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Article Citation - WoS: 1Citation - Scopus: 1Topical Intranasal Insulin Enhances Healing of Nasal Mucosa: an Experimental Animal Study(Sage Publications inc, 2023) Kulekci, Cagri; Ozer, Serdar; Onen, Selin; Korkusuz, Petek; Yilmaz, TanerObjective Aim of this study was to evaluate the effect of topical intranasal insulin on healing of nasal mucosa in a rat model. Methods Forty-eight Wistar rats, weighing between 250 and 300 g and aged 10-12 weeks were used and randomized into two equal groups. 1.9 mm curette was introduced through the left nostril and 1.9 mm mucosa from the left nasal septum was curetted. Postoperatively, animals in the control group received 1 mL of physiologic saline, 3 times a day in a nasal irrigation fashion. Animals in the experimental group received 1 mL of 5 IU/mL regular insulin in saline solution. Subjects were sacrificed after 5, 10, and 15 days and macroscopic and histomorphometric evaluations were performed. Results There were no mucosal synechiae and septal perforation macroscopically. Histological examination revealed that the defect size reduction was 21% in the saline group versus 56% in the insulin group on the fifth day (p = 0.006). There was 62% defect reduction in the saline group versus 79% in the insulin group on the 10th day (p = 0.034). On the 15th day, only 67% of saline group animals had complete defect closure, whereas 100% of animals treated with insulin had complete closure (92% vs 100% mucosal defect reduction, p = 0.036). Both edema and inflammation were less in the insulin group on 15th day (p = 0.006; p = 0.023, respectively). Conclusion The results from this study support the safety and efficacy of topical insulin on wound healing in the literature. This study could guide further experimental studies that examine human sinonasal wound healing.Article Evaluation of Cochlear Angular Orientation in Patients with CHARGE Syndrome(Springer, 2026) Kulekci, Cagri; Eroglu, Ergin; Aydin, Canset; Sennaroglu, LeventPurpose This study aimed to evaluate cochlear angulation in patients with CHARGE syndrome and compare it with indi-viduals with normal cochlear anatomy. Methods Eighteen patients with CHARGE syndrome followed for sensorineural hearing loss were retrospectively reviewed and compared with 18 age-matched controls with normal cochlear anatomy. Temporal bone computed tomography (CT) and magnetic resonance imaging were analyzed to assess inner ear malformations and cochlear nerve status. Cochlear angula-tion was measured on axial CT images by calculating the angle formed between lines passing through the basal turns of both cochleae at the level of the round window. Statistical analyses were performed using chi-square and independent samples t-tests. Results Cochlear hypoplasia type III was the most common anomaly in the CHARGE group. Cochlear nerves were fre-quently hypoplastic or absent, whereas all control ears were normal. Mean cochlear angulation was significantly narrower in the CHARGE group compared with controls (94.49 degrees +/- 10.02 degrees vs. 114.02 degrees +/- 8.17 degrees, p < 0.001). Conclusion CHARGE syndrome is associated with significantly altered cochlear angulation, which may contribute to surgi-cal challenges during cochlear implantation. Preoperative recognition of this feature may facilitate safer and more effective surgical planning
