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Article Citation - Scopus: 6Synthesis and Biological Study of Novel Indole-3 Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors(Bentham Science Publishers, 2013) Kurt,Z.K.; Aydin,D.; Işgör,Y.G.; Işgör,B.S.; Olgen,S.The aim of this study is to design and synthesize novel dual inhibitors of Src protein tyrosine kinase (PTK) and Glutathione S-transferases (GSTs), as a potential drug lead with therapeutic efficacy on cancer and immune disorders. The biological activity profiling of small molecule inhibitors via miniaturized biochemical techniques compatible with medium throughput screening and focused screening methodologies were performed. To determining the effects of small molecule inhibitors on Src kinase and Phase II detoxification enzyme GST isozymes in liver homogenates used to verify their roles in drug resistance mechanism for cancer chemotherapeutics. In this study, 14 indole-3-imine-2-on and N-benzyl indole-3-imine-2-on derivatives were synthesized for dual activities against Src and GST. The chemical structures and purities of compounds were verified by IR, 1H NMR, MASS spectroscopy, and elemental analysis. The compounds 2, 3 and 9 are found slightly active against both enzyme Src and GST. © 2013 Bentham Science Publishers.Article Modeling Surface Water Quality and Nutrient Correlation With Sediment Oxygen Demand at Dam Water Reservoirs(Technoscience Publications, 2022) Abdulqader,N.N.; Işgör,B.S.; Genç,A.N.; Güler,E.; Seymenoǧlu,V.C.The work presented here is a model approach based on WASP8 (Water analysis simulation program) a water quality model simulated to represent contaminants at the surface and bottom sediments of Kurtboǧazi dam reservoir in Ankara city. However, our water quality output variables: are temperature, nitrate, total phosphorus, total Kjeldahl nitrogen, dissolved oxygen, Chlorophyll a, and ammonia. To ensure the model represents the actual case at the reservoir, the results from the simulation model were calibrated using actual data from the Kurtboǧazi dam site, the calibration utilizes statistical techniques. The first method was the goodness-of-fit, R2 between model variables and field data, and the results were in the range of 0.86 to 1.0 indicating excellent linear association. The second technique was the RE, the values of which obtained were less than 1, elaborating acceptable results. The dam reservoir Kurtboǧazi had been affected by the negative impact arising from dissolved oxygen depletion in the hypolimnetic layer during stratification periods and that had been well documented. However, the processes of oxygen consumption at the sediment-water interface are still difficult to grasp conceptually and mainly linked to sediment oxygen depletion and the phenomena of sediment oxygen demand SOD. The novelty of this research work is the development of a quality model to predict the reactions of state variables that are occurring at the water body and how they interact with each other and their influence on the overall quality status of the Kurtboǧazi reservoir, and the crucial factors influencing the depletion of oxygen at the water column; secondly, the effect of anoxic condition on the benthic flux and the impact of anoxia condition on the ratio of nitrogen to phosphorus ratio at the reservoir. It was evident from the results of calibration that the model successfully simulated the correlation of the parameters influencing the anoxic condition, and benthic flux and ratio shift from nitrogen-limited during the summer to phosphorus-limited at the beginning of winter. © 2022 Technoscience Publications. All rights reserved.
