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Book Part JAK Inhibitors/Drug Interactions(Springer Science+Business Media, 2025) Demirci Saadet, E.JAK inhibitors are a group of drugs that can affect the signaling of various cytokines simultaneously. The number of indications in dermatology has been increasing in recent years. JAK inhibitors are largely metabolized by the liver. Therefore, drug–drug interactions may occur when used with cytochrome P450 and CYP2C19 inhibitors or inducers, and drug dosages should be adjusted or not used together. In addition, OAT-3 inhibitors, which are known to play a role in renal elimination, interact with some JAK inhibitors, and dose adjustment is recommended. During treatment, drug–drug interactions should be reviewed in combination with JAK inhibitors and other drugs. © 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.Article Herpes Zoster Hastalarının Demografik ve Klinik Özelliklerinin Değerlendirilmesi(Selcuk University, 2023) Demirci Saadet, E.; Hasanbeyzade, S.Background: Herpes zoster is a disease that is more frequently seen in people aged over 50 years and negatively affects the quality of life due to the development of post-herpetic neuralgia. This study aimed to investigate the demographic and clinical characteristics of patients diagnosed with herpes zoster. Methods: In this cross-sectional study, the data of patients who were followed up with a diagnosis of herpes zoster at the dermatology department between 2013 and 2020 were retrospectively examined. Results: Of 440 patients, 252 (57.3%) were female and 188 (42.7%) were male. The mean age was 48.9±18 (4-94) years. The most common localization was the thoracic region at a rate of 35.5% and the lumbar region at a rate of 21.4%. Disseminated and ophthalmic zoster were more common in elderly patients (p<0.001). The most common comorbidities were hypertension (HT)+coronary artery disease (CAD) (12.6%), cancer (10.3%), and diabetes+HT (5.9%). Severe pain was observed in 19.7% of the patients and was more common in women (p=0.016). The rate of moderate and severe pain was high in the patients with HT+CAD and cancer (p˂0.001). Post-herpetic neuralgia was observed in 15.3% of the patients aged over 50. Conclusions: Herpes zoster is especially common in adults. Since it causes acute pain and can lead to postherpetic neuralgia development, risky patient groups should be more carefully followed up and treated. © 2023, Selcuk University. All rights reserved.Book Part Citation - Scopus: 1Safety, Toxicity Profile and Side Effects(Springer Science+Business Media, 2025) Demirci Saadet, E.; Türsen, B.Since Janus kinases mediate the effects of numerous inflammatory cytokines, various side effects are observed during treatment with JAK inhibitors that inhibit these kinases. Infections are the most common side effects. The development of malignancy, venous thromboembolism, major cardiovascular adverse events, nausea, acne, and various laboratory abnormalities has also been observed with the use of JAK inhibitors. With the long-term use of JAK inhibitors, their safety, toxicity and side effect profiles are better understood. © 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.
