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Author: Hasirci, NesrinSubject: [No Keyword Available]

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    Article
    Citation - WoS: 25
    Citation - Scopus: 28
    Semi-Ipn Chitosan/Peg Microspheres and Films for Biomedical Applications: Characterization and Sustained Release Optimization
    (Amer Chemical Soc, 2012) Gunbas, Ismail Dogan; Sezer, Umran Aydemir; Iz, Sultan Gulce; Gurhan, Ismet Deliloglu; Hasirci, Nesrin
    Micro drug carriers are one of the efficient methods for local or systemic cancer treatment. In this study, the aim was to prepare a novel semi-interpenetrated (semi-IPN) micro system by using biocompatible chitosan (CH) and polyethylene glycol (PEG). Various combinations of the systems were prepared and loaded with a model chemotherapeutic drug, methotrexate (MTX), and the effects of composition on the properties and the release behavior of microspheres were examined. Also, the mechanical and thermal properties were examined on film forms of similar compositions. Increase in cross-linking caused a decrease in particle size of CH from 144 to 91 mu m, while the addition of PEG caused an increase up to 163 mu m. Elastic modulus values of the films first increased and then decreased parallel to PEG content. In vitro studies showed faster MTX release from semi-IPN CH-PEG microspheres as compared to pure CH ones. Promising results were obtained in the development of biodegradable drug vehicles.
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    Book Part
    Citation - WoS: 13
    Surface Modification of Polymeric Biomaterials
    (Blackwell Science Publ, 2013) Guney, Aysun; Kara, Filiz; Ozgen, Ozge; Aksoy, Eda Ayse; Hasirci, Vasif; Hasirci, Nesrin
    [No Abstract Available]
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    Article
    Citation - WoS: 8
    Citation - Scopus: 11
    Gentamicin Loaded Β-Tricalcium Phosphate/Gelatin Composite Microspheres as Biodegradable Bone Fillers
    (Wiley, 2012) Sezer, Umran Aydemir; Aksoy, Eda Ayse; Durucan, Caner; Hasirci, Nesrin
    In this study, novel composite bone fillers with microspherical shape, biodegradable property, and antibacterial effect were designed and prepared. Various fillers with different beta-tricalcium phosphate (beta-TCP)/gelatin (G)/glutaraldeyde (GA) compositions were loaded with a model antibiotic, gentamicin. The effect of composition and preparation conditions on the release of gentamicin was investigated in in vitro conditions. Complete release were observed in 12 h for pure beta-TCP powder, and this period was extended up to 96 h as the gelatin content increased in the microspheres. Morphological and chemical structures of the microspheres, before and after the release studies, were investigated by scanning electron microscopy and Fourier transform infrared, respectively. Antibacterial activities were examined against Escherichia coli by using disc diffusion method and promising results were obtained. It is proposed that these novel beta-TCP/G/GA microspheres can be applied locally to prevent and/or eliminate infection that might occur around a defected region of hard tissue and supports the healing process. POLYM. COMPOS., 2012. (c) 2012 Society of Plastics Engineers