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Article Effectiveness of Boric Acid in Sepsis in Rats With Cecal Perforation(Springer Nature, 2025) Kurtipek, Ali Can; Dursun, Ali Dogan; Yigman, Zeynep; Ozdemir, Cagri; Kucuk, Aysegul; Gonullu, Ugur; Arslan, MustafaIntroduction and AimSepsis is a systemic inflammatory response that develops in the host against microorganisms, which results in end-organ damage. Boric acid (BA) has been shown to have immune modulatory effects in vitro and in animal studies. The aim of the study is to investigate the effects of high dose BA on lung and kidney tissues in rats with sepsis induced by the CLP method.Method28 rats were randomly divided into four groups: Group C (control group), Group BA, Group CLP (cecal ligation and puncture), and Group CLP + BA. Cecum was ligated below the ileocecal valve and punctured. BA was administered to the treatment groups at an intraperitoneal dose of 200 mg/kg, and at the end of 24 h, lung and kidney tissue samples were collected and evaluated for biochemical and histopathological parameters.ResultsHistopathologically, in kidney tissue, CLP + BA group showed significantly less peritubular capillary dilatation and brush border loss in the proximal tubule epithelium compared to the CLP group. In lung tissue, CLP + BA group had significantly less alveolar wall thickening compared to the CLP group. Biochemical analyses indicated that BA administration reduced oxidative stress in both renal and lung tissues.ConclusionWe found that intraperitoneal administration of high dose boric acid partially ameliorated the tissue damage in rats subjected to CLP induced sepsis. Further studies are needed regarding the dosage and application at different time points.Conference Object Citation - Scopus: 6The Use of Semi-Public Spaces as Urban Space and Evaluation in Terms of Urban Space Quality(Springer Nature, 2022) Orhan,M.The rapid physical change and increase in density of today’s cities lead to changes in urban space usage and habits in urban life. This change negatively affects the description and use of public spaces as socialisation spaces, which are one of the most significant urban components. As a result, city dwellers satisfy their need for public spaces with the use of different urban spaces. Urban life shifts from urban public spaces to semi-public spaces. Semi-public spaces are qualified and accessible spaces that ensure transition between private spaces (buildings) and public spaces. These spaces gain different attributes according to the characteristics (commerce, housing, tourism, etc.) of the urban spaces they coexist within and to the functions and designs of the structures surrounding them. These attributes determine their configuration as integrated or dissociated with the city and thus specify their relationship with the city. This relationship changes ‘city–space–structure–human’ interaction, and this change affects urban quality with the spatial quality of semi-public spaces. The aim of this study is to present how and related to which characteristics the use of semi-public spaces as urban spaces has changed, to detect the effects of this change on the urban environment and to establish the role of semi-public spaces in terms of urban quality. In conclusion, semi-public spaces with different characteristics located in different urban spaces will be examined as regards physical, schematic, functional characteristics and use within the scope of this study. In accordance with the data obtained by comparative analysis method, approaches to facilitate their use as urban spaces and to ensure their integration with the city will be introduced. Accordingly, criteria that semi-public spaces should possess in order to increase and sustain urban space quality will be determined. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.Book Part The Effect of Market Orientation on Performance of Private Hospitals: The Pivotal Role of the Marketing Function(Springer Nature, 2016) Tengilimoglu,D.; Atilla,E.A.; Dursun-Kilic,T.The objectives of this study are threefolded: (1) To measure the level of market orientation of private hospitals, (2) to examine the effects of the availability of a formal marketing department on market orientation and hospital performance, and finally (3) to examine the link between market orientation and performance of hospitals at the component level. Managers from 400 private hospitals in Turkey were surveyed with a usable response rate of 25 %. A positive connection was found between the level of the hospital’s market orientation and the presence of a marketing department in the hospital. The study results revealed that market orientation is positively related to general performance. According to the results of the component-level analysis, the three dimensions of market orientation had significant positive impacts on general performance. This study also showed that a statistically significant difference exists between the general performance assessments of the hospitals having a formal marketing department and of those not having a marketing department. Managerial implications of the results were discussed and study limitations and future research suggestions were also provided. © 2016, Academy of Marketing Science.Book Part Citation - Scopus: 7Vibration-Assisted Machining of Aerospace Materials(Springer Nature, 2022) Namlu, R.H.; Sadigh, B.L.Recent technologic advancements, especially in cutting-edge sectors like aerospace industries, call for new materials with superior properties. Like advanced engineering alloys, composites, and superalloys, these new materials provide the required specifications; however, to make use of these materials, they are needed to be formed into a final product. Machining is one of the most used manufacturing processes. Since in this process, the chip removal action occurs with direct contact between the cutting tool and workpiece, therefore, cutting materials with superior mechanical properties become a backbreaking process to be carried out. Along with the desired properties of the new advanced engineering materials in the aerospace industry, superior mechanical properties such as high wear resistance and low thermal conductivity of these materials lead to low machinability and difficulties in producing the desired end products by machining. As traditional machining methods are not efficient enough in machining such materials, new machining techniques have been invented to deal with these problems. Nontraditional machining processes are developed to deal with such obstacles that use chemical, electrochemical, thermal, and mechanical energy sources to facilitate the material removal process, reduce cost, and enhance product quality. However, in some cases, these methods’ low production efficiency forced engineers to combine the advantages of multiple machining methods in one hybrid process and improve the process efficiency by expediting the manufacturing process. One of these hybrid manufacturing methods is vibration-assisted machining. The vibration-assisted machining method aims to improve the material removal process by giving high frequency and low amplitude mechanical energy in vibrations to the workpiece or cutting tool. Vibration-assisted machining methods first emerged in the late 1960s and gained popularity in the early 2000s, and nowadays, research stages have gained momentum and are used even in mass production. Vibration-assisted machining has many benefits over traditional machining processes, like reducing costs, cutting forces, required power, secondary operations, cutting tool wear, and increasing the machined surface quality, tool life, and finally, the process performance. In this chapter, a detailed literature survey on the effects of vibration implementation on the performance of various machining processes, including turning, milling, drilling, and cutting advanced aerospace materials, is systematically summarized and discussed. At the end of this chapter, a case study is provided to understand the topic deeply. The detailed review shows that vibration-assisted machining enhances the cutting process in terms of cutting forces, tool wear, and surface roughness compared to traditional methods. Also, case study outcomes support those findings. Likewise, future studies show that vibration-assisted machining process still needs to be investigated deeply and it is a promising research area. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.Article Basin Evolution in the Gulf of Çandarlı Through Seismic Mapping, Aegean Sea, Offshore Türkiye(Springer Nature, 2025) Kılıç, B.O.; Uluğ, A.; Aydemir, A.Early Miocene lacustrine deposits possessing source rock and reservoir properties are characterised by seismic mapping in the Foça-Çandarlı Basin of the Turkish sector of the Aegean Sea. A similar petroleum system has also been recognised in the adjacent onshore Gediz and Bakırçay grabens. In this study, 800 km of seismic data acquired in 1975 and 1985 have been interpreted. Miocene and Pliocene horizons were mapped, and possible hydrocarbon traps were identified. In this context, the tectonic evolution of the Foça-Çandarlı Basin has been determined. The Foça-Çandarlı Basin opened under NE and SE extension during the Late Oligocene to Early Miocene. The tectonic regime shifted to a transpressional state due to the westward tectonic escape of Anatolia during its collision with the Aegean Block. As a consequence of this tectonic reversal, we observe a clockwise rotation in the compressional deformation along the southern margin of the basin. In contrast, the change may have involved a counterclockwise rotation in the north since the end of the Early Miocene. Faults at the basin boundaries were inverted, and the basin began to close from the west during the Mid-Late Miocene and Pliocene. The seismic mapping accurately demonstrates all these changes. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2025.Book Part Effects of Covid-19 and Recovery Process in the Turkish Tourism Industry(Springer Nature, 2023) Anasori,E.; Küçükergin,K.G.COVID-19 pandemic as the health crisis created an economic and social crisis in a great magnitude for the most countries. The current study analyses the emergent and growth of the coronavirus pandemic in Turkey and reviews the impact of this pandemic on the Turkish economy and society. This face-to-face interview based chapter finds that actions that are been taken by Turkish government during the crisis. Effects of this pandemic on the tourism sector is huge as Turkey is one of the leaders among international tourist destinations. So, consequences of this pandemic on the Turkish tourism sector and, managerial practices are explored in this study. Also, for attaining deeper insight of the impact of the pandemic, locals in the touristic city Antalya are interviewed. Strategies and practices that lead Turkey to handle the crisis successfully and maintain its resilience during this period were examined and highlighted. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.Book Part Text Mining and Topic Modeling in Education: Revealing Insights From Educational Textual Data(Springer Nature, 2025) Ekin, C.Ç.; Sabamehr, M.This book chapter explores the transformative potential of text mining and topic modeling in the field of education. With the exponential growth of digital educational content, the need for effective analysis and understanding of large-scale textual data has become crucial. The chapter provides an overview of text mining techniques, covering data preprocessing and information retrieval. It delves into topic modeling algorithm, Latent Dirichlet Allocation (LDA), and its applications in extracting latent themes from educational texts. The chapter highlights the diverse applications of text mining in education, such as analyzing student essays, academic publications, and online discussions. Leveraging sentiment analysis and opinion mining, it enables educators and administrators to gauge learner emotions and attitudes. Ethical considerations, including data privacy and bias, are also discussed, emphasizing the responsible use of text-mining technologies in educational contexts. In conclusion, “Text Mining and Topic Modeling in Education” serves as a valuable resource for educators, researchers, and policymakers, facilitating data-driven decision-making and fostering innovation in education. By empowering stakeholders with powerful analytical tools, this chapter propels education toward evidence-based practices and a more informed, equitable future. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.
