2 results
Search Results
Now showing 1 - 2 of 2
Article Citation - WoS: 2Citation - Scopus: 2Ultrafast Green Synthesis of Superparamagnetic Hybrid Nanoparticle for Advanced Applications(Wiley, 2025) Kibar, GunesThe integration of superparamagnetic iron oxide nanoparticles (SPIONs) into functional hybrid nanostructures remains a challenge, particularly in preserving their magnetic properties within composite frameworks. Herein, we present a rapid and environmentally friendly synthesis strategy for SPION-decorated polyhedral oligomeric silsesquioxane (POSS) nanoparticles. The process involves UV-induced polymerization to form POSS nanoparticles, followed by in situ SPION precipitation, with comprehensive characterization performed via SEM, FTIR, XRD, and VSM analyses. This approach enables the fabrication of hybrid nanoparticles (similar to 160 nm) within 5 min and subsequent SPION decoration in under an hour, ensuring (10 emu/g) superparamagnetic behavior. The developed method is highly scalable, efficient, and compatible with green chemistry principles, making it a promising platform for engineering advanced hybrid nanostructures. These nanoparticles hold significant potential for applications in biomedicine, catalysis, and next-generation material science.Article Citation - WoS: 2Citation - Scopus: 2Assessment of Anticancer Effects of Aloe Vera on 3D Liver Tumor Spheroids in a Microfluidic Platform(Wiley, 2025) Tevlek, Atakan; Kibar, Gunes; Cetin, BarbarosThe search for effective anticancer therapies has increasingly focused on natural compounds like Aloe vera, renowned for its therapeutic properties. This study investigates the anticancer properties of Aloe vera on 3D liver tumor spheroids via a PDMS-based microfluidic device, providing a more physiologically realistic model compared to traditional 2D cultures. HepG2 cells were cultivated to generate 3D spheroids on-chip, thereafter subjected to different concentrations of Aloe vera and the chemotherapeutic drug Doxorubicin to evaluate cytotoxic effects. The microfluidic system, validated by COMSOL simulations, facilitated continuous perfusion and real-time assessment of cell viability over a duration of 10 days. The results indicated that Aloe vera markedly diminished cell viability by triggering apoptosis at concentrations over 12.5 mg/mL. IC50 values were determined at 72 h: 25 +/- 0.10 mg/mL for Aloe vera and 5.47 +/- 0.03 mu g/mL for Doxorubicin in 2D cultures, but in 3D cultures, the IC50 values were 31.25 +/- 0.14 mg/mL for Aloe vera and 8.33 +/- 0.05 mu g/mL for Doxorubicin. This study underscores the promise of Aloe vera as a natural anticancer agent and illustrates the efficacy of microfluidic platforms for enhanced drug screening and customized medicine applications.
