitro and in vivo. PP functionalization generated a hydrophilic and amphoteric surface with a very good protein and bacterial antifouling property and caused less conformational changes on the secondary structure of surface-adsorbed proteins. In in vivo conditions, no slime layer was formed around bacteria that adhered on the PPfunctionalized surface. It is concluded that the amphoteric nature of the PP-functionalized surface is the reason for the good antifouling property.
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    Article
    Citation - WoS: 21
    Citation - Scopus: 24
    Poly(ε-Caprolactone) Composite Scaffolds Loaded With Gentamicin-Containing Β-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications
    (Wiley, 2014) Sezer, Umran Aydemir; Arslantunali, Damla; Aksoy, Eda Ayse; Hasirci, Vasif; Hasirci, Nesrin
    In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in the mechanical properties and an increase in the pore size and led to a faster release of gentamicin. Human osteosarcoma cells (Saos-2) were seeded on the prepared composite scaffolds, and the viability of cells having alkaline phosphatase (ALP) activity was observed for all of the scaffolds after 3 weeks of incubation. Cell proliferation and differentiation enhanced the mechanical strength of the scaffolds. Promising results were obtained for the development of bone cells on the prepared biocompatible, biodegradable, and antimicrobial composite scaffolds. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40110.